18 results about "Hemorrhagic shock" patented technology

This invention provides a method for preparing Centhaquine, a drug for treating hemorrhagic shock. Specifically, the preparation method provided by this invention includes the following steps: (S1) providing compound II and compound IV; wherein compound II is prepared by the following method, which includes the steps of: (A) reacting compound I with 1,2-dibromoethane in a first solvent in the presence of base 1 to obtain compound II; and compound IV is prepared by the following method, which includes the steps of: (B) reacting compound III with pinacol diborate in a second solvent in the presence of Grignard reagent to obtain compound IV; (S2) preparation of compound A; and reacting compound II and compound IV in a third solvent in the presence of a catalyst and base 2 to obtain Centhaquine. The preparation method of this invention has a simple and safe synthetic route and operation, readily available raw materials, simple post-processing, high yield, and is suitable for industrial production.

The invention provides a state prediction method and device for a traumatic patient, electronic equipment and a storage medium, and belongs to the technical field of artificial intelligence. The method comprises the following steps: acquiring state parameters of a traumatic patient, wherein the state parameters comprise multiple of gender, age, systolic pressure, diastolic pressure, noninvasive blood pressure average value, heart rate, respiratory rate and oxyhemoglobin saturation; standardizing the state parameters to obtain input parameters; inputting the input parameters into a prediction model to obtain a first prediction probability output by the prediction model; wherein the first prediction probability is the probability that the traumatic patient has hemorrhagic shock, the probability that the traumatic patient needs to be infused with erythrocyte products of more than a set unit, the probability that the traumatic patient needs to receive an operation within a set time or the probability that the traumatic patient has poor prognosis. According to the invention, the shock probability, the probability of infusing red blood cell products, the probability of needing operations or the probability of poor prognosis of the traumatic patient can be predicted according to the state parameters of the traumatic patient.

Methods for the reversal of hemorrhagic shock or hemorrhagic trauma.

Methods for the reversal of hemorrhagic shock or hemorrhagic trauma. Methods for reducing levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in a trauma patient through the administration of stored oxygen reduced blood products.

The utility model relates to the technical field of medical teaching, and discloses an auxiliary device for preparing a rabbit hemorrhagic shock model. Bloodletting and rabbit blood pressure monitoring of rabbits can be realized through one-time neck artery intubation. On one hand, by adjusting the height of the blood storage bottle and the height of the transducer, the position of the rabbit heart and the height of the transducer are horizontal, so that the experiment accuracy can be guaranteed, on the other hand, the height difference between the liquid level in the blood storage bottle and the position of the rabbit heart is adjusted to be 55 cm, and the blood pressure of the rabbit can be maintained at 40 mmHg; the bloodletting amount can be sensitively and effectively controlled, and even if the bloodletting amount exceeds the standard in a short time due to improper operation, blood in the blood storage bottle can flow back to the rabbit artery by reducing the height of the blood storage bottle, so that the experiment failure caused by excessive bloodletting amount is prevented; and the reading of the signal acquisition device and the height of the liquid level in the blood storage bottle in the experiment can be subjected to bidirectional comparison and bidirectional verification, so that the accuracy of corresponding data of the experiment is further ensured.

Compositions and methods for treating hemorrhagic shock, multiple organ failure resulting from hemorrhagic shock, and organ complications resultant therefrom such as acute respiratory distress syndrome.

Generation of lipid nano-particles containing purified human hemoglobin as an oxygen carrier was accomplished with the co-encapsulation of metabolic agents. Additionally, the nano-particles described are of the long-circulating variety (Pegylation of the exterior surface) which are more tolerable in vivo when compared against their non-pegylated counterparts. The generated nano-particles are lyophilizable, given proper formulation with lyo-protectants, which are storage stable solids ready for reconstitution prior to use.

