109 results about "Xanthene" patented technology

To provide a salt-forming compound, which is a salt of a xanthene-based compound, exhibiting higher coloring strength and higher color development stability after heat and light history compared with traditional ones, and also to provide a resin composition and a color filter.SOLUTION: There is provided a xanthene-based compound which is a salt composed of an anion forming a xanthene-based chromophore having an anionic functional group represented by general formula (1), and a cation composed of an aromatic nitrogen-containing heterocyclic compound having a linear or branched, saturated or unsaturated hydrocarbon group (optionally containing an ether bond and / or an ester bond within the hydrocarbon group).SELECTED DRAWING: None

The invention relates to the technical field of organic dyes, in particular to a novel xanthene dye for blue photoresist color paste and a synthesis method of the novel xanthene dye. The invention relates to a synthesis method of a novel xanthene dye for blue photoresist color paste, which comprises the following steps: 1) taking rigid cyclic amine as a nucleophilic reagent, and carrying out aromatic nucleophilic substitution reaction on a chlorinated xanthene compound to obtain a xanthene intermediate; 2) performing chlorination reaction on the xanthene intermediate by using a chlorination reagent to obtain a chlorinated xanthene intermediate; 3) mixing active amine and the chlorinated xanthene intermediate, and performing substitution reaction under the action of alkali to obtain the novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste has the advantages of being high in solubility, good in thermal stability and high in contrast ratio.

The invention discloses a near-infrared fluorescent probe based on a xanthene-quinoline conjugated skeleton for detecting Cu < 2 + > as well as a preparation method and bioimaging application of the near-infrared fluorescent probe. The molecular formula of the fluorescent probe is C34H32N4O2. Based on the strategy of inhibiting the PET process, the large Stokes shift near-infrared fluorescent probe for specifically recognizing Cu < 2 + > is constructed, and spectrum experiments show that the probe has excellent recognition performance on Cu < 2 + >, the emission wavelength is 720 nm, and the Stokes shift reaches 170 nm; (2) the specificity is high, and Cu < 2 + > and other biological related metal ions can be effectively distinguished; (3) low detection limit (LOD = 17.6 nM); (4) quick response dynamics (lt; 30s) for a motor vehicle. More importantly, the probe XQ-NH2 is successfully applied to Cu < 2 + > imaging in living cells and living mice, it is proved that XQ-NH2 not only can provide a reliable technical means for Cu < 2 + > detection and imaging research in a complex biological system, but also shows that XQ-NH2 has important application potential in related fields.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of a 9-aryl xanthene compound. The preparation method of the 9-aryl xanthene compound comprises the following steps: adding a xanthene compound, an aromatic amine compound and a nitrogen-doped carbon material into an organic solvent, and reacting in an oxygen atmosphere; the 9-aryl xanthene compound is novel in structure and can be applied to the fields of medicines, agricultural chemicals, material science and the like, and the preparation method has the advantages of mild reaction conditions, simplicity and safety in operation, high raw material economy, wide substrate applicability and functional group compatibility, good chemical and regioselectivity and the like; a new way is provided for the construction of a novel xanthene derivative.

The present application relates to the technical field of electroluminescent device preparation, in particular to an OLED light-emitting composition and an electroluminescent device comprising the composition. The OLED light-emitting composition comprises an electron transport material and a light-emitting material, the electron transport material combines o-phenanthroline and a xanthene group, and has high electron mobility and a low energy level. A boron-nitrogen compound skeleton structure with multiple benzene rings is introduced into the light-emitting material, the skeleton structure is twisted in a planar configuration, the alkyl substituents contained in the large steric group are adjusted, the π-π mutual attraction caused by the introduction of benzene rings is weakened, the intermolecular force is further weakened, and the adverse effects of concentration quenching on efficiency are weakened. The OLED device prepared by using the composition of the present application has low starting voltage, high light-emitting efficiency and better service life, can meet the requirements of current panel manufacturing enterprises for high-performance materials, and has great commercial value.

