42 results about "Cardiogenic shock" patented technology

The invention relates to novel hemoglobin compositions, particularly novel recombinant mutant hemoglobin compositions, which eliminate or substantially reduce 1) the creation of heart lesions, 2) gastrointestinal discomfort, 3) pressor effects, and 4) endotoxin hypersensitivity associated with the administration of extracellular hemoglobin compositions in various therapeutic applications. Applications described include treatments for anemia, head injury, hemorrhage or hypovolemia, ischemia, cachexia, sickle cell crisis and stroke; enhancing cancer treatments; stimulating hematopoiesis; improving repair of physically damaged tissues; alleviating cardiogenic shock; and shock resuscitation.

The present invention provides a method and device for non-invasive anatomical and systemic cooling, fluid removal and / or energy removal. The present invention provides for removal of fluid and cooling of various bodily fluid-containing spaces or surfaces, such as mucus-containing spaces or surfaces via delivery of a dry fluid not including a coolant into or upon the mucus-containing space or surface. Exposure of mucus to the dry fluid yields evaporation of body fluid, removal of energy, cooling of the anatomical feature, and systemic cooling. Therefore, therapeutic hypothermia may be achieved for neuroprotection of various organs after ischemic insult, like the brain after cardiac arrest. Similarly, excess fluid removal is achievable for treatment of cardiogenic shock or other conditions that cause significant fluid build-up, especially in cases of compromised renal function. Additionally, the invention may be used to reduce fever, and other conditions where removal of heat, energy and / or water are beneficial.

The invention relates to a hydroxypropyl-beta-cyclodextrin inclusion compound of ginseng essential oil, a preparation method and application. The ginseng essential oil is a liposoluble constituent indissoluble in water, and is generally applied to ginsenoside preparations in clinics. The hydroxypropyl-beta-cyclodextrin inclusion compound of the invention is prepared from the following ingredients in percentage by weight: 1 of ginseng essential oil and 1 to 100 of hydroxypropyl-beta-cyclodextrin. The ginseng essential oil is added into a water solution containing the hydroxypropyl-beta-cyclodextrin, the ultrasonic treatment is carried out at 30 DEG C at 40 KHz, and then, water-soluble inclusion compounds are formed through being dried. The hydroxypropyl-beta-cyclodextrin inclusion compound can be used as ingredients of medicine for treating body deficiency and prostration, faint pulse and cold extremities, spleen deficiency and poor appetite, pulmonasthenia cough, body fluid deficiency and thirst, internal heat thirst, macronosia deficiency, cardiac shock and the like.

Systems and methods for prediction and detection of circulatory shock using estimates or measurements of arterial blood pressure, heart rate, stroke volume, cardiac output, total peripheral resistance, cardiac ejection fraction, cardiac contractility and ventricular end-diastolic volume are provided. These estimates and measurements are used to determine a type of circulatory shock. In some embodiments, the type of circulatory shock is determined to be one of septic shock, hypovolemic shock, anaphylactic shock, hemorrhagic shock, and cardiogenic shock.

The invention belongs to traditional Chinese medicine preparation and the technical field of the production method thereof. A pulse callbladder-warming decoction new dosage type applies the modernized traditional Chinese medicine theory and the new process, the new technology and the new equipment produced by the traditional Chinese medicine preparation to develop a pulse callbladder-warming decoction new does type peroral traditional Chinese medicine preparation which can fully realize the characteristic of the traditional Chinese medicine preparation and can effectively control the product quality on the basis of the dosage type of the pulse callbladder-warming decoction preparation of the traditional preparation, particularly, the pulse callbladder-warming decoction new dosage type adopts 11 components of traditional Chinese medicine such as pinellia tuber, fresh ginger, bamboo shavings, immature bitter orange, tangerine peel, licorice root, indian bread, Chinese date, ginseng, ophiopogon root and magnolia vine fruit as main raw material to develop a new product of the pulse callbladder-warming decoction new does type traditional Chinese medicine preparation which has the function of supplementing qi and nourishing yin, and removing dampness and resolving heat and is used for pathological symptoms such as coronary heart disease and ventricular extrasystole is developed. The pulse callbladder-warming decoction new does type keeps the inherent characteristic of the original medical broth, has the advantages that the dosage for taking is small, the taking is easy, the dosage is accurate, and the quality is stable, and is suitable for the big production of the mechanization. The invention overcomes the defects that the dosage of the pulse callbladder-warming decoction new does type is big, the carrying is not convenient, the storage can not be long, and the mechanizing production can not be performed.

A freeze-dried powder injection of VC for preventing and treating scurvy, acute and chronic infectious diseases, purpura, Keshan disease, etc is prepared from VC, sodium hydrogen sulfate, and disodium versenate through ultrasonic treating, adding CO2 saturated water for injection in dark condition and N2 atmosphere, regulating pH value and temp, etc.

The invention relates to a traditional Chinese medicinal injection for treating coronary disease, climacteric metancholia, myocardial ischemia, hypoxic encephalopathy and hyperlipoidemia. The invention also discloses its preparing process, new route of administration and new indication errors. The injection is prepared from total saponins of ginseng leaves as raw material, as well as concentrated solution for injection, freeze-dried powder, 5% glucose and 0.9% sodium chloride.

Azolylacryloyl derivatives with hypoxic properties are provided. The compounds have a generic formula: and are suitable for treating sickle cell disease and hypoxia-underlying diseases, e.g. hemorrhagic and traumatic shock, cardiac arrest and cardiogenic shock, traumatic brain injury, cancer, stroke, myocardial infarction, myocardial ischemia, vaso-occlusive crisis, etc.