This invention discloses a microcirculation monitoring device and system for hemorrhagic shock. The device includes: an upper finger clamp and a lower finger clamp arranged opposite to each other. The upper finger clamp is equipped with a first signal transceiver device, and the lower finger clamp is equipped with a second signal transceiver device. The first and second signal transceiver devices are used to monitor the capillary refill time of the finger. An electromagnetic pressure component is connected to the upper finger clamp and the lower finger clamp. A spring-opening component is used to spring the upper finger clamp and the lower finger clamp apart. Based on the electromagnetic pressure component and pressure sensor, this application can accurately control the magnitude of the clamping force applied to the finger. By using the spring-opening component, the upper and lower finger clamps can be quickly released, allowing the finger to refill immediately and avoiding detection errors caused by slow release.

Generation of lipid nano-particles containing purified human hemoglobin as an oxygen carrier was accomplished with the co-encapsulation of metabolic agents. Additionally, the nano-particles described are of the long-circulating variety (Pegylation of the exterior surface) which are more tolerable in vivo when compared against their non-pegylated counterparts. The generated nano-particles are lyophilizable, given proper formulation with lyo-protectants, which are storage stable solids ready for reconstitution prior to use.

This disclosure provides methods and devices for determining a quantitative estimate of thrombomodulin levels in a mammalian subject suspected of internal hemorrhaging. The method includes applying a blood sample from the subject to a handheld assay device capable of providing optical quantitation of the amount of thrombomodulin in the sample, measuring, by means of said assay device, an analyte signal value correlated to a concentration of the thrombomodulin in the blood sample and comparing the analyte signal value to a minimum threshold, wherein an analyte signal value less than the minimum threshold indicates that the subject is not internally hemorrhaging, and an analyte signal value above the minimum threshold indicates the subject is internally hemorrhaging. The methods and devices are adapted to rapidly assess internal hemorrhaging and hemorrhagic shock in a patient outside of hospital settings.

The invention belongs to the technical field of critical disease monitoring, and particularly relates to a staged liquid resuscitation capacity regulation and control method and system for traumatic hemorrhagic shock patients, and the resuscitation process is sequentially divided into four core stages of initial resuscitation, resuscitation optimization, stable monitoring and capacity reactivity evaluation. And clear physiological targets, monitoring parameters and advanced or return standards are set in each stage. According to the method, multiple vital signs and laboratory indexes are subjected to dynamic and tendency analysis, and a complete and standardized decision path from positive resuscitation to stable evacuation is provided for clinicians. The invention not only aims at effectively recovering tissue perfusion, but also aims at reducing the risk of complications such as rebleeding, blood clotting disease and cardiac insufficiency caused by excessive resuscitation or misjudgment of illness conditions to the greatest extent, so that a safer and more reliable practice framework is provided for improving clinical prognosis of patients suffering from traumatic hemorrhage shock.

The present application belongs to the technical field of biomedical materials and blood substitutes, and relates to a hemoglobin oxygen carrier as well as a preparation method and application thereof. The present application realizes preparation of a hemoglobin oxygen carrier with high biocompatibility and high oxygen carrying efficiency through cross-linking modification, and is characterized in that cross-linking of hemoglobin is realized in structure, and the cross-linked hemoglobin is simultaneously modified with a surface hydrophilic molecule. The hemoglobin oxygen carrier can quickly release under low oxygen conditions, thereby enhancing oxygen supply efficiency and achieving ideal long-acting treatment. The molecule can be applied to clinical blood transfusion substitution, trauma hemorrhagic shock first aid, intraoperative blood dilution, organ transplantation preservation and the like, and is especially suitable for clinical emergency situations that require rapid oxygen supply and cannot obtain matched blood in time, and can be used for treatment of hemorrhagic shock of humans or animals.

The invention provides an application of a pharmaceutical composition in relieving injury caused by hemorrhagic shock, and belongs to the technical field of medicines. The pharmaceutical composition provided by the invention comprises fructose, olaparib and pharmacologically acceptable salts of the fructose and the olaparib. According to the invention, the fructose and olaparib are combined for the first time, so that the hemorrhagic shock can be effectively intervened by relieving energy metabolism reduction, redox steady state imbalance and mitochondrial function damage.

