13 results about "Limb ischemia" patented technology

The invention relates to the technical field of ischemia training, in particular to a limb ischemia pre-adaptation training method and device.The limb ischemia pre-adaptation training method comprises the steps that feature parameters, training purposes and cuff feature parameters of an individual AOP of a target user are collected; inputting the obtained feature parameters of the individual AOP of the target user, the training purpose and the feature parameters of the cuff into a pressure prediction model, and outputting a pressure value; inputting the obtained blood vessel health coefficient, the limb perimeter, the pressure value and the training purpose into a pressure blocking time prediction model, and outputting pressure blocking time; according to the method, the optimal pressure value under different training scenes can be dynamically predicted, so that the physiological requirements of different training targets are met, and then the blood vessel health coefficient and pressure application blocking time prediction model is introduced, so that the blood vessel health coefficient and pressure application blocking time prediction accuracy is improved. The training safety is further optimized, and tissue damage caused by too large pressure or too long time is avoided.

Perfusion systems and methods are provided for enhancing perfusion to the vasculature of a patient suffering from reduced blood flow. For example, the system can increase peripheral blood flow to reduce limb ischemia, in which an extracorporeal pump having a controller, and catheter / tubing set, employed alone or in conjunction with an interventional or circulatory assist device, withdraws blood from a patient's vasculature and reintroduces that blood at another location within the patient's vasculature at a controlled local pressure or flow rate, without interfering with operation of the interventional or circulatory assist device or surgical intervention.

An apparatus for detecting limb ischemia in a subject includes a property sensor designed to obtain intramuscular property readings when implanted into the limb; the apparatus features an introducer for sensor placement and a controller that is configured to: receive the property readings from the property sensor; and at least one of: display the property readings on a display; and analyze the property readings to identify a change in an intramuscular property when compared to a reference temperature value, and following the detection, generates a signal or alert indicative of the change in the intramuscular property, whereby the change in the intramuscular property is indicative of a presence of the limb ischemia within the limb; method of use thereof; the apparatus provides a minimally invasive solution for continuous ischemia monitoring, improving early diagnosis, treatment decisions, and patient outcomes.

The present disclosure describes, in part, arterial cannula systems for extracorporeal membrane oxygenation and cardiopulmonary bypass provides pulsatile blood flow and selective flow distribution. The cannula comprises a multi-lumen structure including a central lumen for blood flow, dedicated lumens for helium delivery, a distal orifice for body perfusion, and proximal orifices for limb perfusion. An inflatable cuff positioned between the distal and proximal orifices modulates blood flow through rapid inflation and deflation cycles achieved in milliseconds using helium gas. An external control console with microcontrollers and customized software automates the inflation-deflation cycles based on physiological inputs including ECG, arterial pressure, and tissue oxygenation. The system restores physiologically effective pulsatile flow, prevents limb ischemia, reduces thrombus formation risk, and can provide ECG-synchronized flow modulation to facilitate native cardiac ejection, potentially eliminating the need for separate left ventricular venting during mechanical circulatory support.

The invention discloses a limb fixing device for a critical patient, belongs to the technical field of limb fixing, and aims to solve the problems that the contact area between a bandage and the arm of the patient is small, the constraining force is concentrated, pressure injury is easily formed due to long-time constraining, the pain of the patient is increased, local infection is possibly caused, and the illness state is aggravated. The hospital bed comprises a hospital bed body and two supporting plates fixed to one side of the hospital bed body, restraint straps are arranged on one sides of the supporting plates, a plurality of first pressure air bags are installed on one sides of the restraint straps, a plurality of second pressure air bags are further installed on one sides of the restraint straps, and the second pressure air bags and the first pressure air bags are arranged in a staggered mode. Alternate inflation and deflation of the first pressure air bag and the second pressure air bag are achieved through the two-way air pump, so that the pressed parts of the limbs are continuously alternated, local skin and soft tissue are prevented from being in a pressed state for a long time, local blood circulation is effectively improved, the problems of skin redness, pressure sores, limb ischemia and the like are solved, and the completeness of the limb tissue of a patient is protected.

An apparatus for detecting limb ischemia in a subject includes a temperature sensor designed to obtain intramuscular temperature readings when implanted into the limb; the apparatus features an introducer for sensor placement and a controller that is configured to: receive the temperature readings from the temperature sensor; and at least one of: display the temperature readings on a display; and analyze the temperature readings to identify a decrease in intramuscular temperature when compared to a reference temperature value, and following the detection, generates a signal or alert indicative of the decrease of intramuscular temperature, whereby the decrease in intramuscular temperature is indicative of a presence of the limb ischemia within the limb; method of use thereof; the apparatus provides a minimally invasive solution for continuous ischemia monitoring, improving early diagnosis, treatment decisions, and patient outcomes.

A control air bag is connected with one end of an air pipe through an air bag additional section, the other end of the air pipe is communicated with a function portion, the function portion is fixedly installed on the upper surface of an air cable tie body, and a first hook-and-loop fastener and a second hook-and-loop fastener are installed on the upper surface of one end of the air cable tie body and the lower surface of the other end of the air cable tie body respectively. According to the utility model, the air bag is controlled to inject air to expand the air ribbon body wound on the arm of a patient, and then the pressure state of the air ribbon body is known in time through the barometer, so that the tourniquet can be conveniently used and the pressure of the tourniquet can be controlled to ensure smooth blood sampling; meanwhile, by means of the automatic timing function of a control panel of the functional part and the automatic deflation function of an electric control valve, the use time can be accurately controlled, the air cable tie body can be automatically loosened after timeout, and limb avascular necrosis and even amputation adverse nursing events caused by forgetting to loosen the tourniquet are completely eradicated; and the occurrence rate of blood sample hemolysis caused by long-time use of the tourniquet is reduced.

