81 results about "Local infection" patented technology

The present invention discloses a selective and a non-selective method and means of treating microbial diseases in local infections. The novel method comprising the step of emitting a beam of a blue light towards the tissue to be treated, wherein the beam is having a wavelength from 400 to 550 nanometers and further wherein the temperature of said tissue is not exceeding about 42° C. along the procedure or immediately after it so that a selective phototoxic effect is exerted. A cost effective device for selectively or non-selectively exerting phototoxic effect by emitting a beam of blue light towards a tissue to be treated is also provided useful, especially for dental application.

The invention relates to hydrogel wound dressing for treating laser cauma and burns and scalds. The active components of the hydrogel wound dressing include an antibacterial agent, a humectant and a stabilizer, wherein the antibacterial agent inhibits adhesion and growth of the wound of laser cauma and surrounding bacteria and can kill various pathogenic bacteria at the cauma part, so as to effectively promote union of the laser cauma. The antibacterial agent adopted by the invention does not generate drug resistance, the humectant can maintain moisture of the wound, promote union of the wound surface, prevent formation of scars and alleviate wound pain. With the adoption of the stabilizer, the hydrogel maintains long-time antibacterial effectiveness. Experiments verify that the hydrogel dressing provided by the invention has the effects of effectively relieving wound pain, controlling local infection, maintaining moisture of wound skins, protecting skins, accelerating and promoting union of wound surface and wound and preventing formation of scars, and can be used for healing laser-burned skin wound surfaces (such as laser mole removal and the like) and wound surfaces of burns and scalds.

The present invention discloses a selective and a non-selective method and means of treating microbial diseases in local infections. The novel method comprising the step of emitting a beam of a blue light towards the tissue to be treated, wherein the beam is having a wavelength from 400 to 550 nanometers and further wherein the temperature of said tissue is not exceeding about 42° C. along the procedure or immediately after it so that a selective phototoxic effect is exerted. A cost effective device for selectively or non-selectively exerting phototoxic effect by emitting a beam of blue light towards a tissue to be treated is also provided useful, especially for dental application.

The invention discloses a VEGF and vancomycin-supported multilayer local slow release microsphere preparation with sodium alginate and chitosan as a carrier, a preparation method of the microsphere preparation, and an application of the microsphere preparation in the preparation of medicines for treating bone defects, bone tissue regeneration and wound healing, and belongs to the technical field of medicine slow release microspheres. In the invention, a core sphere is prepared through an instillation process, and other multilayer microspheres are prepared according to a positive and negative charge attraction and layer-by-layer self assembling principle. Sodium alginate and chitosan are natural polymer polysaccharides, chitosan is a polycation polymer material, and the side chain structure of chitosan contains a large number of free amino groups; and sodium alginate is a polyanion material, the molecular side chain of sodium alginate contains a large number of carboxyl groups, sodium alginate and chitosan undergo a complexing reaction through attraction of positive and negative charges, and the core-shell multilayer slow release medicine multilayer sphere is formed by sequentially wrapping according to the layer-by-layer self assembling principle, so multilayer slow release microsphere preparation can promote local angiogenesis, improve blood circulation and control local infection.

The present invention relates to a method for treating a local infection, for example, a periodontal disease, peri-implantitis or dermartitis, comprising applying a composition containing hydrogen peroxide and a polyphenol such as catechins to an infected site, for example, inside oral cavity or skin, and irradiating the site with light for a predetermined period of time.

The application relates to a method and system for prevention and control of infectious diseases. The method comprises: identifying high-risk areas of an infectious disease according to local infection risk data; identifying a user accessing the high-risk areas and a morning departure time, an evening returning time, a home location, a first destination location after departure from home, and a last destination location before returning home of the user based on regular mobile phone data; developing travel time prevention and control measures according to the active time of infectious disease sources, and sending corresponding travel intervention information to the user by combining the morning departure time, the evening returning time and local infection risk values of the home location, the first destination location after departure from home, and the last destination location before returning home of the user. The method and the system send personalized travel intervention information to the user to guide the user to adjust the travel time, so that the input risk of the high-risk areas can be reduced.

