65 results about "Phenothiazine" patented technology

The invention relates to the technical field of solar cells, in particular to a self-assembled monomolecular hole transport material, a preparation method and application thereof, a perovskite solar cell, a preparation method thereof and a photovoltaic module. The self-assembled monomolecular hole transport material provided by the invention has a structure as shown in a formula I. In the formula I, A1, A2 and A3 are respectively and independently anchor groups or hydrogen atoms; the anchoring groups are independently selected from phosphate groups respectively; g is selected from a substituted or unsubstituted carbazolyl group, a substituted or unsubstituted acridinyl group, a substituted or unsubstituted phenothiazinyl group, and a substituted or unsubstituted phenoxazinyl group. The self-assembled monomolecular hole transport material provided by the invention has stronger anchoring binding capacity, conjugation in molecules is enhanced through the aromatic connection unit, and transport of carriers is facilitated; polyphosphonic acid anchoring in the self-assembled monomolecular hole transport material provided by the invention can enhance adsorption and uniformity of molecules, and a formed hole transport interface has better charge transport and defect passivation effects.

The application discloses a phenothiazine self-assembled organic small-molecule hole transport material and application thereof, wherein the structural general formula of the phenothiazine self-assembled organic small-molecule hole transport material is as follows: wherein R is n is 1-5. The disclosed phenothiazine self-assembled organic small-molecule hole transport material is based on a self-assembled monolayer design strategy, carboxylic acid anchoring groups and different bridging units are introduced into the phenothiazine molecular structure, the adjustment of the hole transport material molecular energy level and the improvement of the hole transport layer interface contact are realized. When the material is applied to a perovskite solar cell device as a non-doped hole transport layer, it shows good photoelectric conversion efficiency. Especially important is that the synthesis process is simple, the raw material source is wide and the price is low, so that the material is more competitive in practical application, and is expected to bring a new breakthrough to the development of perovskite solar cells.

This application relates to the field of tail gas absorption technology, specifically disclosing a tail gas absorption device for phenothiazine production. The pretreatment mechanism in this application can induce sublimation of phenothiazine microcrystals in the tail gas through multiple stages, allowing the microcrystals to grow sufficiently to a collectable size before entering the collection zone. Then, a multi-stage blade collection mechanism progressively adheres and collects the grown microcrystals, achieving efficient recovery of the phenothiazine microcrystals. Simultaneously, an absorption tower is set up to absorb hydrogen sulfide from the collected tail gas with alkaline solution, and an activated carbon adsorption tower is set up to deeply purify residual hydrogen sulfide and volatile organic compounds. This forms a complete treatment chain with graded treatment and each stage performing its specific function, effectively solving the problem of blockage caused by microcrystals directly entering the absorption tower in existing technologies, while also achieving the recycling of high-value products.

The application relates to the technical field of organic fluorescent probes, and particularly discloses a lipid droplet and hypochlorous acid sequence response type fluorescent probe, a structural formula of which is as shown in the figure; wherein R is a cyano group, a benzothiazole group, a benzimidazole group, an amido group, an ethoxycarbonyl group or an acetyl group. The precise imaging lipid droplet and hypochlorous acid sequence response fluorescent probe of the application takes a phenothiazine-coumarin dye support as a matrix, utilizes a double trifluoromethyl benzyl group as a lipid droplet targeting group, adjusts the dye emission wavelength by introducing different electron-withdrawing groups, synthesizes a series of probes, and realizes high-targeting sequence imaging of lipid droplets and hypochlorous acid in atherosclerotic plaques.