The invention provides application of sphingosine 1-phosphate in preparation of a medicine for treating burn compound hemorrhagic shock, and belongs to the technical field of biological medicine. The sphingosine 1-phosphate can enhance the activity of p-AMPK in red blood cells, further activate the activity of BPGM and promote conversion from 1, 3-BPG to 2, 3-BPG, so that the oxygen release capacity of the red blood cells is improved, and the intracellular respiration and mitochondrial functions of all organs are improved. The sphingosine 1-phosphate effectively relieves metabolic acidosis and metabolic disorder caused by burn compound hemorrhagic shock, remarkably improves the energy metabolism state and partial pathological indexes of lung tissue and kidney tissue, and provides a solid scientific basis for treating burn compound hemorrhagic shock by using sphingosine 1-phosphate. The potential of the gene in the aspect of improving clinical prognosis is shown.

Therapeutic methods including the coadministration of niacin or niacin-related compound and tranexamic acid are provided. Typically, the treated subject have a hemorrhage (i.e., hemorrhagic injury) and may suffer from hemorrhagic shock. The methods typically include administering the subject an effective amount of niacin or niacin-related compound and tranexamic acid to reduce one or more symptoms of the hemorrhage. Symptoms include those associated with hemorrhagic injuries and shock such as death. The niacin or niacin-related compound and tranexamic acid can be administered in an effective amount to increase the subject's survival. Compositions and kits are also provided. The kits can include the niacin or niacin-related compound and tranexamic acid in the same or separate containers. In some forms, the kit includes a syringe, optionally an autoinjector syringe. For example, the kits can include an autoinjector syringe loaded with an effective amount of niacin or niacin-related compound and tranexamic acid.

The invention relates to the technical field of medicines, in particular to application of curcumin in preparation of a preparation for treating traumatic hemorrhagic shock in a desert dry-hot environment. Curcumin is used for preparing the preparation for treating the traumatic hemorrhagic shock in the desert dry-hot environment, and a patient suffering from the traumatic hemorrhagic shock in the desert dry-hot environment can be protected in a targeted manner, so that the survival rate of the traumatic hemorrhagic shock in the desert dry-hot environment is increased, the prognosis is improved, and the curcumin has a wide application prospect.

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a Yang warming, blood control and hemostasis formula I and application thereof in gastrointestinal hemorrhage, and is particularly suitable for critical patients with hemorrhagic shock. The prescription is composed of 30-60 g of red halloysite, 25 g of prepared rehmannia root, 10-15 g of prepared radix aconiti lateralis preparata (decocted for 30 min), 10 g of dried ginger, 15-30 g of roasted rhizoma atractylodis macrocephalae, 10 g of colla corii asini (melted by heat), 10 g of radix scutellariae, 15 g of cacumen biotae, 10 g of cuttlebone, 30 g of polished round-grained rice, 10 g of charred folium artemisiae argyi and 5-10 g of honey-fried licorice root. The preparation method comprises the following steps: decocting the prepared black radix aconiti lateralis preparata for 30 minutes; the red halloysite is divided into two parts (30-60 g of the red halloysite is taken after being mixed with the decoction and 10 g of the powder), the decoction process is optimized, and the hemostasis time is Melting colla corii asini by heat to control the dissolution rate; the red halloysite micro powder (the particle size is less than or equal to 150 microns) is used for cooperating with the decoction to quickly form a hemostatic barrier. According to the prescription, through a three-way synergistic mechanism of warming yang and relieving desertion (prepared radix aconiti lateralis praeparata slices and dried ginger), controlling blood and stopping bleeding (red halloysite and folium artemisiae argyi charcoal) and enriching blood and nourishing yin (prepared rhizome of rehmannia and donkey-hide gelatin), the hemostasis efficiency is remarkably improved, rebleeding is prevented, and the survival rate of critical patients is increased.