The present invention relates to the field of medical technology. By using carboxymerhyl chitosan as slow-releasing assistant and antiseptic as carrier and through emulsification and crosslinking process, a kind of degradable slow-releasing microball is prepared capable of being implanted in operation incision to prevnet post-operational local infection. The slow-releasing preparation of the present invention has the features of degradability and small volume, and avoids the shield to biological repair in oganism.

An optical skin germicidal device and method that uses germicidal ultraviolet light to treat local infections. The device includes a germicidal light source connected to a flexible optical fiber and a hollow needle designed to receive the optical fiber. The optical fiber, which is designed to slide freely inside the needle, is covered with cladding except for the distal end or section that slides into the needle. Formed on the inside surface of the needle is an elongated slot that allows rays of optical light to exit the needle. The slot is sufficient in width so that the optical fiber remains at all times inside the curved needle. By moving the optical fiber along the needle, the tissue surround the inside surface of the needle adjacent to the slot may be treated with germicidal light. Using the device, a method of treatment is also provided.

The invention discloses a nasal polymer gel filling material and a preparation method thereof. The nasal polymer gel filling material is prepared from the following raw materials: gel and a crosslinking agent which is 0.1-2% of the mass of the gel. The preparation method comprises the following steps: adding the crosslinking agent to a water solution of gel to obtain a mixed solution; carrying out crosslinking reaction under the condition at 40-80 DEG C to obtain modified gel; soaking the modified gel into distilled water for 12-48 hours; replacing the water once at an interval of two hours; and carrying out freeze drying, so as to obtain the nasal polymer gel filling material. The gel filling material forms a compressed state when being placed, and is easy to put in, and light in adhesion with tissues, so that the expanded filling material is soft, and not easy to be extracted, and does not lead to adhesion of a nasal cavity. The inhibition ratio of the filling material on microorganisms such as staphylococcus aureus and escherichia coli can be up to over 90%, prevention of local infection is facilitated, and the anti-inflammatory action after chronic sinusitis-nasosinusitis surgery is improved.

The invention relates to a medicinal composition for treating canker sore and local infection of body surface and reducing inflammation, a product and application thereof. The medicinal composition comprises aminoglycoside antibiotics, local anaesthetics and glucocorticoids in weight ratio of (0.1-10):(1-10):(0.01-10). Compared with the prior art, the medicinal composition has the advantages that local anaesthetics can alleviate pains of patients in time; antibiotics has the antibiotic effect of treating infection caused by bacteria; and the glucocorticoids has the anti-inflammatory effect of reducing focus hyperemia, reducing permeability of capillary and inhibiting inflammatory cells from transferring to the inflammatory part; and the synergistic action of the three medicaments promotes the healing of canker sore so as to achieve good treatment effect.

The invention discloses a slow-release antibacterial composite film capable of guiding bone tissue regeneration and a preparation method thereof. The preparation method comprises the following steps: by using a bacterial cellulose membrane as a substrate, supporting nano calcium phosphate on the bacterial cellulose membrane to obtain a nano calcium phosphate / bacterial cellulose membrane, and modifying the nano calcium phosphate / bacterial cellulose membrane by using dopamine, thereby obtaining the dopamine-modified bacterial cellulose membrane; preparing gamma-polyglutamic acid / levodopa gel microspheres, and supporting an antibacterial drug to obtain a functionalized gel; and pouring the functionalized gel onto the surface of the dopamine-modified bacterial cellulose membrane, and drying to obtain the slow-release antibacterial composite film capable of guiding bone tissue regeneration. The slow-release antibacterial composite film capable of guiding bone tissue regeneration has the firmly combined interface, has certain mechanical properties, bone guiding activity and bone conduction activity, and can slowly release the antibacterial drug to prevent or treat local infection.

The invention relates to chitosan anti-tumor hydrogel and application. The chitosan anti-tumor hydrogel is obtained by reaction of water-soluble chitosan, a crosslinking agent and water-soluble anti-tumor medicine. According to the chitosan anti-tumor hydrogel, safety is high, the effect of tumor inhibition is obvious, the intensity of the hydrogel can be adjusted according to required releasing time, meanwhile, the chitosan anti-tumor hydrogel has a certain bacteria resistance and bacteria inhibition characteristics, and local infection of implantation can be effectively prevented.