This invention relates to the field of organic synthesis technology, specifically to a highly efficient and stable Grignard preparation and its green preparation method. By weight, it comprises 8-18 parts of a magnesium source, 40-92 parts of a halogenated hydrocarbon, 150-200 parts of a green solvent, 15-20 parts of ethylene glycol dimethyl ether, and 2.3-3.2 parts of a synergistic stabilizer. The green solvent is 2-methyltetrahydrofuran, or a composite solvent with a weight ratio of 2-methyltetrahydrofuran:methyl tert-butyl ether of 150-160:40-50. The synergistic stabilizer is composed of 1.5-2.0 parts of N,N,N',N'-tetramethylethylenediamine and 0.8-1.2 parts of butylated hydroxytoluene, or composed of 1.5-2.0 parts of N,N,N',N'-tetramethylethylenediamine and 1.0 part of phenothiazine. This invention uses a green solvent system to replace traditional toxic and harmful solvents, and combines it with a solvent recovery process to achieve solvent recycling, which greatly reduces waste emissions and makes the production process safer and more environmentally friendly, in line with the development direction of green chemical industry.

The application belongs to the field of detection reagents, and particularly relates to a single-component luminol chemiluminescence substrate liquid and a preparation method thereof. The single-component luminol chemiluminescence substrate liquid comprises the following components: sodium acetate, sodium perborate, N-N dimethylacetamide, beta-cyclodextrin, luminol, 4-morpholinopyridine, p-acetylaminophenol, 4-hydroxyphenylacetic acid, phenothiazine-10-yl-propyl sulfonic acid sodium salt and isothiazolinone. The purpose of the application is to solve the technical defects that the luminol chemiluminescence substrate liquid in the prior art must be packaged in two components due to the instability of the luminous agent and the oxidizing agent in the liquid phase, leading to inconvenient use and easy introduction of operation errors, so as to provide a single-component luminol chemiluminescence substrate liquid and a preparation method thereof, which have high storage stability, high luminous performance and convenient use.

The invention discloses a phosphabicyclo [3, 2, 0] organic phosphorus compound as well as a preparation method and application thereof. Diallyl-containing tertiary phosphine oxide and phosphine sulfur compounds are used as raw materials, 10-phenyl phenothiazine is used as a photocatalyst, the photocatalyst is excited under a light source of 390 nm to activate double bonds, high-stereoselectivity [2 + 2] cycloaddition reaction is realized, the phosphorus heterocyclic bicyclo [3, 2, 0] organophosphorus compound containing two quaternary carbon centers is synthesized, diastereoisomers can be separated, and the yield is high. A single diastereoisomer product is as high as 97%, and excellent diastereoselectivity is achieved. The invention provides a green reaction mode for photocatalytic synthesis of the phosphabicyclo [3, 2, 0] organophosphorus compound, the conditions are mild, and the substrate universality is good. The obtained phosphabicyclo [3, 2, 0] organophosphorus compound is applied to a primary alcohol chlorination reaction as a catalyst, shows high reaction activity, and has more excellent catalytic activity compared with a reported catalytic system.

The invention belongs to the technical field of fluorescent probes, and particularly relates to a single-molecule fluorescent probe based on a phenothiazine structure as well as a preparation method and application of the single-molecule fluorescent probe. The preparation method comprises the following steps: firstly introducing an alkyl chain to a nitrogen atom of a raw material to obtain the phenothiazine structure-based single-molecule fluorescent probe, then carrying out regioselective formylation on the raw material to obtain the phenothiazine structure-based single-molecule fluorescent probe, then treating the raw material by adopting aluminum trichloride to realize O-demethylation, and finally carrying out intramolecular cyclization reaction on the raw material and 1H-benzimidazole-2-acetonitrile to obtain the phenothiazine structure-based single-molecule fluorescent probe. The single-molecule fluorescent probe based on the phenothiazine structure prepared by the invention is compatible with orthogonal chemical reaction activity and maintains controllable electron transfer, so that different chemical events are converted into specific optical signals, and selective and mechanism specific fluorescent response to phosgene, copper ions and hypochlorite is realized.

The present invention relates to sulfoxylated phenothiazine for use as a medicament. The present invention also relates to sulfoxylated phenothiazine for use in the treatment of painful sensations induced by neuropathy. The present invention also relates to a pharmaceutical composition comprising at least one sulfoxylated phenothiazine.

