6 results about "Thienopyrrole" patented technology

Disclosed is crystalline Form I of the compound (S)-N-[5-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-4,6-dioxo-5,6-dihydro-4H-thieno[3,4-c]pyrrol-1-yl]acetamide.

The present invention discloses a method for the prevention or treatment of Sjögren's syndrome comprising the step of administering a prophylactic or therapeutically effective amount of N-[5-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-4,6-dioxo-5,6-dihydro-4H-thieno[3,4-c]pyrrole-1-yl]acetamide, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof to an individual in need thereof. Equation (I)

The present disclosure relates generally to thioeno[3, 2-], pyrrole derivatives pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and / or inflammatory condition, including systemic lupus erythematosus and cutaneous lupus erythematosus.

The application belongs to the technical field of biological medical materials, and provides a H-aggregated pyrrole derivative, a preparation method and application thereof, the derivative has a molecule with a donor-acceptor (D-A) structure, the donor structure is an aromatic amine derivative, the bridge structure is a dithieno[3,2-b:2,3-d]pyrrole, and the acceptor structure is 2-(3-cyano-4,5,5-trimethylfuran-2(5H)-methylene)malonitrile or 2-[3-cyano-4-methyl-5-phenyl-5-trifluoromethyl-2(5H)-furyl]-malonitrile. Through the synergistic molecular design of "strong donor-large plane bridge-strong acceptor", the application successfully guides the self-assembly of the molecule to form a stable H-aggregate, realizes the "integration" and "synergistic enhancement" of the type I photodynamic and photothermal properties on a single material, and thus can synchronously trigger two kinds of efficient treatment mechanisms under single-wavelength near-infrared light irradiation.

The application belongs to the technical field of polymer synthesis and organic photovoltaic cells, and discloses a preparation method of thienopyrrole diketone polymer, which is a three-component polymer containing a TPD unit and prepared by one-step polymerization based on dialdehyde, cyclic imide and elemental sulfur. The polymer has unique optical properties, high molecular weight, and a weight average molecular weight ranging from 5000 to 20000 g / mol. The synthesis method has the advantages of easy raw materials, simple operation steps and few by-products.