20 results about "Local infection" patented technology

The invention relates to the technical field of materials for preventing and treating local infection, in particular to drug-loaded composite nanoparticles as well as a preparation method and application thereof. The drug-loaded composite nanoparticles provided by the invention comprise hollow polydopamine grafted with vancomycin and lipoic acid-quaternary ammonium salt ionic liquid loaded into a cavity of the hollow polydopamine. In the invention, the HPDA nanoparticles have a hollow structure, and the structure provides sufficient space for loading of drug molecules. The lipoic acid-quaternary ammonium salt ionic liquid can generate heat energy under the microwave heat effect, and bacteria are effectively killed. Besides, under microwave stimulation, the lipoic acid-quaternary ammonium salt ionic liquid not only can enhance the sterilization effect, but also can reduce inflammatory response caused by bacterial infection through the synergistic effect of microwave heat effect and chemical sterilization.

The application relates to the technical field of duck breeding, and provides an intelligent marking and egg laying breeding device for breeding ducks, which comprises a net bed and an egg laying row nest, the egg laying row nest is arranged around the net bed, padding is arranged in the egg laying row nest, and the device further comprises independent egg laying nests, the independent egg laying nests are arranged in the egg laying row nest, and the device has the advantages that the two times of weighing when a duck enters and walks out of the independent egg laying nest are compared, when the difference between the two times of weighing is greater than or equal to a specified value, the duck is defined as having laid an egg, the pigment in a pigment spray tank can be sprayed on the duck through the perforation to mark the duck, the color on the duck can be observed in the daily feeding process to accurately lock the target duck that has not laid an egg for a long time, the duck cannot be caused to have persistent physiological stress and local infection, the duck that has low egg laying efficiency can be timely eliminated, and the feed cost and environmental pollution of a breeding farm can be reduced.

The utility model relates to the technical field of gastrostomy, and discloses an improved gastrostomy device which comprises an injection needle, a wire penetrates through the injection needle, the upper end of the wire is connected with a PEG feeding tube, the top of the PEG feeding tube is fixedly sleeved with a stop block, the outer end of the PEG feeding tube is sleeved with a protection assembly, and the stop block is located in the protection assembly. The upper end of the guide wire is connected with the PEG feeding tube through a connecting assembly, the connecting assembly comprises a connecting plate, the connecting plate is installed at the lower end of the PEG feeding tube, a connecting insertion cylinder is fixedly installed at the lower end of the connecting plate, the upper end of the guide wire is detachably inserted into the connecting insertion cylinder, and a silica gel positioning block is arranged in the connecting insertion cylinder. According to the stomach fistulization device, the protection assembly is additionally arranged on the basis of an original pull-out method stomach fistulization device, tumor planting caused by the pull-out method can be reduced, mucous membrane damage and tumor bleeding caused by the pull-out method can be avoided, meanwhile, the local infection occurrence rate can be reduced, the safety of the pull-out method is better improved, and the clinical treatment effect is improved.

Provided herein are rapid and effective local infection therapy methods, systems, and devices that significantly reduce the mortality, morbidity, and the cost of care in rare musculoskeletal infections. Continuous delivery of antibiotic therapy locally, at the infection site, reduces edema and provides antibiotic irrigation, significantly improving outcomes while reducing the need for systemic antibiotics.

The invention discloses a limb fixing device for a critical patient, belongs to the technical field of limb fixing, and aims to solve the problems that the contact area between a bandage and the arm of the patient is small, the constraining force is concentrated, pressure injury is easily formed due to long-time constraining, the pain of the patient is increased, local infection is possibly caused, and the illness state is aggravated. The hospital bed comprises a hospital bed body and two supporting plates fixed to one side of the hospital bed body, restraint straps are arranged on one sides of the supporting plates, a plurality of first pressure air bags are installed on one sides of the restraint straps, a plurality of second pressure air bags are further installed on one sides of the restraint straps, and the second pressure air bags and the first pressure air bags are arranged in a staggered mode. Alternate inflation and deflation of the first pressure air bag and the second pressure air bag are achieved through the two-way air pump, so that the pressed parts of the limbs are continuously alternated, local skin and soft tissue are prevented from being in a pressed state for a long time, local blood circulation is effectively improved, the problems of skin redness, pressure sores, limb ischemia and the like are solved, and the completeness of the limb tissue of a patient is protected.

