42 results about "Membrane oxygenators" patented technology

The invention discloses an extracorporeal circulation system and a control method thereof, and relates to the technical field of medical instruments. The extracorporeal circulation system comprises a membrane oxygenator, a microembolus filter, a rolling pump, a first pressure detector and a second pressure detector; a liquid inlet of the membrane oxygenator is communicated with the arterial cannula; the microembolus filter is circularly communicated with the membrane oxygenator, and the liquid outlet end of the microembolus filter is communicated with the venous cannula; the rolling pump is circularly communicated with the membrane oxygenator; the first pressure detector is communicated with the rolling pump and is used for detecting the outlet liquid pressure of the rolling pump and generating a first pressure signal; the second pressure detector is communicated with the microplug filter and is used for detecting the inlet liquid pressure of the microplug filter and generating a second pressure signal; the structure of the extracorporeal circulation system and the control method of the extracorporeal circulation system are improved, the accuracy and timeliness of medical staff for judging the oxygenation effect of the membrane type oxygenator are improved, the membrane type oxygenator can be replaced in time, a large number of complications can be avoided, and the death rate of patients is reduced.

The invention provides a membrane type oxygenator and an extracorporeal life support system, the oxygenator comprises: a housing assembly, the housing assembly is provided with a liquid inlet, at least two liquid outlets, an air inlet and an air outlet, the housing assembly comprises a first end cover, an outer cylinder and a second end cover which are connected in sequence; the inner cylinder is arranged in the outer cylinder, the inner cylinder and the outer cylinder form an oxygenation cavity, and the inner cylinder is connected with the first end cover to form a liquid separation cavity; and the plurality of oxygenation membrane wires are arranged in the oxygenation cavity. The liquid outlet direction of each liquid outlet is perpendicular to the liquid inlet direction of the liquid inlet. The device can accord with the physiological characteristics of umbilical cord blood vessels of the premature infants, facilitates connection of the oxygenator and is suitable for providing in-vitro life support for the premature infants. Moreover, due to the fact that the flowing path of blood in the oxygenation cavity is minimum, extremely low transmembrane pressure difference is achieved, blood pressure generated by the heart of the premature infant can be directly utilized, and blood extracorporeal circulation can be achieved through the membrane type oxygenator without depending on a blood pump.

The application provides a fixing device for a membrane oxygenator, and belongs to the technical field of fixing membrane oxygenators, and comprises a connecting plate, a fixing part is arranged on the back surface of the connecting plate, a longitudinal adjusting part is arranged on the connecting plate, a supporting part is arranged at the lower end of the longitudinal adjusting part, and a fastening part is arranged at the upper end of the longitudinal adjusting part. The application solves the problem that the existing fixing device for the membrane oxygenator is inconvenient to assemble and has low practicability when fastening the membrane oxygenator, and the problem that the fixing mode is relatively rigid and may cause damage to the outer wall of the membrane oxygenator.

1. The name of the design product: membrane oxygenator. 2. The use of the design product: for replacing the function of the lung to oxygenate blood and remove carbon dioxide. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view 1.

This invention belongs to the field of extracorporeal circulation monitoring technology and discloses a multi-parameter linkage monitoring system for an artificial heart-lung machine, including an artificial heart-lung machine circuit, a detection component, an execution component, and a controller. The artificial heart-lung machine circuit includes a venous drainage line, a blood reservoir, a blood pump, a membrane oxygenator, an arterial perfusion line, and a gas supply line. The detection component is used to detect venous pressure, fluid level, pressure before and after the membrane oxygenator, arterial perfusion flow rate, blood oxygen, and gas supply pressure and flow rate. The controller performs time alignment on the detection signals within the same sampling period and, combined with changes in similar detection signals in adjacent sampling periods, distinguishes between insufficient drainage, increased membrane oxygenator resistance, and abnormal gas supply, outputting corresponding deceleration, speed limiting, gas supply adjustment, gas supply switching, pump shutdown, alarm, and lockout control signals. This system is used for linkage monitoring and control of abnormal sources in the extracorporeal circulation circuit.

