62 results about "Membrane oxygenators" patented technology

The invention discloses a microcapsule floating fluid-bed biological reactor of artificial liver in the medically biological technical domain, which is characterized by the following: displaying hopper shape with small bottom radius and large top radius; setting cell screen 8 at upper neck and cell screen 7 at lower bottom; depositing cell filter 8 at liquid outlet 2; setting buffer cavity 12 between liquid inlet 1 and cell screen 7, and between cell filter 11 and cell screen 8 respectively; containing the microcapsule liver cell 9 between cell screen 8 and cell screen 7; making the liquid inlet connect the membrane oxygenator 14 to connect immune adsorber 15 to adsorb immune macromolecule. The invention makes the moving trail of flow impaction as adjustment parabola to satisfy the character of fluid mechanics, which avoids dead perfusion cavity and ineffective perfusion to develop treating effect of biologically artificial liver obviously.

The invention relates to a membrane type oxygenator which comprises a lower cover, an oxygenation portion and an upper cover. The lower cover is provided with an air outlet tube, the oxygenation portion is arranged in the lower cover and comprises a mandrel structure, an oxygenation housing and an oxygenating silk film structure, the oxygenation housing is provided with a blood outlet tube, and the blood outlet tube is close to the lower cover. The upper cover is arranged on the oxygenation portion and is provided with an eddy structure, a blood inlet structure and an oxygen inlet tube, and the eddy structure corresponds to the mandrel structure. The mandrel structure comprises a mandrel body and an annular guide plate, the mandrel body is provided with a first end and a second end, a blood channel is formed between the first end and the eddy structure, and the mandrel body is sleeved with the annular guide plate. The mandrel structure of the membrane type oxygenator is provided with the annular guide plate, the annular guide plate guides blood diffusion, the contact area and the diffusion area of blood and the silk film structure are increased, and the utilization rate of the silk film structure is improved.

The invention relates to a spiral flow-guide integrated membrane oxygenator comprising a lower cover, an oxygenation portion and an upper cover. The lower cover is provided with an air outlet pipe. The oxygenation portion is arranged to the lower cover and comprises a spindle structure, an oxygenation shell and an oxygenation cortina structure, and the oxygenation shell is provided with a blood outlet pipe close to the lower cover. The upper cover is arranged to the oxygenation portion and is provided with a blood inlet pipe and an oxygen inlet pipe. The spindle structure comprises a spindle body and an annular flow guide plate, the spindle body is provided with a first end and a second end, a blood channel is formed between the first end and the upper cover, the annular flow guide plate sleeves the spindle body and is provided with at least one flow guide through hole, and the flow guide through holes of the annular flow guide plate are distributed in the annular flow guide plate. The spindle structure of the spiral flow-guide integrated membrane oxygenator is provided with the annular flow guide plate, the annular flow guide plate guides blood to diffuse through the flow guide structure with the flow guide through holes, contact area and diffusion area of blood and the cortina structure are increased, and utilization rate of the cortina structure is increased.

The invention relates to a membrane structure and a membrane-type oxygenator. The membrane structure includes multiple first hollow fiber layers and multiple second hollow fiber layers arranged with the first hollow fiber layers in a staggered mode, and each first hollow fiber layer and each second hollow fiber layer are provided with a plurality of hollow fiber pipes arranged in an annular mode respectively; the section of each hollow fiber pipe has a minimum circumscribed circle and a maximum inscribed circle; each hollow fiber pipe of each first hollow fiber layer forms an included angle with each hollow fiber pipe of the corresponding adjacent second hollow fiber layer. According to the membrane structure and the membrane-type oxygenator using the membrane structure, the membrane structure can effectively reduce pre-loading volume of blood, and decrease the blood pressure to avoid damage to the blood; shunting of the blood can be achieved to make the blood form a thin blood membrane, increase the contact area between the blood and oxygen, and improve the oxygenation efficiency of the blood and the oxygen.