The utility model discloses a dual-channel anti-acupuncture arterial blood sample collector, relates to the technical field of medical instruments, and solves the problems in the prior art that the risk of local infection is increased and the working efficiency is reduced as multiple times of puncture are required to extract a blood sample. Comprising a puncture needle tube and a double-channel blood guide valve, the double-channel blood guide valve is arranged at the rear end of the puncture needle tube and comprises a valve body and a rotary core, a first blood guide tube and a second blood guide tube are perpendicularly arranged in the valve body in a crossed mode, and the front end of the first blood guide tube and the front end of the second blood guide tube are both communicated with an inner cavity of the puncture needle tube. The rear ends respectively correspond to the first valve port and the second valve port; the first valve port and the second valve port are respectively connected with a sample storage device and a heparin cap; the rotary core is rotationally connected into the valve body, and a blood guide groove is formed in the rotary core. The puncture needle has the advantages that passages can be switched by rotating the rotary core, sample collection is achieved after one-time puncture, working efficiency is improved, and infection risks are reduced.

The invention relates to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine external cleaning agent for treating balanitis as well as a preparation method and application of the traditional Chinese medicine external cleaning agent. The cleaning agent is prepared from the following components in parts by weight: 20-40 parts of radix sophorae flavescentis; 5-15 parts by weight of honeysuckle flower; 20-40 parts by weight of rhizoma smilacis glabrae; 20-40 parts by weight of folium artemisiae argyi; 20-40 parts by weight of cortex dictamni; and 10-20 parts by weight of talc. The cleaning agent is prepared into a water decoction through the processes of cleaning, soaking, decocting, filtering and the like. The traditional Chinese medicine composition can quickly improve clinical symptoms of balanitis, remarkably improve the treatment effective rate, effectively regulate traditional Chinese medicine syndromes and control local infection, and has good safety and patient satisfaction.

The invention discloses a knee joint prosthesis. The knee joint prosthesis comprises a thighbone component, a tibia component and a prosthesis coating. The tibia component comprises a tibia cushion block mechanism, a tibia articular surface liner mechanism, a tibia long rod mechanism, a medicine inserting cavity and a long rod slow-release medicine guide hole. The bending and stretching movement of a natural knee joint can be simulated between the thighbone component and the tibia component; in the postoperative stage, a sustained-release drug tablet is inserted into a drug insertion cavity, is guided downwards through a long-rod sustained-release drug guide hole, sequentially passes through a tibia cushion block mechanism and a tibia long-rod mechanism, and is gradually released to peripheral tissues of a knee joint prosthesis through the long-rod sustained-release drug guide hole; longitudinal three-dimensional medicine slow release from the articular surface to the marrow cavity is achieved, local infection can be restrained, postoperative inflammatory response can be relieved, the anti-infection effect is improved, the overall structure is designed in a modular mode, surgical operation, medicine supplement and assembly maintenance are facilitated, and good use convenience and safety are achieved.

The invention discloses an intramedullary nail capable of slowly releasing antibiotics. The intramedullary nail comprises an intramedullary nail body, a medicine cavity is formed in a rod body of the intramedullary nail body, a plurality of microspheres are put into the medicine cavity, the antibiotics are wrapped in the microspheres, and a plurality of releasing micropores are formed in the rod body, corresponding to the medicine cavity, of the intramedullary nail body. According to the intramedullary nail, the microspheres sealed with antibiotics can be put into the intramedullary nail, the antibiotics can be slowly released through the release micropores, the anti-infection effect on osteomyelitis and local infection patients can be achieved, the microspheres do not need to be taken out in a short time, the pain of the patients is relieved, and the intramedullary nail has the advantages of being simple in structure, convenient to use, low in cost and the like.

The invention discloses a medical sodium hyaluronate gel and a preparation method thereof, and belongs to the technical field of sodium hyaluronate gels, and the preparation method comprises the steps of buffer solution preparation, antibacterial mother solution preparation, collagen tripeptide solution preparation, premixing, intermediate preparation, high-pressure homogenization, filling, sterilization lamp inspection, inner packaging, delivery inspection, outer packaging and warehousing. According to the invention, the immunoreaction after injection can be effectively relieved, uncomfortable symptoms such as red and swollen, swelling pain and the like of an injection part are reduced, meanwhile, the local infection risk caused by continuous immunoreaction is reduced, and the use safety and comfort of the product are remarkably improved.

The invention relates to the technical field of pharmaceutical preparations, and particularly provides an MCP-1 response type microneedle, a microneedle patch and a preparation method and application of the MCP-1 response type microneedle and the microneedle patch. The MCP-1 response type microneedle loaded glucan modified silver nanoparticles and the heparin modified taurine PLGA microspheres are used for targeted elimination of bacteria and reprogramming of an immune microenvironment. The invention develops a double-layer microneedle system responding to a bacterial microenvironment, and by integrating antibiosis, antioxidation and M2 type macrophage polarization capability into the double-layer microneedle structure, local infection control, immune regulation and tissue regeneration can be synergistically combined, so that the key obstacle of wound repair is effectively overcome, the complex wound healing obstacle can be solved, and the wound healing effect is improved. And particularly, a comprehensive solution is provided for infectious and chronic wounds such as diabetes mellitus and the like.

