31results about How to "Short route" patented technology

The invention relates to the field of medicine synthesis and preparation, in particular to a synthesis method of toxyanib phosphate. The use amount of acetic acid is greatly reduced in the preparation process, so that excessive acid does not need to be neutralized in the post-treatment process, and a large amount of wastewater is not generated; in addition, the use amount of sodium nitrite is reduced, and the environment and health are facilitated; the enamine reduction reaction does not use acetic acid as a solvent and a hydrogenation reaction catalyzed by heavy metal palladium, so that the safety of the reaction is improved, and the purity of the product is also improved; a decarboxylation reaction and a Vilsmeier-Haack reaction are carried out by a one-pot method, so that the reaction steps are reduced, and the product purity is improved; when aldol reaction is carried out in side chain splicing, side reaction and generation of isomer impurities are reduced. The method is short in route, mild in reaction condition, low in equipment requirement and convenient to operate, industrial production is easy to achieve, and a complex purification method is not needed.

The utility model belongs to the technical field of agricultural product processing, and particularly relates to an agricultural product processing device which comprises a cleaning machine and two ultrasonic cleaning machines, one side of the cleaning machine is provided with a feeding port cabin door, the other side of the cleaning machine is provided with a discharging port, and the inner wall of the cleaning machine is rotatably connected with a rotary net cylinder. A plurality of material pushing net plates are fixedly connected to the side wall of the rotating net cylinder, a filtering box is fixedly connected to one side of the cleaning machine, a water inlet pipe is fixedly connected to one side of the filtering box, and a circulating water pump is installed at the bottom end of the filtering box; agricultural products are pushed in the cleaning machine through a plurality of material pushing net plates, so that continuous operation can be realized when the device cleans the agricultural products, the labor consumption is reduced, and the processing efficiency is improved; the two filter screens are driven by the rotary carrying disc to rotate and operate alternately, so that the filter screens in a non-working state can be cleaned by the push plate, timely cleaning and more efficient operation are realized, and the filter screens in the water source recovery system are prevented from being blocked by impurities.

The invention discloses a preparation method of an (R) 2-(4-chloro-2-methylphenoxy) isooctyl propionate root inhibitor. The method comprises the following steps: carrying out condensation reaction on L-2-chloropropionic acid and o-cresol under the promotion of alkali to obtain (R) 2-methylphenoxypropionic acid; carrying out esterification reaction on the (R) 2-methyl phenoxy propionic acid and isooctyl alcohol (2-ethyl hexanol) under the action of a catalyst to obtain (R) 2-methyl phenoxy isooctyl propionate; the (R) 2-methyl phenoxy isooctyl propionate is chlorinated by a chlorination reagent to obtain (R) 2-(4-chloro-2-methyl phenoxy) isooctyl propionate; the (R) 2-(4-chloro-2-methylphenoxy) isooctyl propionate obtained by the method disclosed by the invention is high in yield, good in optical activity and excellent in quality; the method has the advantages of novel synthesis route, easily available raw materials, low cost, simple and feasible process operation, short time consumption, less waste, small pollution and suitability for industrial production, and can fill the domestic blank and relieve the current situation of dependence on import.

The invention discloses a preparation method of a vibron key intermediate with a structural formula II and application of the vibron key intermediate in preparation of vibron. The preparation method comprises the following steps: A, taking a compound shown as a structural formula III as a starting raw material, and carrying out acylation reaction on the compound and a sulfonyl chloride compound in the presence of alkali to obtain a compound shown as a structural formula IV; b, in the presence of alkali, reacting the compound as shown in the structural formula IV with the compound as shown in the structural formula V to obtain a compound as shown in a structural formula VI; c, decarboxylating the compound shown in the structural formula VI in the presence of alkali, removing a protecting group in the presence of acid, and cyclizing to obtain a compound shown in a structural formula VII; and D, reducing the compound as shown in the structural formula VII into the vibron key intermediate as shown in the structural formula II under the action of a metal catalyst and hydrogen. In the imgabs0 #, R1 is selected from a methylsulfonyl group or a phenylsulfonyl group; and R2 is selected from C1-C2 alkyl or benzyl.

