206 results about "Aluminum trichloride" patented technology

The invention discloses a high-toughness polyetherketoneketone polymer and a preparation method thereof, and belongs to the technical field of macromolecular special engineering plastics. The high-toughness polyether ketone ketone polymer is obtained by reacting diphenyl ether, paraphthaloyl chloride, a compound 1 and anhydrous aluminum trichloride according to a molar ratio of 1: a: (1-a): (3-5), the value of a is 0.5-0.9, and the compound 1 is isophthaloyl chloride with a flexible polyether side chain. According to the high-toughness PEKK polymer disclosed by the invention, a flexible polyether side chain is introduced into a rigid polymer main chain, so that compared with a traditional PEKK polymer molecule with a pure rigid structure, the high-toughness PEKK polymer shows better flexibility, and harmony and unification of strength, rigidity and flexibility are realized.

The invention relates to the technical field of metallurgy, and provides a method and system for preparing a spongy TC4 alloy raw material, and the method comprises the following steps: heating and mechanically stirring titanium tetrachloride, aluminum trichloride and vanadium tetrachloride according to a component proportion required for preparing a TC4 alloy to form a uniform chloride mixture; the chloride mixture is subjected to a reduction distillation reaction in the presence of magnesium, and inert gas is continuously introduced in the reaction process for stirring; and after the reaction is completed, separating the byproduct magnesium chloride to obtain the spongy TC4 alloy raw material. According to the scheme, use of high-cost metal raw materials is avoided from the source, meanwhile, the complex steps of electrode preparation and repeated smelting are omitted through the one-step reduction distillation reaction, and energy consumption and time cost are greatly reduced.

The invention relates to the technical field of perfume production, in particular to a composite catalyst, a preparation method thereof and a synthesis method of ambergris. The composite catalyst disclosed by the invention is obtained by quaternizing porous silicon dioxide and then loading aluminum trichloride; when the composite catalyst is applied to synthesis of ambergris, the composite catalyst can be matched with potassium borohydride, so that sclareolide can be subjected to a one-step reduction reaction to generate ambergris, the reaction condition is mild, the method is stable, generation of sclareolide ring-opening byproducts is reduced, the product yield is increased, and the yield can reach 95% or above.

The invention discloses an environment-friendly p-hydroxyacetophenone production process, and particularly relates to the technical field of p-hydroxyacetophenone production, which comprises the following steps: step 1, respectively putting dissolved phenol and acetic anhydride into a synthesis reaction kettle, stirring and heating to 128 DEG C, refluxing for 5 hours at normal pressure, then carrying out heat preservation treatment, and reacting to generate phenyl acetate; 2, cooling phenyl acetate generated by the reaction to 60 DEG C, washing with water, standing for layering, and discharging phenyl acetate to generate a small amount of by-products containing 90% of glacial acetic acid; and 3, pumping the dehydrated phenyl acetate into a reaction kettle by a vacuum pump, gradually adding aluminum trichloride, then adding acidic water for hydrolysis, cooling to 60 DEG C, and discharging to obtain a liquid crude product of p-hydroxyacetophenone and o-hydroxyacetophenone. The environment-friendly performance of implementation is good, conditions needed by the technology are mild, the unstable condition is not prone to occurring in the operation process, and the practical application effect of the method is ideal.

The embodiment of the invention provides a preparation method of bis-ethylhexyloxyphenol methoxyphenyl triazine, and the preparation method comprises the following steps: taking 2, 4-dichloro-6-(4-methoxyphenyl) triazine and resorcinol mono-isooctane ether as raw materials, taking a synergistic activated resin as a catalyst, and reacting at the temperature of 80-90 DEG C to obtain the bis-ethylhexyloxyphenol methoxyphenyl triazine. The preparation method comprises the following steps: synthesizing bis-ethyl hexyloxyphenol methoxyphenyl triazine through a direct alkylation method; wherein the synergistic activated resin is acidic resin loaded with metal ions. According to the preparation method provided by the embodiment of the invention, at least the catalyst can be recycled and reused, a large amount of aluminum trichloride wastewater existing in a traditional synthesis method is avoided, and the preparation method is easily applied to actual industrial production.