The invention discloses preparation and visual detection application of an Ag / {001} Bi2Fe4O9 nanosheet, relates to the technical field of visual ultra-sensitive detection of 2, 4-dichlorophenol, and aims to realize an in-situ and ultra-sensitive visual detection method for the 2, 4-dichlorophenol. The method comprises the following steps: uniformly mixing a xanthene dye fluorescein aqueous solution, an Ag / {001} Bi2Fe4O9 nanosheet suspension and a 2, 4-dichlorophenol aqueous solution to obtain a solution to be detected; the method comprises the following steps: putting a solution to be detected into a Pomfiley multi-channel photocatalytic reactor, carrying out dark adsorption by stirring without illumination, then starting visible light, carrying out sufficient illumination, filtering by adopting a 22-micron water-phase filtering membrane, and finally testing by adopting an ultraviolet and visible spectrophotometer, thereby completing photosensitization detection of 2, 4-dichlorophenol. According to the invention, the Ag / {001} Bi2Fe4O9 nanosheet can be prepared and applied to visual detection.

The invention discloses a xanthene nitroreductase-responsive fluorescent dye compound as well as a preparation method and application thereof, and belongs to the technical field of xanthene derivatives. The fluorescent dye compound can be used for quickly and specifically recognizing overexpressed nitroreductase in tumor cells; after the fluorescent probe acts with nitroreductase, the fluorescence intensity of the fluorescent probe at 718 nm is obviously enhanced, and the fluorescent probe has excellent targeting capability on mitochondria; meanwhile, under the excitation of illumination with the specific wavelength of 660 nm, an acting product of the fluorescent dye compound and nitroreductase can efficiently generate reactive oxygen species (ROS), and then the effect of specifically killing tumor cells is achieved. The xanthene nitroreductase response type fluorescent dye compound provided by the invention can achieve the goal of integration of diagnosis and treatment of solid tumors, and has important clinical application value.

The present application relates to an electronic device comprising a xanthene or thioxanthene compound of a particular formula. The electronic device is preferably an organic electroluminescent device (OLED). The application further relates to particular xanthene or thioxanthene compounds as such, and to the use thereof in the abovementioned devices, and to processes for preparation thereof.

This invention discloses a ratiometric nitric oxide-responsive near-infrared fluorescent molecular probe, its preparation method, and its application. The near-infrared fluorescent molecular probe has a nitric oxide-responsive mechanism, with an electron-donating group consisting of an oxanthracene group linked to two amino groups. When the probe molecule interacts with the analyte, the diaminophenyl group of the hemicyanine core undergoes cyclization to form a triazole-containing ring, thereby causing intramolecular charge transfer and resulting in a ratiometric change in its corresponding ultraviolet absorption and fluorescence emission spectra. The near-infrared fluorescent molecular probe of this invention exhibits a selective response to nitric oxide, effectively reducing background signal interference and can be applied to the accurate detection of NO.

The application discloses a 2-cyano-2-(9H-xanthen-9-ylidene)acetamide compound and a preparation method, a pharmaceutical composition and an application thereof. The compound structure is as shown in the formula (I), and the compound also comprises pharmaceutically acceptable salts thereof. The compound can effectively inhibit a target point ZNF207 and can be used for treating various tumors. In addition, the preparation method disclosed by the application is simple and easy to operate.

The invention belongs to the technical field of biological medicine analysis, and particularly relates to a fluorescent probe sequentially responding to gamma-glutamyltranspeptidase and monoamine oxidase and application of the fluorescent probe. The structure of the fluorescent probe is as shown in a formula 1, the fluorescent probe in the formula 1 is constructed by sequentially covalently connecting gamma-glutamyltranspeptidase and specific recognition groups of monoamine oxidase and integrating the gamma-glutamyltranspeptidase and the specific recognition groups of monoamine oxidase into a benzothiazole-xanthene fluorescent parent structure, and the fluorescent probe has near-infrared fluorescence luminescence performance. The probe adopts a double enzyme response activation strategy, and can be activated and generate a fluorescence signal only when gamma-glutamyltranspeptidase and monoamine oxidase exist at the same time, so that the fluorescence probe is high in specificity and has excellent accuracy and specificity in the aspects of pathological imaging, drug safety evaluation and the like.