The invention relates to a preparation method of a nerofloxacin intermediate 2, 4-difluoro-3-methoxy-1-benzoic acid. The invention further relates to a preparation method of the nerofloxacin intermediate 2, 4-difluoro-3-methoxy-1-benzoic acid. Specifically, the invention discloses a preparation method for preparing 2, 4-difluoro-3-methoxy-1-benzoic acid in the presence of a non-nucleophilic strong alkali reagent, the 2, 4-difluoro-3-methoxy-1-benzoic acid reacts with methyl peroxide in the presence of a non-nucleophilic strong alkali reagent, a methoxy substitution reaction is directly carried out, and then the 2, 4-difluoro-3-methoxy-1-benzoic acid is prepared in the presence of magnesium metal and carbon dioxide. Reaction conditions are mild, and industrial production is very easy.

The invention relates to a novel synthesis method of (E)-2-(2-chloromethylphenyl)-2-methoxyiminoacetic acid methyl ester. The method comprises the following steps: Step 1: 2-methyl-α-methoxyiminophenylacetonitrile is used as a raw material and dissolved in a methanol solvent; Step 2: the temperature is controlled at 40-50 DEG C, chlorine is slowly introduced, and the heat preservation reaction time is 5-6 hours; Step 3: methyl is chlorinated, and the hydrogen chloride generated at the same time causes the cyano group to be esterified, so that the key intermediate (E)-2-(2-chloromethylphenyl)-2-methoxyiminoacetic acid methyl ester of trifloxystrobin or kresoxim-methyl is obtained by a "one-pot method", and the temperature is lowered to 0-5 degrees after the heat preservation reaction is completed, and the product is filtered out. The invention uses 2-methyl-α-methoxyiminophenylacetonitrile as a raw material and adopts safe and reliable sodium nitrite as an oximation reagent, avoids the use of inflammable and explosive nitrites, avoids the use of expensive o-hydroxymethylphenylacetic acid lactone, has a safe and reliable reaction, low raw material cost, adopts a "one-pot method", has a simple and smooth process, a short route, and is suitable for industrialized scale-up production.

The invention relates to a synthesis method of (4-chlorphenyl) (4-hydroxy-3, 5-dimethoxyphenyl) ketone, belongs to the field of organic chemical synthesis, and provides a method for solving the problems of high cost, low yield and more byproducts in the existing preparation method, and the method comprises the following steps: 1) reacting a compound shown as a formula I with an acyl chloride substance under the protection of nitrogen to obtain a compound II; 2) mixing the compound shown in the formula II with alkali, dropwise adding a Grignard reagent, and carrying out Grignard reaction to obtain a compound shown in a formula III; and 3) demethylating the compound in the formula III under the action of Lewis acid to obtain a compound in a formula IV. The technical scheme provided by the invention has the beneficial effects that the method for synthesizing (4-chlorphenyl) (4-hydroxy-3, 5-dimethoxyphenyl) ketone is novel in process route, the total yield is greater than 50%, and the method has the characteristics of short route, high chemical purity, easiness in production and the like.

The invention discloses a method for synthesizing a bisoprolol European Pharmacopoeia EP impurity E, comprising the following steps: (1) using free bisoprolol API as a starting material, protecting the amino group with p-methoxybenzyl chloride, and obtaining an intermediate 1; (2) brominating the hydroxyl group of the intermediate 1 with triphenylphosphine and carbon tetrabromide, and obtaining an intermediate 2; (3) eliminating the bromine from the intermediate 2 with a base to generate a double bond, and obtaining an intermediate 3; and (4) removing the p-methoxybenzyl protection from the intermediate 3 with an oxidant, and obtaining a target product, bisoprolol EP impurity E. ... and comprising the following steps: (1) using free bisoprolol API as a starting material, protecting the amino group with p-methoxybenzyl chloride, and obtaining an intermediate 1; (2) brominating the hydroxyl group of the intermediate 1 with triphenylphosphine and carbon tetrabromide, and obtaining an intermediate 2; (3) removing the bromine from the intermediate 2 with a base to generate a double bond, and obtaining an intermediate 3; and (4) removing the p-methoxybenzyl