The embodiments of the present application provide an electronic air-oxygen mixer and a method for detecting carbon dioxide clearance, relating to the field of extracorporeal life support technology. The embodiments of the present application utilize an oxygen concentration flow sensor and a carbon dioxide gas concentration sensor integrated into the electronic air-oxygen mixer to monitor the volume flow of the mixed gas and the carbon dioxide concentration at the outlet of the membrane oxygenator in real time, enabling the electronic air-oxygen mixer to calculate and update the carbon dioxide clearance rate in real time and continuously. This not only helps reduce errors caused by periodic sampling and improves the accuracy and reliability of carbon dioxide clearance rate data, but also enables doctors to respond quickly based on carbon dioxide clearance rate data, promptly detecting functional decline or blockage of the membrane oxygenator, and avoiding carbon dioxide retention in the patient's body, thereby enhancing patient safety.

This invention relates to a membrane oxygenator performance testing device and method. The membrane oxygenator performance testing device includes a gas input component and a liquid circulation component. The gas input component's outlet is connected to the membrane oxygenator's inlet to input gas into the membrane oxygenator. The liquid circulation component has a liquid outlet and a liquid return end; the liquid outlet is connected to the membrane oxygenator's liquid inlet, and the liquid return end is connected to the membrane oxygenator's liquid outlet. The liquid circulation component provides power to circulate liquid within the membrane oxygenator. The gas input component can adjust and acquire the gas pressure at the outlet; and / or, the liquid circulation component can adjust and acquire the hydraulic pressure at the outlet. The aforementioned membrane oxygenator performance testing device can test both its performance against gas burst pressure and its performance against liquid burst pressure.

The embodiment of the invention provides an electronic air-oxygen mixer and a method for detecting the carbon dioxide clearance rate, and relates to the technical field of in-vitro life support. According to the embodiment of the invention, through the oxygen concentration flow sensor and the carbon dioxide gas concentration sensor which are integrated in the electronic air-oxygen mixer, the volume flow of the mixed gas and the carbon dioxide concentration of the gas outlet of the membrane oxygenator can be monitored in real time; therefore, the electronic air-oxygen mixer can continuously calculate and update the carbon dioxide clearance rate in real time. Therefore, errors caused by regular sampling can be reduced, the accuracy and the reliability of carbon dioxide clearance rate data are improved, a doctor can quickly respond according to the carbon dioxide clearance rate data and timely discover the function decline or blockage condition of the membrane oxygenator, carbon dioxide retention in the body of a patient is avoided, and the safety of the patient is improved. Therefore, the safety of the patient is enhanced.

The invention relates to the technical field of medical apparatus and instruments, and particularly discloses an integrated membrane type oxygenator which comprises a blood storage cylinder, an oxygenator body, a membrane assembly, an oxygenator cover, an oxygen supply pipe, an oxygen supply pipe, an oxygen supply pipe, an oxygen supply pipe, an oxygen supply pipe, an oxygen supply pipe, an oxygen supply pipe, an oxygen supply pipe, an oxygen supply pipe, an oxygen supply pipe and an oxygen supply pipe, the oxygenation shell comprises a variable-temperature silk membrane structure and an oxygenation silk membrane structure from inside to outside, the fluid optimization structure is arranged in the oxygenation shell and used for optimizing the blood flowing state or purifying blood, the oxygenation shell is provided with a blood outlet pipe, the blood outlet pipe is arranged close to the lower cover, and the lower cover is provided with a water inlet pipe; by integrating the blood storage cylinder, the oxygenator body and the fluid optimization structure, the integrated function of blood storage, oxygenation and flowing or purification is achieved, the basic structure is adaptive to various clinical scenes, and the integration level and practicability of the device are improved.

