Arterial cannula device and method with pulsatility and flow reversal

WO2026090463A3 Publication Date: 2026-06-04DUKE UNIV
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Patent Information

Application Number
PCT/US2025/052344
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-10-24
Filing Date
2025-10-24
Publication Date
2026-06-04

AI Technical Summary

Technical Problem

Conventional mechanical circulatory support systems, such as cardiopulmonary bypass and ECMO, generate non-pulsatile continuous blood flow, leading to endothelial dysfunction, thrombosis, limb ischemia, and vascular trauma due to blood stagnation and large cannula diameters, which are not suitable for less invasive procedures requiring peripheral cannulation.

Method used

A multi-lumen arterial cannula with an inflatable balloon or cuff between distal and proximal orifices, controlled by helium delivery for rapid inflation and deflation, creating pulsatile flow patterns synchronized with the cardiac cycle to prevent thrombosis and maintain limb perfusion.

Benefits of technology

The system restores pulsatility, reduces thrombus formation, prevents limb ischemia, and optimizes blood flow distribution, minimizing vessel occlusion and embolic risks while allowing ECG-synchronized flow interruptions.

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Abstract

The present disclosure describes, in part, arterial cannula systems for extracorporeal membrane oxygenation and cardiopulmonary bypass provides pulsatile blood flow and selective flow distribution. The cannula comprises a multi-lumen structure including a central lumen for blood flow, dedicated lumens for helium delivery, a distal orifice for body perfusion, and proximal orifices for limb perfusion. An inflatable cuff positioned between the distal and proximal orifices modulates blood flow through rapid inflation and deflation cycles achieved in milliseconds using helium gas. An external control console with microcontrollers and customized software automates the inflation-deflation cycles based on physiological inputs including ECG, arterial pressure, and tissue oxygenation. The system restores physiologically effective pulsatile flow, prevents limb ischemia, reduces thrombus formation risk, and can provide ECG-synchronized flow modulation to facilitate native cardiac ejection, potentially eliminating the need for separate left ventricular venting during mechanical circulatory support.
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