The utility model discloses a range hood. The range hood comprises an exhaust fume collecting hood. The switch assembly is arranged on the front side of the exhaust fume collecting hood. The case is arranged on the upper side of the exhaust fume collecting hood and communicates with the exhaust fume collecting hood, the cleaning assembly comprises a water pump and a water pipe connected with the water pump, and the water pump is arranged on the first side of the top of the case; the air outlet seat is arranged on the second side of the top of the case, and the first side of the top of the case and the second side of the top of the case are oppositely arranged; the control panel is arranged on the first side of the top of the case and connected with the switch assembly through a wire. A first wire passing groove is formed in the first side of the front portion of the case, a second wire passing groove is formed in the first side of the rear portion of the case, a wire of the switch assembly is wired to the first side of the upper portion of the case through the first wire passing groove and connected with the control panel, and a water pipe of the extractor hood is wired to the first side of the upper portion of the case through the second wire passing groove and connected with the water pump.

This invention discloses a chemical-biological fusion method for cholesterol synthesis. Using plant-derived 21-hydroxy-20-methylpregn-4-en-3-one, also known as bis(2-hydroxy-2-yl)-3-one (BA), as a raw material, cholesterol is synthesized through a four-step reaction involving sulfonation, acetylation, enzymatic hydrolysis and reduction, and Grignard coupling. Addressing the drawbacks of traditional animal-derived cholesterol, which carries unpredictable risks of pathogenic bacteria and viruses, this invention uses plant-derived steroidal raw material BA to synthesize cholesterol. This method not only offers high safety, avoiding the risk of pathogenic bacteria and viral infections, but also utilizes the tandem catalysis of esterase and carbonyl reductase during synthesis, along with coenzyme regeneration, to obtain key intermediates with high stereoselectivity and in a safe and clean manner. This significantly shortens the cholesterol synthesis route, increases efficiency, simplifies operation, minimizes solvent recycling losses, reduces waste, and allows for mild reaction conditions. This method is safe, economical, and suitable for industrial production.

The invention discloses a novel method for synthesizing a plant growth regulator dihydrogibberellin without protecting carboxyl. The invention provides a novel method for synthesizing a plant growth regulator dihydrogibberellin without protecting carboxyl, which comprises the following steps: 1) in an organic solvent B, mixing a compound as shown in a formula II with a catalyst A, and carrying out hydrogenation reduction reaction in a hydrogen atmosphere to obtain a compound as shown in a formula III; 2) in an organic solvent C, mixing the compound as shown in the formula III with a saturated aqueous solution of alkali, and carrying out selective deacetylation reaction to obtain a compound as shown in a formula IV; and 3) in an organic solvent D, carrying out a dehydration elimination reaction on the substance as shown in the formula IV in the presence of triphenylphosphine and an elimination reagent to obtain the dihydrogibberellin as shown in a formula V. The synthesis method of dihydrogibberellin can be simplified, and large-scale production and synthesis are facilitated. # imgabs0 #

An amide-containing aromatic diamine has the following structural formula: where Ar is a group with an aromatic ring structure. The preparation method includes the following steps: (1) mixing and reacting components including aromatic diamine, p-nitrobenzoic acid, alkyl phosphoric anhydride and polar aprotic organic solvent; (2) adding carboxylic acid and halogen-free quaternary ammonium salt to the product obtained in step (1) to obtain a mixed solution, which is placed in the cathode cell of an H-type electrolytic cell; the anode cell and the cathode cell are separated by a Nafion membrane; adding the same polar aprotic organic solvent and halogen-free organic electrolyte as the cathode cell to the anode cell of the H-type electrolytic cell, and adding a metal ion-free reducing agent; and conducting the reaction by electrolysis; (3) purifying the cathode reaction solution obtained in step (2) by post-treatment to obtain the amide-containing aromatic diamine. The yield, purity and whiteness of the amide-containing aromatic diamine are higher.

