38 results about "Limb ischemia" patented technology

The invention relates to the technical field of ischemia training, in particular to a limb ischemia pre-adaptation training method and device.The limb ischemia pre-adaptation training method comprises the steps that feature parameters, training purposes and cuff feature parameters of an individual AOP of a target user are collected; inputting the obtained feature parameters of the individual AOP of the target user, the training purpose and the feature parameters of the cuff into a pressure prediction model, and outputting a pressure value; inputting the obtained blood vessel health coefficient, the limb perimeter, the pressure value and the training purpose into a pressure blocking time prediction model, and outputting pressure blocking time; according to the method, the optimal pressure value under different training scenes can be dynamically predicted, so that the physiological requirements of different training targets are met, and then the blood vessel health coefficient and pressure application blocking time prediction model is introduced, so that the blood vessel health coefficient and pressure application blocking time prediction accuracy is improved. The training safety is further optimized, and tissue damage caused by too large pressure or too long time is avoided.

The utility model provides an electric pneumatic hemostatic device, including an electric pneumatic hemostatic instrument body, an air circuit connection hose and a tourniquet. The electric pneumatic hemostatic instrument body is provided with a display, a controller, an air pump assembly, a photoelectric blood oxygen saturation probe, an air circuit connection interface and a probe connection interface. The display and the air pump assembly are respectively electrically connected to the controller. The photoelectric blood oxygen saturation probe is used to obtain the blood oxygen pulse signal of the distal end of the patient's limb. A pressure sensor is provided in the tourniquet. The pressure sensor is used to obtain the limb pulse signal of the patient wearing the tourniquet. The number of tourniquets is at least two, and each tourniquet is connected to an air pump assembly through an air circuit connection hose and an air circuit connection interface in turn. The utility model is convenient for reminding the operator to adjust the tourniquet pressure setting in time to reduce safety risks; ensure that the limb of the patient wearing the tourniquet has a trace amount of bleeding, and avoid the risk of limb ischemic necrosis.

Perfusion systems and methods are provided for enhancing perfusion to the vasculature of a patient suffering from reduced blood flow. For example, the system can increase peripheral blood flow to reduce limb ischemia, in which an extracorporeal pump having a controller, and catheter / tubing set, employed alone or in conjunction with an interventional or circulatory assist device, withdraws blood from a patient's vasculature and reintroduces that blood at another location within the patient's vasculature at a controlled local pressure or flow rate, without interfering with operation of the interventional or circulatory assist device or surgical intervention.

Devices and methods are provided for minimizing and / or preventing limb ischemia, such as when a medical device inserted into a patient's vasculature obstructs a blood vessel. The device may include a tubular member and one or more expandable features having a metal wire disposed about the tubular member, the one or more wires disposed about the tubular member configured to expand at a target site, thereby allowing blood to surround and flow through any possibly occluded medical device.

Various systems and devices are provided, such as sheaths configured for forward and retrograde insertion into a patient's vasculature, to help prevent limb ischemia due to the use of mechanical circulation support. Such systems and devices may include various combinations of hub, sheath, and needle designs to allow for, for example, insertion of multiple medical devices into the vasculature of a patient while minimizing occlusion of the blood vessel.

The present invention discloses a communication device for bridging vascular injuries, comprising a bridging tube, with connecting portions provided at both ends of the bridging tube, the connecting portions being provided between the blood vessel and the bridging tube; a branch tube being provided on the outer periphery of the bridging tube to provide a channel for blood vessel supply, the branch tube being provided perpendicular to the axis of the bridging tube; the connecting portion comprising a straight section and a tapered section, both of which are integrally formed; a connecting thread being provided on the outer periphery of the straight section, a connecting thread being provided on the inner sidewall of the end of the bridging tube, the straight section of the connecting portion being threadedly connected to the bridging tube; and the tapered section of the connecting portion being inserted into the blood vessel and fixed by adhesive. The communication device for bridging vascular injuries provided by the present invention has a reasonable structure and is easy to connect, effectively ensuring normal blood supply and avoiding limb ischemia, necrosis, and disability caused by insufficient blood supply.