The invention belongs to the technical field of fluorescence sensing, and particularly relates to a zinc-based coordination polymer based on a heterocyclic ligand and a preparation method and application thereof. The method comprises the following steps: dissolving 3, 7-dibromo-10H-phenothiazine, pyridine-4-boric acid and K2CO3 in a mixed solution of DMF (Dimethyl Formamide) and H2O, uniformly stirring, then adding tetrakis (triphenylphosphine) palladium, carrying out a heating reflux reaction under protective gas, removing a solvent after the reaction is finished, separating impurities, and purifying to obtain 3, 7-bis (4-pyridyl) phenothiazine; the preparation method comprises the following steps: preparing a heterocyclic ligand, dissolving the heterocyclic ligand and zinc nitrate hexahydrate in a mixed solution of DMF and H2O, uniformly stirring, heating to react, and washing and drying after the reaction is finished to obtain the zinc-based coordination polymer based on the heterocyclic ligand. According to the present invention, by using the butterfly conformation and electron donating effect of the ligand molecule 3, 7-bis (4-pyridyl) phenothiazine and the coordination binding capacity synergistic effect of pyridine, the ligand molecule 3, 7-bis (4-pyridyl) phenothiazine is coordinated with zinc ions to construct the novel material with excellent luminescence property;

This invention belongs to the field of organic solar cells, specifically disclosing the application of an asymmetric boron / nitrogen / sulfur helicene-type multiple resonance-thermally activated delayed fluorescence material in organic solar cells. This multiple resonance-thermally activated delayed fluorescence material has a sulfur pseudoplanar helicene structure, composed of different donor units such as phenothiazine and diphenyl acridine. For the first time, it is used as a solid photovoltaic promoter, doped into fullerene or non-fullerene binary organic solar cell devices, significantly improving the energy conversion efficiency and stability of the devices. Specifically, when doped into PM6:Y6 binary non-fullerene organic solar cells, the energy conversion efficiency of the organic solar cell increased from 16.01% to 17.17%, and when doped into PM6:PC... 71 In BM binary fullerene organic solar cells, the energy conversion efficiency of organic solar cells increased from 8.49% to 9.30%.

The application discloses a synthesis method and application of a kind of phenothiazine leuco photo-caged compound, and relates to the application in the field of biological medicine.The compound is formed by using oxygen, sulfur and selenium containing phenothiazine leuco as matrix, connecting different functional groups by amide bond, especially STAT3 inhibitor molecules, forming a photo-controllable release platform that can be activated under near infrared light 650 or 660nm.In addition, the dye has good biocompatibility and low cytotoxicity, and experiments prove that it also has excellent imaging and treatment effect on specific tumor cells.

The application discloses a kind of benzimidazole compounds and its application, belong to crop growth regulation technical field.The benzimidazole compound structural formula is;Wherein, R1 It is phenothiazine group, NH2 Or halogen;R2 It is H, CH3 Or F;R3 It is phenothiazine group, CH3, NH2, NO2 Or halogen.Benzimidazole compound is 5-nitro-2-(N-phenothiazine group)-1H-benzimidazole, 5-(N-phenothiazine group)-1H-benzimidazole or 2-bromo-5-amino-1H-benzimidazole.The application is modified to different sites of benzimidazole, designs new benzimidazole compound.The raw material of this preparation method is easy to obtain, low in cost, and operation is relatively simple.This benzimidazole compound can promote crop growth and inhibit the activity of pathogenic bacteria, and has good development prospect.

