163 results about "Phenothiazine" patented technology

The invention relates to the technical field of photovoltaic cells, in particular to a hole transport material and a preparation method thereof, a solar cell and an optoelectronic device. The hole transport material comprises a hole transport polymer, and the hole transport polymer has at least one of repetitive units shown in formulas (I)-(III). According to the hole transport material provided by the invention, thienopyrrole, carbazole and phenothiazine are adopted as conjugated units of the hole transport polymer, a cyano phosphate group is adopted as an anchoring unit of the hole transport polymer, and through the synergistic effect of the conjugated units and the anchoring unit, the efficiency and stability of a perovskite solar cell are improved, and the service life of the perovskite solar cell is prolonged.

The invention provides anthracene methyl phenothiazine for a photosensitive resin composition, and relates to the field of photopolymerization. The invention further comprises a photosensitive resin composition containing the anthracene methyl phenothiazine, a photosensitive dry film containing the anthracene methyl phenothiazine and application of the photosensitive resin composition and the photosensitive dry film. The anthracene methyl phenothiazine disclosed by the invention has photosensitivity, can be used as a photosensitizer in the photosensitive resin composition, can improve the adhesive force of the photosensitive resin composition on various metal surfaces, and has the characteristic of low migration; the method can be widely applied to the photo-curing fields of dry films, paints, coatings, printing ink, forming materials and the like.

The invention belongs to the field of perovskite solar cells, and particularly relates to application of a bulk phase and interface synergistic passivator in a perovskite solar cell. The invention provides a bulk phase / interface synergistic passivation innovative strategy, molecules with a tricyclic sulfur-nitrogen heterocyclic ring structure are introduced as a synergistic passivator, and defect global repair of each functional layer of a device is realized. The molecular design of the structural derivative taking phenothiazine as the core has the following advantages: skeleton characteristics: a conjugated tricyclic system forms an electron transport network through pi-pi stacking, endows molecules with excellent electron delocalization ability, and effectively regulates and controls carrier kinetics; the thioether group is used for dynamically repairing an ion migration channel through oxidation-reduction activity and inhibiting formation of deep-energy-level defects; and the secondary amine group is used as a hydrogen bond donor for anchoring uncoordinated halide ions and synchronously passivating surface and grain boundary defects.

The invention relates to the technical field of fluorescent probes, and provides a low-concentration ratio type high-concentration enhanced fluorescent probe as well as a preparation method and application thereof in order to solve the problems that a traditional fluorescent probe depends on a high-concentration use condition and is often faced with fast probe consumption, increased biotoxicity, non-specific target binding and the like in a biological sample. The preparation method of the fluorescent probe comprises the following steps: step 1, preparing phenothiazine dialdehyde; and 2, mixing phenothiazine dialdehyde, malononitrile, ethanol, acetonitrile, DMF and piperidine, and carrying out a reflux reaction to obtain the low-concentration ratio-type high-concentration enhanced fluorescent probe. The probe provided by the invention realizes quantitative detection of HClO through synchronous change of two emission channels, and the detection sensitivity and reliability are remarkably improved; when the concentration is high, an enhanced single-channel fluorescence amplification effect is shown, and strong signal identification and macroscopic visual imaging in specific application are facilitated, so that the dual requirements of trace monitoring and high-throughput screening are met.

The invention discloses a phenothiazinyl two-dimensional covalent organic framework material as well as a preparation method and application thereof. The two-dimensional covalent organic framework material has a structure as shown in a formula (I) or a formula (II): # imgabs0 #. The two-dimensional covalent organic framework material has high crystallinity and specific surface area, uniform pore size distribution and good thermal stability, also has good photosensitive groups and a suitable optical band gap, and can be used for preparing a light-sensitive material. The method has good application in the photocatalytic oxidation coupling direction.