The invention discloses a filling rack perfusion biological reactor of artificial liver in the medically biological technical domain, which is characterized by the following: the appearance is cylinder shaped container; the liquid outlets 1 and 2 are upper and lower ends of the cylinder container; the outlet 3 and 4 are distributed in the center of lateral wall symmetrically; the physical rack 6 has 14-16 biological racks as crossing arrangement to deposit separation area and support liver cell; the liquid buffer area 7 is set in the middle of the inner rack of the reactor; setting cell screen and cell screen brush at outlet; connecting the upstream of two outlets of biological reactor with membrane oxygenator 14; connecting the downstream of two outlets with immune adsorber 15; the biological rack of the liver cell is chitose rack or alginic acid/chitose and modified alginic acid/galactose chitose/heparin rack; possessing good biological compatibility; fitting for growing liver cell and developing the function; avoiding collapse of the biological rack of the liver cell.

A system and method for perfusing an organ with a normothermic extracorporeal perfusion system is disclosed. The perfusion system is an active flow system using a centrifugal pump to aid in circulation. The system includes a dialyzer that removes excess fluid and impurities, while maintaining the pH, which allows the perfusion system to be used for an extended period that may exceed 24 hours. The system includes a parallel circuit, which includes at least one centrifugal pump, a membrane oxygenator comprising a heat exchanger; a dialyzer; a measurement cell for real-time monitoring of oxygen saturation and hematocrit in the liver; more than one flow probe; and an organ chamber.

Disclosed is a an economical method of efficiently oxygenating yeast slurry without bubble formation. The method employs a membrane oxygenator comprising at least one hydrophobic, microporous membrane having a gas side and a liquid side. The yeast slurry flows over the liquid side of the membrane; oxygen is delivered to the gas side of the membrane and passes through the pores to the yeast slurry.

The invention relates to a double-spiral stream guidance integrated membrane oxygenator, which comprises a lower cover, an oxygenation part and an upper cover, wherein a venting tube is arranged on the lower cover; the oxygenation part is arranged on the lower cover and comprises a mandrel structure, an oxygenation shell and an oxygenation silk film structure; a blood discharge tube is arranged on the oxygenation shell, and the blood discharge tube is close to the lower cover; the upper cover is arranged on the oxygenation part and is provided with a blood feeding tube and an oxygen feeding tube, wherein the mandrel structure comprises a mandrel body and an annular stream guidance plate; the mandrel body is provided with a first end and a second end; a blood passage is kept between the first end and the upper cover; the annular stream guidance plate sleeves the mandrel body; and the annular stream guidance plate is provided with at least one blood passing port and at least one spiral stream guidance groove which are distributed in an annular form. According to the double-spiral stream guidance integrated membrane oxygenator provided by the invention, by virtue of the mandrel structure, blood spread is guided by virtue of the annular stream guidance plate which is of a stream guidance structure provided with the spiral stream guidance groove, so that a contact area and a spread area of blood and a silk film structure are increased, and the utilization rate of the silk film structure is improved.

The invention relates to a normal-temperature in-vitro heart transfer device which comprises a protective shell, a first cover and a base, universal wheels are arranged at the bottom of the base, a temperature adjusting pipeline is arranged on the inner wall of the protective shell, a partition plate is arranged in the protective shell, and a heart storage device is arranged above the partition plate. The heart storage device is fixedly connected with the partition plate through a fixing rod. A peristaltic pump, a heart perfusate storage device, a temperature changer, a membrane oxygenator anda heart perfusate filter are arranged on the upper part of the base, and the heart storage device, the heart perfusate filter, the peristaltic pump, the heart perfusate storage device, the temperature changer and the membrane oxygenator are sequentially communicated through a perfusate conveying pipe. The cardiac perfusate filter is positioned on the bottom end surface of the partition plate; a buzzer, an operation panel and a control box are arranged on the front end face of the protective shell, and a second cover is arranged on the lower portion of the front end face of the protective shell.

