33 results about "Hemorrhagic shock" patented technology

The invention discloses equipment for establishing a mouse hemorrhagic shock resuscitation model. The equipment comprises a surgery operation table, a body temperature maintaining device, a puncture module, an in-vitro blood heat preservation device, an artery puncture device, a blood transfusion / bloodletting device, a blood temporary storage device, an arterial blood pressure monitoring device and a three-way device. According to the invention, venipuncture catheterization is not needed in the blood transfusion / letting process, the purposes of blood transfusion / letting and real-time arterial blood pressure monitoring can be achieved only through arterial puncture catheterization, and the retention of veins can not only reduce the difficulty of the operation, but also ensure the backflow of tissue blood after the operation, so that the injury caused by the operation is reduced. According to the in-vitro blood heat preservation device, the in-vitro blood can be kept at a constant temperature, and the death risk of mice caused by body temperature changes can be effectively reduced. According to the blood transfusion / bloodletting device, the blood transfusion / bloodletting speed can be manually controlled, the problem that the blood transfusion / bloodletting speed cannot be controlled by manual bloodletting can be effectively solved, and heart failure caused by rapid and massive blood transfusion is avoided.

The invention relates to the technical field of risk scoring tools, in particular to a non-invasive simple risk scoring tool for traumatic hemorrhagic shock for wearable equipment. The method has the advantages that a non-invasive simple risk scoring tool for traumatic hemorrhagic shock is combined with clinical practice, economic benefits and time benefits are comprehensively considered, five vital sign indexes including systolic pressure, diastolic pressure, heart rate, respiratory rate and oxyhemoglobin saturation are used as the basis, a multi-factor Logistic regression method is used for constructing the risk scoring tool, and the risk scoring tool is used for evaluating the risk of traumatic hemorrhagic shock. The evaluation process does not need to depend on laboratory detection or highly specialized operators, and the first-aid personnel can master the use method in a short time and quickly complete evaluation. Due to the light design and the low operation threshold of the tool, the tool can be effectively applied in a non-professional scene, meanwhile, extra wounds to the wounded are reduced, the operation complexity is greatly reduced, and the risk scoring tool is more suitable for pre-hospital first aid and rapid deployment and application requirements in special scenes.

The embodiments of the present application provide a blood monitoring device and a blood monitoring method for traumatic shock, wherein the device comprises: a first detection module, configured to obtain a common carotid artery velocity time integral and a heart rate by detecting carotid artery blood flow; a second detection module, configured to obtain a blood oxygen saturation by detecting the blood oxygen status of the arterial blood flow; a processing module, configured to determine a carotid artery oxygen delivery reflecting the oxygen supply capacity of the carotid artery to the head according to the common carotid artery velocity time integral, the heart rate, the blood oxygen saturation, the common carotid artery area and the hemoglobin value in the blood; in this way, the detection of multiple parameters is achieved, and it is beneficial to quickly obtain the status and changes of the patient's brain oxygen supply and systemic oxygen supply, comprehensively consider the patient's compensatory capacity, thereby judging the patient's overall risk and reducing the probability of the patient suffering from hemorrhagic shock.

This invention provides a method for preparing Centhaquine, a drug for treating hemorrhagic shock. Specifically, the preparation method provided by this invention includes the following steps: (S1) providing compound II and compound IV; wherein compound II is prepared by the following method, which includes the steps of: (A) reacting compound I with 1,2-dibromoethane in a first solvent in the presence of base 1 to obtain compound II; and compound IV is prepared by the following method, which includes the steps of: (B) reacting compound III with pinacol diborate in a second solvent in the presence of Grignard reagent to obtain compound IV; (S2) preparation of compound A; and reacting compound II and compound IV in a third solvent in the presence of a catalyst and base 2 to obtain Centhaquine. The preparation method of this invention has a simple and safe synthetic route and operation, readily available raw materials, simple post-processing, high yield, and is suitable for industrial production.