The invention relates to a 5, 9-di-tert-butyl naphtho-indolizine phenothiazine compound as well as a preparation method and medical application thereof. The compound is efficiently synthesized through Ullmann coupling and palladium-catalyzed intramolecular arylation reaction. In-vitro anti-tumor activity research shows that the compound has remarkable selective inhibitory activity on various human tumor cell lines, and particularly, the inhibitory effect on non-small cell lung cancer A549 cells (IC50 = 0.21 mu M) is improved by two orders of magnitude compared with that of cis-platinum; iC50 (half maximal inhibitory concentration) of other cell lines are as follows: 1.26 mu M of prostate cancer PC-3 cells, 6.78 mu M of liver cancer HepG2 cells, 7.99 mu M of cervical cancer Hela cells and 25.46 mu M of breast cancer MCF-7 cells. Preliminary toxicity experiments prove that the compound has the characteristic of low cytotoxicity. The compound can be used as a novel high-efficiency low-toxicity anti-tumor lead compound, and provides an important structural basis for the development of anti-cancer drugs.

The present invention belongs to the field of biomedicine, and specifically relates to a light-controlled release of ONOO － Compounds and preparation methods and applications thereof. The present invention provides ONOO ‑ The donor is composed of a diphenyl phenothiazine analogue and arginine covalently linked. Its strong conjugation effect makes it extremely photoresponsive. The polymer has near-infrared light emission and excellent reactive oxygen and reactive nitrogen generation capabilities. When L6 is irradiated with a 660nm laser, it will produce superoxide anions and singlet oxygen. Singlet oxygen oxidizes the guanidine group of arginine to produce NO and ·O2 ‑ and NO to form peroxynitrite (ONOO ‑ ), achieving the goal of highly effective tumor cell killing. Therefore, this compound is a potentially highly effective photosensitizer for tumor killing. Compared to conventional photosensitizers, this killing method has stronger oxidative and nitrative cell damage capabilities, and its development cycle is shorter than that of other photosensitizers, thus possessing great potential application value in clinical treatment.

The invention discloses a donor-receptor porphyrin molecular engineering-based high-sensitivity hypochlorous acid fluorescent probe and a synthesis method thereof, the structural formula of the probe is as follows: # imgabs0 #, the probe can detect hypochlorous acid (HClO) with high sensitivity, phenothiazine groups are introduced at two meso positions of porphyrin, and a donor-receptor (D-A) system is formed in molecules. The probe has rapid response performance to hypochlorous acid, sulfur atoms in phenothiazine are oxidized through hypochlorous acid, phenothiazine electrons are prevented from being transferred to porphyrin under light excitation, and therefore red fluorescence is shown, and selective detection of hypochlorous acid is achieved. After the probe reacts with hypochlorous acid, 667 nm red fluorescence is emitted under the excitation wavelength of 450 nm, the fluorescence appears obviously, and the Stokes shift is 217 nm. The reaction product has the advantages of good water solubility, high fluorescence quantum yield, large Stokes shift and the like. The probe can detect hypochlorous acid with high sensitivity, and has a huge application prospect in the technical fields of analytical chemistry, life science, environment detection, biomedical treatment and the like.

The invention discloses a benzothiazine phenothiazine oxide polyacrylamide copolymer phosphorescent material as well as a preparation method and application thereof, belongs to the technical field of organic phosphorescent materials, and solves the problems of harsh ORTP preparation conditions and unsatisfactory product performance in the prior art. The room-temperature phosphorescent material is obtained mainly by introducing different connecting units to the benzothiazine phenothiazine oxide and then carrying out free radical copolymerization with acrylamide, the reaction conditions are mild, the synthesis method is simple and convenient, and the materials are easy to obtain.