The invention relates to the technical field of drainage equipment, and particularly discloses clinical ascites drainage equipment for the gastroenterology department, the clinical ascites drainage equipment comprises a cart, the top end of the cart is fixedly connected with an ascites collecting box, one side of the ascites collecting box is fixedly connected with a drainage hose, and when ascites in the box is accumulated to a preset liquid level, the drainage hose is connected with the ascites collecting box. The floating plate pushes the touch plate to move upwards along with rising of the liquid level, the touch rod makes contact with the touch switch to trigger alarm, medical staff can be reminded of timely treatment in real time, ascites overflow caused by the fact that the medical staff cannot observe in real time is avoided, the medical environment is effectively prevented from being polluted, and the local infection risk caused by the fact that ascites makes contact with a puncture part or the skin of a patient is reduced. Medical staff do not need to stare at the liquid level in real time, other work can be reasonably arranged, meanwhile, treatment can be conducted in time before the collecting box overflows, it is avoided that drainage operation is forced to be interrupted due to the fact that the collecting box overflows, the continuous and stable ascites drainage process is guaranteed, and treatment continuity is guaranteed.

This invention discloses a cerebral vascular targeted therapy and neuromodulation system based on magnetically controlled microcapsules, belonging to the field of medical device and neuromodulation technology. The system includes a magnetic navigation device, an alternating magnetic field generator, microcapsules, and a delivery catheter. The shell of the microcapsule is made of biodegradable hydrogel, internally loaded with magnetic nanoparticles and therapeutic drugs, and optionally, a contrast agent. The microcapsule is released into the vicinity of a targeted intracranial blood vessel through the delivery catheter. Under the combined action of a static magnetic field and a gradient magnetic field, the microcapsule navigates and positions itself within complex and tortuous small blood vessels. Subsequently, the alternating magnetic field drives the microcapsule to generate mechanical vibration or rotation, enhancing the contact and diffusion of local drugs with thrombi or lesions, improving the treatment efficiency for distal small vessel thrombosis, local infections, or tumors. When close to a specific brain region, the magnetomechanical or magnetothermal effects of the microcapsule can also provide controllable stimulation to local neurons, achieving high spatial resolution neuromodulation. Compared with traditional mechanical thrombectomy, systemic thrombolysis, and transcranial magnetic / electrical stimulation, this invention improves targeting and spatial accuracy while ensuring minimally invasiveness and reducing the risk of systemic side effects.

The nostril ventilation type cannula with the medicine coating protection function comprises a protection layer and a contact used for containing supplementary medicine, the protection layer is internally provided with the medicine coating and a cannula body in sequence, a medicine applying pipe is arranged at the parallel position of the protection layer, a push rod is slidably connected into the medicine applying pipe, and the medicine applying pipe is connected with the contact. According to the nostril ventilation type cannula with the medicine coating protection function, a segmented structure is arranged in the medicine applying tube, so that when the push rod pushes medicine into the inner cavity of the contact, the pushing dosage of the medicine can be controlled, the medicine directly acts on the inner wall of the nostril, and local infection caused by the cannula is prevented; the protective layer is dissolved when encountering nasal mucus, so that the drug coating is exposed, the drug is slowly released through the nano-microspheres, common pathogens such as staphylococcus aureus are inhibited, and meanwhile epidermal growth factors are released to accelerate repair of mucous membranes around the cannula.

The invention relates to a tuberculosis antigen-specific host biomarker for diagnosing tuberculous pleural effusion and a kit, and belongs to the technical field of biological medicines. The host biomarker provided by the invention comprises the following components: IFN (interferon) gamma, IL-2 (interleukin-2), IL-12RB2 (interleukin-12R < 2 >), GZMB (Growth Zehnder Microorganism Blanket), IL-3 (interleukin-3), CXCL10 (C X-ray cell line 10), IL-12B (interleukin-12B), IL-18RAP ( According to the present invention, the mycobacterium tuberculosis RD1 region antigen or peptide fragment and the mycobacterium tuberculosis RD2 region antigen or peptide fragment are jointly used as the antigen irritants to stimulate the pleural effusion sample to be detected, and then the expression change of the host biomarker is detected so as to effectively identify and diagnose the tuberculous pleural effusion. By combining tuberculosis specific antigen stimulation and local infection microenvironment transcriptome analysis, the non-specificity defect of an existing host biomarker is overcome, and the host biomarker has high sensitivity and specificity in diagnosis of tuberculous pleural effusion.

