23 results about "Quinuclidine" patented technology

Disclosed herein are nanostructured hierarchical zeolitic materials comprising: a plurality of zeolite nanotubes, each zeolite nanotube comprising a zeolitic wall perforated by a plurality of pores, the zeolitic wall defining a single longitudinal lumen. Also disclosed herein are bolaform structure directing agents comprising: a first hydrophilic end and a second hydrophilic end with a hydrophobic core therebetween; the hydrophobic core comprising one or more aromatic rings and one or more hydrophobic alkyl groups; the one or more aromatic rings comprising a biphenyl group; the one or more hydrophobic alkyl groups each independently comprising a C10 alkyl group; and the first hydrophilic end and the second hydrophilic end each independently comprising a quinuclidinium group. Also disclosed herein are methods of making and use of the plurality of zeolite nanotubes and the bolaform structure directing agents.

An anion exchange polymer according to a preferred embodiment of the present invention includes a 4-X-quinuclidinium structure in which carbon corresponding to position 4 of a quinuclidinium ring is connected to a polymer main chain (X), and due to the absence of β-hydrogen placed in an anti-periplanar conformation with a nitrogen atom in the quinuclidinium ring, a Hoffmann elimination reaction does not occur. Therefore, there is the effect of having a chemically stable structure in a basic driving environment.

The present invention relates to a process for the preparation of (2S,3S)-2-benzhydryl-N-(5-tert-butyl-2-methoxybenzyl) quinuclidin-3-amine represented by the following structural formula-1a and its pharmaceutically acceptable salts thereof. Further, the present invention provides 2S,3S)-2-benzhydryl-N-(5-tert-butyl-2-methoxybenzyl) quinuclidin-3-amine salts with purity greater than 99.0% by High-performance liquid chromatography (HPLC). It further relates to a process for the preparation of (S)-2-benzhydrylquinuclidin-3-one (6) with purity greater than 99.0% by High-performance liquid chromatography (HPLC).

The present invention belongs to the technical field of organic complex synthesis, and specifically relates to a metal complex and its preparation method and application. The general formula of the metal complex is L-M, wherein L is a ligand, M is a metal salt, and the ligand is diphenylmethylbenzylamine or diphenylmethylquinuclidine-3-amine. The diphenylmethylbenzylamine is prepared by reacting imine and sodium cyanoborohydride; the diphenylmethylquinuclidine-3-amine is prepared by reacting diphenylmethylbenzylamine and ammonium formate. The preparation method of the metal complex is to dropwise add a metal salt solution to a methanol solution containing the ligand, carry out a coordination reaction, and filter to obtain a target product. The preparation method has the advantages of simple process, mild conditions, low cost, and easy industrialization. The metal complex provided by the present invention can be used to prepare an antibacterial agent, which has the advantages of high efficiency, low toxicity, and environmental protection.

An anion exchange polymer according to a preferred embodiment of the present invention includes a 4-X-quinuclidinium structure in which carbon corresponding to position 4 of a quinuclidinium ring is connected to a polymer main chain (X), and due to the absence of β-hydrogen placed in an anti-periplanar conformation with a nitrogen atom in the quinuclidinium ring, a Hoffmann elimination reaction does not occur. Therefore, there is the effect of having a chemically stable structure in a basic driving environment.

The application belongs to the technical field of organic synthesis, and particularly relates to a preparation method of maropintan and an intermediate thereof. The preparation method comprises the following steps: S1: 3-quinuclidinone or a salt thereof is reacted with benzophenone under the condition of a base, a first solvent, to obtain 2-(diphenyl methylene) quinuclidin-3-one; S2: the obtained 2-(diphenyl methylene) quinuclidin-3-one is reacted with an amine source and hydrogen under the condition of a chiral ruthenium catalyst, an optional additive and a second solvent, to obtain an intermediate (2S, 3S)-2-diphenyl methyl quinuclidin-3-amine; and S3: the obtained (2S, 3S)-2-diphenyl methyl quinuclidin-3-amine is subjected to a condensation reaction with 5-tert-butyl-2-methoxy benzaldehyde (formula V) in the presence of an acid and a third solvent, and is reduced by palladium carbon or platinum carbon and hydrogen to obtain maropintan. The method has the advantages of low-cost and easily-available raw materials, a short synthesis route, high-yield one-step reaction of double chiral centers, good selectivity, simple process, high product yield and low cost.