The application discloses a method for preparing fluorine-containing diphenylmethane compounds by using sulfur hexafluoride as a fluorination reagent, and belongs to the technical field of organic chemical synthesis. The preparation method comprises the following steps: (1) mixing a photocatalyst, a solvent and a reducing agent, and performing ultrasonic treatment to obtain solution A; mixing a reaction substrate and the solvent to obtain solution B; the photocatalyst is one or more of 4CzIPN, Ir[dF(CF3)ppy]2(dtbpy))PF6, 9-thioxanthone and 10-phenylphenothiazine; the reaction substrate is a compound with a structural formula of R1 and R2 are both H, alkoxy or halogen; (2) mixing the obtained solution A and solution B in a sulfur hexafluoride gas atmosphere, and performing reaction under blue light illumination, and the fluorine-containing diphenylmethane compounds are obtained. The method has the beneficial effects that the fluorine-containing diphenylmethane compounds are efficiently prepared by using sulfur hexafluoride as the fluorination reagent, and by selecting raw materials and catalysts with certain proportions; the reaction raw materials are cheap; the preparation process is safe, mild, has good substrate compatibility and high preparation efficiency.

The application discloses a visible light driven deaminative bromosulfonylation method. The method comprises the following steps: under the protection of inert gas, sulfonamide shown in formula (I), alkyne shown in formula (II), 10H-phenothiazine and carbon tetrabromide are dissolved in an organic solvent, tert-butyl nitrite and trifluoroacetic acid are added, and reaction is carried out under visible light irradiation to obtain (E)-beta-bromo vinyl sulfone shown in formula (III); wherein, R 1 is selected from aryl, substituted aryl, heteroaryl, alkyl or cycloalkyl; R 2 is selected from aryl, substituted aryl, heteroaryl, alkyl or cycloalkyl; R 3 is selected from alkyl; the photocatalyst is 10H-phenothiazine; the bromine source is carbon tetrabromide; the organic solvent is 1,4-dioxane, N,N-dimethylformamide, dimethyl sulfoxide or acetonitrile; and the wavelength of visible light is 420-520 nm. The method has the advantages of high stereoselectivity, mild reaction condition and wide substrate application range.

The invention discloses a preparation method and application of a hypochlorite photoelectrochemical sensing platform, and belongs to the technical field of analytical chemistry. According to the preparation process, adopted raw materials are easy to obtain, and reaction conditions are mild and easy to control. The sensing platform is designed and synthesized based on phenothiazine-chromone photosensitive micromolecules as a photosensitizer, and photoelectrochemical (PEC) sensing is realized. The sensing platform has the characteristics of high specificity, high sensitivity and easiness in preparation, quantitative photoelectrochemical signals of pypocholoride can be realized, and the PEC detection electrode is 1.64 nM.

The present invention relates to a process for the preparation of C1 to C 22 - (meth)acrylates, comprising an adsorption step, wherein a product mixture (2) comprising C1 to C 22 - (meth)acrylates and phenothiazine (PTZ) is contacted with an adsorption material (6) and a product composition (8) is obtained. The present invention further relates to polymers based on the product composition.

The application discloses a phenothiazine compound or a pharmaceutically acceptable salt thereof, and a preparation and application thereof. 1‑5 The application can inhibit HSC-LX2 activity, and has no significant toxicity to liver cells at the dose. In-vivo and in-vitro experimental results show that CCOPTZBr has excellent anti-hepatic fibrosis activity, whether in improvement of mouse hepatic fibrosis as a whole or in inhibition of HSC proliferation and induction of activated HSC aging, and therefore CCOPTZBr can be used for preparation of an anti-hepatic fibrosis drug, and has a good drug-making prospect.

The application provides a fluorescent probe for detecting Tau protein and a preparation method and application thereof, the fluorescent probe is a phenothiazine compound with a specific conjugated structure, has characteristic absorption in an ultraviolet-visible light region, produces stable fluorescent emission in a visible light to near infrared wave band, can be selectively combined with Tau protein aggregates and produce a significant fluorescent signal change, thereby realizing high-sensitivity detection and pathological evaluation of Tau protein abnormal deposition.

The application provides a high-efficiency polymerization inhibitor and a preparation method and application thereof, and the method comprises the following steps: dispersing demethylated lignin, a mercapto carboxylic acid compound, a phenothiazine carboxylic acid derivative, a carbodiimide coupling agent and a carboxyl activating agent in anhydrous aprotic solvent, and performing esterification reaction between alcohol hydroxyl groups of the demethylated lignin and carboxyl groups of the mercapto carboxylic acid compound and the phenothiazine carboxylic acid derivative to obtain the high-efficiency polymerization inhibitor. The polymerization inhibitor is suitable for storage and transportation of acrylate monomers, and can significantly improve the storage stability and heat resistance of polymers.