The present invention provides a membrane oxygenator, comprising: a housing having a first air cavity, a gas exchange cavity, and a second air cavity arranged in sequence along a vertical direction; a partition disposed within the first air cavity and the gas exchange cavity to divide the first air cavity into a first inner gas cavity and a first outer gas cavity, and further to divide the gas exchange cavity into an inner gas exchange cavity and an outer gas exchange cavity; a communication port between the inner gas exchange cavity and the outer gas exchange cavity; a blood inlet communicating with the inner gas exchange cavity; a blood outlet communicating with the outer gas exchange cavity; a gas inlet communicating with the first outer gas cavity; a first gas outlet communicating with the second air cavity; and a second gas outlet communicating with the first inner gas cavity; wherein the partition is provided with a first flow port located within the first air cavity; and the first flow port is configured to be openable and closable. The present invention solves the problem of low gas exchange efficiency in conventional membrane oxygenators.

The invention relates to the technical field of organ preservation, in particular to a portable oxygen supply device and method for organ perfusion and transfer. The module comprises a portable oxygen generator, an air-oxygen mixer, a gas supercharging device and a control unit. High-concentration oxygen is generated through the oxygen generator, the high-concentration oxygen is mixed with ambient air according to needs through the air-oxygen mixer, and then the mixture is pressurized and conveyed to the membrane type oxygenator. According to the invention, a high-pressure gas cylinder is abandoned, and the problems of transportation limitation, poor portability, logistics dependence and the like are solved. A degradation working mode and safety redundancy are innovatively introduced, when the main oxygen generation system breaks down, the system can be automatically switched to ambient air for oxygen supply, and the reliability of the system is greatly improved. Meanwhile, an intelligent closed-loop control function based on metabolic feedback is achieved, and gas parameters can be dynamically adjusted to optimize the organ maintenance state. The safe, portable, intelligent and efficient oxygen supply source is realized, and the efficiency of organ transplantation and transfer is greatly improved.

The application discloses a method for adjusting the pressure of a main pump in an extracorporeal circulation process, and the method comprises the following steps: after the pre-charging of a membrane oxygenator is completed, an arterial pipeline connected with the membrane oxygenator is clamped and closed, and only a small side pipeline is left to communicate with the membrane oxygenator; a pump pressure gauge is arranged on the small side pipeline; the main pump is adjusted to a required position, and the pressure of the main pump on the circulating pipeline is adjusted, and the pressure is adjusted to 150mmHg-250mmHg. The specific pressure value of the main pump when the pressure is adjusted is displayed by the pump pressure gauge, so that the adjustment process and result can be visualized, the adjustment result is converted into the specific pressure value of the pump pressure gauge, the reference data of the adjustment of the pressure of the main pump is standardized, the adjustment precision is effectively ensured without relying on experience and feeling, the adjustment mode is quick and accurate, the adjustment efficiency can be improved, and the stability of the adjustment pressure is ensured by controlling the pressure of the main pump, so that the backflow of arterial blood caused by unstable pressure can be avoided.

The invention discloses a woven membrane with an inclination angle, a double-layer woven degassing membrane prepared from the woven membrane and application of the double-layer woven degassing membrane. The woven membrane is formed by weaving a plurality of membrane filaments and weaving yarns, and the weaving direction of the membrane filaments and the weaving direction of the weaving yarns form a non-vertical included angle; the double-layer woven membrane comprises two woven membrane pieces, one woven membrane piece is rotated by 180 degrees in the warp direction and then attached to the other woven membrane piece, and a liquid flow channel with non-parallel wall faces is formed between the two woven membrane pieces. The prepared double-layer woven degassing film can actively enhance fluid disturbance and improve the mass transfer coefficient; according to the membrane type oxygenator prepared by using the degassing membrane, the pre-filling amount can be reduced to an acceptable range of small animals.