The present invention belongs to the technical field of organic synthesis, and specifically relates to a synthesis process of high-yield 1,4-bis(4-phenoxybenzoyl)benzene. The process is mainly prepared by using excess diphenyl ether and terephthaloyl chloride as reaction raw materials, using o-dichlorobenzene as reaction solvent, and under the catalytic action of aluminum chloride. The synthesis process of 1,4-bis(4-phenoxybenzoyl)benzene provided by the present invention successfully overcomes many challenges existing in traditional synthesis methods, such as many side reactions, low yield, and purification difficulties, by optimizing key parameters such as reaction conditions, solvent selection, catalyst dosage, and sample addition order. It is not only easy to operate, but also significantly improves the yield of the target compound, and also ensures the high purity and low impurity content of the product.

The invention relates to the technical field of chemical wastewater treatment, in particular to a heat treatment device and a treatment method for synthesizing polyaluminum chloride from aluminum trichloride wastewater. The heat treatment device for synthesizing the polyaluminum chloride from the aluminum trichloride wastewater comprises a main body, a reaction cavity is formed in the main body, and a feeding pipe and an exhaust pipe are arranged at the top of the reaction cavity; the four-shaft stirring mechanism is arranged at the top of the main body and comprises a stirring motor, a transmission assembly and four stirring paddle groups, the stirring motor is in driving connection with the stirring paddle groups through the transmission assembly, and the stirring motor enables the adjacent stirring paddle groups to rotate in opposite directions; the heating ring sleeve is arranged outside the main body; the rotary heat exchange mechanism extends upwards from the bottom of the main body, is positioned in the center of the reaction cavity, and is embedded in the middle of the four-shaft stirring mechanism. According to the heat treatment device provided by the invention, the controllable dynamic curing effect can be achieved in the process of synthesizing aluminum trichloride wastewater into polyaluminum chloride, and the treatment effect and efficiency are effectively improved.

The invention discloses a preparation method of a polyaluminum chloride water purifying agent. Comprising the following steps: step 1, dissolving aluminum trichloride hexahydrate in deionized water, raising the temperature to 70-80 DEG C, slowly dropwise adding a sodium hydroxide solution, reacting for 1-2 hours, and then curing for 24 hours to obtain a polyaluminum chloride solution; and 2, adding the modified chitosan into glacial acetic acid, carrying out ultrasonic stirring for 30-40 min, raising the temperature to 70-80 DEG C, slowly adding a polyaluminum chloride solution, dropwise adding a sodium hydroxide solution, carrying out a reaction for 1-2 h, and after the reaction is completed, carrying out static curing for 24 h to obtain the polyaluminum chloride water purifying agent. The water purifying agent has the beneficial effects that the chitosan is modified and compounded with the polyaluminum chloride, so that the water purifying capability is effectively improved.

The invention relates to the technical field of chemical catalysis, in particular to a polyether polymerization catalyst which comprises the following components: double metal cyanide (DMC) of which the average particle size is 20-50nm, a cocatalyst of which the addition amount is 3-5% of the total mass of the catalyst, a Lewis acid-alkali pair catalyst of which the addition amount is 3-5% of the total mass of the catalyst, and a dispersing aid of which the addition amount is 1-2% of the total mass of the catalyst, the preparation method comprises the following steps: preparing a granular catalyst suitable for an industrial scale through a spray drying molding technology, improving the catalytic efficiency by 20% or more and reducing side reactions by 30% or more under the condition of 60-80 DEG C, and the generated polyether has narrow molecular weight distribution (PDilt, PDIt, PDIt, PDIt, PDIt, PDIt, PDIt, PDIt, PDIt, PDIt, PDIt, PDIt, PDIt, PDIt, PDIt and PDIt); 1.2) and a low degree of unsaturation (lt; the quality of the product is obviously improved, and the product is suitable for high-end application of polyurethane, lubricating oil and green chemicals.

