20 results about "Membrane oxygenators" patented technology

The application provides a fixing device for a membrane oxygenator, and belongs to the technical field of fixing membrane oxygenators, and comprises a connecting plate, a fixing part is arranged on the back surface of the connecting plate, a longitudinal adjusting part is arranged on the connecting plate, a supporting part is arranged at the lower end of the longitudinal adjusting part, and a fastening part is arranged at the upper end of the longitudinal adjusting part. The application solves the problem that the existing fixing device for the membrane oxygenator is inconvenient to assemble and has low practicability when fastening the membrane oxygenator, and the problem that the fixing mode is relatively rigid and may cause damage to the outer wall of the membrane oxygenator.

This invention belongs to the field of extracorporeal circulation monitoring technology and discloses a multi-parameter linkage monitoring system for an artificial heart-lung machine, including an artificial heart-lung machine circuit, a detection component, an execution component, and a controller. The artificial heart-lung machine circuit includes a venous drainage line, a blood reservoir, a blood pump, a membrane oxygenator, an arterial perfusion line, and a gas supply line. The detection component is used to detect venous pressure, fluid level, pressure before and after the membrane oxygenator, arterial perfusion flow rate, blood oxygen, and gas supply pressure and flow rate. The controller performs time alignment on the detection signals within the same sampling period and, combined with changes in similar detection signals in adjacent sampling periods, distinguishes between insufficient drainage, increased membrane oxygenator resistance, and abnormal gas supply, outputting corresponding deceleration, speed limiting, gas supply adjustment, gas supply switching, pump shutdown, alarm, and lockout control signals. This system is used for linkage monitoring and control of abnormal sources in the extracorporeal circulation circuit.

This invention relates to a membrane oxygenator performance testing device and method. The membrane oxygenator performance testing device includes a gas input component and a liquid circulation component. The gas input component's outlet is connected to the membrane oxygenator's inlet to input gas into the membrane oxygenator. The liquid circulation component has a liquid outlet and a liquid return end; the liquid outlet is connected to the membrane oxygenator's liquid inlet, and the liquid return end is connected to the membrane oxygenator's liquid outlet. The liquid circulation component provides power to circulate liquid within the membrane oxygenator. The gas input component can adjust and acquire the gas pressure at the outlet; and / or, the liquid circulation component can adjust and acquire the hydraulic pressure at the outlet. The aforementioned membrane oxygenator performance testing device can test both its performance against gas burst pressure and its performance against liquid burst pressure.

The invention relates to the technical field of organ preservation, in particular to a portable oxygen supply device and method for organ perfusion and transfer. The module comprises a portable oxygen generator, an air-oxygen mixer, a gas supercharging device and a control unit. High-concentration oxygen is generated through the oxygen generator, the high-concentration oxygen is mixed with ambient air according to needs through the air-oxygen mixer, and then the mixture is pressurized and conveyed to the membrane type oxygenator. According to the invention, a high-pressure gas cylinder is abandoned, and the problems of transportation limitation, poor portability, logistics dependence and the like are solved. A degradation working mode and safety redundancy are innovatively introduced, when the main oxygen generation system breaks down, the system can be automatically switched to ambient air for oxygen supply, and the reliability of the system is greatly improved. Meanwhile, an intelligent closed-loop control function based on metabolic feedback is achieved, and gas parameters can be dynamically adjusted to optimize the organ maintenance state. The safe, portable, intelligent and efficient oxygen supply source is realized, and the efficiency of organ transplantation and transfer is greatly improved.

The application discloses a method for adjusting the pressure of a main pump in an extracorporeal circulation process, and the method comprises the following steps: after the pre-charging of a membrane oxygenator is completed, an arterial pipeline connected with the membrane oxygenator is clamped and closed, and only a small side pipeline is left to communicate with the membrane oxygenator; a pump pressure gauge is arranged on the small side pipeline; the main pump is adjusted to a required position, and the pressure of the main pump on the circulating pipeline is adjusted, and the pressure is adjusted to 150mmHg-250mmHg. The specific pressure value of the main pump when the pressure is adjusted is displayed by the pump pressure gauge, so that the adjustment process and result can be visualized, the adjustment result is converted into the specific pressure value of the pump pressure gauge, the reference data of the adjustment of the pressure of the main pump is standardized, the adjustment precision is effectively ensured without relying on experience and feeling, the adjustment mode is quick and accurate, the adjustment efficiency can be improved, and the stability of the adjustment pressure is ensured by controlling the pressure of the main pump, so that the backflow of arterial blood caused by unstable pressure can be avoided.