The application provides a kind of electrolyte that can reduce gas production, secondary battery.The electrolyte includes organic solvent, lithium salt, film-forming additive and quinuclidine additive.The application introduces quinuclidine into electrolyte, which can capture hydrofluoric acid produced by side reaction inside the battery through complexation, reduce the reactivity of hydrofluoric acid, slow down the rate of structural rupture of positive and negative electrode interface film due to continuous corrosion by hydrofluoric acid, and further slow down the rate of gas production due to the exposure of positive and negative electrode interface active sites and the catalysis of solvent decomposition, thereby reducing the rate of side reaction gas production during battery cycling, ensuring that the battery can still maintain a low gas production rate after long-term cycling, reducing the risk of battery swelling, and improving battery life and safety.

The anion exchange polymer according to the preferred embodiment of the present application includes a 4-X-quinuclidinium structure in which carbon of No. 4 position of a quinuclidinium ring is connected to a main chain (X) of a polymer, and β-hydrogen in the quinuclidinium ring is not in an anti-periplanar conformation with a nitrogen atom, so that a Hofmann elimination reaction does not occur. Thus, it has an effect of having a stable chemical structure in an alkaline driving environment.

The invention relates to an economical, eco-friendly, and industrially viable process of preparing high-quality product cis-2-methylspiro(1,3-oxathiolane-5,3') quinuclidine hydrochloride known as Cis Cevimeline Hydrochloride prepared by isomerizing racemic cevimeline hydrochloride salt using a metal catalyst to produce Cis cevimeline base in situ, which is further reacted to produce an organic acid salt, preferably, pure p-nitro benzoic acid salt of Cis cevimeline. Cis Cevimeline Hydrochloride so prepared contains i) Not more than 0.5 %, preferably not more than 0.3 % of Trans isomer. ii) Not more than 0.1 % of single largest unspecified impurity; and iii) Not more than 0.15 % of single largest specified impurity, including new Cevimeline impurity-1 and 2. The invention also covers a pure mixture of Cevimeline impurity-1 and 2. Additionally, by subjecting Cis Cevimeline Hydrochloride to a solvent treatment, the desired particle size distribution is achieved.

The invention discloses a process for synthesizing methylated flavonoids derivatives by utilizing a photocatalysis technology, which comprises the following steps: firstly, placing flavonoids derivatives in a glass test tube, then adding dimethyl sulfoxide (DMSO) as a methyl donor and a solvent, and adopting eosin Y as a photocatalyst to synthesize the methylated flavonoids derivatives. And 1-azabicyclo [2.2. 2] octane (quinuclidine) is added as an alkaline additive. Under the condition of room temperature, a blue light source with the power being 18 watts and the wavelength being 455 nanometers is used for carrying out illumination stirring reaction. And separating and purifying the crude product to obtain the 3-methyl flavonoid derivative. The invention realizes a photochemical C-H alkylation reaction of dimethyl sulfoxide and flavonoid derivatives, a series of functionalized methylated flavonoid derivatives can be constructed through simple operation, and compared with the traditional synthesis method, the method has the main advantages that: 1) the reaction condition is mild, and the reaction can be smoothly carried out at room temperature; the method has the advantages of simple operation, no need of metal catalysts and strong oxidants, no need of strong acids, simple operation, no need of nitrogen protection, high yield and good tolerance of functional groups.

The invention relates to the technical field of water electrolysis hydrogen production and fuel cells, in particular to an aldehyde monomer containing a quinuclidine ring, a suspension type polyaryl quinuclidine ring polymer and a preparation method and application thereof. According to the quinine ring-containing aldehyde monomer provided by the invention, a functional group connected with an electron-rich benzene ring, namely an aldehyde group, is migrated to the position outside the quinine ring, so that the quinine ring is suspended outside an aryl main chain in a polymer, namely the rigid structure of the quinine ring is prevented from being damaged, the high symmetry of the quinine ring is kept, and the ultrahigh stability function of the quinine ring is shown; and the anion transmission rate and the chemical stability are further improved.