The utility model discloses a catcher for aluminum trichloride, which relates to the technical field of chemical equipment and comprises a barrel, a material inlet, a tail gas outlet and a material outlet are sequentially arranged on the outer wall of the barrel from top to bottom, a supporting inner barrel is mounted in the barrel, and a plurality of scrapers are mounted on the outer wall of the supporting inner barrel. The top of the supporting inner barrel is rotationally connected with the top of the barrel, a first shaft is arranged at the bottom of the supporting inner barrel, and a power mechanism for driving the first shaft to rotate is arranged at the bottom of the barrel. Therefore, firstly, the scraper is telescopic through the supporting spring, so that the end part of the scraper can be attached to the inner wall of the barrel body, and the scraping effect is ensured to the greatest extent; and secondly, the first shaft body, the second shaft body and the supporting inner cylinder in the scheme are hollow, when a thermal medium is introduced into the first shaft body, the second shaft body and the supporting inner cylinder, the supporting inner cylinder and the scraper are heated, at the moment, aluminum trichloride is only separated out on the inner wall of the cylinder body, and then aluminum trichloride particles are prevented from being attached to the outer wall of the supporting inner cylinder.

The utility model provides a stannous chloride production system capable of preventing pipeline blockage, which comprises a stannous chloride synthesis kettle, a stannous chloride storage tank and an aluminum trichloride waste liquid storage tank, a discharge port at the bottom of the stannous chloride synthesis kettle is connected with two liquid discharge pipelines, a first pipeline is connected with the aluminum trichloride waste liquid storage tank, a second pipeline is connected with the stannous chloride storage tank, and a third pipeline is connected with the stannous chloride storage tank. A first valve and a second valve are respectively arranged on the first pipeline and the second pipeline; a polytetrafluoroethylene filter element is arranged at a discharge hole in the bottom of the stannous chloride synthesis kettle; a first filter and a first pneumatic pump are arranged on the first pipeline, and a second filter and a second pneumatic pump are arranged on the second pipeline. According to the utility model, the polytetrafluoroethylene filter element is arranged at the discharge port at the bottom of the stannous chloride synthesis kettle to filter tin particles, and the tin particles can be thoroughly filtered and intercepted through the first filter and the second filter, so that the tin particles are prevented from being discharged into aluminum trichloride wastewater to cause waste, the blockage of a pipeline is avoided, and the production efficiency can be improved.

The application discloses a method for synthesizing tervalent tetraaryl iron porphyrin from pyrrole, aromatic aldehyde and ferrous salt, which comprises the following steps: adding anhydrous aluminum chloride, aromatic aldehyde, pyrrole and ferrous salt into DMF under stirring, and then heating and refluxing the reaction mixture for 0.5 hours under nitrogen; removing the nitrogen and continuing to heat the reaction mixture for a certain time; stopping the reaction; cooling the reaction mixture; and placing the reaction mixture at 273K overnight; and finally filtering the reaction mixture to obtain the iron porphyrin.

The utility model relates to the technical field of flow dividers, in particular to a cyclone separator for cleaning tail gas in anhydrous aluminum trichloride production, which comprises a cyclone separator body, a gas outlet pipe is arranged on the top surface of the cyclone separator body, and a gas inlet pipe is arranged at the upper part of the cyclone separator body; a dust collecting mechanism is arranged at the bottom of the cyclone separator body and comprises a collecting shell, a separating assembly and a dust collecting box, the top of the collecting shell is fixedly connected with a discharging port of the cyclone separator body, the bottom of the collecting shell is fixedly connected with the top face of the separating assembly, and the bottom face of the separating assembly is in butt joint with a box opening of the dust collecting box. The separation assembly is used for separating dust in the dust collection box from the cyclone separator body, dynamic sealing is achieved through the separation assembly, gas leakage and dust backmixing are avoided, the separation efficiency is improved, a detachable fixing structure of the dust collection box and the separation assembly supports rapid replacement, shutdown is not needed, and production continuity is guaranteed.

