Application of penehyclidine hydrochloride in preparing medicament for treating cardiogenic shock

A kind of penehyclidine hydrochloride, cardiogenic shock technology, applied in the field of medicine

Inactive Publication Date: 2009-07-08
CHENGDU LIST PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Digoxin not routinely used in shock but may be of value in patients with supraventricular tachycardia

Method used

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  • Application of penehyclidine hydrochloride in preparing medicament for treating cardiogenic shock
  • Application of penehyclidine hydrochloride in preparing medicament for treating cardiogenic shock
  • Application of penehyclidine hydrochloride in preparing medicament for treating cardiogenic shock

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0191] Penehyclidine Hydrochloride 0.1g

[0192] water 1000ml

[0193] Prepare 1,000 sticks of penehyclidine hydrochloride injection or 50 bottles of spray for treating cardiogenic shock disease.

Embodiment 2

[0195] Penehyclidine Hydrochloride 1g

[0196] water 1000ml

[0197] Prepare 1,000 sticks of penehyclidine hydrochloride injection or 50 bottles of spray for treating cardiogenic shock disease.

Embodiment 3

[0199] Penehyclidine Hydrochloride 5g

[0200] water 1000ml

[0201] Prepare 1,000 sticks of penehyclidine hydrochloride injection or 50 bottles of spray for treating cardiogenic shock disease.

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PUM

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Abstract

The invention relates to the use of penehyclidine hydrochloride in the preparation of medicines for treating cardiogenic shock diseases indicating that, in pathological changes, systolic pressure and mean arterial pressure decrease at least by 40%, the maximum rise speed of internal pressure of left ventricle (LV+dp / dtmax) decreases at least 80%, cardiac output decreases at least 40%. The application effect of the invention is shown by the influence of the penehyclidine hydrochloride on acute cardiogenic shock modles.

Description

technical field [0001] The invention belongs to the field of medicines, in particular to the new medical application of penehyclidine hydrochloride, in particular to the application of penehyclidine hydrochloride in the preparation of medicines for treating cardiogenic shock diseases. The pathological changes of the cardiogenic shock are as follows: the systolic blood pressure and the mean arterial pressure drop by at least 40%, the maximum rate of increase in the left ventricular pressure (LV+dp / dt max ) decreased by at least 80%, and cardiac output decreased by at least 40%. Background technique [0002] Penehyclidine hydrochloride, English name Penehyclidine Hydrochloride, chemical name 3-(2-cyclopentyl-2-hydroxy-2-phenylethoxy)quinuclidine hydrochloride, molecular formula C 20 h 29 NO 2 • HCl, molecular weight 351.92. [0003] Penehyclidine hydrochloride is a new type of anticholinergic drug with selective M 1 , M 3 and N 1 , N 2 Receptor antagonism, has a strong...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/439A61P9/00A61K9/08A61K9/20A61K9/48
Inventor 朱登军赵力科杨礼茹
Owner CHENGDU LIST PHARMA
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