The invention provides a state prediction method and device for a traumatic patient, electronic equipment and a storage medium, and belongs to the technical field of artificial intelligence. The method comprises the following steps: acquiring state parameters of a traumatic patient, wherein the state parameters comprise multiple of gender, age, systolic pressure, diastolic pressure, noninvasive blood pressure average value, heart rate, respiratory rate and oxyhemoglobin saturation; standardizing the state parameters to obtain input parameters; inputting the input parameters into a prediction model to obtain a first prediction probability output by the prediction model; wherein the first prediction probability is the probability that the traumatic patient has hemorrhagic shock, the probability that the traumatic patient needs to be infused with erythrocyte products of more than a set unit, the probability that the traumatic patient needs to receive an operation within a set time or the probability that the traumatic patient has poor prognosis. According to the invention, the shock probability, the probability of infusing red blood cell products, the probability of needing operations or the probability of poor prognosis of the traumatic patient can be predicted according to the state parameters of the traumatic patient.

Methods for the reversal of hemorrhagic shock or hemorrhagic trauma.

The invention discloses an application of an lncRNA-MALAT1 / miR-145 / BNIP3 regulation axis in preparation of a medicine for treating hemorrhagic shock ischemia reperfusion intestinal injury. In existing treatment, conventional liquid resuscitation easily causes serious inflammation and pathological apoptosis, the intestinal barrier repair effect is limited, and the molecular mechanism is not completely clarified. The invention discloses that a regulatory axis participates in an intestinal injury process through a ceRNA mechanism (MALAT1 is used as miR-145 sponge to inhibit regulation of BNIP3 and mediate controlled programmed cell death instead of pathological apoptosis), and provides a new molecular target for treatment. The medicine aiming at the regulation shaft can relieve inflammatory response, reduce pathological apoptosis and promote intestinal barrier repair, and has a good application prospect.

Methods, devices, systems, and computer-readable media are described for providing adaptive and closed loop hemorrhagic shock resuscitation. A computing device may cause activation of an automated tourniquet configured to impede extremity bleeding. The computing device may additionally cause activation of an adaptive resuscitation controller by determining a desired mean arterial pressure setpoint and causing, based on the desired mean arterial pressure setpoint, the adaptive resuscitation controller to infuse fluids into the patient. The computing device may then monitor component pressure measurements of the automated tourniquet and blood pressure parameters of the patient. The computing device may then, based on the component pressure measurements, cause modification of one or more operating parameters of the automated tourniquet. The computing device may additionally and / or alternatively, based on comparing the blood pressure parameters to the desired mean arterial pressure setpoint, cause the adaptive resuscitation controller to infuse fluids into the patient.

Methods for the reversal of hemorrhagic shock or hemorrhagic trauma. Methods for reducing levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in a trauma patient through the administration of stored oxygen reduced blood products.

Methods for the reversal of hemorrhagic shock or hemorrhagic trauma.

The utility model relates to the technical field of medical teaching, and discloses an auxiliary device for preparing a rabbit hemorrhagic shock model. Bloodletting and rabbit blood pressure monitoring of rabbits can be realized through one-time neck artery intubation. On one hand, by adjusting the height of the blood storage bottle and the height of the transducer, the position of the rabbit heart and the height of the transducer are horizontal, so that the experiment accuracy can be guaranteed, on the other hand, the height difference between the liquid level in the blood storage bottle and the position of the rabbit heart is adjusted to be 55 cm, and the blood pressure of the rabbit can be maintained at 40 mmHg; the bloodletting amount can be sensitively and effectively controlled, and even if the bloodletting amount exceeds the standard in a short time due to improper operation, blood in the blood storage bottle can flow back to the rabbit artery by reducing the height of the blood storage bottle, so that the experiment failure caused by excessive bloodletting amount is prevented; and the reading of the signal acquisition device and the height of the liquid level in the blood storage bottle in the experiment can be subjected to bidirectional comparison and bidirectional verification, so that the accuracy of corresponding data of the experiment is further ensured.

Method of treating and / or preventing hemorrhagic shock, comprising administering to a subject in need thereof a therapeutically effective amount of a water-soluble polymer having a polymer backbone and pendant groups covalently coupled thereto that associate water on administration to the subject thereby functioning as a plasma volume expander.