The invention belongs to the technical field of hollow fibers, and discloses a co-extruded asymmetric poly (4-methyl-1-pentene) hollow fiber as well as a preparation method and application thereof. The method comprises the following steps: plasticizing, melting and extruding a mixture of poly (4-methyl-1-pentene) with a low melt index, poly (4-methyl-1-pentene) with a high melt index and polyolefin by adopting a twin-screw extruder, cooling, pelletizing and drying to obtain a polymer blend; the preparation method comprises the following steps: respectively adding a blend of poly (4-methyl-1-pentene) with a high melt index and a polymer into different extruders, carrying out co-extrusion molding, cooling and traction to obtain primary fibers of poly (4-methyl-1-pentene) hollow fibers; the primary fiber of the fiber is subjected to stretching and pore forming at the temperature of 60-90 DEG C and heat setting at the temperature of 70-100 DEG C, the co-extruded asymmetric poly (4-methyl-1-pentene) hollow fiber is obtained, the outer layer is poly (4-methyl-1-pentene) with the high melt index, the inner layer is a polymer blend, and the co-extruded asymmetric poly (4-methyl-1-pentene) hollow fiber can be applied to the field of in-vitro membrane lung oxygenators.

The invention discloses a simulation cycle test system for extracorporeal membrane oxygenation ECMO, and relates to the technical field of medical instrument extracorporeal test. The system comprises a training data acquisition module for acquiring blood flow characteristic parameters of users with different body characteristic parameters and generating a training sample data set. The prediction model training module establishes a neural network model and trains the blood flow feature extraction model. The physiological feature analysis module predicts blood flow feature parameters by simulating body feature parameters of a user and sets blood exchange flow velocity and pressure according to predicted values. The exchange parameter adjusting module is used for dynamically adjusting the set flow velocity and pressure and acquiring blood quality parameters under the operation condition. The blood quality adjusting module is used for correcting the gas flow of the membrane oxygenator according to the obtained blood quality parameters, the ECMO simulation cycle test is completed, refined gas flow management is achieved, and the oxygenation efficiency is improved.

To provide a method for treating a heart condition by perfusing a drug to an unarrested beating heart of a patient.SOLUTION: A closed circuit may be formed by using a first drug delivery catheter 122 positioned in a patient's right coronary artery, a second drug delivery catheter 124 positioned in the patient's left main coronary artery, a drug collection catheter positioned in a coronary sinus, the coronary artery, the coronary venous system, and an external membrane oxygenator 120 interspersed between the venous and arterial branches. A drug for treating a heart condition may be perfused through the closed circuit.SELECTED DRAWING: Figure 1A

The invention relates to the technical field of medical instrument detection, and provides an in-vitro testing device for the gas exchange performance of a membrane oxygenator. The in-vitro testing device for the gas exchange performance of the membrane oxygenator comprises a first blood storage container, a second blood storage container, a first heater, a second heater, a driving pump, a deaerator, a deoxygenation gas source, an oxygenation gas source and an oxygenator to be evaluated, an inlet of the driving pump is connected with the first blood storage container, an outlet of the driving pump is connected with the deaerator and the oxygenator to be evaluated in an on-off manner, and the inlet of the first blood storage container is connected with a blood outlet of the deaerator in an on-off manner; the first heater is connected with a heat exchange channel of the deaerator; the deoxygenation gas source is connected with a gas inlet of the deaerator; a blood outlet of the oxygenator to be evaluated is connected with the first blood storage container and the second blood storage container in an on-off manner, and an outlet of the second blood storage container is connected with an inlet of the first blood storage container in an on-off manner; the second heater is connected with a heat exchange channel of the oxygenator to be evaluated; and the oxygen filling source is connected with a gas inlet of the oxygenator to be evaluated.

The application relates to a preparation method of a hollow fiber anticoagulation coating for a membrane oxygenator, and more particularly to a hollow fiber membrane loaded with an anticoagulation coating, a preparation method and a membrane oxygenator, and belongs to the field of biomedical materials. After a compound with a ring cavity structure is modified on the surface of the hollow fiber membrane, the controlled release of the drug can be effectively improved, the anticoagulation of the hollow fiber membrane under a long running time is realized, and the purpose of preventing the adhesion of proteins in blood is achieved.