The invention discloses a woven membrane with an inclination angle, a double-layer woven degassing membrane prepared from the woven membrane and application of the double-layer woven degassing membrane. The woven membrane is formed by weaving a plurality of membrane filaments and weaving yarns, and the weaving direction of the membrane filaments and the weaving direction of the weaving yarns form a non-vertical included angle; the double-layer woven membrane comprises two woven membrane pieces, one woven membrane piece is rotated by 180 degrees in the warp direction and then attached to the other woven membrane piece, and a liquid flow channel with non-parallel wall faces is formed between the two woven membrane pieces. The prepared double-layer woven degassing film can actively enhance fluid disturbance and improve the mass transfer coefficient; according to the membrane type oxygenator prepared by using the degassing membrane, the pre-filling amount can be reduced to an acceptable range of small animals.

The invention belongs to the technical field of hollow fibers, and discloses a co-extruded asymmetric poly (4-methyl-1-pentene) hollow fiber as well as a preparation method and application thereof. The method comprises the following steps: plasticizing, melting and extruding a mixture of poly (4-methyl-1-pentene) with a low melt index, poly (4-methyl-1-pentene) with a high melt index and polyolefin by adopting a twin-screw extruder, cooling, pelletizing and drying to obtain a polymer blend; the preparation method comprises the following steps: respectively adding a blend of poly (4-methyl-1-pentene) with a high melt index and a polymer into different extruders, carrying out co-extrusion molding, cooling and traction to obtain primary fibers of poly (4-methyl-1-pentene) hollow fibers; the primary fiber of the fiber is subjected to stretching and pore forming at the temperature of 60-90 DEG C and heat setting at the temperature of 70-100 DEG C, the co-extruded asymmetric poly (4-methyl-1-pentene) hollow fiber is obtained, the outer layer is poly (4-methyl-1-pentene) with the high melt index, the inner layer is a polymer blend, and the co-extruded asymmetric poly (4-methyl-1-pentene) hollow fiber can be applied to the field of in-vitro membrane lung oxygenators.

The invention provides a membrane type oxygenator and blood storage device assembling structure, and belongs to the technical field of medical instruments, the membrane type oxygenator and blood storage device assembling structure comprises a blood storage device body and a membrane type oxygenator body, the bottom of the blood storage device body is fixedly connected with an upper butt joint pipe in a penetrating mode, the top of the membrane type oxygenator body is fixedly connected with a lower butt joint pipe in a penetrating mode, and a plugging piece is arranged at the bottom of the upper butt joint pipe; and the plugging piece is connected with the lower butt joint pipe through an assembly piece. The membrane type oxygenator and blood storage device assembly structure solves the problems that an existing membrane type oxygenator and blood storage device assembly structure is mostly assembled in a threaded connection mode, the assembly mode cannot guarantee the anti-leakage function of the butt joint position, normal work between a membrane type oxygenator and a blood storage device cannot be guaranteed once leakage occurs, butt joint can be completed only through repeated rotation, and the work efficiency is high. And the use is relatively inconvenient.

The invention belongs to the technical field of extracorporeal membrane lung oxygenation, and provides a volute type square box laminated structure membrane lung oxygenator and a pre-filling method thereof.A volute type runner is arranged in a square box laminated structure of the square box laminated structure membrane lung oxygenator and comprises a spiral section and a plurality of flow dividing sections, the input ends of the flow dividing sections are connected with the spiral section, and the output ends of the flow dividing sections are connected with the spiral section; the output end is located at the internal corner position of the square box laminated structure, high-flow-speed pre-filled liquid enters the spiral section at the inlet, then flows to the flow dividing section under the high-speed inertia effect and preferentially flows to the internal corner position of the square box laminated structure, and the effect of discharging bubbles at the four corners of the square box laminated structure is guaranteed. Moreover, by means of the cooperation of the volute type flow channel and the high-speed pre-filled liquid, the flushing capacity of all positions in the membrane lung oxygenator is improved, the membrane lung oxygenator does not need to be shaken, oscillated and the like, the workload of medical staff is reduced, and the problem that consumable items are damaged due to improper shaking and flapping actions is solved.

The invention relates to the technical field of fixing devices, in particular to a membrane lung oxygenator integrated support which comprises a fixing plate, a locking mechanism, a clamping and pushing mechanism, a dehumidifying mechanism and a drying mechanism. The connector of the blood inlet and outlet pipeline and the oxygenator is wrapped and locked through the locking sleeve, the pipeline is clamped through the clamping pin, the clamping pin is forced to drive the pipeline to keep the inserting tendency of the oxygenator through the pull-back effect of the jacking spring, so that the connection tightness is guaranteed, condensate water generated by the outer wall of the pipeline is absorbed through the absorbent cotton, and the water absorption effect is improved. The air heater is communicated with the guide pipe and the air blowing box to blow hot air into the cavity, so that the wet absorbent cotton and the connecting cotton can be subjected to hot air drying, the condensate water absorption effect of the absorbent cotton is guaranteed, and the temperature is kept relatively stable.