The invention discloses compounds of Formula (I), wherein the compounds are used as anti-inflammatory agents, for treatment or prevention of a number of diseases or conditions such as atherosclerosis, auto-immune diseases, psoriasis, multiple sclerosis, transplant rejection, asthma, bacterial infection, rhinovirus infection, brain ischemia, ischemia-reperfusion injury, limb ischemia, acute kidney injury, diabetic nephropathy, sepsis, acute respiratory distress syndrome (ARDS), cancer, osteoarthritis, sepsis-induced kidney injury, liver disease, and septic and cardiogenic shock.

An apparatus for detecting limb ischemia in a subject includes a property sensor designed to obtain intramuscular property readings when implanted into the limb; the apparatus features an introducer for sensor placement and a controller that is configured to: receive the property readings from the property sensor; and at least one of: display the property readings on a display; and analyze the property readings to identify a change in an intramuscular property when compared to a reference temperature value, and following the detection, generates a signal or alert indicative of the change in the intramuscular property, whereby the change in the intramuscular property is indicative of a presence of the limb ischemia within the limb; method of use thereof; the apparatus provides a minimally invasive solution for continuous ischemia monitoring, improving early diagnosis, treatment decisions, and patient outcomes.

The invention discloses a gel composition and application thereof in preparation of medicines for treating limb ischemia, the gel composition comprises mesenchymal stem cells and a gel carrier containing selenium, the gel carrier comprises a copolymer of PLGA and PEG, and in the gel carrier, the concentration of selenium is greater than 0 [mu] M and not greater than 2 [mu] M. The gel composition has a good prospect in application to preparation of medicines for treating limb ischemia.

The present disclosure describes, in part, arterial cannula systems for extracorporeal membrane oxygenation and cardiopulmonary bypass provides pulsatile blood flow and selective flow distribution. The cannula comprises a multi-lumen structure including a central lumen for blood flow, dedicated lumens for helium delivery, a distal orifice for body perfusion, and proximal orifices for limb perfusion. An inflatable cuff positioned between the distal and proximal orifices modulates blood flow through rapid inflation and deflation cycles achieved in milliseconds using helium gas. An external control console with microcontrollers and customized software automates the inflation-deflation cycles based on physiological inputs including ECG, arterial pressure, and tissue oxygenation. The system restores physiologically effective pulsatile flow, prevents limb ischemia, reduces thrombus formation risk, and can provide ECG-synchronized flow modulation to facilitate native cardiac ejection, potentially eliminating the need for separate left ventricular venting during mechanical circulatory support.

A method of treatment of critical limb ischemia within a foot of a patient and / or critical hand ischemia within a hand of a patient, the method including the steps of delivering a venous reducer by way of the patient's vasculature to a first delivery location within a vein of the foot and / or hand, the venous reducer comprising an expandable structure that when expanded includes an upstream portion and a downstream portion that are connected by a narrowed connection portion, and expanding the venous reducer within the vasculature of the foot and / or hand of the patient and thus creating an hourglass shaped structure within the vasculature where the narrowed connection portion acts as a restriction for blood flow

The present invention provides a method for constructing a rat model simulating the clinical characteristics of peripheral arterial disease, comprising the following steps: Step 1: A unilateral femoral artery of a diabetic rat is ligated with an Ameroid constrictor ring, and the rat is raised for a period of time; Step 2: The femoral artery of the rat surviving after being raised in Step 1 is ligated. In Step 1 and Step 2, the ligation of the Ameroid constrictor ring and the femoral artery ligation are both located on the same side femoral artery of the rat. The present invention establishes a chronic limb ischemia animal model conforming to the clinical characteristics of peripheral arterial disease. The present invention intends to induce type 2 diabetes in rats by feeding them with a high-fat and high-sugar diet, use an Ameroid constrictor ring on the femoral artery to cause progressive limb ischemia, and then ligate the femoral artery to cause vascular occlusion to simulate critical limb ischemia. The "staged" chronic limb ischemia in diabetic rats provides a suitable animal model for the basic research of peripheral arterial disease.