The invention provides a membrane type oxygenator and blood storage device assembling structure, and belongs to the technical field of medical instruments, the membrane type oxygenator and blood storage device assembling structure comprises a blood storage device body and a membrane type oxygenator body, the bottom of the blood storage device body is fixedly connected with an upper butt joint pipe in a penetrating mode, the top of the membrane type oxygenator body is fixedly connected with a lower butt joint pipe in a penetrating mode, and a plugging piece is arranged at the bottom of the upper butt joint pipe; and the plugging piece is connected with the lower butt joint pipe through an assembly piece. The membrane type oxygenator and blood storage device assembly structure solves the problems that an existing membrane type oxygenator and blood storage device assembly structure is mostly assembled in a threaded connection mode, the assembly mode cannot guarantee the anti-leakage function of the butt joint position, normal work between a membrane type oxygenator and a blood storage device cannot be guaranteed once leakage occurs, butt joint can be completed only through repeated rotation, and the work efficiency is high. And the use is relatively inconvenient.

The present invention provides a moisture condensation prevention device for a membrane oxygenator, which is applied to the technical field of medical devices. The moisture condensation prevention device for the membrane oxygenator includes a clamping frame and a constant temperature heating mechanism. The clamping frame is used to fix the membrane oxygenator, and the constant temperature heating mechanism is used to emit heat at a preset temperature. The heat can be transferred to the membrane oxygenator through the clamping frame to prevent the generation of condensed water in the membrane oxygenator. When the membrane oxygenator starts to work, the constant temperature heating mechanism can be turned on. The constant temperature heating mechanism emits heat and transfers the heat to the membrane oxygenator, thereby preventing the generation of condensed water in the membrane oxygenator. Compared with the prior art, the moisture condensation prevention device for the membrane oxygenator disclosed by the present invention can not only support and fix the membrane oxygenator in clinical applications, but also continuously prevent condensed water for the membrane oxygenator, thereby long-term keeping no condensed water generated in the membrane oxygenator and improving the gas-blood exchange performance.

The application discloses a lung membrane oxygenation device, which comprises a lung membrane oxygenator, a telescopic chamber, a centrifugal pump and a controller in sequence through a catheter, the controller is used for controlling the switch of the centrifugal pump to form pulse blood supply, the centrifugal pump comprises a hollow shell, the hollow shell is provided with a blood inlet and a blood outlet, a connecting piece is fixedly arranged on the inner bottom wall of the hollow shell, a rotating piece is arranged in the hollow shell, the bottom of the rotating piece is rotationally connected with the connecting piece, so that the rotating piece can rotate in the hollow shell, a magnet array is arranged in the rotating piece, an electromagnetic driver is sleeved on the hollow shell, and the electromagnetic driver is used for driving the rotating piece to rotate, and the telescopic chamber comprises an outer shell and an inner membrane, the inner membrane is arranged in the outer shell, the inner membrane divides the inner space of the outer shell into a first space and a second space, and the first space is used for blood circulation. By adopting the application, the damage caused by mechanical contact with blood is reduced during blood pumping, and the blood transfusion quality is improved.

The invention belongs to the technical field of extracorporeal membrane lung oxygenation, and provides a volute type square box laminated structure membrane lung oxygenator and a pre-filling method thereof.A volute type runner is arranged in a square box laminated structure of the square box laminated structure membrane lung oxygenator and comprises a spiral section and a plurality of flow dividing sections, the input ends of the flow dividing sections are connected with the spiral section, and the output ends of the flow dividing sections are connected with the spiral section; the output end is located at the internal corner position of the square box laminated structure, high-flow-speed pre-filled liquid enters the spiral section at the inlet, then flows to the flow dividing section under the high-speed inertia effect and preferentially flows to the internal corner position of the square box laminated structure, and the effect of discharging bubbles at the four corners of the square box laminated structure is guaranteed. Moreover, by means of the cooperation of the volute type flow channel and the high-speed pre-filled liquid, the flushing capacity of all positions in the membrane lung oxygenator is improved, the membrane lung oxygenator does not need to be shaken, oscillated and the like, the workload of medical staff is reduced, and the problem that consumable items are damaged due to improper shaking and flapping actions is solved.