The invention relates to a multifunctional composite binder and a preparation method and application thereof.The preparation method comprises the steps that methyl acrylate serves as a polymer main body structure, double bonds are introduced firstly, then the double bonds, hydroxyl, cyano or ester groups are introduced, a polymer with a network branched chain and polyfunctional groups is formed, then sodium ions, lithium ions or potassium ions are introduced, and the multifunctional composite binder is obtained. The binder is obtained through solvent dissolution or emulsification, and the binder is applied to the battery. The composite binder disclosed by the invention has good solubility and is high in dissolution speed and solubility in a solvent, and the required solvent is safe, environment-friendly and non-toxic; meanwhile, the method is simple in technological process, short in route, easy to industrialize, free of three wastes, green, environment-friendly and pollution-free. The electrode prepared from the negative electrode slurry prepared from the composite binder has good conductivity and lithium ion conductivity, and the prepared lithium battery can realize long circulation and has a better capacity retention rate in the circulation process.

The invention belongs to the technical field of friction material processing, and discloses forming equipment for friction material processing. The forming equipment for friction material processing comprises a placing table and is characterized in that a driving mechanism is arranged in the placing table, the driving mechanism comprises a moving plate, the moving plate is arranged in the placing table, a clamping mechanism and a processing mechanism are arranged in the moving plate, the driving mechanism comprises a linear rail, and the linear rail is arranged on the clamping mechanism. The linear rails are fixedly installed on the inner walls of the front side and the rear side of the containing table. According to the forming equipment for friction material machining, through the design of the driving mechanism, the time spent on production and machining on multiple pieces of equipment in the past is shortened, the machining and production route is shortened, certain working efficiency is improved, the stability in the hot pressing process and the moving process is improved in cooperation with the clamping mechanism, and the machining efficiency is improved. And the situation that shaking occurs or firm clamping cannot be achieved is avoided, and the production and machining quality is improved.

The application discloses givinostat and a synthesis method thereof, wherein compound 1 is used for synthesizing compound 2 in step 01; compound 3 is used for synthesizing compound 4 in step 02; compound 4 is used for synthesizing compound 5 in step 03; compound 5 is used for synthesizing compound 6 in step 04; and compound 6 and compound 2 are used for synthesizing givinostat in step 05. After optimization, the yield of compound 1 to compound 2 reaches more than 80 %, raw materials and reagents used in the reaction are cheap and easy to obtain, and the preparation cost is very low; only four steps are needed from compound 3 to the target product, the route is short, and the operation is simple; and after optimization, the total yield of compound 3 to the target product reaches more than 40 %, the yield is high, and the preparation cost is significantly reduced.

The present application relates to a kind of devices and refining methods for removing acetal in ethanol, device includes the light tower (2) of removal, acetal removal tower (3) and refining tower (4) connected in sequence by pipeline, the light tower (2) of removal is used to separate out light component in the system to be separated, the acetal removal tower (3) is used to separate out acetal, ethyl ester in the system to be separated, the refining tower (4) is used to separate out ethanol rectification and purify in the system to be separated.Compared with prior art, the present application is developed by special acetal removal tower, acetal is removed by using the method of negative pressure rectification, so that its content is reduced to 150ppm below, meet the quality requirements of high-purity ethanol.

The invention discloses a general chiral catalyst with (hydrogenated) cinchona alkali (thio) urea and o-pyridine oxazoline structural units and a preparation method thereof, and belongs to the field of catalysts, the structure of the catalyst is characterized in that additional nitrogen ligand (pyridine and oxazoline) groups capable of being coordinated are introduced at proper positions of (hydrogenated) cinchona alkali, therefore, the novel compound with a specific function forms an asymmetric metal catalyst through coordination of a bidentate ligand and metal; the catalyst disclosed by the invention not only can be independently used as a chiral small molecule catalyst, but also can be independently used for realizing asymmetric metal catalysis through metal coordination, or can be used for realizing common catalysis of chiral small molecules and metal through different combinations, and is expected to become a transboundary'universal 'chiral catalyst and chiral ligand to realize more and richer asymmetric catalytic reactions; in addition, the preparation method disclosed by the invention has the advantages of wide raw material source, mild reaction conditions, short route, low cost and the like, and has a very good application prospect.