The invention belongs to the field of organic synthesis and medicinal chemistry, and particularly provides an efficient synthesis method of an N, N-diphenyl aniline compound based on a naphtho-indolizino-phenothiazine skeleton and anti-tumor application of the N, N-diphenyl aniline compound based on the naphtho-indolizino-phenothiazine skeleton. Through Suzuki reaction, functional coupling based on a naphtho-indolizino-phenothiazine skeleton and an N, N-diphenyl aniline group is realized for the first time. In-vitro anti-tumor evaluation shows that the compound has remarkable inhibitory activity on various human tumor cells, especially has the strongest effect on breast cancer MCF-7 cells (IC50 = 0.15 mu M), and the activity is improved by 266 times compared with that of cis-platinum; prostate cancer PC-3, liver cancer HepG2, lung adenocarcinoma A549 and cervical cancer Hela cells are also remarkably inhibited. The toxicity to normal umbilical vein endothelial cells (HUVEC) is far lower than that of tumor cells, and the selectivity is excellent. The research provides a lead compound with great potential for developing high-efficiency and low-toxicity targeted anti-tumor drugs.

The invention relates to the technical field of solar cells, in particular to a self-assembled monomolecular hole transport material, a preparation method and application thereof, a perovskite solar cell, a preparation method thereof and a photovoltaic module. The self-assembled monomolecular hole transport material provided by the invention has a structure as shown in a formula I. In the formula I, A1, A2 and A3 are respectively and independently anchor groups or hydrogen atoms; the anchoring groups are independently selected from phosphate groups respectively; g is selected from a substituted or unsubstituted carbazolyl group, a substituted or unsubstituted acridinyl group, a substituted or unsubstituted phenothiazinyl group, and a substituted or unsubstituted phenoxazinyl group. The self-assembled monomolecular hole transport material provided by the invention has stronger anchoring binding capacity, conjugation in molecules is enhanced through the aromatic connection unit, and transport of carriers is facilitated; polyphosphonic acid anchoring in the self-assembled monomolecular hole transport material provided by the invention can enhance adsorption and uniformity of molecules, and a formed hole transport interface has better charge transport and defect passivation effects.

The application discloses a phenothiazine self-assembled organic small-molecule hole transport material and application thereof, wherein the structural general formula of the phenothiazine self-assembled organic small-molecule hole transport material is as follows: wherein R is n is 1-5. The disclosed phenothiazine self-assembled organic small-molecule hole transport material is based on a self-assembled monolayer design strategy, carboxylic acid anchoring groups and different bridging units are introduced into the phenothiazine molecular structure, the adjustment of the hole transport material molecular energy level and the improvement of the hole transport layer interface contact are realized. When the material is applied to a perovskite solar cell device as a non-doped hole transport layer, it shows good photoelectric conversion efficiency. Especially important is that the synthesis process is simple, the raw material source is wide and the price is low, so that the material is more competitive in practical application, and is expected to bring a new breakthrough to the development of perovskite solar cells.

This application relates to the field of tail gas absorption technology, specifically disclosing a tail gas absorption device for phenothiazine production. The pretreatment mechanism in this application can induce sublimation of phenothiazine microcrystals in the tail gas through multiple stages, allowing the microcrystals to grow sufficiently to a collectable size before entering the collection zone. Then, a multi-stage blade collection mechanism progressively adheres and collects the grown microcrystals, achieving efficient recovery of the phenothiazine microcrystals. Simultaneously, an absorption tower is set up to absorb hydrogen sulfide from the collected tail gas with alkaline solution, and an activated carbon adsorption tower is set up to deeply purify residual hydrogen sulfide and volatile organic compounds. This forms a complete treatment chain with graded treatment and each stage performing its specific function, effectively solving the problem of blockage caused by microcrystals directly entering the absorption tower in existing technologies, while also achieving the recycling of high-value products.

The application relates to the technical field of organic fluorescent probes, and particularly discloses a lipid droplet and hypochlorous acid sequence response type fluorescent probe, a structural formula of which is as shown in the figure; wherein R is a cyano group, a benzothiazole group, a benzimidazole group, an amido group, an ethoxycarbonyl group or an acetyl group. The precise imaging lipid droplet and hypochlorous acid sequence response fluorescent probe of the application takes a phenothiazine-coumarin dye support as a matrix, utilizes a double trifluoromethyl benzyl group as a lipid droplet targeting group, adjusts the dye emission wavelength by introducing different electron-withdrawing groups, synthesizes a series of probes, and realizes high-targeting sequence imaging of lipid droplets and hypochlorous acid in atherosclerotic plaques.