The invention relates to the use of penehyclidine hydrochloride in the preparation of medicines for treating cardiogenic shock diseases indicating that, in pathological changes, systolic pressure and mean arterial pressure decrease at least by 40%, the maximum rise speed of internal pressure of left ventricle (LV+dp / dtmax) decreases at least 80%, cardiac output decreases at least 40%. The application effect of the invention is shown by the influence of the penehyclidine hydrochloride on acute cardiogenic shock modles.

The invention relates to inhibitors of Multi drug Resistant Protein 4 (MRP4) for the treatment and / or the prevention of cardiac disorders, such as acute or chronic heart failure and cardiogenic shock. The invention also relates to agents stimulating MRP4 activity for the treatment and / or the prevention of cardiac hypertrophy.

The invention provides a new ginseng composition, the content of the total alkaloids in the composition is greater than or equal to 50%, the quality of the ginseng composition provided in the invention is controllable, the stability is good, and the pharmacological effect is obviously better than The listed Shenfu Injection. Among them, the aconitine aconitine extract is a special treatment of the aconite, and the diester aconitine in the aconitum is hydrolyzed to convert it into a very low toxicity alcohol ammonia alkaloid. The invention provides the application of the Shenfu composition in preparing and treating septic shock, hemorrhagic shock and cardiogenic shock.

The invention relates to a pulse-activating preparation for injection and a preparation method thereof. The pulse-activating preparation contains red ginseng, ophiopogon root and Chinese magnoliavine fruit and is mainly used for treating deficiency of both qi and yin, cardiopalmus caused by feeble pulse, breath shortage, cold limbs, sweating, feeble and impalpable pulse, myocardial infraction, cardiogenic shock and infectious shock. The invention has more stable preparation quality and simple and convenient preparation processes, is safe and reliable, and provides the reasonable and realisticpreparation method for large-scale production of Chinese injection preparation.

The present invention provides a method and device for non-invasive anatomical and systemic cooling, fluid removal and / or energy removal. The present invention provides for removal of fluid and cooling of various bodily fluid-containing spaces or surfaces, such as mucus-containing spaces or surfaces via delivery of a dry fluid not including a coolant into or upon the mucus-containing space or surface. Exposure of mucus to the dry fluid yields evaporation of body fluid, removal of energy, cooling of the anatomical feature, and systemic cooling. Therefore, therapeutic hypothermia may be achieved for neuroprotection of various organs after ischemic insult, like the brain after cardiac arrest. Similarly, excess fluid removal is achievable for treatment of cardiogenic shock or other conditions that cause significant fluid build-up, especially in cases of compromised renal function. Additionally, the invention may be used to reduce fever, and other conditions where removal of heat, energy and / or water are beneficial.

The invention relates to a novel stable protein kinase activator adenosine cyclophosphate derivative, which has good storage stability and preparation performance and can be applied to preparations of medicaments for treating or preventing human and mammal diseases, such as angina pectoris, heart failure, myocardial infarction, myocarditis, arrhythmia, acute leukemia, neurological diseases, respiratory system disease, senile chronic bronchitis, hepatitis and psoriasis, etc, and medicaments for improving symptoms of palpitaition, dyspnea and chest distress of rheumatic heart disease.

The relates to the application of panaxadiol saponin in preparing anti-shock medicine, and belongs to the field of new use of effective Chinese medicine components. The present invention aims at applying panaxadiol saponin in preparing medicine for resisting cardiac shock. The present invention has the features of less side effect and high curative effect, and is superior to available anti-shock Western medicines, such as dexamethasone.

The present invention relates to compositions and methods of use thereof for treatment of clinical conditions manifested from and / or exacerbated by a decrease or an inhibition of Na / K ATPase activity. The invention relates to composition comprises monoclonal or polyclonal antibodies to bufalin and / or bufalin sulfate, or vaccination against bufalin and / or bufalin sulfate, which prevents or attenuates inhibition of Na / K ATPase activity thereby attenuating the adverse physiological effects of bufalin and / or bufalin sulfate inhibition. The invention also relates to methods of treating hemorrhagic, septic shock, cardiogenic shock, shock resulting from physical trauma, diabetes, mental depression, bipolar disorder and schizophrenia comprising administering a therapeutically effective amount of an bufalin monoclonal or polyclonal antibody.

The invention discloses a medicine composition for treating cardiac and pulmonary multi-viscera failure, which is prepared from 27 types of medicines, such as unprocessed radix aconiti lateralis, honey monkshood, rhizoma zingiberis, radix glycyrrhizae preparata, ginseng, fructus corni and the like. On the aspect of compatibility of medicines, a medicine boiling method is improved. Honey is added into the whole medicine to be mutually boiled, and a long boiling method keeps constant effect, is safe and stable and does not have risks. The medicine composition has an obvious curative effect on circulation failure caused cardiogenic shock, toxic shock, atrophic lung disease, gurgling sound of phlegm in the throat, hemorrhagic shock and emergency, can prevent typhoid fever, common cold and flu, and has the efficacy of delaying the ageing speed of viscera, nourishing yin, tonifying Yang, improving immunity, soothing the liver and relieving depression.

The present invention relates to compositions and methods of use thereof for treatment of clinical conditions manifested from and / or exacerbated by a decrease or an inhibition of Na / K ATPase activity. The invention relates to composition comprises monoclonal or polyclonal antibodies to bufalin and / or bufalin sulfate, or vaccination against bufalin and / or bufalin sulfate, which prevents or attenuates inhibition of Na / K ATPase activity thereby attenuating the adverse physiological effects of bufalin and / or bufalin sulfate inhibition. The invention also relates to methods of treating hemorrhagic, septic shock, cardiogenic shock, shock resulting from physical trauma, diabetes, mental depression, bipolar disorder and schizophrenia comprising administering a therapeutically effective amount of an bufalin monoclonal or polyclonal antibody.