The invention relates to the field of the medicines for preventing postoperative wound infection and specifically discloses a medicine for preventing postoperative infection and scars. The medicine is prepared from the following raw materials by weight: 1-5g of muskone, 1-5g of saffron crocus, 3-10g of dragon's blood, 10-30g of coptis chinensis, 3-10g of frankincense, 3-10g of myrrh, 3-10g of scutellaria baicalensis, 3-10g of rheum officinale, 3-10g of pearl, 1-6g of calculus bovis, 10-25g of beewax and a proper amount of vaseline base. The medicine for preventing postoperative infection and scars has the effects of sterilization, inflammation diminishing, detumescence, pain relieving and slough removing and tissue regeneration promoting on various wounds, burn and scald, and is capable of promoting quick growth of granulation tissues and accelerating healing of wounds. The medicine is capable of preventing local infection, eliminating suture reaction and preventing scars; as a result, the problem of easy postoperative infection and scar formation in the prior art, and the problems of slow wound recovery and healing and easy infection and scar formation after an operation are solved. Besides, the medicine has the effects of relieving pain and accelerating healing of wounds.

The invention discloses a clindamycin phosphate oral pharmaceutical preparation, which is mainly prepared from raw materials in the following weight ratio: (1) a buccal tablet which comprises 1 to 100 portions of clindamycin phosphate counted on clindamycin, 0 to 100 portions of disintegrant, and 5 to 500 portions of filler; (2) a filmogen which comprises 1 to 100 portions of the clindamycin phosphate counted on the clindamycin, and 5 to 500 portions of film-forming material; and (3) an oral patch which comprises 1 to 100 portions of the clindamycin phosphate counted on the clindamycin, 5 to 500 portions of the filler, and 1 to 100 portions of adhesive material. The clindamycin phosphate oral pharmaceutical preparation is directly applied to a local infection and has high local drug concentration and fast effect, and the dose is low and adverse reactions are few.

The present invention discloses a compound of an chlorhexidine acetate local membrane forming gel, which comprises the components of the following weight percentages comprising 0.5 percentage to 7 percentage of alkyl cellulose, 1 percentage to 10 percentage of etherifying agent, 0.5 percentage to 5 percentage of cross linking agent,75 percentage to 90 percentage of dissolvent, 0.01 percentage to 3 percentage of chlorhexidine acetate. The cross linking agent is the saturated fat or the alcoholic acid, the chemical general formula of which is CnH2n+2-m-l(OH)m(COOH)l. Among the formula, m or n or 1 is the integer and the n is no less than m, which is no less than 2. 1 is no less than 0 and the result of m plus 1 is 4 to 8. The result of n plus 1 is 4 to 8. In the present invention, the compound of the chlorhexidine acetate local membrane forming gel is applied in the treatment of the local infection in the mucosa or the skin. A water drain protective membrane with smooth property, firm property, wear-resisting property and duration property is formed on the surface of the ulcer when the present invention is applied. Compared with all kinds of local formulation of the chlorhexidine acetate, the membrane formed by the gel compound is not likely to experience fracture, dissolution or corrosion. The membrane has properties of long maintenance time and slow releasing of the medicine. The membrane can be effectively maintained in the skin surface for over 8 hours and the membrane can be effectively maintained on the mouth mucosa surface for over 5 hours.

The invention discloses a Chinese and Western external preparation for treating burns and scalds. The preparation comprises antibiotic, distilled water, as well as Chinese angelica and garden burnet at a weight ratio of 1:(30-80):(30-50). A preparation method of a Chinese angelica and garden burnet equal extract comprises the steps of mixing and cooking the Chinese angelica and the garden burnet in the same parts by weight with the distilled water at a weight ratio of 1:13, and filtering and extracting juice, namely the Chinese angelica and garden burnet equal extract, 10 minutes after boiling. The Chinese and Western external preparation has the advantages that the preparation has the characteristics of no need of isolation and skin grafting, short treatment cycle, high cure rate, low possibility of infection, low probability of scars, lower treatment cost and the like; the probability of the scars is lower, and no pigmentation occurs after curing for second-third-degree burn and scald patients with burn and scald areas less than 50%. The medicine can inhibit great proliferation of fibroblasts, has functions of resisting local infection and promoting quick formation of skin islands in burnt sites, and achieves the purpose of quickly curing the burns.