The invention provides a membrane oxygenator with high-efficiency gas-fluid exchange. The membrane oxygenator mainly comprises parts including a carbon discharge chamber, an oxygenation chamber, a temperature control chamber, a vacuum pump, a pure oxygen cylinder, a flow meter and the like. When flowing through a hollow silicone hydrogel tube placed in the carbon discharge chamber, venous blood drained from a human body permeates a tube wall to release carbon dioxide into a chamber body; a vacuum pump is utilized to apply micro-negative pressure to the carbon discharge chamber, so that the carbon dioxide is efficiently discharged; then the blood flows into a hollow silicone hydrogel spiral tube placed in the oxygenation chamber, and the pump is utilized to apply micro-positive pressure tothe oxygenation chamber, so that oxygen enters the blood efficiently and is combined with red blood cells; and the carbon discharge chamber and the oxygenation chamber are both placed in the temperature control chamber. The membrane oxygenator of the invention performs discharge of the carbon dioxide and absorption of oxygen in the blood step by step, and supplemented by a moderate negative pressure environment and positive pressure environment, the gas-fluid exchange efficiency can be effectively improved, the situation that acral necrosis of a patient is caused by using an existing oxygenator for long term to threaten life is avoided, the treatment rate is increased and sequelae are reduced.

The embodiment of the invention provides a membrane oxygenator. The membrane oxygenator comprises a shell, an oxygenation structure, a heat exchange structure and a first flow guide structure, wherein the oxygenation structure, the heat exchange structure and the first flow guide structure are arranged in the shell; a blood inlet channel, a blood outlet channel, an air inlet channel and an air outlet channel are formed in the shell; a through hole communicated with the blood inlet channel is formed in the first flow guide structure, and a blood outlet groove communicated with the through hole is formed in the side face of the first flow guide structure; the heat exchange structure and the oxygenation structure are sequentially arranged on the periphery of the first flow guide structure from inside to outside, and the oxygenation structure is communicated with the air inlet channel and the air outlet channel in the shell; and blood sequentially passes through the blood inlet channel, the first flow guide structure and the heat exchange structure on the shell, flows to the oxygenation structure to be oxygenated and flows out of the blood outlet channel. According to the membrane oxygenator, the first flow guide structure is arranged in the middle of the interior of the shell, the effect that the blood is evenly distributed in the oxygenator is effectively achieved, and the oxygenation efficiency of the oxygenator is high.

The invention discloses a life rescue box for first aid of sudden cardiac arrest and acute respiratory failure patients, which is characterized in that main components such as a blood pump, a membrane oxygenator and the like required by extracorporeal life support are assembled in the life rescue box, and the blood pump and the membrane oxygenator are fastened on an upright post in a magnetic force manner; the blood pump is provided with a first interface and a second interface, wherein the first interface is connected with a venous cannula, and the second interface is connected with the membrane oxygenator through a connecting pipe; and the membrane oxygenator is provided with a first interface and a second interface, wherein the first interface is connected with an arterial cannula, and the second interface is connected with the blood pump through a connecting pipe to form a blood circulation loop with the blood vessel of human bodies for alternatively completing the cardio-pulmonary function of the sudden cardiac arrest and acute respiratory failure patients. Due to small size, the life rescue box can be carried with an ambulance and an on-vehicle stretcher, is convenient to move and simple to operate, can reach the primary disease outbreak scene with medical personnel in the shortest time during first aid and can be generally used for the first aid of the sudden cardiac arrest and acute respiratory failure patients.

The invention provides a poly (4-methyl-1-pentene) hollow fiber alloy membrane as well as a preparation method and application thereof. The poly (4-methyl-1-pentene) hollow fiber alloy membrane comprises 100 parts by weight of poly (4-methyl-1-pentene) and 0.1-50 parts by weight of a fluorine-containing polymer. The poly (4-methyl-1-pentene) hollow fiber alloy membrane provided by the invention not only has excellent mechanical strength and gas permeability, but also has excellent oleophobicity and blood compatibility, and can be used in a membrane oxygenator and an in-vitro membrane lung oxygenation system.

