The invention relates to the technical field of a clinical scientific research, and discloses preparing experimental materials: a 18gage needle, a 5F arterial cannula, a 4F angiography catheter, a 0.25mm angiography micro-guidewire, a digital subtraction angiography (DSA) system, a MRI System, a nuclear magnetic resonance compatible respirator, a nuclear magnetic resonance compatible physiologicalsignal detection system. The development method is characterized in that a stable cerebral ischemia-reperfusion animal model of cynomolgus monkey is accurately prepared by intravascular coil embolization, the infarct size of the experimental animal is moderate and no hemorrhagic transformation in the infarct area is generated after reperfusion, the animal can survive for a long time, has the corresponding symptoms of neurological deficit, and the stability of the model is proved through long-term imaging and behavioral evaluation. The method can accurately control the location and extent of stroke, and the experimental animals are able to maintain stable clinical symptoms, so the model is suitable for the assessment of the safety and efficacy of new therapy and new drugs for stroke.