The invention discloses a limb fixing device for a critical patient, belongs to the technical field of limb fixing, and aims to solve the problems that the contact area between a bandage and the arm of the patient is small, the constraining force is concentrated, pressure injury is easily formed due to long-time constraining, the pain of the patient is increased, local infection is possibly caused, and the illness state is aggravated. The hospital bed comprises a hospital bed body and two supporting plates fixed to one side of the hospital bed body, restraint straps are arranged on one sides of the supporting plates, a plurality of first pressure air bags are installed on one sides of the restraint straps, a plurality of second pressure air bags are further installed on one sides of the restraint straps, and the second pressure air bags and the first pressure air bags are arranged in a staggered mode. Alternate inflation and deflation of the first pressure air bag and the second pressure air bag are achieved through the two-way air pump, so that the pressed parts of the limbs are continuously alternated, local skin and soft tissue are prevented from being in a pressed state for a long time, local blood circulation is effectively improved, the problems of skin redness, pressure sores, limb ischemia and the like are solved, and the completeness of the limb tissue of a patient is protected.

Perfusion systems and methods are provided for increasing peripheral blood flow to reduce limb ischemia, in which an extracorporeal pump having a controller, and catheter / tubing set, employed alone or in conjunction with an interventional or circulatory assist device, withdraws blood from a patient's vasculature and reintroduces that blood at another location within the patient's vasculature at a controlled local pressure or flow rate, without interfering with operation of the interventional or circulatory assist device or surgical intervention.

An apparatus for detecting limb ischemia in a subject includes a temperature sensor designed to obtain intramuscular temperature readings when implanted into the limb; the apparatus features an introducer for sensor placement and a controller that is configured to: receive the temperature readings from the temperature sensor; and at least one of: display the temperature readings on a display; and analyze the temperature readings to identify a decrease in intramuscular temperature when compared to a reference temperature value, and following the detection, generates a signal or alert indicative of the decrease of intramuscular temperature, whereby the decrease in intramuscular temperature is indicative of a presence of the limb ischemia within the limb; method of use thereof; the apparatus provides a minimally invasive solution for continuous ischemia monitoring, improving early diagnosis, treatment decisions, and patient outcomes.

The present invention relates generally to medical compositions, methods and devices / systems for treating vascular diseases. More particularly, the invention relates to medical methods, devices and kits for distributing drug to surrounding vascular tissue to treat neointimal growth. More specifically, the described invention is intended to overcome shortcomings of existing treatments for peripheral artery disease (PAD). Devices and methods of the present invention are specifically intended to treat patients with PAD involving the infrapopliteal (tibial) arteries, e.g., patients having a clinical indication for treatment below the knees (e.g., claudication and / or critical limb ischemia (CLI), and patients with complex disease states, for reducing one or more of morbidity; treatment complications in treated patient populations, a reduction in target lesion revascularization (TLR) rates; and a reduction in patients populations requiring any type of leg amputation.

A control air bag is connected with one end of an air pipe through an air bag additional section, the other end of the air pipe is communicated with a function portion, the function portion is fixedly installed on the upper surface of an air cable tie body, and a first hook-and-loop fastener and a second hook-and-loop fastener are installed on the upper surface of one end of the air cable tie body and the lower surface of the other end of the air cable tie body respectively. According to the utility model, the air bag is controlled to inject air to expand the air ribbon body wound on the arm of a patient, and then the pressure state of the air ribbon body is known in time through the barometer, so that the tourniquet can be conveniently used and the pressure of the tourniquet can be controlled to ensure smooth blood sampling; meanwhile, by means of the automatic timing function of a control panel of the functional part and the automatic deflation function of an electric control valve, the use time can be accurately controlled, the air cable tie body can be automatically loosened after timeout, and limb avascular necrosis and even amputation adverse nursing events caused by forgetting to loosen the tourniquet are completely eradicated; and the occurrence rate of blood sample hemolysis caused by long-time use of the tourniquet is reduced.

Devices and methods are provided for minimizing and / or preventing limb ischemia, such as for minimizing and / or preventing limb ischemia resulting from possibly occluding blood vessels when a medical device is inserted into the vasculature of a patient. The device may include a tubular member and one or more radially expandable features (such as balloons and / or hydrostatic bones, etc.) configured to expand at a target location to allow blood to flow around and / or through the radially expandable features.