The present invention provides a novel salt of (S)-quinuclidin-3-yl ((R)-5-(3-chloro-4-isopropoxyphenyl)-2,2-di-methyl-2,3-dihydro-1H-inden-1-yl)carbamate, i.e., (1S)-(+)-10-camphorsulfonic acid salt thereof and a process for preparing the same. The (1S)-(+)-10-camphorsulfonic acid salt of (S)-quinuclidin-3-yl ((R)-5-(3-chloro-4-isopropoxyphenyl)-2,2-dimethyl-2,3-di-hydro-1H-inden-1-yl)carbamate is obtained in a crystalline form and has high purity, high stability, high water-solubility, and low hygroscopicity.

The invention discloses a method for catalyzing enantioselective ring-opening polymerization of oxygen ring anhydride by using a cinchona alkali derivative, and belongs to the technical field of enantioselective polymerization. The invention solves the problem that the existing catalytic system cannot realize chiral recognition and enantioselective polymerization of the OCA monomer. In a certain solvent and at a certain temperature, a chiral cinchona base catalyst is utilized to catalyze ring-opening polymerization of a chiral substituted OCA monomer to obtain a polyester material with a specific structure. According to the invention, the recognition and enantioselective ring opening polymerization of the chiral OCA by the chiral catalyst are realized for the first time. Different from the traditional OCA stereoselective polymerization which is based on a chain end recognition mechanism, the method disclosed by the invention realizes the process of catalyzing the asymmetric resolution polymerization of the OCA based on enantiomer position point control for the first time. In addition, the catalyst used in the invention has the advantages of commercially available, low price, green and environmental protection.

The present invention provides an anion exchange polymer containing a zwitterionic side chain structure and its application, the polymer includes a sulfonate group with a negative charge, an ammonium salt with a positive charge and a carbon chain connecting the ammonium salt and the sulfonate group, and obtains one or more combinations of quaternary ammonium salt-sulfonate zwitterions, imidazolammonium salt-sulfonate zwitterions, cyclic piperidinium salt-sulfonates, quinuclidine ammonium salt-sulfonates represented by cyclic quaternary ammonium salt-sulfonate zwitterions, pyridinium salt-sulfonate zwitterions, and quinuclidine ammonium salt-sulfonate zwitterions. First, the zwitterionic side chain structure embodies good chemical stability, and the anion exchange membrane containing the zwitterionic side chain structure can be adjusted by adjusting the content of its zwitterions, so that hydroxide is accelerated to pass along the direction of the electric field under the electrostatic repulsion, thereby improving ionic conductivity, and at the same time, due to the electrostatic action of the sulfonate and ammonium salts between the molecular chains, the mechanical properties of the anion exchange membrane are improved.

The invention discloses a series of substituted quinine ring derivatives and application thereof, and particularly discloses compounds shown in the description, and stereoisomers and pharmaceutically acceptable salts thereof.

In particular, the present invention provides a resist underlayer film having a high dry etching rate, a resist underlayer film forming composition, a resist pattern forming method, and a semiconductor device manufacturing method. [Solution] A resist underlayer film forming composition comprising a reaction product of an epoxy group-containing compound and a heterocyclic compound containing one moiety reactive with an epoxy group, and a solvent. Preferably, the heterocyclic compound is selected from furan, pyrrole, pyran, imidazole, pyrazole, oxazole, thiophene, thiazole, thiadiazole, imidazolidine, thiazolidine, imidazoline, dioxane, morpholine, diazine, thiaidine, triazole, tetrazole, dioxolane, pyridazine, pyrimidine, pyrazine, piperidine, piperazine, indole, purine, quinoline, isoquinoline, quinuclidine, chromene, thianthlene, phenothiazine, phenoxazine, xanthene, acridine, phenazine, and carbazole.

The application relates to a preparation method and application of an antiemetic drug compound, and the specific steps are as follows: 1) taking 2-diphenylmethyl quinuclidin-3-one as a starting material, an intermediate 1, (2S)-2-diphenylmethyl quinuclidin-3-one, is obtained through a resolution reaction; the resolution agent 1 is selected from L-glutamic acid; 2) the intermediate 1 and (5-(tert-butyl)-2-methoxyphenyl)methylamine are subjected to condensation hydrolysis reaction and reduction reaction, so as to prepare an intermediate 2, 2-diphenylmethyl-N-(5-tert-butyl-2-methoxybenzyl) quinuclidin-3-amine; 3) the intermediate 2 is subjected to a resolution reaction, so as to prepare maropitant, and the resolution agent 2 is selected from D-(+)-dibenzoyl tartaric acid; 4) maropitant and citric acid are subjected to a salt reaction in a solvent, so as to prepare maropitant citrate, the yield is more than 80%, the optical purity is more than 99% and 98%, and in the resolution reaction process, optical transformation can be achieved, so that the resolution yield is greater than 50%, the reaction yield is greatly improved, and the optical purity of the obtained product can meet the requirements of subsequent preparation and clinical efficacy.