The present application relates to a DNA drug, a gene targeting delivery system and its application in the treatment of lower extremity peripheral arterial disease. Specifically, the present application relates to a microcrystalline nanocarbon targeted drug delivery system and a plasmid containing human interleukin-4 gene loaded thereon. The delivery system comprises a matrix microcrystalline nanocarbon, and folate, polyethyleneimine and polyethylene glycol modified on the surface thereof. The matrix microcrystalline nanocarbon has a size of 5-20 nanometers, a crystallinity of >80%, a rich mesoporous structure, a high specific surface area and good biocompatibility. The present application also provides a preparation method of the system, which comprises the steps of synthesizing a matrix by pulse modulation radio frequency plasma enhanced chemical vapor deposition, surface functionalization modification and plasmid loading. After injection into the lower extremity muscle, the system can actively target the macrophages in the ischemic site, realize long-term expression of the IL-4 gene at the lesion site. It can effectively promote stable, mature functional angiogenesis by inducing macrophages to polarize to the repair M2 phenotype and regulating the OSM / GSNOR / ENG signal axis, thereby improving limb ischemia. The present application has important application value in the field of gene therapy for ischemic diseases, especially peripheral arterial disease and severe limb ischemia.

The invention relates to the technical field of medical instruments, in particular to a vascular surgery hemostasis device which comprises a bracket, auxiliary frames are fixedly connected to the two sides of the bracket respectively, a hemostasis mechanism is fixedly connected to the tops of the two auxiliary frames, and the hemostasis mechanism comprises a blood vessel pressing assembly and an auxiliary hemostasis assembly which are slidably connected to the tops of the two auxiliary frames. A switching mechanism used for switching the blood vessel pressing assembly and the auxiliary hemostasis assembly is arranged in the auxiliary frame. According to the device, blood vessels above a wound of a patient can be effectively pressed through cooperation of an arc-shaped pressing plate and an inflatable air bag, hemostasis is achieved, through arrangement of a switching mechanism, after pressing is conducted for a period of time, the arc-shaped pressing plate and an auxiliary pressing plate can be switched, limb avascular necrosis caused by long-time pressing is avoided, and the patient is prevented from being injured. When the arc-shaped pressing plate is moved away, the wound can be prevented from bleeding again through pressing of the auxiliary pressurizing plate and the hemostatic cotton, and a good environment is provided for blood vessel recovery.

The present disclosure describes, in part, arterial cannula systems for extracorporeal membrane oxygenation and cardiopulmonary bypass provides pulsatile blood flow and selective flow distribution. The cannula comprises a multi-lumen structure including a central lumen for blood flow, dedicated lumens for helium delivery, a distal orifice for body perfusion, and proximal orifices for limb perfusion. An inflatable cuff positioned between the distal and proximal orifices modulates blood flow through rapid inflation and deflation cycles achieved in milliseconds using helium gas. An external control console with microcontrollers and customized software automates the inflation-deflation cycles based on physiological inputs including ECG, arterial pressure, and tissue oxygenation. The system restores physiologically effective pulsatile flow, prevents limb ischemia, reduces thrombus formation risk, and can provide ECG-synchronized flow modulation to facilitate native cardiac ejection, potentially eliminating the need for separate left ventricular venting during mechanical circulatory support.

Perfusion systems and methods are provided for increasing peripheral blood flow to reduce limb ischemia, in which an extracorporeal pump having a controller, and catheter / tubing set, employed alone or in conjunction with an interventional or circulatory assist device, withdraws blood from a patient's vasculature and reintroduces that blood at another location within the patient's vasculature at a controlled local pressure or flow rate, without interfering with operation of the interventional or circulatory assist device or surgical intervention.

The present invention relates to a spheroid composed of skeletal muscle progenitor cells (SKMP) and induced mesenchymal stem cells (iMSCs) and formed as a three-dimensional structure with a diameter of about 100 to 150 μm, wherein the spheroid inhibits early differentiation of SKMP and exhibits a wider distribution in tissue and an effect of inducing myofiber fusion compared to administration of SKMP alone. In a limb ischemia model, the spheroid demonstrated significant therapeutic effects, including improved blood flow reperfusion, increased capillary density, enhanced muscle regeneration, and limb salvage rates. It was also confirmed to contribute to vascular regeneration by inducing cell cycle activity of vascular endothelial cells. Therefore, the spheroid of the present invention can be usefully used as a cell therapy product or quasi-drug for preventing and treating limb ischemia.

The present invention relates to an agent that inhibits the expression or activity of the G Protein-Coupled Receptor 182 (GPR182) protein for use in the treatment or prevention of a pathological condition selected from myocardial infarction, myocardial ischemia, myocardial necrosis, cardiac hypertrophy, cardiac fibrosis, limb ischemia, ischemia-related tissue degeneration, stroke and a cancer, wherein (a) the agent that inhibits the expression of the GPR182 protein is selected from an siRNA, miRNA, shRNA, a ribozyme and an antisense nucleic acid molecule; and / or (b) the agent that inhibits the activity of the GPR182 protein specifically binds to the GPR182 protein and inhibits binding of one or more endogenous ligands to the GPR182 protein, and wherein the agent is selected from an antibody, an Fc fusion polypeptide, an adnectin, an affibody, an affilin, an anticalin, an atrimer, an avimer, an evibody, a Kunitz-type domain, a designed ankyrin repeat protein (DARPin), a fynomer, a peptide or peptidomimetic, an aptamer, and a small molecule; or any combination and / or hetero-or homo-oligomeric, covalent or non-covalent complex thereof.