The present application relates to a DNA drug, a gene targeting delivery system and its application in the treatment of lower extremity peripheral arterial disease. Specifically, the present application relates to a microcrystalline nanocarbon targeted drug delivery system and a plasmid containing human interleukin-4 gene loaded thereon. The delivery system comprises a matrix microcrystalline nanocarbon, and folate, polyethyleneimine and polyethylene glycol modified on the surface thereof. The matrix microcrystalline nanocarbon has a size of 5-20 nanometers, a crystallinity of >80%, a rich mesoporous structure, a high specific surface area and good biocompatibility. The present application also provides a preparation method of the system, which comprises the steps of synthesizing a matrix by pulse modulation radio frequency plasma enhanced chemical vapor deposition, surface functionalization modification and plasmid loading. After injection into the lower extremity muscle, the system can actively target the macrophages in the ischemic site, realize long-term expression of the IL-4 gene at the lesion site. It can effectively promote stable, mature functional angiogenesis by inducing macrophages to polarize to the repair M2 phenotype and regulating the OSM / GSNOR / ENG signal axis, thereby improving limb ischemia. The present application has important application value in the field of gene therapy for ischemic diseases, especially peripheral arterial disease and severe limb ischemia.

Perfusion systems and methods for increasing peripheral blood flow to reduce limb ischemia are provided in which an extracorporeal pump and catheter / conduit set with a controller, used alone or in combination with an interventional or circulatory assist device, draws blood from the vasculature of a patient, and reintroduces the blood into another location within the patient's vasculature at a controllable local pressure or flow rate without interfering with the operation of an interventional or circulatory assist device or surgical intervention.

A method of treatment of critical limb ischemia within a foot of a patient and / or critical hand ischemia within a hand of a patient, the method including the steps of delivering a venous reducer by way of the patient's vasculature to a first delivery location within a vein of the foot and / or hand, the venous reducer comprising an expandable structure that when expanded includes an upstream portion and a downstream portion that are connected by a narrowed connection portion, and expanding the venous reducer within the vasculature of the foot and / or hand of the patient and thus creating an hourglass shaped structure within the vasculature where the narrowed connection portion acts as a restriction for blood flow.

A method for treatment of critical limb ischemia that includes determining if a patient has pain, establishing if the pain is an ulcer via testing, treating inflow (if existent), determining if a targeted vessel has blood flow, determining if a targeted lesion has blood flow, establishing if outflow is a cause of the occlusion, treating outflow (if existent), performing cardiovascular-death targeted lesion reintervention when applicable, performing a targeted lesion blood flow analytical angiography when applicable, and establishing if an occlusion is narrowed, establishing if an occlusion is blocked and treating each outcome.

A system and method for treatment of ischemia limb by operating the sodium-potassium (Na / K) pumps of the ischemia limb to consume one ATP to actively extrude 3 Na+ and pumping in 2 K+ ions, synchronizing the Na / K pump molecules down to individual steps in a pumping cycle and then switching to a noncanonical mode to synthesize one ATP molecule at end of each pumping cycle. The synthesis of ATP molecule compensates the ATP consumed in actively transporting ions. As a result, the zero-consumption of ATP for the electrically modulated Na / K pumps controlled by the system and method of the present invention save the residual limited ATP molecules in the ischemia limb to maintain the living environment of the cells in the ischemia limb, and therefore recover the functions of the limb.

The application relates to the technical field of medical devices, and discloses a compression type hemostasis device based on cardiology nursing, which comprises a bandage, a monitoring mechanism arranged at the top of the bandage, and a fixing mechanism arranged in the bandage and used for fixing the whole device; the monitoring mechanism comprises a bottom plate arranged at the top of the bandage and used for providing support for working components, a lifting unit arranged at the top of the bottom plate and used for adjusting the compression strength of the device on the human body, a stepped hole opened at the bottom of the bottom plate and capable of accommodating the working components to lift, and an indication unit arranged in the lifting unit and capable of displaying the real-time compression strength of the device on the human body. Through the arrangement of the monitoring mechanism, the compression strength applied to the human body can be sensed and displayed in real time, the compression strength can be adjusted according to the specific condition of a patient, long-time compression on the same part is avoided, blood circulation is prevented from being continuously blocked, and the risk of limb ischemia is reduced.

