59 results about "Penehyclidine hydrochloride" patented technology

The invention discloses a process for preparing a penehyclidine hydrochloride injection and belongs to the field of medicines. The specific preparation process of the injection is as follows: (1) treating inner packaging materials with acid in advance, then washing the inner packaging materials with purified water and water for injection and then pasteurizing and drying the inner packaging materials for standby application; (2) weighing penehyclidine hydrochloride based on the prescription dose, adding a defined amount of water for injection to dissolve penehyclidine hydrochloride, then adding water for injection to reach the total amount and stirring the liquid medicine uniformly; and (3) measuring the pH value and the content, filtering the liquid medicine after the pH value and the content are qualified, filling and sealing the filtrate in the inner packaging materials for standby application and carrying out pasteurization, thus obtaining the penehyclidine hydrochloride injection. The process has the following beneficial effects: not only can the pH value and content of the penehyclidine hydrochloride injection product obtained by the process be more stable, but also the product quality is more easily ensured; and meanwhile, the final product is proved to be safe and effective by animal long-term toxicity tests and pharmacodynamics tests.

The invention discloses a method for preparing a penehyclidine hydrochloride injection and belongs to the field of medicines. The specific preparation process of the injection is as follows: (1) washing inner packaging materials with purified water and water for injection and then pasteurizing and drying the inner packaging materials for standby application; (2) weighing penehyclidine hydrochloride based on the prescription dose, adding a defined amount of water for injection to dissolve penehyclidine hydrochloride, regulating the pH value of the liquid medicine to 4.6-4.8 with a pH regulator, then adding water for injection to reach the total amount and stirring the liquid medicine uniformly; and (3) measuring the pH value and the content, filtering the liquid medicine after the pH valueand the content are qualified, filling and sealing the filtrate in the inner packaging materials for standby application and carrying out pasteurization, thus obtaining the penehyclidine hydrochloride injection. The method has the following beneficial effects: not only can the pH value and content of the penehyclidine hydrochloride injection product obtained by the method be more stable, but alsothe product quality is more easily ensured; and meanwhile, the final product is proved to be safe and effective by animal long-term toxicity tests and pharmacodynamics tests.

The invention discloses an evaluation method of influences of penehyclidine hydrochloride to calcium ions in dysmenorrhea animal model cells. The method comprises the following steps: obtaining a blank cell suspension; adding oxytocin into the blank cell suspension, and mixing for acting for 5 to 15 minutes so as to obtain an animal model cell suspension; dividing the animal model cell suspension into three groups, and adding reagents in equal volume into three groups of animal model cell suspension, wherein one group is a positive control group in which a contrast reagent is added and acts for 10 to 20 minutes, one group is an experimental group in which penehyclidine hydrochloride in different doses is added and acts for the same time with the positive control group, and one group is a model group without adding the reagent; and contrasting differences of the concentration of the calcium ions in the cells of the experimental group with the concentration of the calcium ions in the cells of the model group and the positive control group. The embodiment of the invention can reveal the influences of penehyclidine hydrochloride to the concentration of the calcium ions in the dysmenorrhea animal model cells, and can ensure that the efficacy of penehyclidine hydrochloride in different concentrations is evaluated by contrasting the concentration of the calcium ions in the cells of the experimental group with the concentration of the calcium ions in the cells of the positive control group and the model group.