The invention discloses a gallium-contained polycaprolactone / bioglass porous bone repair 3D printing support and the application thereof in infectious bone defect repair. Gallium has the good antibacterial property, and can inhibit bone damage differentiation as well, so that gallium can effectively inhibit osteolysis which might exist in bone infection. Bioglass has the capability of promoting osteogenic differentiation, and mesoporous bioglass particles have pore channel structures, and thereby being capable of being loaded with ingredients and releasing the ingredients slowly. According tothe gallium-contained polycaprolactone / bioglass porous bone repair 3D printing support and the application thereof in infectious bone defect repair, the antibacterial property and the bone damage inhibition effect of gallium, and the bone differentiation promotion effect of bioglass are combined, a local infection focus is directly removed, and the balance between osteogenesis and bone damage in the bone repair process can be further adjusted; and the functional bone repair support is built by applying the 3D printing technology and utilizing the good biocompatibility and the dynamic supporting action of polycaprolactone, the structure of the support can be flexibly designed according to the features of a damaged part, the size of the support is controllable, and the support has the significant application prospect in bone defect repair.

The invention provides a sustained-release injection or sustained-release implant containing lincomycin antibiotic. The sustained-release injection comprises sustained-release microspheres and solvent. The microspheres contain sustained-release adjuvants and antibiotics, and the solvent is a special solvent containing suspending agent such as sodium carboxymethylcellulose and having viscosity of 100-3000cp (20-30 DEG C); and the sustained-release adjuvants are selected from poly(ethylene-co-vinylacetate) (EVAc), polifeprosan, poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), sebacic acid copolymer, albumin glue and gelatin. The sustained-release implant is made from microspheres or by other methods. The sustained-release implant or injection can be locally placed or injected into foci to locally sustained-release of drug for more than 10 days, so as to obtain and maintain local drug effective concentration while remarkably reduce the systemic toxicity of the drug. The sustained-release injection has distinct and unique therapeutic effect on local infection diseases caused by Staphylococci, Streptococci, Peptostreptococcus, Propionibacterium acnes, Enterobacter, Mycobacterium tuberculosis, Gonococcus or Meningococcus, such as chronic osteomyelitis, severe decubital ulcer, refractory skin ulcer, diabetic foot, femoral head necrosis, abscess, etc.

The invention discloses an effective treatment method for the kiwi fruit canker. The method comprises the following steps that 1, the severely-diseased part is cut away; 2, an agent directly enters the phloem for absorption, and through up-down delivery, pathogenic bacteria are killed; 3, the agent is slowly supplied for a long time; 4, the pathogenic bacteria are insulated and prevented from spreading; 5, sunniness heating is used for inhibiting the pathogenic bacteria; 6, by wrapping wounds and conducting shading, healing of the wounds is accelerated. According to the effective treatment method for the kiwi fruit canker, based on the characteristics of low drug resistance to the kiwi fruit canker (the kiwi fruit canker cannot be treated mainly because of the concealing of the pathogenicbacteria, which causes the agent not to be in contact with the pathogenic bacteria), local infection and low tolerance of high temperature (inhibition is caused at 28 DEG C, and death is caused at 30DEG C), through diseased peel cutting, agent storage by an inner wrapping layer, agent reservation by an outer wrapping layer and agent injection, the situation is avoided that in the prior art, the agent cannot be supplied to the phloem for sterilization for a long time. The canker is effectively prevented and controlled, and a good treatment effect is achieved.