The invention discloses a cardiopulmonary bypass system. The system comprises a monitoring main unit, a portable monitoring main unit, a pump and a membrane-type oxygenator. The monitoring main unit and the portable monitoring main unit are electrically connected with the pump, the pump is connected with the membrane-type oxygenator through a pipeline, the pump and the membrane-type oxygenator areconnected with an in vivo blood vessel through medical inserting pipes respectively, and when the blood in the in vivo blood vessel is circulated through the pump and the membrane-type oxygenator, the state of the blood is monitored through the monitoring main unit and the portable monitoring main unit. The cardiopulmonary bypass system has the advantages that the system is provided with double monitoring main units, the monitoring main units can be separately used or simultaneously used, wherein the weight of the portable monitoring main unit is lower than that of the monitoring main unit, and the portable monitoring main unit can be conveniently carried and used in an emergency state when emergency and hospital transferring are conducted.

The invention discloses a cell circulation biological artificial liver device with oxygen supply, relates to the technical field of medical equipment, and solves the technical problems of improving working efficiency and liver cell activity. The artificial liver device comprises a blood introducing pipe, a blood returning pipe, a hepatocyte pump, a membrane oxygenator, a cell culture device, two-stage plasma separators and two-stage blood pumps; after the blood in the body of a patient is led out by the blood introducing pipe, the blood sequentially passes through a primary blood pump, the primary side of a primary plasma separator and the blood returning pipe, and then returns to the body of the patient; the plasma separated from the secondary side of the primary plasma separator sequentially passes through a secondary blood pump, the primary side of a secondary plasma separator and the blood returning pipe, and then returns to the body of the patient; and after matrix carrying hepatocytes in the cell culture device flows out from a liquid outlet, the matrix sequentially passes through the secondary side of the secondary plasma separator, the hepatocyte pump and the membrane oxygenator, and then returns to the cell culture device. The artificial liver device provided by the invention can realize the functions of detoxification, metabolism and synthesis of the liver.

An extracorporeal circulation machine remaining blood reinfusion device comprises a venous cannula, a venous blood return chamber, a power pump, a membrane oxygenator, a fine thrombus filter, a main artery cannula and a blood recovering machine, wherein the venous cannula, the venous blood return chamber, the power pump, the membrane oxygenator and the fine thrombus filter are sequentially connected through extracorporeal circulation pipelines, and the blood recovering machine is connected with the main artery cannula. The main artery cannula is connected with the blood recovering machine through a pressure lengthening pipe, and normal saline is connected with an inputting opening of venous blood return chamber. The device has the advantages that the device can ensure that the extracorporeal circulation pipelines are always in state capable of transferring at any time after extracorporeal circulation is completed, blood in the pipelines is timely recovered and reinfused into the body of a patient, and the machine blood reinfusion method is safe, effect and economical and saves blood resources.

The invention discloses a method for adjusting dissolved gases in boiler feed water. The steam of a boiler forms condensed water after the work of a steam turbine; the condensed water flows out of a condenser and enters a polishing apparatus through a condensed water pump; the condensed water is subjected to degassing or oxygenation treatment by a membrane degasser or membrane oxygenator, wherein the membrane degasser is connected with a vacuum pump, and the membrane oxygenator is connected with an oxygen bottle; the treated water enters the boiler through a low-pressure heater, a water feed pump and a high-pressure heater; and the membrane degasser and the membrane oxygenator are fiber membrane contactors. According to the adjusting method, a fiber membrane is adopted as a gas-liquid exchange interface; according to different water qualities, membrane degassing treatment is carried out in AVT (all-volatile treatment) working condition, and membrane oxygenation treatment is carried out in OT (oxygenated treatment) working condition; and the gas content of the boiler feed water can be quickly and accurately adjusted, the flow accelerated corrosion (FAC) is avoided, and the operation safety of the unit is improved.