This invention belongs to the technical field of biomedical materials, artificial organs, and extracorporeal circulation support devices, and relates to a hydrophilic modified siloxane hollow fiber composite membrane, its preparation method, and its applications. The hydrophilic modified siloxane hollow fiber composite membrane consists of a porous hollow fiber base membrane and a dense hydrophilic organosilicon functional layer constructed on the outer surface of the porous hollow fiber base membrane. Based on the hydrophilic modified siloxane hollow fiber composite membrane, this invention further constructs a small membrane oxygenator based on this composite membrane, which can be used for extracorporeal circulation gas exchange and is suitable for establishing animal extracorporeal circulation models and preclinical experimental studies. This device features a compact structure, high gas exchange efficiency, low blood damage, and good operational stability.

The application relates to a simulated lung for detecting a physiological closed-loop control function of a breathing machine, comprising a blood circulation system, in which blood circulates; a gas circulation system, in which oxygen circulates; the gas circulation system and the blood circulation system are independent of each other; a membrane oxygenator for realizing blood-oxygen exchange; the blood circulation system circulates blood through the membrane oxygenator, and the gas circulation system circulates oxygen through the membrane oxygenator; a data acquisition system connected with the blood circulation system at one end to realize blood data monitoring; and connected with the gas circulation system at the other end, wherein the gas circulation system adjusts ventilation according to the blood data. Compared with the prior art, the application combines the membrane oxygenator with the water-sealed simulated lung to detect the breathing machine with the PCLC function, so that the accuracy, reliability and safety of the breathing machine can be improved.

The application relates to a spiral guide integrated membrane oxygenator, which comprises a lower cover with an air outlet pipe, an oxygenation part including a mandrel structure, an oxygenation shell and an oxygenation wire membrane structure, the oxygenation shell being provided with a blood outlet pipe, and an upper cover provided with a blood inlet pipe and an oxygen inlet pipe, the oxygen inlet pipe and the air outlet pipe being communicated with the space between the mandrel structure and the oxygenation shell; wherein the mandrel structure comprises a mandrel body and an annular guide plate, a blood passage is arranged between the first end and the upper cover, the annular guide plate is provided with a plurality of guide holes, and the plurality of guide holes of the annular guide plate are distributed on the annular guide plate; the oxygenation wire membrane structure comprises a plurality of hollow fiber layers, each hollow fiber layer is provided with a plurality of hollow fiber pipes, the plurality of hollow fiber pipes are inclined at an angle relative to a vertical plane, and the inclined directions of the plurality of hollow fiber pipes of each hollow fiber layer are different from and cross the inclined directions of the plurality of hollow fiber pipes of adjacent hollow fiber layers. In this way, the utilization rate of the wire membrane structure and the oxygenation efficiency can be improved.

The present application relates to the technical field of membrane oxygenator products, and particularly relates to a membrane oxygenator plasma leakage testing device and a testing method thereof. The membrane oxygenator plasma leakage testing device comprises a gas supply device, a fluid circulation device, a condensation device, a leakage collection device and a weight measuring device. The gas supply device is connected to a gas inlet of the membrane oxygenator. The fluid circulation device is arranged outside the membrane oxygenator and connects a fluid inlet and a fluid outlet. The leakage collection device is connected to a gas outlet of the membrane oxygenator through the condensation device. The weight measuring device can measure the weight of the leakage amount of the leakage collection device. The membrane oxygenator plasma leakage testing device has simple components and simple connection relationship, and can be configured according to actual application scenarios.

The invention relates to the technical field of medical equipment, and provides an extracorporeal circulation cannula which comprises a cannula body. A first opening area is arranged at the position, away from the first end by a first distance, of the side wall of the cannula body, and a plurality of first side holes are formed in the first opening area. The first side holes are arranged in the side wall of the cannula body in an array mode. According to the intubation tube for extracorporeal circulation, the first end of the intubation tube body is inserted into the venous blood vessel and communicated with the venous blood vessel, and the second end of the intubation tube body is communicated with the external equipment, so that the intubation tube is matched with the external equipment and the arterial intubation tube to form a circulation loop, and blood is drained out of the body from the body; after being subjected to gas exchange by the membrane type oxygenator, the gas is transfused back into the body through the arterial cannula to temporarily replace the cardiopulmonary function, so that rescue treatment is provided for critical patients; meanwhile, the first side holes which are arranged in an array mode are formed in the position, close to the first end, of the cannula body, the first side holes can effectively improve the flow field near an outlet of the cannula, and the recirculation rate can be reduced easily.