The application provides a fluorescent probe compound for simultaneously detecting HClO and SO2 at double sites and synthesis and application thereof. The probe compound takes phenothiazine as a response group of HClO, expands the conjugated structure of phenothiazine, and introduces a response group of SO2 and an organelle positioning group on the near-infrared fluorescent skeleton, thereby constructing an endoplasmic reticulum-targeted fluorescent probe BQTPA for simultaneously detecting HClO and SO2. The probe can realize dual-channel simultaneous detection of HClO and SO2 through two completely separated emission channels (λem=598 nm and 448 nm), and exhibits excellent selectivity, high sensitivity (detection limits are 7.9 nM and 33.8 nM, respectively) and good light stability to the response of HClO and SO2. The probe is successfully used for monitoring the changes of exogenous and endogenous HClO and SO2 levels in cells, further reveals the dynamic changes of the two in the process of drug-induced liver injury and ferroptosis, and clarifies the role of ferroptosis in liver injury.

The invention discloses application of phenothiazine compounds in preparation of antituberculosis drugs, and belongs to the technical field of biomedicine. The invention discloses application of phenothiazine compounds in preparation of antituberculous drugs, phenothiazine compounds X79 serve as a photosensitizer to mediate photodynamic therapy to generate active oxygen to achieve host-oriented treatment, a brand new treatment strategy is provided for infection of intracellular bacteria such as mycobacterium tuberculosis, biocompatibility is excellent, functional modification is easy to achieve, and the phenothiazine compounds X79 can be applied to preparation of antituberculous drugs. Good application prospects are realized in the field of tuberculosis treatment.

An electrocatalyst includes a substrate and a microporous polymer on the substrate. The microporous polymer includes, in polymerized form, a triptycene of Formula (I)and a phenothiazine of Formula (II)where in Formula (I), R1-14 each individually represent hydrogen, an optionally substituted alkyl, an optionally substituted aryl, with at least two representing hydrogen and in Formula (II), R15-23 each individually represent hydrogen, an optionally substituted alkyl. The triptycene of Formula (I) and the phenothiazine of Formula (II) are linked by methylene units.

The application relates to a preparation method of hollow tubular carbon material and application of the hollow tubular carbon material as a negative electrode material in a sodium ion battery. The preparation method of the hollow tubular carbon material comprises the following steps: dispersing phenothiazine in 1,2-dichloroethane, taking iron trichloride as a catalyst, taking dimethylol urea as a crosslinking agent, heating at 60-100 DEG C for 12-24 h through a one-step polymerization and controllable pyrolysis method, and carbonizing at 500-900 DEG C for 1-4 h under a nitrogen atmosphere to obtain the hollow tubular carbon material. The hollow tubular carbon material has good charge-discharge capacity and cycle stability, and as a negative electrode of a sodium ion battery, can still maintain more than 90% reversible capacity after 1000 cycles under a current density of 1 A / g. In addition, the preparation method is simple and easy to operate, the morphology is controllable, and the product yield is high.

The invention relates to the technical field of fluorescent nano sensors, in particular to a synthesis method of a fluorescent nano sensor for monitoring the content of ferric ions in sewage. The method comprises the following steps: 1, carrying out anhydrous and anaerobic treatment on a reactor, cooling to room temperature, adding an F127 or P123 solution into the reactor, and adding 10-ethyl-3, 7-diformaldehyde phenothiazine under a stirring condition to synthesize fluorescein isothiocyanate with the concentration of (1-9) * 10 <-4 > mol / L; and 2, adding ethanol into fluorescein isothiocyanate, fully stirring, adding tetraethoxysilane, reacting, adding a terminator, continuously stirring, filtering by using a water-based filter membrane, and dialyzing by using deionized water until particles are neutral, thereby obtaining the fluorescent nano sensor. The size of the synthesized fluorescent nano sensor is lower than 20 nm, the water compatibility is good, the luminous intensity in water is high, the online detection capability is achieved, the detection method is visual and effective, and the method can be suitable for chemical sewage and domestic sewage.

