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555results about How to "Short route" patented technology

Storage switching mechanism for multi-vehicle-type vehicle body mixed line forming station clamps

The invention relates to the field of vehicle welding in a vehicle production line, in particular to a storage switching mechanism for multi-vehicle-type vehicle body mixed line forming station clamps. The storage switching mechanism comprises four sets of clamp storage banks, and a clamp conveying device is installed below the clamp storage banks. The storage switching mechanism further comprises a clamp transfer device and a clamp in-place device. The clamp transfer device and the clamp in-place device are fixed between two sets of clamp storage banks located on the same side of a welding production line. The two ends of the clamp in-place device and the two ends of the clamp transfer device are connected with the clamp conveying device in the two sets of clamp storage banks on the same side respectively to form an annular clamp conveying system. The clamp storage banks are reasonable in arrangement structure, the occupied area of a factory is saved, the whole arrangement structure is more reasonable, the clamps can be well conveyed to designated positions through the cooperation of three-dimensional conveying mechanisms, the transfer device and the in-place device, the transfer efficiency of the clamps on the welding production line is improved, and high promotional value is achieved.
Owner:DONGFENG MOTOR CORP HUBEI

Chiral single phosphorus ligand PC-Phos based on xanthene framework, preparation method of full structure of ligand and application

The invention discloses a novel single phosphorus ligand PC-Phos of a xanthene framework. The ligand is a compound as shown in a formula (1) or an enantiomer, racemate or diastereoisomer of the compound as shown in the specification. The invention further discloses a preparation method of the ligand. A formula 2 and a formula 4 as shown in the specification serve as raw materials, and substitution reaction, addition reaction, condensation reaction and reduction reaction are performed to prepare the ligand. Alternatively, a formula 6 and the formula 4 as shown in the specification serve as raw materials, are subjected to condensation reaction and subjected to addition reaction with a formula as shown in the specification to prepare the ligand. Chiral sulfonamide 4 with two structures and different types of metallic reagents are subjected to addition reaction, and optical voidness of four full structures 1 (S, Rs), 1 (R, Rs), 1 (S, Ss) and 1 (R, Ss) of the chiral single phosphorus ligand can be obtained. The invention further discloses an application of the ligand to asymmetric cyclization reaction in catalytic allene amine molecules. The ligand has quite high reaction activity, stereo-selectivity and wide application values.
Owner:EAST CHINA NORMAL UNIV

Ursodesoxycholic acid preparation method

The invention discloses an ursodesoxycholic acid preparation method. The method comprises the following steps: 1, adding chenodeoxycholic acid and a solvent A to a reaction container, stirring for dissolving, adding 7-alphaHSDH, 7-betaHSDH and a coenzyme II, and carrying out a reaction at a controlled temperature at a controlled pH value to convert chenodeoxycholic acid into ursodesoxycholic acid in order to obtain a conversion liquid; 2, heating the conversion liquid obtained in step 1 to denaturalize the 7-alphaHSDH and the 7-betaHSDH, centrifuging through a high speed centrifuge, removing proteins, adding a sodium hydroxide solution to the above obtained solution, distilling to remove the solvent A, adding water to dissolve obtained distillation residues, adding an acid, and crystallizing to obtain crude ursodesoxycholic acid; and 3, adding the crude ursodesoxycholic acid obtained in step 2 and a solvent B to the reaction container, heating and refluxing the crude ursodesoxycholic acid and the solvent B for 1h, cooling the obtained reaction product to normal temperature, and filtering the cooled product to obtain ursodesoxycholic acid with the purity being greater than 99%. The ursodesoxycholic acid preparation method has the advantages of simple technology, short synthesis route, high conversion rate, easy post-treatment and environmental protection.
Owner:ZHONGSHAN BAILING BIOTECHNOLOGY CO LTD

Polyhalogenated isoquinoline class derivate and synthetic method thereof

The invention discloses a novel polyhalogenated isoquinoline class derivate and a synthetic method thereof. The structure of the polyhalogenated isoquinoline class derivate is as a formula I, wherein Z=NH, NR', O, S; n=1,2,3; the R' is alkyl and aryl; R is the alkyl, the aryl, heteroaryl, condensed aryl, alkoxyl and alkylthio group; R1 is a halogen atom, a hydrogen atom, the alkyl, the aryl, alkylamino radical, arylamine, alkylthio group and arylthio; R2 is cyano-group, nitryl, ester group, the halogen atom, the hydrogen atom, the alkyl, the aryl, the alkylamino radical, the arylamine, the alkylthio group and the arylthio; X1 is the halogen atom; and the X2 is also the halogen atom. The synthetic method of the polyhalogenated isoquinoline class derivate including the steps of porphyrizing and heating polyhalogenated cyanobenzene and heterocyclic ketene aminals derivates in a mortar. When raw materials are basically completely disappeared, and the polyhalogenated cyanobenzene and the heterocyclic ketene aminals derivates are all transferred to a round bottom flask by menstruum and then reacted to synthesize the polyhalogenated isoquinoline class derivate with potential medicine activity in the formula I after a catalyst is added into the round bottom flask. The invention has simple synthesis technology, high productive rate, stable products, simple routes, rapidness, and the like, realizes a parallel high-efficiency heterocyclic compound library and really realizes the molecular diversity.
Owner:YUNNAN UNIV
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