This disclosure relates to a testing method, apparatus, and system for a hollow fiber oxygenation membrane in a membrane oxygenator. The method includes: controlling the flow of feed liquid in a feed liquid storage device in a sequential manner, passing through the output end of the feed liquid storage device, the input end of a membrane module, the output end of the membrane module, and the input end of the feed liquid storage device, wherein the membrane module is made of the hollow fiber oxygenation membrane to be tested; determining the mass transfer rate of oxygen and / or carbon dioxide in the membrane module at various times; and determining that feed liquid leakage has occurred in the membrane module when the mass transfer rate of oxygen and / or carbon dioxide in the membrane module begins to decrease at a rate greater than a preset decrease rate, and the decrease reaches or exceeds a preset range, and determining the duration of feed liquid leakage resistance of the membrane module. Embodiments of this disclosure can provide real-time feedback on the oxygenation performance of the oxygenation membrane, accurately determine the duration of feed liquid leakage resistance of the oxygenation membrane (i.e., the hollow fiber oxygenation membrane), and achieve accurate prediction of the oxygenation performance and service life of the hollow fiber membrane.

The extracorporeal circulation integrated pipeline structure comprises a membrane type oxygenator body, one end of the membrane type oxygenator body is provided with a first vein backflow end, and the first vein backflow end and the end of the membrane type oxygenator body are integrally formed. The first vein backflow end is provided with an integrally-formed first vein backflow pipe, the other end of the membrane type oxygenator body is provided with a second vein backflow end, and the second vein backflow end is provided with an integrally-formed second vein backflow pipe; pressure control valve bodies are arranged on the first venous return pipe and the second venous return pipe, each pressure control valve body comprises a valve seat, a stepped threaded section is arranged on one side of each valve seat, a multi-stage self-sealing structure is further arranged in each valve seat, and each valve seat is detachably connected with a CRRT pipeline connector. Meanwhile, the on-machine time is shortened, the treatment cost of a patient is reduced, and the valve seat can be automatically opened and subjected to multi-stage sealing.

The utility model provides a cylindrical membrane oxygenator which comprises a shell assembly and a liquid separation column, and the shell assembly comprises a first end cover assembly, a barrel assembly and a second end cover assembly. The barrel assembly comprises an inner barrel, a middle barrel and an outer barrel. The inner barrel comprises a first barrel part, a plurality of liquid separation fins and a second barrel part. A liquid separation cavity is defined by one axial end of the liquid separation column and the first barrel part, the other end of the liquid separation column is connected with the second barrel part, the peripheral face of the liquid separation column is connected with the first barrel part through liquid separation fins, and a liquid separation groove with the large upper portion and the small lower portion is formed among every two adjacent liquid separation fins, the liquid separation column and the heat exchange film wires. A liquid outlet channel is formed in the end, away from the liquid inlet channel, of the outer cylinder, and the liquid inlet channel communicates with the liquid outlet channel through the liquid separation cavity and the liquid separation groove. Based on the structural design of the liquid separation tank, the oxygenator can utilize different membrane areas under different flow rates, the oxygenation efficiency under the high flow rate is guaranteed, and it is guaranteed that the problems of excessive oxygenation of blood and excessive carbon dioxide removal are avoided under the low flow rate.

The application provides a membrane oxygenator and an extracorporeal life support system. The oxygenator comprises a shell assembly provided with a liquid inlet, at least two liquid outlets, a gas inlet and a gas outlet, the shell assembly comprising a first end cover, an outer cylinder and a second end cover connected in sequence; an inner cylinder arranged in the outer cylinder and forming an oxygenation cavity with the outer cylinder, and the inner cylinder is connected with the first end cover and forms a distribution cavity; a plurality of oxygenation membrane filaments arranged in the oxygenation cavity. The liquid outlet direction of each liquid outlet is perpendicular to the liquid inlet direction of the liquid inlet. The application can match the physiological characteristics of the umbilical cord blood vessels of premature infants, and is convenient for the oxygenator to be connected to the extracorporeal life support system suitable for premature infants. Moreover, since the blood flow path in the oxygenation cavity in the application is the smallest, an extremely low transmembrane pressure difference is realized, the blood pressure generated by the heart of the premature infant can be directly utilized, and the blood extracorporeal circulation can be realized by using the membrane oxygenator of the application without relying on a blood pump.