The invention provides a synthesis method of (3R, 4S)-3-methyl-2-oxa-8-azaspiro [4.5] decane-4-amine hydrochloride (compound I), and the synthesis route is as follows: # imgabs0 #, and X is halogen. The preparation method has the advantages of short synthesis steps, single reaction product configuration, avoidance of chiral resolution in post-treatment and high yield, and an efficient synthesis method is provided for synthesis of the compound.

The application belongs to the field of pharmaceutical chemical synthesis, and particularly relates to a preparation method of a varenicline intermediate. The method comprises the following steps: 1) in the presence of an organic solvent A, a compound of formula 4 is used as raw material, ammonium acetate and a reducing agent are added, and a compound of formula 3 or a salt thereof is obtained through reaction; 2) in an organic solvent B, the compound of formula 3 or the salt thereof is reacted with trifluoroacetic anhydride or trifluoroacetic ethyl ester under the action of a base to obtain a compound of formula 2; and 3) in the presence of a solvent C and a catalyst, the compound of formula 2 is subjected to nitration reaction with a nitrating agent to obtain a compound of formula 1. The application solves the problems of the prior art, such as complicated steps, low atom utilization rate, high cost and the like, provides a novel route, directly introduces an amino group, does not need to be deprotected, has good atom economy, has mild reaction conditions, is simple in post-treatment, and is suitable for industrial production.

The invention discloses a preparation method of an imrecoxib oxide impurity (compound 1). The preparation method comprises the following steps: carrying out oxidation one-step reaction on imrecoxib under the action of alkali; and synthesizing to obtain the target product imrecoxib oxide impurity (compound 1). The route provides a simple and effective method for preparing the imrecoxib oxide impurity (compound 1). Compared with a conventional synthesis route, the method has the advantages that the reaction route is shorter, the reaction is more economical, expensive reagents are not needed, and the like.

The present invention belongs to the technical field of pharmaceutical chemical intermediate synthesis, and specifically relates to a method for synthesizing an intermediate of a substituted tricyclic PRMT5 inhibitor. 2-Chloro-5-fluoropyridine is selected as a raw material, and a carboxyl group, SN AR Substitution, methyl esterification, and reduction ring closure are a total of four steps to obtain 7'-chloro-2'-,3'-dihydro-1'-H-spiro[cyclopropane-1,4'-[2,6]naphthyridine]-1'-one product, which has a short route and obvious process advantages. AR The substitution reaction, a one-step reaction, solves the problem of high cost and low yield of the two-step reaction of palladium catalyst coupling and Corey-Chaykovsky reaction to prepare cyclopropyl in the previous process.

The invention discloses a (2-nitromethyl) aryl formate compound and application thereof, and the structural general formula of the (2-nitromethyl) aryl formate compound is as shown in formula I, the isoquinolone compound can be obtained by carrying out a one-pot reaction of'nitro Mannich-lactamization-nitro elimination 'on a (2-nitromethyl) aryl formate compound and substituted cyclic imine under the action of an additive. The preparation method of the isoquinolone compound is mild in reaction condition, high in product yield, good in reproducibility, simple and convenient to operate, easy in process amplification and economical and easily available in raw materials, and overcomes the condition that a strong base or a transition metal is used for catalysis in a conventional synthesis route. The method can be used for preparing a series of alkaloids containing isoquinolone structures, such as berberine or wingceleine and the like, which have remarkable biological activity, can integrally and remarkably improve the total yield of the product, is more suitable for industrial large-scale preparation, and has higher application value. # imgabs0 #

The invention relates to the technical field of biological medicine, in particular to a mosapride citrate impurity compound and a preparation method thereof. The mosapride citrate impurity compound has a structure as shown in a formula IV. The mosapride citrate impurity compound provided by the invention is a mosapride citrate process impurity, has high structural similarity with a mosapride citrate compound, and is difficult to separate and remove by a process. The impurity compound can be used as an impurity reference substance in a mosapride citrate finished product detection standard, and is used for a quality control link of qualitative and quantitative analysis of impurities in a mosapride citrate production process. The synthesis method is short in route, stable in process, high in product purity and simple to operate, can provide a qualified impurity reference substance for quality control of mosapride, and has important application value. # imgabs0 #

The present application provides an intermediate compound and a preparation method therefor and an application thereof. The intermediate compound has the following structural formula (I). By using the intermediate compound of the present application, dedrogesterone can be conveniently synthesized only by performing AB ring double bond construction and side chain modification, the total yield is high, and the route is short.