This invention relates to the field of organic synthesis technology, specifically to a highly efficient and stable Grignard preparation and its green preparation method. By weight, it comprises 8-18 parts of a magnesium source, 40-92 parts of a halogenated hydrocarbon, 150-200 parts of a green solvent, 15-20 parts of ethylene glycol dimethyl ether, and 2.3-3.2 parts of a synergistic stabilizer. The green solvent is 2-methyltetrahydrofuran, or a composite solvent with a weight ratio of 2-methyltetrahydrofuran:methyl tert-butyl ether of 150-160:40-50. The synergistic stabilizer is composed of 1.5-2.0 parts of N,N,N',N'-tetramethylethylenediamine and 0.8-1.2 parts of butylated hydroxytoluene, or composed of 1.5-2.0 parts of N,N,N',N'-tetramethylethylenediamine and 1.0 part of phenothiazine. This invention uses a green solvent system to replace traditional toxic and harmful solvents, and combines it with a solvent recovery process to achieve solvent recycling, which greatly reduces waste emissions and makes the production process safer and more environmentally friendly, in line with the development direction of green chemical industry.

The application belongs to the field of detection reagents, and particularly relates to a single-component luminol chemiluminescence substrate liquid and a preparation method thereof. The single-component luminol chemiluminescence substrate liquid comprises the following components: sodium acetate, sodium perborate, N-N dimethylacetamide, beta-cyclodextrin, luminol, 4-morpholinopyridine, p-acetylaminophenol, 4-hydroxyphenylacetic acid, phenothiazine-10-yl-propyl sulfonic acid sodium salt and isothiazolinone. The purpose of the application is to solve the technical defects that the luminol chemiluminescence substrate liquid in the prior art must be packaged in two components due to the instability of the luminous agent and the oxidizing agent in the liquid phase, leading to inconvenient use and easy introduction of operation errors, so as to provide a single-component luminol chemiluminescence substrate liquid and a preparation method thereof, which have high storage stability, high luminous performance and convenient use.

The invention relates to the technical field of tumor treatment, in particular to a phenolic thiazinyl photosensitizer conjugated with different planar electrons as well as a preparation method and application thereof, and the general formula of the phenolic thiazinyl photosensitizer is as follows: # imgabs0 #. The photosensitizer can solve the problems of poor light penetrability of the photosensitizer and poor fluorescence imaging capability, low curative effect and the like caused by a tumor hypoxic microenvironment in the prior art.

The invention discloses a phosphabicyclo [3, 2, 0] organic phosphorus compound as well as a preparation method and application thereof. Diallyl-containing tertiary phosphine oxide and phosphine sulfur compounds are used as raw materials, 10-phenyl phenothiazine is used as a photocatalyst, the photocatalyst is excited under a light source of 390 nm to activate double bonds, high-stereoselectivity [2 + 2] cycloaddition reaction is realized, the phosphorus heterocyclic bicyclo [3, 2, 0] organophosphorus compound containing two quaternary carbon centers is synthesized, diastereoisomers can be separated, and the yield is high. A single diastereoisomer product is as high as 97%, and excellent diastereoselectivity is achieved. The invention provides a green reaction mode for photocatalytic synthesis of the phosphabicyclo [3, 2, 0] organophosphorus compound, the conditions are mild, and the substrate universality is good. The obtained phosphabicyclo [3, 2, 0] organophosphorus compound is applied to a primary alcohol chlorination reaction as a catalyst, shows high reaction activity, and has more excellent catalytic activity compared with a reported catalytic system.