The application discloses a medical sodium hyaluronate gel and a preparation method thereof, and belongs to the technical field of sodium hyaluronate gel, and comprises the following steps: preparing a buffer solution, preparing an antibacterial mother liquor, preparing a collagen tripeptide solution, premixing, preparing an intermediate, high-pressure homogenization, filling, sterilization lamp inspection, inner packaging, factory inspection, outer packaging and warehousing; the application can effectively alleviate the immune response after injection, reduces the uncomfortable symptoms such as redness and swelling of the injection site, and reduces the risk of local infection caused by continuous immune response, and significantly improves the safety and comfort of product use.

This invention relates to the field of materials for the prevention and treatment of local infections, and more particularly to a drug-loaded composite nanoparticle, its preparation method, and its application. The drug-loaded composite nanoparticles provided by this invention comprise hollow polydopamine grafted with vancomycin and a lipoic acid-quaternary ammonium salt ionic liquid loaded into the hollow polydopamine cavity. In this invention, the HPDA nanoparticles have a hollow structure, which provides ample space for the loading of drug molecules. The lipoic acid-quaternary ammonium salt ionic liquid can generate heat energy under microwave thermal effects, effectively killing bacteria. Furthermore, under microwave stimulation, the lipoic acid-quaternary ammonium salt ionic liquid, through the synergistic effect of microwave thermal effects and chemical sterilization, can not only enhance the bactericidal effect but also reduce the inflammatory response caused by bacterial infection.

The invention discloses a scald cold compress device, and relates to the technical field of scald cold compress, the scald cold compress device comprises an infusion base, and also comprises a conduction structure comprising a cold compress shell fixedly connected to the surface of the infusion base, a lower sealing sheet fixedly connected to the bottom of the cold compress shell, and an upper sealing sheet fixedly connected to the top of the cold compress shell, the liquid passing columns are fixedly connected to the surface of the cold compress shell and are linearly arranged, the adjusting assembly is fixedly connected to the surfaces of the liquid passing columns, and the conduction assembly is rotationally connected to the surface of the adjusting assembly; the expansion structure comprises a linkage layer fixedly connected to the surface of the adjusting assembly, a cold compress cushion fixedly connected to the surface of the linkage layer and a plurality of air holes formed in the surface of the cold compress cushion. Continuous mechanical compression caused by traditional static cold compress on the wound surface can be effectively avoided, the risks of pressure sores and local infection of a patient are remarkably reduced, and intermittent contact and relaxation are beneficial to promoting capillary circulation and tissue fluid drainage.

The invention discloses a polyion liquid antibacterial nano spinning membrane for removing gold staphylococcus membrane vesicles (MVs) and application of the polyion liquid antibacterial nano spinning membrane in local and systemic infection. The preparation method comprises the following steps: copolymerizing imidazolyl ionic liquid monomers with different alkyl chain lengths and acrylonitrile, and carrying out electrostatic spinning on the copolymerized imidazolyl ionic liquid monomers and polyacrylonitrile to obtain the nano spinning membrane (PIL-C4 / C8 / C12). In-vitro experiments show that the PIL-C4 membrane can efficiently sterilize and adsorb and remove staphylococcus aureus MVs and virulence factors thereof, can reduce MVs-mediated bacterial drug resistance transmission, and is good in biocompatibility. In-vivo experiments are combined with proteomics analysis to prove that the PIL-C4 membrane can remarkably improve exudative necrosis of local infected wounds and prevent lethal injury of important organs such as lungs caused by MVs systemic infection. The invention provides a new solution for protection of bacterial MVs-related infection, and expands the application potential of the cationic polymer in the anti-infection protection field.

The utility model provides a self-adhesive throat pad, and belongs to the technical field of medical equipment. The self-adhesive throat pad comprises a sterile square yarn, a first Y-shaped groove and a second Y-shaped groove are symmetrically formed in the sterile square yarn, a round hole is formed in the middle of the sterile square yarn, a straight groove is formed in the sterile square yarn, the straight groove is connected with the round hole, three pasting plates are fixedly connected to the outer wall of one side of the sterile square yarn, and protective films are pasted to the pasting plates. And the fixing assembly is used for limiting and fixing the sleeve handle, and the fixing assembly is connected with the sterile square yarn. By arranging the fixing assembly, friction between the cannula handle and the throat skin of a patient can be avoided, so that skin injury at a wound is prevented, in addition, the fixing assembly can limit and fix the cannula and the cannula handle, displacement of the cannula handle caused by mistaken touch of the patient is effectively avoided, meanwhile, the fixing assembly can absorb wound seepage of the patient, and the wound is prevented from being damaged. The local infection risk of the wound is effectively reduced, and discomfort is reduced.