The present invention discloses a xanthene derivative having absorption / emission in the near-infrared region II (1000-1700 nm) as shown in formula (1). The absorption / emission wavelength of this type of xanthene derivative is significantly red-shifted, with the longest wavelength exceeding 1200 nm, a high molar extinction coefficient and fluorescence quantum yield, and can effectively generate reactive oxygen species and heat under near-infrared region II laser irradiation. It has excellent photostability, photothermal stability, pH stability and biocompatibility, and can therefore be used as a near-infrared region II fluorescent / photothermal reagent, with good application potential in near-infrared region II fluorescence bioimaging, photodynamic / photothermal anti-tumor / antibacterial.

Provided are compositions and methods relating to antimicrobial compositions. In particular, the disclosure relates to antimicrobial compositions providing a xanthene dye and component that acts in synergy with the xanthene dye and methods of using antimicrobial compositions for treatment of biological tissues. In particular, the component acting in synergy with the xanthene dye is a fungicide or fungistatic molecule.

The present invention relates to: a photocatalyst comprising methane monooxygenase (MMO) hydroxylase (MMOH), a halogenated xanthene dye as a light harvester, and MMOB as a catalyst conductivity enhancer; and a use thereof for methanol production, and exhibits catalytic activity superior to that in a natural biocatalytic reaction using MMO-based enzymes.

The invention discloses a 2-cyano-2-(9H-xanthine-9-subunit) acetamide compound as well as a preparation method, a pharmaceutical composition and application of the 2-cyano-2-(9H-xanthine-9-subunit) acetamide compound. The structure of the compound is as shown in formula (I), and the compound also comprises pharmaceutically acceptable salts thereof, can effectively inhibit a target ZNF207, and can be used for treating various tumors. In addition, the preparation method disclosed by the invention is simple and easy to operate.

The application provides a spiro fluorene heteroanthracene compound and application thereof in a light-emitting layer doping material. The compound shown in formula I provided by the application takes the groups shown in (I-1) to (I-6) as a basic mother nucleus structure, and is connected with spiro fluorene oxygen heteroanthracene or spiro fluorene sulfur heteroanthracene through N, so as to improve the material performance, so that the organic electroluminescent device prepared by using the compound has higher light-emitting efficiency, lower driving voltage and longer service life. Meanwhile, part of the structure can be used for green light doping material, and the performance is relatively excellent.

The invention relates to an ionic carbonyl cobalt-phosphine complex. The complex has a structure as shown in a formula I, wherein R1 to R8 are respectively any one of independently aryl, benzyl or cycloalkylene formed in pairs; x is an integer of 1-3; y is a counter anion; the xanthene ligand is any one of phenyl, diphenyl ether group, xanthene group, biphenyl group, dinaphthyl group, silyl group and cyclosiloxy / nitrogen alkyl ligand skeleton; and the dotted line part only represents a complex structure composed of tridentate or more phosphine compounds and cobalt. Meanwhile, the invention also discloses a synthesis method and application of the complex. The synthesis method is simple and high in yield, and the obtained ionic carbonyl cobalt-phosphine complex has more excellent stability and oxidation resistance, is more convenient to store, transport and use in long-period hydroformylation reaction, has the advantages of being capable of being separated, recycled and reused and the like, and is more suitable for industrial amplification application.

The invention belongs to the technical field of organic photoelectric semiconductor materials, and discloses a xanthene-based small organic molecule material as well as a preparation method and application thereof. According to the xanthene-based organic small molecule material structure, triphenylamine is used as a core, a large-volume xanthene spirofluorene unit, a dibenzofuran unit and a carbazole unit are introduced, and the molecular size is increased while the excellent hole mobility of the triphenylamine core is preserved, so that excitons close to an active aromatic amine core are eliminated; the micromolecule has the effect of limiting electron leakage, can keep stable under the action of electrons and excitons, is beneficial to hole injection and transmission, and has the following structural general formula. The xanthene-based small organic molecule material can effectively improve the luminous efficiency and prolong the service life of an organic electroluminescent device.