The present invention concerns the therapeutic use of extracellular vesicles isolated from a genetically modified cell line over-expressing SerpinB3. In particular, said therapeutic use aimed at the treatment of acute pathologies characterized by ischemic or inflammatory tissue damage or by cell injury due to oxidative stress, such as cardiac, cerebral, intestinal, renal or limb ischaemia. Further examples of use consist of the preservation of transplant organs, including heart, lung, liver, bladder, pancreas and intestine. In a further aspect the invention relates to the use of a pharmaceutical composition comprising extracellular vesicles isolated from a genetically modified cell line over-expressing SerpinB3 and a pharmaceutically acceptable vehicle.

The present invention provides mesenchymal stem cells treated with analgin for treating limb ischemia in human patients. The present invention provides a pharmaceutical product, which is used for angiogenesis growth to replace occluded blood vessels to avoid limb amputation. By activating mesenchymal stem cells (MSCs), the secretion of angiogenesis growth factors VEGFA, HGF, bFGF, TEK is stimulated and the level of pro-inflammatory cytokines IF6, CXCF8, CCF2, IL1-RN is reduced. According to the treatment results, MSCs produce proteins and signaling molecules for the growth of new blood vessels, thereby accelerating the growth of new arteries.

The invention relates to the technical field of medical instruments, in particular to a vascular surgery hemostasis device which comprises a bracket, auxiliary frames are fixedly connected to the two sides of the bracket respectively, a hemostasis mechanism is fixedly connected to the tops of the two auxiliary frames, and the hemostasis mechanism comprises a blood vessel pressing assembly and an auxiliary hemostasis assembly which are slidably connected to the tops of the two auxiliary frames. A switching mechanism used for switching the blood vessel pressing assembly and the auxiliary hemostasis assembly is arranged in the auxiliary frame. According to the device, blood vessels above a wound of a patient can be effectively pressed through cooperation of an arc-shaped pressing plate and an inflatable air bag, hemostasis is achieved, through arrangement of a switching mechanism, after pressing is conducted for a period of time, the arc-shaped pressing plate and an auxiliary pressing plate can be switched, limb avascular necrosis caused by long-time pressing is avoided, and the patient is prevented from being injured. When the arc-shaped pressing plate is moved away, the wound can be prevented from bleeding again through pressing of the auxiliary pressurizing plate and the hemostatic cotton, and a good environment is provided for blood vessel recovery.

Devices and methods are provided for minimizing and / or preventing limb ischemia, such as when a medical device inserted into a patient's vasculature obstructs a blood vessel. The device may include a tubular member and a first anchor configured to maintain a position of the tubular member relative to a blood vessel. The first anchor is configured to apposition an inner wall of a blood vessel. The second anchor may cooperate with the first anchor to maintain a position of the tubular member relative to the blood vessel.

The invention relates to the technical field of medical apparatus and instruments, and discloses a compression type hemostasis device for cardiology department nursing, which comprises a bandage, a monitoring mechanism arranged at the top of the bandage, and a fixing mechanism arranged in the bandage and used for fixing the whole device; the monitoring mechanism comprises a bottom plate arranged at the top of the bandage, a lifting unit arranged at the top of the bottom plate and used for supporting the working part, a stepped hole formed in the bottom of the bottom plate and capable of accommodating the working part for lifting, and an indicating unit arranged in the lifting unit; the indicating unit can display the real-time oppression force of the device on the human body. By arranging the monitoring mechanism, the compression force applied to the human body can be sensed and displayed in real time, the compression force can be adjusted according to the specific condition of a patient, the same part is prevented from being compressed for a long time, blood circulation can be prevented from being continuously blocked, and the risk of limb ischemia is reduced.

The invention discloses compounds of Formula (I), wherein the compounds are used as anti-inflammatory agents, for treatment or prevention of a number of diseases or conditions such as atherosclerosis, auto-immune diseases, psoriasis, multiple sclerosis, transplant rejection, asthma, bacterial infection, rhinovirus infection, brain ischemia, ischemia-reperfusion injury, limb ischemia, acute kidney injury, diabetic nephropathy, sepsis, acute respiratory distress syndrome (ARDS), cancer, osteoarthritis, sepsis-induced kidney injury, liver disease, and septic and cardiogenic shock.