The invention belongs to the technical field of organic synthesis and medicinal chemistry, and particularly relates to a synthesis method of a novel polycyclic aromatic hydrocarbon derivate 2, 6-di-tert-butyl pyrene and indolizine phenothiazine compound and application of the compound in the aspect of anti-cancer drugs. The synthesis process is simple and convenient, conditions are mild, and the yield is ideal. Pharmacodynamic evaluation shows that the compound shows strong inhibitory activity on various human cancer cell lines, and the IC50 values are respectively cervical cancer Hela cells (0.17 mu M), lung cancer A549 cells (0.3 mu M), prostatic cancer PC-3 cells (0.42 mu M) and liver cancer HepG2 cells (10.79 mu M), which are respectively reduced by 109 times, 173 times, 35 times and 1.8 times compared with positive control drug cis-platinum. In addition to efficiently inhibiting cancer cells, the compound has low toxicity to normal cells, meets the basic requirements of excellent anti-cancer drugs, and shows important application value and potential in the field of research and development of novel anti-cancer drugs.

The invention belongs to the technical field of organic synthesis and medicinal chemistry, and particularly relates to a synthesis method and anti-tumor application of a novel polycyclic aromatic hydrocarbon derivative 2, 6-di-tert-butyl phenanthroindolizino phenothiazine compound. The synthesis process is simple and convenient, and the yield is ideal. Pharmacodynamic evaluation shows that the compound has remarkable selective inhibitory activity on various human tumor cells, and the IC50 values of the compound are respectively as follows: Helaa (0.1 [mu] M), PC-3 (0.43 [mu] M), HepG2 (11.38 [mu] M), A549 (1457 [mu] M) and MCF-7 (88.25 [mu] M). Compared with cis-platinum, the compound has the advantages that the inhibiting effect on MCF-7 is weak, the inhibiting activity on other tumor cell lines is remarkably enhanced, and particularly, the IC50 value on Hela and PC-3 cells is reduced by two orders of magnitude. The compound has excellent anti-tumor activity and relatively low cytotoxicity, and has a good prospect in research and development of anti-tumor drugs.

The invention discloses a pinene pyrimidine tetradentate platinum (II) and palladium (II) complex and its preparation method and application, the complex is an asymmetric chiral tetradentate complex based on the pyrimidine ligand of pinene, and the general structural formula of the complex is a compound represented by the following formula (I) and formula (II): wherein R is one of N-carbazolyl, N-diphenylamine, N-phenothiazine, N-phenoxazine, N-dimethylacridinyl, 2,6-dimethyl substituted phenoxy, 2,6-diisopropyl substituted phenoxy, and hexahydropyridine. The pinene pyrimidine tetradentate platinum (II) and palladium (II) complex provided by the invention has excellent photoelectric performance, stability, film forming property, solubility and other properties, and is simple to prepare, low in cost, has aggregated luminescence and pressure-induced color performance, can be used as a light-emitting layer in electroluminescent devices, or in sensors, anti-counterfeiting, storage and display fields.

The invention belongs to the technical field of fluorescent probes, and particularly relates to a single-molecule fluorescent probe based on a phenothiazine structure as well as a preparation method and application of the single-molecule fluorescent probe. The preparation method comprises the following steps: firstly introducing an alkyl chain to a nitrogen atom of a raw material to obtain the phenothiazine structure-based single-molecule fluorescent probe, then carrying out regioselective formylation on the raw material to obtain the phenothiazine structure-based single-molecule fluorescent probe, then treating the raw material by adopting aluminum trichloride to realize O-demethylation, and finally carrying out intramolecular cyclization reaction on the raw material and 1H-benzimidazole-2-acetonitrile to obtain the phenothiazine structure-based single-molecule fluorescent probe. The single-molecule fluorescent probe based on the phenothiazine structure prepared by the invention is compatible with orthogonal chemical reaction activity and maintains controllable electron transfer, so that different chemical events are converted into specific optical signals, and selective and mechanism specific fluorescent response to phosgene, copper ions and hypochlorite is realized.