A synergistic polymerization inhibitor composition, the composition having a copper salt, and a manganese salt; a copper salt or a manganese salt, and a cationic polymer; or a phenothiazine and a manganese salt. A method for inhibiting polymerization of unsaturated polymerizable monomers, the method providing adding a synergistic polymerization inhibitor composition to an methacrylic acid manufacturing system or component thereof, the composition having a copper salt, and a manganese salt; a copper salt or a manganese salt, and a cationic polymer; or a phenothiazine and a manganese salt.

This invention relates to the field of nanobiomedical imaging technology, and in particular to a near-infrared-II compound, its preparation method, and its application in near-infrared-II photoacoustic imaging contrast agents. The near-infrared-II compound uses triphenylamine and piperazine groups as electron acceptors, and an electron-rich phenothiazine group as the hypochlorous acid recognition response site and electron acceptor precursor. The near-infrared-II compound of this invention, after activation with hypochlorous acid, exhibits near-infrared-II absorption and intramolecular charge transfer properties. It is a typical D-A-D type organic small molecule, enabling better photoacoustic imaging effects and providing a highly sensitive imaging method for disease diagnosis.

The invention discloses an anti-biological reduction protective agent applicable to phenothiazine photosensitive dyes and application of the anti-biological reduction protective agent in the aspects of phototherapy and immunological enhancement. The protective agent is a biosafe electron acceptor (such as thymoquinone TQ, cytochrome c and ethidium dihydrogen), can effectively inhibit MB from being reduced into colorless LMB in a physiological simulation environment containing NADH / NADPH, accelerates reoxidation of LMB into active MB, and significantly improves the ROS yield (up to 4 times or more). The combined system not only greatly enhances the photodynamic effect of MB in tumor cells and bacteria, but also can strengthen the release of immunogenic death factors (CRT, HMGB1 and ATP), and provides a brand new strategy for developing high-performance phototherapy materials, in-vitro antibacterial systems and immune regulation tools.

The invention discloses a preparation method of 3-aminophenothiazine, which comprises the following steps: by taking phenothiazine as an initial raw material, carrying out nitration reaction in a solvent under the action of a nitrating agent to synthesize 3-nitrophenothiazine, and then carrying out reduction reaction on the 3-nitrophenothiazine and H2 under the action of a hydrogenation catalyst to generate the 3-aminophenothiazine, a solvent for the nitration reaction comprises a first organic solvent and a second organic solvent, and the first organic solvent is a polar organic solvent; the method for preparing the 3-aminophenothiazine is simple in reaction process, the raw materials are easy to obtain, part of the solvent can be repeatedly used, cost reduction is facilitated, the reaction time is short, the product yield is high, and the method is suitable for industrial production.

The application discloses an organic fluorescent small-molecule material, a synthesis method and application, and belongs to the technical field of fluorescent materials. The provided organic fluorescent small-molecule material is formed by connecting a phenothiazine compound and a dioxothiophene compound through a double bond, and a functional group is connected to N of the phenothiazine compound. The above can adjust a large pi conjugated system by adjusting the connecting position and quantity of the phenothiazine group and the dioxothiophene, and enhance the push-pull electron system by adding a modification group at a specific site, so that a series of fluorescent molecules with the characteristics of wavelength adjustable, large stokes shift and high fluorescence quantum yield are designed. The obtained fluorescent molecules are widely applied to fields such as fluorescent labeling, fluorescent imaging and the like, such as gene sequencing, nucleic acid detection, immune detection, immunofluorescence lateral chromatography, flow cytometry fluorescent labeling, surgical navigation and the like.