The invention relates to a preparation method of a modified peptide. The preparation method comprises the following steps: covalently coupling a polypeptide with a photosensitizer through three glycines (GGG), wherein the conjugate has a relatively strong antibacterial effect (the antibacterial rate) of 50%, and can effectively kill most microorganisms including drug-resistant bacteria under illumination, and the sterilization rate reaches 99.999%. The conjugate has the effects of preventing infection and promoting healing on cut wounds of mice. The compound is simple in preparation method, relatively high in yield and convenient to store, can be used for preparing products such as antibacterial reagents and antibacterial drugs, and has a good application prospect in the fields of clinicaltreatment of local infection and wound dressing.

The invention adopts a method of cryptocaryon irritans locally-infected epinephelus coioides one-sided skin for immunity for the first time, adopts an optimized infection concentration and infection duration time to construct an immune model of the cryptocaryon irritans locally-infected epinephelus coioides one-sided skin for the first time, thoroughly eliminates an adverse effect brought by ''congenital differences'' in the process of local skin mucosal immune response in fish, and provides an ideal immune model for researching a local mucosal immune response law. The construction method forthe immune model mainly comprises the following five steps: (1) collecting live larvae of the cryptocaryon irritans and calculating a concentration; (2) grouping the epinephelus coioides and performing domestication; and (3) performing local skin immunization; (4) measuring infection intensity; and (5) performing treatment on locally-infected fish bodies.

The invention belongs to the technical field of veterinary drugs and relates to livestock cefquinome colon-targeted pills. The livestock cefquinome colon-targeted pills comprise cefquinome serving as a main drug, and empty pellets are covered with a drug layer made of the cefquinome, 8 percent of a block layer made of cetanol, 2 percent of a time lag layer made of HPMC, and 15 percent of a pH sensitive film made of eudragit S100 respectively to form the livestock cefquinome colon-targeted pills. The livestock cefquinome colon-targeted pellets combining time lag and pH sensitivity can release drug at fixed positions of the colons of livestock, greatly improve the treatment effect on local infection and general infection, have low toxicity and little residue in edible animal tissues, and can be widely applied to clinic treatment of the livestock.

The present invention enables modification of an intraosseous implant device that is not only biologically non-inert, but can stimulate bone and vascular growth; decrease localized inflammation; and fight local infections. The method of the present invention provides a fiber with any of the following modifications: (1) Nanofiber with PDGF, (2) Nanofiber with PDGF+BMP2, and (3) Nanofiber with BMP2 and Ag. Nanofiber can be modified with other growth factors that have been shown to improve bone growth and maturation—BMP and PDGF being the most common. Nanofiber can be applied on the surface of the implant in several ways. First, a spiral micro-notching can be applied on the implant in the same direction as the threads with the nanofibers embedded into the notches. Second, the entire surface of the implant may be coated with a mesh of nanofibers. Third, it can be a combination of both embedding and notching.

The invention relates to the use of the peptide toxin APETx2 that blocks the ASIC3 cationic channels and that is derived from the Anthopleura elegantissima sea anemone, and to the use of the analogs and derivatives thereof as a drug, particularly as an analgesic pain associated with the activation of ASIC3 (Acid Sensing Ion Channel 3) channels, in particular pain occurring upon an inflammation and potentially upon any painful situation associated with tissue acidosis (ischemiae, fractures, hematoma, oedema, phlyctena, local infections, tissue lesions, ocular wounds, tumours, etc.)

The invention relates to the use of the peptide toxin APETx2 that blocks the ASIC3 cationic channels and that is derived from the Anthopleura elegantissima sea anemone, and to the use of the analogs and derivatives thereof as a drug, particularly as an analgesic pain associated with the activation of ASIC3 (Acid Sensing Ion Channel 3) channels, in particular pain occurring upon an inflammation and potentially upon any painful situation associated with tissue acidosis (ischemiae, fractures, hematoma, oedema, phlyctena, local infections, tissue lesions, ocular wounds, tumours, etc.).