This invention belongs to the field of compound synthesis technology and provides a method for preparing lithium aluminum hydride. The method includes the following steps: mixing an organic solution of aluminum trichloride and an organic solution of lithium hydride to perform a displacement reaction, obtaining a mixture of lithium aluminum hydride; mixing the lithium aluminum hydride mixture with a hydrocarbon solvent and performing solid-liquid separation to obtain lithium aluminum hydride. Lithium aluminum hydride is insoluble in hydrocarbon solvents and precipitates out, further improving the yield of lithium aluminum hydride; simultaneously, unreacted aluminum trichloride dissolves in the hydrocarbon solvent, thereby increasing the main content of lithium aluminum hydride. The preparation process of this invention has high yield, stable product content, and is easy to implement and industrialize.

This application relates to a method for preparing melitracen hydrochloride intermediates, belonging to the field of chemical preparation. The preparation method includes the following steps: dissolving 3,3-dimethyl-2-benzofuran-1(3H)-one in an organic solvent, adding a catalyst and heating the reaction, followed by purification after the reaction to obtain 10,10-dimethylanthrone. The catalyst includes at least one selected from ferric chloride, ferrous chloride, zinc chloride, and anhydrous aluminum trichloride; the organic solvent includes benzene. This preparation method has not been reported in the literature, significantly shortens the process flow for synthesizing melitracen intermediates, avoids the use of concentrated sulfuric acid, reduces waste, and saves costs.

The invention discloses a preparation method of a cyclopofol intermediate B (cyclopropyl [2-hydroxy-3-(propyl-2-yl) phenyl] ketone) and cyclopofol. The preparation method comprises the following steps: esterifying 2-isopropyl phenol serving as a starting material and cyclopropylformyl chloride to obtain a compound A, carrying out rearrangement reaction on the compound A through aluminum trichloride to obtain an intermediate compound B, carrying out ylide reaction on the intermediate compound B and methyltriphenylphosphorus bromide to obtain a compound C, and carrying out recrystallization on the compound C to obtain a compound D; splitting (R)-(+)-1-phenylethyl isocyanate to obtain a compound E ({[(1R)-1-phenylethyl] amino} methanoic acid-6-[(1R)-1-cyclopropylethyl]-2-(propyl-2-yl) phenyl ester with a single configuration, wherein {[(1R)-1-phenylethyl] amino} methanoic acid-6-[(1R)-1-cyclopropylethyl]-2-(propyl-2-yl) phenyl ester; the purity of the finished cyclopofol finished product obtained through refining can reach 99.9%, the cost is low, operation is easy and convenient, and industrial production is easy.

The present invention relates to a method for preparing 4,4'-difluorobenzophenone from 4-chlorofluorobenzene, which comprises the following steps: (1) Using 4-chlorofluorobenzene as the starting material, reacting with magnesium chips in a solvent to prepare a 4-fluorophenylmagnesium chloride solution; (2) Adding the 4-fluorophenylmagnesium chloride solution to a triphosgene solution, and reacting to obtain the target product 4,4'-difluorobenzophenone. In the present invention, the ketone carbonyl group is introduced through triphosgene, the reaction conditions are mild, the Friedel-Crafts reaction or diazotization reaction can be avoided, the use of aluminum trichloride or the generation of diazonium salts with explosion hazards can be avoided, the environmental pollution is small, the operation is safe and simple, and there is no corrosion to the equipment; the starting material 4-chlorofluorobenzene used has a wide source and low cost; the present invention has high yield and repeatability and is easy to be industrially produced.