The invention discloses a method and a device for dynamically predicting hemorrhagic shock after gastrointestinal hemorrhage. The method comprises the following steps: acquiring a physiological parameter data set of a user; the physiological parameter data set comprises a heart rate data sequence, an electroencephalogram data sequence, an electrocardio data sequence and an oxyhemoglobin saturation data sequence; preprocessing the physiological parameter data set to obtain a preprocessed physiological parameter data set; and processing the preprocessed physiological parameter data set by using a trained shock dynamic prediction model to obtain a hemorrhagic shock dynamic prediction result value. According to the method, only common noninvasive parameters are used, laboratory data are not needed, various kinds of interference and noise are effectively restrained by preprocessing the data, rolling prediction and real-time monitoring are achieved at the same time, and the prediction accuracy is improved.

The invention relates to the technical field of medical instruments, and discloses a compression hemostasis device for postoperative hemorrhage of anorectal diseases. The anorectal disease postoperative bleeding compression hemostasis device comprises an insertion plug, a columnar cavity extending into the insertion plug is formed in the bottom of the insertion plug, a compression drug delivery assembly extending to the top of the insertion plug is arranged in the columnar cavity, an air channel extending to the top of the insertion plug and communicated with the compression drug delivery assembly is arranged in the insertion plug, and the air channel is communicated with the compression drug delivery assembly. The device has the advantages of carrying out compression hemostasis on the inner wall of the intestinal tract after the anorectal disease operation and conveying hemostasis medicine into the intestinal tract, and the problem of massive hemorrhage after the anorectal disease operation is solved. Although the occurrence rate of massive hemorrhage after anorectal disease operation is not high, about 0.5%-1.0% is inquired according to domestic literature data. However, if the patient does not pay attention and is not treated in time, serious consequences can be caused, hemorrhagic shock of the patient is caused, and even the life of the patient can be endangered when the hemorrhagic shock is serious.

Compositions and methods for treating hemorrhagic shock, multiple organ failure resulting from hemorrhagic shock, and organ complications resultant therefrom such as acute respiratory distress syndrome.

Generation of lipid nano-particles containing purified human hemoglobin as an oxygen carrier was accomplished with the co-encapsulation of metabolic agents. Additionally, the nano-particles described are of the long-circulating variety (Pegylation of the exterior surface) which are more tolerable in vivo when compared against their non-pegylated counterparts. The generated nano-particles are lyophilizable, given proper formulation with lyo-protectants, which are storage stable solids ready for reconstitution prior to use.

This invention discloses a microcirculation monitoring device and system for hemorrhagic shock. The device includes: an upper finger clamp and a lower finger clamp arranged opposite to each other. The upper finger clamp is equipped with a first signal transceiver device, and the lower finger clamp is equipped with a second signal transceiver device. The first and second signal transceiver devices are used to monitor the capillary refill time of the finger. An electromagnetic pressure component is connected to the upper finger clamp and the lower finger clamp. A spring-opening component is used to spring the upper finger clamp and the lower finger clamp apart. Based on the electromagnetic pressure component and pressure sensor, this application can accurately control the magnitude of the clamping force applied to the finger. By using the spring-opening component, the upper and lower finger clamps can be quickly released, allowing the finger to refill immediately and avoiding detection errors caused by slow release.

The present invention provides a VATS compression hemostat, comprising: a compression device, a hollow connecting end is arranged on the top, and a plurality of drainage channels are extended from the connecting end toward the side wall and the bottom of the compression device; a hollow support rod, one end of which is screwed to the connecting end, and the other end is connected to an aspirator; a pop-up compression piece, which can be slidably arranged in a side wall of the compression device; and a controller, which is arranged on the side wall of the support rod away from one end of the compression device, and is used to control the pop-up length of the pop-up compression piece; a spring is abutted on one side of the pop-up compression piece, and a pull wire is connected to the pop-up compression piece, which passes through the spring and is connected to the controller. The use of the VATS compression hemostat can avoid vascular damage during VATS and turn to thoracotomy, and can quickly find bleeding points and treat them, greatly reducing the risk of hemorrhagic shock, while not increasing the rapid recovery factor.

