3 results about "Limb ischemia" patented technology

The invention discloses a limb fixing device for a critical patient, belongs to the technical field of limb fixing, and aims to solve the problems that the contact area between a bandage and the arm of the patient is small, the constraining force is concentrated, pressure injury is easily formed due to long-time constraining, the pain of the patient is increased, local infection is possibly caused, and the illness state is aggravated. The hospital bed comprises a hospital bed body and two supporting plates fixed to one side of the hospital bed body, restraint straps are arranged on one sides of the supporting plates, a plurality of first pressure air bags are installed on one sides of the restraint straps, a plurality of second pressure air bags are further installed on one sides of the restraint straps, and the second pressure air bags and the first pressure air bags are arranged in a staggered mode. Alternate inflation and deflation of the first pressure air bag and the second pressure air bag are achieved through the two-way air pump, so that the pressed parts of the limbs are continuously alternated, local skin and soft tissue are prevented from being in a pressed state for a long time, local blood circulation is effectively improved, the problems of skin redness, pressure sores, limb ischemia and the like are solved, and the completeness of the limb tissue of a patient is protected.

The present application relates to a DNA drug, a gene targeting delivery system and its application in the treatment of lower extremity peripheral arterial disease. Specifically, the present application relates to a microcrystalline nanocarbon targeted drug delivery system and a plasmid containing human interleukin-4 gene loaded thereon. The delivery system comprises a matrix microcrystalline nanocarbon, and folate, polyethyleneimine and polyethylene glycol modified on the surface thereof. The matrix microcrystalline nanocarbon has a size of 5-20 nanometers, a crystallinity of >80%, a rich mesoporous structure, a high specific surface area and good biocompatibility. The present application also provides a preparation method of the system, which comprises the steps of synthesizing a matrix by pulse modulation radio frequency plasma enhanced chemical vapor deposition, surface functionalization modification and plasmid loading. After injection into the lower extremity muscle, the system can actively target the macrophages in the ischemic site, realize long-term expression of the IL-4 gene at the lesion site. It can effectively promote stable, mature functional angiogenesis by inducing macrophages to polarize to the repair M2 phenotype and regulating the OSM / GSNOR / ENG signal axis, thereby improving limb ischemia. The present application has important application value in the field of gene therapy for ischemic diseases, especially peripheral arterial disease and severe limb ischemia.

The present disclosure describes, in part, arterial cannula systems for extracorporeal membrane oxygenation and cardiopulmonary bypass provides pulsatile blood flow and selective flow distribution. The cannula comprises a multi-lumen structure including a central lumen for blood flow, dedicated lumens for helium delivery, a distal orifice for body perfusion, and proximal orifices for limb perfusion. An inflatable cuff positioned between the distal and proximal orifices modulates blood flow through rapid inflation and deflation cycles achieved in milliseconds using helium gas. An external control console with microcontrollers and customized software automates the inflation-deflation cycles based on physiological inputs including ECG, arterial pressure, and tissue oxygenation. The system restores physiologically effective pulsatile flow, prevents limb ischemia, reduces thrombus formation risk, and can provide ECG-synchronized flow modulation to facilitate native cardiac ejection, potentially eliminating the need for separate left ventricular venting during mechanical circulatory support.