The application belongs to the technical field of anion exchange membranes, and discloses a method for preparing a quinine type anion exchange membrane through pre-irradiation grafting. Linear carbon chain polymer is used as a base material, and a vinyl monomer is used as a grafting monomer. The linear carbon chain polymer is pre-irradiated by an electron beam radiation source, then the pre-irradiated base material is subjected to a grafting reaction in a vinyl monomer solution, and then the obtained grafted polymer is subjected to a quaternary ammonium reaction with a quinine ring solution, so as to obtain a quinine type anion exchange membrane. The overall process is relatively simple, the reaction conditions are mild, the reaction time is relatively short, and the cost is relatively low. The prepared quinine type anion exchange membrane has higher anion conductivity and better mechanical strength compared with a biphenyl quinine anion exchange membrane. The prepared quinine type anion exchange membrane has stronger chemical stability compared with a piperidine type and a trimethylamine type anion exchange membrane, so that it can be applied to the fields of fuel cells, water electrolysis, and flow batteries.

An anion exchange branched co-polymer includes poly(aryl) and a branched compound and quinuclininuium side chains. The co-polymer may include xanthene or bibenzofuran. The anion exchange branched co-polymer may be more durable and have less creep and may have a higher ion exchange capacity (IEC) due to the structure and because some of the side chains may have multiple functional sites. The co-polymer may be cross-linked and may also include free radical inhibitors. The co-polymer may be incorporated into a support material and used in an anion exchange membrane or membrane electrode assembly.

The present application relates to the technical field of compound medicine, and in particular to a quinuclidine derivative, a preparation method and application thereof.The quinuclidine derivative of the present application has a structure general formula as shown in formula I.The quinuclidine derivative of the present application has obvious inhibitory effect on PD-1 or PD-L1, and can be used for drug research and development to treat diseases related to the PD-1 or PD-L1 signal pathway, such as cancer, infectious diseases and autoimmune diseases.The present application provides a lead compound and a new active skeleton for drug research and development of diseases related to the PD-1 or PD-L1 signal pathway.

This disclosure relates to a method of treating a ciliopathy in a subject, the method comprising administering to the subject an effective amount of a quinuclidine compound. Also disclosed is a pharmaceutical composition comprising a quinuclidine compound for use in said method.

The application belongs to the technical field of organic synthesis, and particularly relates to a preparation method of 2-(diphenylalkenyl)quinuclidin-3-one. The 3-quinuclidinone or a salt thereof and the benzophenone are used as raw materials, and the reaction is carried out under the condition of a base and a solvent, so that the core intermediate 2-(diphenylalkenyl)quinuclidin-3-one in a maropitant synthesis path is successfully prepared. The raw material of the above method is cheap and easy to obtain, the reaction only needs one step, the reaction time is relatively short, the operation is simple, efficient and convenient for post-treatment, the yield is excellent, and the method has obvious competitive advantages in production cost.

The present invention provides a resist underlayer film having a particularly high dry etching rate, a composition for forming the resist underlayer film, a resist pattern forming method, and a method for manufacturing a semiconductor device. A composition for forming a resist underlayer film, comprising: a compound containing an epoxy group, a reaction product with a heterocyclic compound containing 1 site having reactivity with the epoxy group; and a solvent. It is preferable that the heterocyclic ring contained in the above-mentioned heterocyclic compound be selected from the group consisting of furan, pyrrole, pyran, imidazole, pyrazole, oxazole, thiophene, thiazole, thiadiazole, imidazolidine, thiazolidine, imidazoline, dioxane, morpholine, diazine, thiazine, triazole, tetrazole, dioxolane, pyridazine, pyrimidine, pyrazine, piperidine, piperazine, indole, purine, quinoline, isoquinoline, quinuclidine, chromene, thioxanthene, phenothiazine, phenoxazine, xanthene, acridine, phenazine, and carbazole.