The invention discloses a method for immunization by using cryptocaryon irritans to locally infect the unilateral gill of epinephelus coioides for the first time, the optimized infection concentrationand infection duration are used to construct an immune model of the cryptocaryon irritans to locally infect gill tissues of the epinephelus coioides for the first time, the negative effects caused bycongenital difference in the immune response process of fish local gill tissue mucous membranes are completely eliminated, and an ideal immune model is provided for studying the local mucous membraneimmune response rule. A construction method for the immune model mainly comprises five steps of (1), collecting cryptocaryon irritans live larvae, and conducting concentration calculation; (2), conducting grouping and domestication on the epinephelus coioides; (3), conducting local gill tissue immunization; (4), measuring infection intensity; (5) treating a fish body after local infection.

The invention discloses a nasal polymer gel filling material and a preparation method thereof. The nasal polymer gel filling material is prepared from the following raw materials: gel and a crosslinking agent which is 0.1-2% of the mass of the gel. The preparation method comprises the following steps: adding the crosslinking agent to a water solution of gel to obtain a mixed solution; carrying out crosslinking reaction under the condition at 40-80 DEG C to obtain modified gel; soaking the modified gel into distilled water for 12-48 hours; replacing the water once at an interval of two hours; and carrying out freeze drying, so as to obtain the nasal polymer gel filling material. The gel filling material forms a compressed state when being placed, and is easy to put in, and light in adhesion with tissues, so that the expanded filling material is soft, and not easy to be extracted, and does not lead to adhesion of a nasal cavity. The inhibition ratio of the filling material on microorganisms such as staphylococcus aureus and escherichia coli can be up to over 90%, prevention of local infection is facilitated, and the anti-inflammatory action after chronic sinusitis-nasosinusitis surgery is improved.

Disclosed is a method of inhibiting the growth of neoplastic tumors and lesions and localized infections by administering an Immune Response Modifier (IRM) drug to human patients suffering from such tumors, lesions or infections. IRMs act by stimulating cellular immunity and have been found to have both anti-viral and anti-tumor effects. By administering IRM drugs directly into a tumor, lesion or infection, the cells of the tumor, lesion or infection, as well as those surrounding the tumor, lesion or infection can be stimulated to increase their cellular response, thereby inhibiting the growth of such tumors, lesions or infections.

The invention discloses a gallium-containing polycaprolactone / bioglass porous bone repair 3D printing scaffold and its application in the repair of infectious bone defects. Gallium has good antibacterial properties, and can also inhibit osteoclast differentiation, effectively inhibiting possible osteolysis in bone infection. Bioglass has the ability to promote osteogenic differentiation, and mesoporous bioglass particles have a pore structure that can load components and release them slowly. The invention combines the antibacterial and osteocracking effects of gallium and the osteogenic differentiation promoting effect of bioglass, directly removes local infection foci and further regulates the balance of osteogenesis and osteoclastion in the process of bone repair. The invention applies 3D printing technology and utilizes the good biocompatibility and mechanical support of polycaprolactone to construct a functional bone repair scaffold whose structure can be flexibly designed according to the characteristics of the defect site and whose size is controllable. has important application prospects.

The invention provides a sustained-release injection or sustained-release implant containing antibacterial drugs. The sustained-release injection comprises sustained-release microspheres and solvent. The microspheres contain sustained-release adjuvants and antibiotics, and the solvent is a special solvent containing suspending agent such as sodium carboxymethylcellulose and having viscosity of 100-3000cp (20-30 DEG C); and the sustained-release adjuvants are selected from EVAc, polifeprosan, poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), sebacic acid copolymer, albumin glue and gelatin. The sustained-release implant is made from microspheres or by other methods. The sustained-release implant or injection can be locally placed or injected into foci to locally sustained-release of drug for more than 10 days, so as to obtain and maintain local drug effective concentration while remarkably reduce the systemic toxicity of the drug. The sustained-release injection has distinct and unique therapeutic effect on local infection diseases caused by Staphylococci, Streptococci, Peptostreptococcus, Propionibacterium acnes, Enterobacter, Mycobacterium tuberculosis, Gonococcus or Meningococcus, such as chronic osteomyelitis, severe decubital ulcer, refractory skin ulcer, diabetic foot, femoral head necrosis, abscess, etc.