The invention relates to a preparation method of a natural product pterostilbene. The method comprises the following steps: (1) carrying out bromination reaction on a compound 1 (the chemical name is 3, 5-dimethoxybenzyl alcohol) to obtain an intermediate compound 2; (2) reacting the compound 2 with triethyl phosphite to obtain an intermediate compound 3; (3) reacting the compound 4 (the chemical name is 4-hydroxybenzaldehyde) with a corresponding protecting group to obtain a compound 5; (5) obtaining pterostilbene 6 from the compound 3 and a compound 5 under the action of strong base; the process route provided by the invention has the advantages of cheap and easily available raw materials, short reaction route, simple operation, high yield, no use of a heavy metal catalyst, and suitableness for large-scale industrial production.

The invention provides an efficient preparation method of tetrahydrofuran type lignan Sumatranin A. The efficient preparation method specifically comprises the following steps: removing methyl protection from asaraldehyde to obtain a compound 1; performing benzyl protection to obtain a compound 2; carrying out continuous Wittig reaction to obtain a compound 3; reacting SN2 among molecules to obtain a cyclization precursor 4; an intermediate 5 is obtained through Ni catalysis series cyclization; removing benzyl protection to obtain a compound 6; and finally, carrying out ring closing under an acidic condition to obtain the tetrahydrofuran type lignan Sumatranin A. The preparation method has the three characteristics of high yield, low cost and short route; the total synthesis of the tetrahydrofuran type lignan Sumatranin A racemate serving as a natural active medicine is realized; good popularization and application prospects are realized.

The invention belongs to the technical field of drug synthesis, and particularly relates to a preparation method of a ticagrelor intermediate, which comprises the following five steps: S1, preparing an intermediate II; s2, preparing an intermediate III; s3, preparing an intermediate IV; s4, preparing an intermediate V; and S5, preparing an intermediate VI. Compared with a multi-step and complex synthesis process in the prior art, the method has the advantages that the route of the ticagrelor key intermediate V is greatly shortened, the synthesis process of the intermediate V is simplified, the production efficiency and the yield are remarkably improved, the production period is shortened, the raw material consumption and the generation of byproducts are reduced, and the requirements of industrial production are met.

The invention provides a preparation method of 1-cyclopropylpiperazine, which comprises the following steps: reacting a compound II and / or a salt thereof with cyclopropylamine to obtain the 1-cyclopropylpiperazine, and the synthetic route is as follows: # imgabs0 #, in which X is CI and Br, and I and X can be the same or different, for example, X is Cl and Br at the same time, or X is Cl and the other is Br. The invention provides synthesis of 1-cyclopropylpiperazine, which is convenient to operate, short in route, easy in reaction control and high in yield, and is suitable for process amplification production.

The invention discloses a bicyclo [2.2. 1] heptanone derivative as well as a synthesis method and application thereof. The invention relates to a bicyclo [2.2. 1] heptanone derivative, which has a structure shown as a formula IV, and in the formula IV, R1 is aryl or heteroaryl; r2 can be alkyl, ester group, CN or amide; and R3 is methyl, OTBS or phenyl. The invention provides a novel method for preparing the electroluminescent material monomer I. The preparation method of the electroluminescent material monomer I provided by the invention only needs four steps. Compared with the prior art, the method provided by the invention has the advantages of short route, simple and easily available raw materials, easy reaction control, avoiding of the use of a noble metal catalyst, reduction of the reaction cost, and high economic value. # imgabs0 #

The invention provides a preparation method of bepedioic acid and an intermediate thereof, the preparation method of the bepedioic acid comprises the following steps: reacting a compound 4 with a compound 5 in the presence of alkali to obtain a compound 6, and hydrolyzing the compound 6 and removing a hydroxyl protecting group to obtain the bepedioic acid, and the reaction formula is shown in the specification. The preparation method of the bepedioic acid is short in route, low in cost, high in yield of each step of reaction, few in by-products and suitable for industrial large-scale production.