The application discloses a kind of continuous co-production diphenyl dichlorosilane and triphenyl chlorosilane method and system, belong to organic silicon monomer synthesis technical field.The method will silicon powder and chlorobenzene direct method synthesis high-temperature gas phase product, after cyclone separation precision filtration dust removal, in turn through cascade condensation, obtain rich one phenyl trichlorosilane stream;It is directly introduced into disproportionation reaction kettle, and aluminium trichloride catalyst is added to carry out disproportionation and redistribution reaction;After reaction, add tertiary butyl alcohol, make aluminium trichloride into solid tertiary butyl alcohol aluminum, and remove by solid-liquid separation;Filtrate is separated by reduced pressure distillation, ultra vacuum distillation, and high-purity diphenyl dichlorosilane and triphenyl chlorosilane are obtained.The process coupling is closely, and heat energy is reasonably utilized, and catalyst treatment is green and environmental protection, and no strong corrosive gas and chlorine-containing wastewater is generated, the yield and selectivity of high value-added phenyl chlorosilane monomer are significantly improved, and the process is continuous and stable, with high degree of automation, suitable for large-scale industrial production.

The present invention relates to the technical field of nano material preparation, and specifically to a preparation method of a high solid content nano alumina dispersion and its product, which at least includes the following steps: S1, synthesizing nano alumina powder by high temperature gas phase hydrolysis method; S2, dissolving the prepared nano alumina powder in deionized water; the high temperature gas phase hydrolysis method is to react gasified elemental aluminum with chlorine to form gaseous aluminum trichloride, and then react with water vapor to form nano alumina powder. By controlling the reaction temperature and simultaneously limiting the median particle size, water content, pH value, zeta potential, angle of repose and other parameters of the prepared nano alumina powder, the problems of viscosity, poor fluidity and easy coagulation of nano powder at high solid content are solved, and the defects of easy scratching and pores of nano alumina in the use process of polishing liquid, ceramics and other fields are improved, which is of great significance to the quality improvement of nano powder and its industrial production application.

The invention relates to a green synthesis method of triphenylphosphine, which belongs to the technical field of organic synthesis, and comprises the following steps: Step 1: adding a solvent, benzene and a catalyst aluminum trichloride into a reaction flask, heating to 25-30 DEG C, dropwise adding phosphorus oxychloride, after addition, carrying out heat preservation reaction, and after the reaction is finished, cooling to room temperature to obtain a reaction product; the heat preservation temperature is 25-30 DEG C, and the heat preservation time is 3-4 hours; 2, after the reaction is finished, water is added for washing and layering, an organic phase is concentrated, the solvent is recycled, and triphenylphosphine oxide is obtained; 3, reducing the triphenylphosphine oxide in a solvent through a reducing agent to obtain triphenylphosphine, wherein the reducing agent is a triethyl silane / oxine copper reduction system; and Step 4, after the reaction is finished, cooling to room temperature, adding water for washing and layering, concentrating an organic phase, and recovering the solvent to obtain the triphenylphosphine. The synthesis method is safer and more environment-friendly, the greenization of the process is embodied, the safety and environmental protection pressure is greatly relieved, the technological process is simple, the yield is high, and the synthesis method is suitable for industrial large-scale production.

The invention discloses a preparation process of 2-chloro-4-(methylsulfonyl)-3-methyl benzoic acid, and relates to the technical field of preparation of inorganic compounds. The invention relates to a preparation process of 2-chloro-4-(methylsulfonyl)-3-methyl benzoic acid, which comprises the following steps: reacting 3-chloro-2-methylaniline with hydrochloric acid and sodium methyl mercaptide to form an intermediate C1, reacting with acetyl chloride, catalyzing with anhydrous aluminum trichloride to form an intermediate C2, reacting with hydrogen peroxide and sodium hypochlorite to form an intermediate C4, and reacting with sodium chloride to form the 2-chloro-4-(methylsulfonyl)-3-methyl benzoic acid. The 2-chloro-4-(methylsulfonyl)-3-methyl benzoic acid is obtained after the reaction is completed.