This invention discloses a method for integrating and optimizing the arterial filtration function of a membrane oxygenator, relating to the field of membrane oxygenator technology. The method includes the following steps: setting performance target parameters for an integrated membrane oxygenator; using a dynamic tension control process to wind gas exchange membrane fibers around its periphery to construct a temperature-changing unit and an oxygenation unit; during the winding process in step S2, placing multi-layer filter screens at preset positions to construct multi-layer filter screens between the gas exchange membrane fiber layers; using a centrifugal potting process to inject encapsulation material into the end of the component, curing it in one step to form a sealed end that isolates the blood phase, gas phase, and water phase; introducing a biomimetic coating solution into the molded blood channel to construct a biocompatible coating on the substrate surface; performing performance tests on the finished product and comparing it with the performance target parameters in S1; adjusting the process parameters of at least one step from S2 to S5 based on deviation feedback until the product meets the standards; this invention ensures the consistency and compliance rate of product performance.

Disclosed is a method for treating a renal condition by loco-regional perfusion of one or both of a patient's kidneys. A closed circuit may be formed with a perfusion catheter positioned in the renal artery of the kidney, a recovery catheter positioned in the renal vein of the kidney, and an external membrane oxygenator disposed therebetween. A perfusate containing, for example, a drug may be circulated through the closed circuit while isolating the closed circuit from the patient's systemic circulation.

The application belongs to the technical field of extracorporeal membrane oxygenation, and provides a volute type square box laminated structure membrane oxygenator and a pre-charging method thereof. In the square box laminated structure membrane oxygenator, a volute type flow channel is arranged in the square box laminated structure, the volute type flow channel comprises a spiral section and a plurality of shunt sections, the input end of the shunt section is connected with the spiral section, and the output end is located at the internal corner position of the square box laminated structure. After the high-flow-rate pre-charging liquid enters the spiral section at the inlet, the pre-charging liquid flows to the shunt section under the high-speed inertia effect, preferentially flows to the internal corner position of the square box laminated structure, and the bubble discharge effect at the four corners of the square box laminated structure is ensured. In addition, by means of the cooperation of the volute type flow channel and the high-speed pre-charging liquid, the flushing capacity of each position in the membrane oxygenator is improved, the shaking and oscillation operations of the membrane oxygenator are not needed, the workload of medical staff is reduced, and the problem of damage to consumables caused by improper shaking and beating actions is avoided.

The application discloses a kind of cardioplegic solution perfusion monitoring device and monitoring method, it is related to medical instrument technical field.The device includes cardioplegic solution perfusion pipeline, cardioplegic solution backflow pipeline, membrane oxygenator, first detection sensor and second detection sensor;The input end of cardioplegic solution perfusion pipeline is suitable for being introduced into cardioplegic solution, and the output end of cardioplegic solution perfusion pipeline is suitable for being inserted in heart;The input end of cardioplegic solution backflow pipeline is suitable for being communicated with heart chamber;The output end of cardioplegic solution backflow pipeline is communicated with membrane oxygenator;First detection sensor is arranged on cardioplegic solution perfusion pipeline, and first detection sensor is used to detect the composition of cardioplegic solution transported to heart;Second detection sensor is arranged on cardioplegic solution backflow pipeline, and second detection sensor is used to detect the composition of cardioplegic solution extracted backflow by heart chamber.The application provides a kind of cardioplegic solution perfusion monitoring device and monitoring method, realizes the monitoring of cardioplegic solution composition, is helpful to improve myocardial protection effect and reduce the risk of postoperative complication of heart.

The invention relates to the technical field of medical instruments, and provides a membrane oxygenator, which is characterized in that a shell assembly is provided with an air inlet and an air outlet; the membrane core is arranged in the shell assembly and comprises a hollow fiber membrane bundle for gas exchange; the at least one gas inlet buffer distribution cavity is arranged on a gas flow path between the gas inlet and the membrane core, and the internal structure of the gas inlet buffer distribution cavity is configured to be used for prolonging the gas flow path and changing the gas flow direction before gas enters the hollow fiber membrane bundle; therefore, gas is uniformly distributed when entering the cross section of the hollow fiber membrane bundle. According to the invention, by introducing the structured gas inlet buffer distribution cavity, the flow field form of the gas is pretreated from destructive and low-efficiency point-shaped injection pretreatment to uniform planar propulsion before the gas is in contact with the functional membrane material, so that the pressure of the gas entering the cross section of the inlet of the membrane core is highly consistent; and a local high-pressure area and a far-end low-pressure dead area caused by gas direct flushing are eliminated.