The invention relates to the technical field of fixing devices, in particular to a membrane lung oxygenator integrated support which comprises a fixing plate, a locking mechanism, a clamping and pushing mechanism, a dehumidifying mechanism and a drying mechanism. The connector of the blood inlet and outlet pipeline and the oxygenator is wrapped and locked through the locking sleeve, the pipeline is clamped through the clamping pin, the clamping pin is forced to drive the pipeline to keep the inserting tendency of the oxygenator through the pull-back effect of the jacking spring, so that the connection tightness is guaranteed, condensate water generated by the outer wall of the pipeline is absorbed through the absorbent cotton, and the water absorption effect is improved. The air heater is communicated with the guide pipe and the air blowing box to blow hot air into the cavity, so that the wet absorbent cotton and the connecting cotton can be subjected to hot air drying, the condensate water absorption effect of the absorbent cotton is guaranteed, and the temperature is kept relatively stable.

This invention belongs to the technical field of biomedical materials, artificial organs, and extracorporeal circulation support devices, and relates to a hydrophilic modified siloxane hollow fiber composite membrane, its preparation method, and its applications. The hydrophilic modified siloxane hollow fiber composite membrane consists of a porous hollow fiber base membrane and a dense hydrophilic organosilicon functional layer constructed on the outer surface of the porous hollow fiber base membrane. Based on the hydrophilic modified siloxane hollow fiber composite membrane, this invention further constructs a small membrane oxygenator based on this composite membrane, which can be used for extracorporeal circulation gas exchange and is suitable for establishing animal extracorporeal circulation models and preclinical experimental studies. This device features a compact structure, high gas exchange efficiency, low blood damage, and good operational stability.

The temperature monitor comprises a meter head, a threaded rod, an adjusting sleeve, a rotating sleeve and a temperature probe, one end of the threaded rod is fixedly connected with the meter head through a connecting sleeve, one end of the adjusting sleeve is fixedly connected with the rotating sleeve, the adjusting sleeve is in threaded connection with the other end of the threaded rod, and the temperature probe and the rotating sleeve are fixed in an inserted mode. Wherein the connecting sleeve, the threaded rod, the adjusting sleeve, the rotating sleeve and the low-temperature probe are coaxially arranged. According to the monitor, the adjusting sleeve can be driven to rotate at different positions on the threaded rod by rotating the rotating sleeve, the monitor can be adapted to blood storage tanks with different heights for temperature monitoring by adjusting the overall length of the monitor, and the monitor has good adaptability. A built-in battery and a display screen are arranged, real-time monitoring can be achieved without an external power source, the temperature value of blood can be displayed through the display screen, and use convenience is improved.

The application relates to a simulated lung for detecting a physiological closed-loop control function of a breathing machine, comprising a blood circulation system, in which blood circulates; a gas circulation system, in which oxygen circulates; the gas circulation system and the blood circulation system are independent of each other; a membrane oxygenator for realizing blood-oxygen exchange; the blood circulation system circulates blood through the membrane oxygenator, and the gas circulation system circulates oxygen through the membrane oxygenator; a data acquisition system connected with the blood circulation system at one end to realize blood data monitoring; and connected with the gas circulation system at the other end, wherein the gas circulation system adjusts ventilation according to the blood data. Compared with the prior art, the application combines the membrane oxygenator with the water-sealed simulated lung to detect the breathing machine with the PCLC function, so that the accuracy, reliability and safety of the breathing machine can be improved.