The invention relates to a membrane oxygenator. The membrane oxygenator comprises a cavity, a blood inlet and a blood outlet, wherein the blood inlet and the blood outlet are formed in two ends of thecavity; the cavity comprises a diffusion section, an oxygenation section, a gathering section and an observation section which sequentially communicate; the front end of the diffusion section is connected with the blood inlet; an oxygen inlet is formed in the upper part of the oxygenation section, a gas outlet is formed in the lower part of the oxygenation section, the oxygenation section is divided into a plurality of flow guide channels by a plurality of flow guide partition pieces in the cavity, and hollow oxygenation wires arranged in an array mode are arranged in the flow guide channels;and a flexible single-end free piece is connected to the tail part of each flow guide partition piece, and is located in the observation section, and the tail end of the observation section is connected with the blood outlet. In the process that blood passes through the oxygenator cavity in the radial direction, due to the fact that the first-order derivative of a flowing space sectional area iscontinuous and the second-order derivative of the flowing space sectional area is zero, a blood flow field is evenly distributed, and vortexes and dead zones are not generated.

The invention relates to a membrane oxygenator homing state recognition platform, and the platform comprises a treatment vehicle body which is located in a treatment ward of a gas exchanger, is disposed at one side of a sickbed of a patient needing the treatment of the gas exchanger, and is used for placing all parts of the gas exchanger; a manual brake arranged on a base of the treatment vehiclebody and used for locking the treatment vehicle body under manual operation so as to prevent the treatment vehicle body from sliding; a signal capturing mechanism located on the roof of the treatmentward of the gas exchanger and used for capturing image signals of the environment where the treatment vehicle body is located so as to obtain corresponding images around the vehicle body. The membraneoxygenator homing state recognition platform is effective in monitoring and compact in structure. Due to the fact that whether the membrane oxygenator is normally located on the treatment vehicle body where all components of the gas exchanger are placed or not can be monitored in real time in the process that the gas exchanger is used for treating a patient, on-site alarming is executed when themembrane oxygenator does not normally return to the original position.

The invention discloses an ECMO (extracorporeal membrane oxygenation) system. The system comprises a host, a blood pump, a membrane oxygenator, a blood input pipeline, a blood transport pipeline, a main blood output pipeline, a blood output pipeline and multiple flowmeters, wherein the blood pump is connected with the host, the blood input pipeline is connected with a blood pump input end of the blood pump, the blood transport pipeline is connected with a blood pump output end of the blood pump and an oxygenator input end of the membrane oxygenator, the main blood output pipeline is connectedwith an oxygenator output end of the membrane oxygenator, the blood output pipeline is connected with the main blood output pipeline or/and blood transport pipeline, and the multiple flowmeters are arranged on the blood input pipeline and the blood output pipeline respectively. The flowmeters are arranged on the blood input pipeline and the blood output pipeline of the ECMO system, the host timelymonitors the blood state in the blood input pipeline and the blood output pipeline through the multiple flowmeters, and the safety of the medical process is improved.

The invention discloses an endovenous oxygen transporting device and an oxygen transporting method. The oxygen transporting device comprises a vein oxygen catheter which is inserted in a vein, and a control device which is connected to the end, extending out the vein, of the vein oxygen catheter, wherein by virtue of the control device, an oxygen concentration supplied into the vein oxygen catheter can be precisely controlled. Oxygen is transported to the vein by virtue of the vein oxygen catheter which is inserted in the vein, and the oxygen, bypassing alveolus pulmonis having diffusion dysfunction, directly enters blood and oxygenates with hemoglobin, so as to better replace a lung in the case that lung failure occurs or an oxygenating effect cannot be developed temporarily; in comparison with a membrane oxygenator, an oxygen-carrying substitute or a liquid oxygen filling method, the device is simple in structure, convenient to use and capable of preventing in vitro drainage of the blood, so that various possible infections are avoided; and the device is high in blood-carrying-oxygen content and relatively good in stability.