A system and method for separating aluminum trichloride from cold-hydrogenated silicon tetrachloride includes a pressure-reducing tank, a condenser, a first extraction tank, a second extraction tank, a clear liquid filter, and a clear liquid tank. The system is characterized by: a silicon tetrachloride inlet pipe at the top of the pressure-reducing tank; the bottom of the pressure-reducing tank being connected to the first and second extraction tanks via pipes; the bottoms of the first and second extraction tanks being connected to a dryer via pipes; the side walls of the first and second extraction tanks being connected to the clear liquid filter via pipes; the tops of the first and second extraction tanks being connected to the condenser via pipes; the bottom of the condenser having a liquid outlet pipe connected to the top of the clear liquid tank; and the bottom of the clear liquid tank having a silicon tetrachloride recovery pipe; and the clear liquid filter being connected to the liquid outlet pipe via a pipe. This invention improves the clogging situation of the entire cold hydrogenation system, solves the problem of long-term operation of the cold hydrogenation system, and reduces the equipment failure rate.

The utility model provides an exhaust gas collection device for aluminum chloride processing, comprising a neutralization tank with an opening at the top and a conical lower end, a support leg, a liquid outlet pipe, a control valve, and a top cover. The bottom side end of the neutralization tank is provided with an air inlet pipe, a vertical rod, and a horizontal plate. A plurality of horizontal plates are respectively provided with an inlet and outlet hole, and a plurality of inlet and outlet holes are arranged on the corresponding horizontal plates in a serpentine dislocation manner. An exhaust pipe and a liquid adding bucket are also provided on the top cover. According to the exhaust gas collection device for aluminum chloride processing of the utility model, not only can the basic demand for neutralization of exhaust gas be met, but also the running path of exhaust gas in alkaline neutralization liquid can be generally extended to make the exhaust gas fully contact with the alkaline neutralization liquid, thereby fully neutralizing the exhaust gas.

The invention provides a novel process for producing high-purity aluminum trichloride, and belongs to the technical field of aluminum chloride. The production method comprises the steps of pretreatment, preparation of aluminum trichloride and purification. The purification method comprises the following steps: heating aluminum trichloride to 330-350 DEG C, maintaining the current temperature, introducing gaseous aluminum trichloride into a fixed bed loaded with aluminum powder under the protection of nitrogen for 20-40 seconds, and cooling the output gas to obtain high-purity aluminum trichloride, according to the novel process for producing the high-purity aluminum trichloride, the purity of the obtained high-purity aluminum trichloride is 99.81 to 99.85 percent, and the yield of the obtained high-purity aluminum trichloride is 89.94 to 91.16 percent.

This application relates to the technical field of titanium dioxide production by the chlorination process, and particularly to a preparation system and a preparation method of aluminum trichloride. The aluminum trichloride preparation system includes a gravity feeding device, a reaction device, and a premixing device. Along the height direction of the reaction device, the gravity feeding device is arranged above the reaction device and is used to add excessive aluminum particles to the reaction device by gravity. The gravity feeding device includes a silo, a control valve, and a weighing sensor, and the aluminum particles placed in the silo are controlled by the control valve and the weighing sensor to add excessive aluminum particles to the reaction device according to a preset quantity and by gravity. The premixing device includes a premixing container and a premixing flowmeter arranged in the premixing container, and is used to premix appropriate amounts of chlorine gas and aluminum tetrachloride gas according to a preset ratio. The reaction device is used to mix and react the aluminum particles put by the gravity feeding device and the premixed gas transported by the premixing device to produce aluminum trichloride.