In a general form, the present invention relates to a two-component mortar composition comprising a resin component (A) containing at least one radical-curable resin as a curable component, and a curing agent component (B) containing a curing agent for the radical-curable resin of the resin component (A), wherein the resin component (A) contains one or more polymerization inhibitors selected from phenolic polymerization inhibitors, phenothiazine and / or its derivatives, stable organic radicals, oximes, and pyrimidinol or pyridinol compounds substituted at the para position with respect to the hydroxyl group. In the mortar composition, the resin component (A) further contains an alkoxyamine compound (I) of the formula R-O-N(R’R”) (wherein R is an alkyl group and R’ or R” is an organic group), and this compound has an activation energy E for the homolysis of the R-O bond in the range of 100 kJ / mol to 120 kJ / mol a characterized by having the above. In another embodiment, the present invention relates to a two-component mortar composition comprising a resin component (A) containing at least one radical-curable resin as a curable component, and a curing agent component (B) containing a curing agent for the radical-curable resin of the resin component (A), wherein the resin component (A) contains one or more polymerization inhibitors selected from phenolic polymerization inhibitors, phenothiazine and / or its derivatives, stable organic radicals, oximes, and pyrimidinol or pyridinol compounds substituted at the para position with respect to the hydroxyl group, and the resin component (A) further contains an alkoxyamine compound of the following formula (II) TIFF2025518937000015.tif18150. Furthermore, the present invention relates to the use of a two-component mortar composition for chemically fixing fixing elements such as anchor threaded rods, reinforcing bars, threaded sleeves, and screws in drilled holes of building materials such as wood or mineral substrates.

The present invention relates to sulfoxylated phenothiazine for use as a medicament. The present invention also relates to sulfoxylated phenothiazine for use in the treatment of painful sensations induced by neuropathy. The present invention also relates to a pharmaceutical composition comprising at least one sulfoxylated phenothiazine.

The invention discloses a red light delayed fluorescent material based on naphthalimide as well as a preparation method and application thereof, and belongs to the technical field of organic light emitting diodes, naphthalimide is taken as an acceptor core, 4-(1-pyrrolyl) aniline is combined to design a naphthalimide derivative, and then different donors 9, 9-dimethyl acridine (DMAC) and phenothiazine are connected to obtain the red light delayed fluorescent material based on naphthalimide. Two red-light delayed fluorescent materials are synthesized, and have deeper LUMO (lowest unoccupied molecular orbital) energy level and higher rigidity; when the synthesized material is applied to red light delayed fluorescence, red light emission can be realized, and meanwhile, non-radiative transition is well inhibited, so that the device efficiency is improved, the application prospect is wide and optimistic, and the material is expected to be widely applied to the fields of display, illumination and the like.

A polymerization inhibitor composition is provided. 【Solution means】The polymerization inhibitor composition includes at least a first inhibitor compound having phenothiazine or a derivative thereof, a second inhibitor compound having phenylenediamine or a derivative thereof, and a solvent. A method for inhibiting the polymerization of a monomer using the composition of the present disclosure is also provided. The method for inhibiting the polymerization of a monomer includes the step of adding the composition of the present disclosure to the monomer. In some cases, the monomer is an ethylenically unsaturated monomer. Such ethylenically unsaturated monomers include, but are not limited to, (meth)acrylic acid, methyl methacrylate, acrylic acid, acrylic esters, methacrylamide sulfate, vinyl acetate, acrylonitrile, acrolein, acrylates, methacrylates, 1,3-butadiene, styrene, isoprene, and combinations thereof. A method for preparing the polymerization inhibitor and composition of the present disclosure is also provided.