The invention provides an intelligent infusion device for treating hemorrhagic shock, and relates to the technical field of medical equipment. A fixed cylinder is fixed to the base plate, a movable frame capable of moving up and down is installed in the fixed cylinder, a welding rod is welded and fixed to the movable frame, a plane structure is arranged on the right side of the welding rod, a rail base is installed on the plane structure on the right side of the welding rod, and two connecting plates are fixed between the rail base and the welding rod. A lifting plate capable of moving up and down is mounted on the rail seat, and a lead screw is mounted on the rail seat through a bearing; through a first motor, a lead screw, a first hydraulic rod and other structures, accurate clamping and position adjustment of an infusion tube plug are achieved, manual intervention is reduced, the liquid level is monitored in real time through a visual detector, when liquid medicine is emptied, a system automatically controls a clamping plate to plug and unplug an infusion tube, and automatic switching of liquid storage bottles is completed in cooperation with a second motor, a gearbox and the like; a full-process automatic closed loop is formed, manual dependence is avoided, and the infusion automation degree is greatly improved.

Compositions and methods for treating hemorrhagic shock, multiple organ failure resulting from hemorrhagic shock, and organ complications resultant therefrom such as acute respiratory distress syndrome.

Generation of lipid nano-particles containing purified human hemoglobin as an oxygen carrier was accomplished with the co-encapsulation of metabolic agents. Additionally, the nano-particles described are of the long-circulating variety (Pegylation of the exterior surface) which are more tolerable in vivo when compared against their non-pegylated counterparts. The generated nano-particles are lyophilizable, given proper formulation with lyo-protectants, which are storage stable solids ready for reconstitution prior to use.

The present disclosure provides polymer-drug conjugates comprising suberoylanilide hydroxamic acid (SAHA), derivatives thereof, and salts thereof. The disclosure further provides nanoparticles comprising the polymer-drug conjugate. The disclosure provides methods of treating a disease or disorder in a subject by administering the conjugate or a plurality of nanoparticles comprising the conjugate to the subject. In some embodiments, the disease or disorder is sepsis, septic shock, hemorrhagic shock, or poly-trauma.

This disclosure provides methods and devices for determining a quantitative estimate of thrombomodulin levels in a mammalian subject suspected of internal hemorrhaging. The method includes applying a blood sample from the subject to a handheld assay device capable of providing optical quantitation of the amount of thrombomodulin in the sample, measuring, by means of said assay device, an analyte signal value correlated to a concentration of the thrombomodulin in the blood sample and comparing the analyte signal value to a minimum threshold, wherein an analyte signal value less than the minimum threshold indicates that the subject is not internally hemorrhaging, and an analyte signal value above the minimum threshold indicates the subject is internally hemorrhaging. The methods and devices are adapted to rapidly assess internal hemorrhaging and hemorrhagic shock in a patient outside of hospital settings.

The invention belongs to the technical field of critical disease monitoring, and particularly relates to a staged liquid resuscitation capacity regulation and control method and system for traumatic hemorrhagic shock patients, and the resuscitation process is sequentially divided into four core stages of initial resuscitation, resuscitation optimization, stable monitoring and capacity reactivity evaluation. And clear physiological targets, monitoring parameters and advanced or return standards are set in each stage. According to the method, multiple vital signs and laboratory indexes are subjected to dynamic and tendency analysis, and a complete and standardized decision path from positive resuscitation to stable evacuation is provided for clinicians. The invention not only aims at effectively recovering tissue perfusion, but also aims at reducing the risk of complications such as rebleeding, blood clotting disease and cardiac insufficiency caused by excessive resuscitation or misjudgment of illness conditions to the greatest extent, so that a safer and more reliable practice framework is provided for improving clinical prognosis of patients suffering from traumatic hemorrhage shock.