The invention provides a continuous synthesis method of 2-(4 '-pentylbenzoyl) benzoic acid, and relates to the field of synthesis of 2-(4'-pentylbenzoyl) benzoic acid. The continuous synthesis method of the 2-(4 '-pentylbenzoyl) benzoic acid comprises the following steps: continuous catalytic reaction and post-treatment. The continuous synthesis method of the 2-(4 '-pentylbenzoyl) benzoic acid can effectively realize continuous and stable synthesis of the 2-(4'-pentylbenzoyl) benzoic acid on the premise of reducing the dosage of the traditional aluminum trichloride catalyst, improves the yield and purity of the continuously prepared 2-(4 '-pentylbenzoyl) benzoic acid, and reduces by-products.

The invention relates to the technical field of organic synthesis, and discloses a synthetic method of aromatic acyl chloride, which comprises the following steps: at normal temperature, adding carboxyl modified quaternized cardanol into a reaction kettle, then adding anhydrous aluminum trichloride and trichlorotoluene, slowly heating to 70-75 DEG C, heating to 105-110 DEG C after no bubble is generated in the reaction, reacting for 1-2 hours, and cooling to room temperature to obtain the aromatic acyl chloride. And after the reaction is finished, transferring the reaction liquid into a distillation flask, and distilling to obtain the aromatic acyl chloride. The aromatic acyl chloride provided by the invention solves the problem of high energy consumption or introduction of other organic solvents, and has a good antibacterial effect.

The invention relates to the technical field of chlorination-process titanium dioxide production, in particular to a chlorination-process titanium dioxide particle size control method which comprises the following steps: mixing hot oxygen, aluminum trichloride and preheated titanium tetrachloride in an oxidizing furnace, and reacting to obtain primary titanium dioxide particles; the pressure of the tail of the oxidizing furnace is controlled to be 180-400 kPa, so that the pressure of the furnace end is controllable within the range of 280-500 kPa, and target regulation and control of the particle size of the primary titanium dioxide particles within the range of 160-350 nm are achieved by controlling the pressure of the system. According to the method, the particle size of the primary titanium dioxide particles can be efficiently and quickly controlled within the range of 160-350 nm.

The invention belongs to the technical field of fluorescent probes, and particularly relates to a single-molecule fluorescent probe based on a phenothiazine structure as well as a preparation method and application of the single-molecule fluorescent probe. The preparation method comprises the following steps: firstly introducing an alkyl chain to a nitrogen atom of a raw material to obtain the phenothiazine structure-based single-molecule fluorescent probe, then carrying out regioselective formylation on the raw material to obtain the phenothiazine structure-based single-molecule fluorescent probe, then treating the raw material by adopting aluminum trichloride to realize O-demethylation, and finally carrying out intramolecular cyclization reaction on the raw material and 1H-benzimidazole-2-acetonitrile to obtain the phenothiazine structure-based single-molecule fluorescent probe. The single-molecule fluorescent probe based on the phenothiazine structure prepared by the invention is compatible with orthogonal chemical reaction activity and maintains controllable electron transfer, so that different chemical events are converted into specific optical signals, and selective and mechanism specific fluorescent response to phosgene, copper ions and hypochlorite is realized.

This invention discloses a synthetic process for an empagliflozin intermediate, belonging to the technical field of pharmaceutical intermediate synthesis. The synthetic process is as follows: 2-chloro-5-bromobenzoic acid is first mixed with dichloromethane and N,N-dimethylformamide, and thionyl chloride is added dropwise to obtain a dichloromethane solution of acyl chloride. Then, it is reacted with fluorobenzene under anhydrous aluminum trichloride catalysis to obtain intermediate EGAB-3. Then, it is dehydrated by azeotropic reaction with potassium hydroxide aqueous solution in toluene, and then refluxed with 3-hydroxytetrahydrofuran under tetrabutylammonium bromide catalysis to obtain intermediate EGAB-7. Then, it is reacted with 1,1,3,3-tetramethyldisiloxane under anhydrous aluminum trichloride and nitrogen protection, dried, and tested to be qualified to obtain empagliflozin intermediate. This process achieves high purity, high yield, and low isomer impurities in the preparation of empagliflozin intermediate.