The invention relates to a prediction method for
veterinary drug residue concentration in tissue of a domestic rabbit. According to the method,
physiology and
anatomy parameters of the domestic rabbit are collected from existing documentations, and an area method is utilized for comparing and calculating to obtain tissue-
plasma distribution coefficients of drugs in the livers, the kidneys, the muscles and the lungs of the domestic rabbit; tissue-
plasma distribution coefficients of the drugs in all other pieces of tissue are obtained through parameter optimization; a parameter optimizing method is utilized for obtaining other parameters in a model; differential equations representing
drug concentration in the tissue and
drug mass in content of each section of the
digestive tract changing along with time are written according to the
mass balance principle and compiled with acsl languages, all the parameters are defined and assigned, dosage
regimen parameters and model operating parameters are determined, and the model is set up. The model is operated later, and the
drug residue concentration in each piece of tissue at different time points after the domestic rabbit takes the drugs according to different dosage regimens is obtained. The method can reduce test cost and workloads, and is convenient to operate, and the prediction result is accurate.