The invention provides an establishment method and application of a mesenteric artery hemorrhagic shock animal model, and the establishment method comprises the following steps: S1, anesthetizing an animal, performing superior mesenteric artery digital subtraction angiography, artificial pneumoperitoneum and laparoscopic surgery after anesthesia, and performing hemorrhagic operation on a target blood vessel; and S2, after the animal has hemorrhagic shock for 10-15 minutes, injecting 0.9% sodium chloride injection into the animal for fluid infusion so as to maintain the stability of the blood pressure and heart rate of the animal, thereby obtaining the animal model of the abdominal traumatic hemorrhagic shock. A pig is used as an animal for establishing a model, vital signs and hemodynamic indexes of the animal are monitored in real time, and an auxiliary judgment standard of mesenteric artery hemorrhagic shock and a judgment standard of shock correction are determined according to the change trend of the indexes. According to the method, the animal model of the abdominal traumatic hemorrhagic shock is established, various indexes of the animal are continuously recorded, the shock condition and the shock correction condition are more accurately judged, and the shocked wounded can be rescued in time.

The present application belongs to the technical field of biomedical materials and blood substitutes, and relates to a hemoglobin oxygen carrier as well as a preparation method and application thereof. The present application realizes preparation of a hemoglobin oxygen carrier with high biocompatibility and high oxygen carrying efficiency through cross-linking modification, and is characterized in that cross-linking of hemoglobin is realized in structure, and the cross-linked hemoglobin is simultaneously modified with a surface hydrophilic molecule. The hemoglobin oxygen carrier can quickly release under low oxygen conditions, thereby enhancing oxygen supply efficiency and achieving ideal long-acting treatment. The molecule can be applied to clinical blood transfusion substitution, trauma hemorrhagic shock first aid, intraoperative blood dilution, organ transplantation preservation and the like, and is especially suitable for clinical emergency situations that require rapid oxygen supply and cannot obtain matched blood in time, and can be used for treatment of hemorrhagic shock of humans or animals.

The invention provides an application of a pharmaceutical composition in relieving injury caused by hemorrhagic shock, and belongs to the technical field of medicines. The pharmaceutical composition provided by the invention comprises fructose, olaparib and pharmacologically acceptable salts of the fructose and the olaparib. According to the invention, the fructose and olaparib are combined for the first time, so that the hemorrhagic shock can be effectively intervened by relieving energy metabolism reduction, redox steady state imbalance and mitochondrial function damage.

The invention provides application of sphingosine 1-phosphate in preparation of a medicine for treating burn compound hemorrhagic shock, and belongs to the technical field of biological medicine. The sphingosine 1-phosphate can enhance the activity of p-AMPK in red blood cells, further activate the activity of BPGM and promote conversion from 1, 3-BPG to 2, 3-BPG, so that the oxygen release capacity of the red blood cells is improved, and the intracellular respiration and mitochondrial functions of all organs are improved. The sphingosine 1-phosphate effectively relieves metabolic acidosis and metabolic disorder caused by burn compound hemorrhagic shock, remarkably improves the energy metabolism state and partial pathological indexes of lung tissue and kidney tissue, and provides a solid scientific basis for treating burn compound hemorrhagic shock by using sphingosine 1-phosphate. The potential of the gene in the aspect of improving clinical prognosis is shown.

Therapeutic methods including the coadministration of niacin or niacin-related compound and tranexamic acid are provided. Typically, the treated subject have a hemorrhage (i.e., hemorrhagic injury) and may suffer from hemorrhagic shock. The methods typically include administering the subject an effective amount of niacin or niacin-related compound and tranexamic acid to reduce one or more symptoms of the hemorrhage. Symptoms include those associated with hemorrhagic injuries and shock such as death. The niacin or niacin-related compound and tranexamic acid can be administered in an effective amount to increase the subject's survival. Compositions and kits are also provided. The kits can include the niacin or niacin-related compound and tranexamic acid in the same or separate containers. In some forms, the kit includes a syringe, optionally an autoinjector syringe. For example, the kits can include an autoinjector syringe loaded with an effective amount of niacin or niacin-related compound and tranexamic acid.