The application belongs to the technical field of organic synthesis, and provides a star structure carbazole derivative, a preparation method thereof and a carbazole conductive polymer. The application obtains an intermediate by mixing 10-phenyl-10H-phenothiazine, N-bromosuccinimide and a first organic solvent for reaction; obtains the star structure carbazole derivative by mixing the intermediate, 9H-carbazole-2-boronic acid pinacol ester, tetrakis(triphenylphosphine)palladium, an accelerator and a second organic solvent for reaction; and obtains the carbazole conductive polymer by mixing the star structure carbazole derivative and an electrolyte solution for cyclic voltammetry electrochemical polymerization. The method is simple, has few by-products, and the star structure carbazole derivative obtained by the method is a non-coplanar star structure, which is beneficial to the embedding and discharging of electrolyte ions, so that the carbazole conductive polymer has excellent electrochemical performance and energy storage properties, and the conductive polymer also has excellent electrochromic performance.

The invention belongs to the technical field of fluorescence sensing, and particularly relates to a zinc-based coordination polymer based on a heterocyclic ligand and a preparation method and application thereof. The method comprises the following steps: dissolving 3, 7-dibromo-10H-phenothiazine, pyridine-4-boric acid and K2CO3 in a mixed solution of DMF (Dimethyl Formamide) and H2O, uniformly stirring, then adding tetrakis (triphenylphosphine) palladium, carrying out a heating reflux reaction under protective gas, removing a solvent after the reaction is finished, separating impurities, and purifying to obtain 3, 7-bis (4-pyridyl) phenothiazine; the preparation method comprises the following steps: preparing a heterocyclic ligand, dissolving the heterocyclic ligand and zinc nitrate hexahydrate in a mixed solution of DMF and H2O, uniformly stirring, heating to react, and washing and drying after the reaction is finished to obtain the zinc-based coordination polymer based on the heterocyclic ligand. According to the present invention, by using the butterfly conformation and electron donating effect of the ligand molecule 3, 7-bis (4-pyridyl) phenothiazine and the coordination binding capacity synergistic effect of pyridine, the ligand molecule 3, 7-bis (4-pyridyl) phenothiazine is coordinated with zinc ions to construct the novel material with excellent luminescence property;

The invention discloses a quick response type near-infrared fluorescent probe for detecting Hg < 2 + >, a preparation method of the quick response type near-infrared fluorescent probe and application of the quick response type near-infrared fluorescent probe in actual water samples and biological imaging. The molecular formula of the fluorescent probe is C32H28N2O2S2. On the basis of a strategy of introducing phenothiazine heterocycle to expand xanthene pi conjugation, a large Stokes shift near infrared fluorescent probe for specifically recognizing Hg < 2 + > is constructed. An optical experiment shows that the emission wavelength of the probe for detecting Hg < 2 + > is 780nm, the Stokes shift reaches 166nm, and the probe has the advantages of high sensitivity (the detection limit is 13.4 nM), specificity, quick response (within 1s) and the like when being used for identifying Hg < 2 + >. Due to the excellent photophysical property, the fluorescent probe not only can be used for quantitatively detecting Hg < 2 + > in an environmental water sample, but also can be successfully applied to fluorescence imaging detection of Hg < 2 + > in cells and living bodies.

The invention provides application of phenothiazine in preparation of a medicine for treating toxoplasmosis, and particularly relates to application of phenothiazine in preparation of a medicine for preventing or treating toxoplasmosis infection and a composition for preventing or treating toxoplasmosis infection, and the active ingredient of the composition comprises phenothiazine. The inventor finds and verifies that phenothiazine has a remarkable inhibitory activity effect on intracellular parasitic protozoa toxoplasma gondii through a large number of researches and experiments, Vero cells infected with the toxoplasma gondii serve as cells of an experimental model, and EC50 determination shows that phenothiazine has a half of the inhibitory effect on the toxoplasma gondii when the application amount is 29.00 mu M. Meanwhile, when the application amount of phenothiazine is 5000 [mu] M, the phenothiazine has no cytotoxicity to Vero cells. Compared with existing drugs for treating toxoplasma gondii infection, the effective inhibition concentration of phenothiazine provided by the invention is far smaller than the cytotoxicity of phenothiazine, and phenothiazine used for preparing drugs for preventing or treating toxoplasma gondii infection has the remarkable advantages of high efficiency, low toxicity and safety.