This invention discloses a method for degrading dyes using dye decolorization peroxidase, belonging to the field of biotechnology. This invention expresses a DyP (RhDyPB) derived from the bacterium *Rhodococcus jostii* in *Escherichia coli*. By adjusting the pH, manganese ion, hydrogen peroxide, and Tween-80 content during the decolorization process, the decolorization efficiency of RhDyPB and *E. coli* expressing RhDyPB on the anthraquinone dye Reactive Blue 19, the oxanthracene dye Eosin Y, the indigo dye Indigo Carmine, and the triphenylmethane dye Malachite Green is effectively improved.

The invention discloses a quick response type near-infrared fluorescent probe for detecting Hg < 2 + >, a preparation method of the quick response type near-infrared fluorescent probe and application of the quick response type near-infrared fluorescent probe in actual water samples and biological imaging. The molecular formula of the fluorescent probe is C32H28N2O2S2. On the basis of a strategy of introducing phenothiazine heterocycle to expand xanthene pi conjugation, a large Stokes shift near infrared fluorescent probe for specifically recognizing Hg < 2 + > is constructed. An optical experiment shows that the emission wavelength of the probe for detecting Hg < 2 + > is 780nm, the Stokes shift reaches 166nm, and the probe has the advantages of high sensitivity (the detection limit is 13.4 nM), specificity, quick response (within 1s) and the like when being used for identifying Hg < 2 + >. Due to the excellent photophysical property, the fluorescent probe not only can be used for quantitatively detecting Hg < 2 + > in an environmental water sample, but also can be successfully applied to fluorescence imaging detection of Hg < 2 + > in cells and living bodies.

The invention discloses a method for realizing benzyl inert C-H bond oxidation hydroxylation reaction by taking a xanthene compound I as a raw material and green solvent water as a hydroxyl source under an organic electrochemical condition through one-step reaction direct oxidation. Compared with an existing method for preparing the benzyl alcohol compound, the method has the advantages that raw materials do not need to be pre-functionalized and are cheap and easy to obtain, water serves as a green hydroxyl source, reaction conditions are mild, electrochemical electrons serve as an oxidizing agent, other exogenous catalysts and additives are not needed, and the reaction process is easy to operate.

Provided is a xanthene dye excellent in solubility, clarity, and heat resistance. 【Solution means】A xanthene dye represented by general formula (1). TIFF2026065145000049.tif15169 [In formula (1), Xn 1 , Xn 2 each independently represents a group represented by formula (2), Ar represents an aromatic hydrocarbon group or a heterocyclic group, An represents an anion, a represents an integer of 1 to 3, and b represents an integer of 0 to 6. When b is 2 or more, the plurality of An may be the same or different. R 1 ~R 4 each independently represents H, an alkyl group, or an aromatic hydrocarbon group. R 5 , R 6 each independently represents H, a halogen atom, an alkyl group, or an aromatic hydrocarbon group, and R 1 ~R 6 may be bonded to each other to form a ring with adjacent groups. The wavy line represents the bonding part with Ar.] TIFF2026065145000050.tif30169

The polyamic acid composition contains a polyamic acid and an organic solvent. The polyamic acid has a tetracarboxylic dianhydride residue and a diamine residue. The tetracarboxylic acid dianhydride residues comprise a 3, 3 ', 4, 4'-biphenyl tetracarboxylic acid dianhydride residue and a spiro [11H-difuran [3, 4-b: 3 ', 4'-i] xanthene-11, 9 '-[9H] fluorene]-1, 3, 7, 9-tetraketone residue. The diamine residue contains a p-phenylenediamine residue. At least one of the tetracarboxylic dianhydride residue and the diamine residue further includes a residue having an ester bond. The tetracarboxylic dianhydride residue and / or the diamine residue further contains a residue having a diphenyl ether structure.

Provided are compositions and methods relating to antimicrobial compositions. In particular, the disclosure relates to antimicrobial compositions providing a xanthene dye and component that acts in synergy with the xanthene dye and methods of using antimicrobial compositions for treatment of biological tissues. In particular, the component acting in synergy with the xanthene dye is a fungicide or fungistatic molecule.

The present invention contemplates a topical ophthalmic system for treating a Gram-positive bacterially-infected mammalian eye. The system comprises an ophthalmic composition containing a halogenated fluorescein or a pharmaceutically acceptable salt or ester thereof dissolved or dispersed in an aqueous ophthalmic carrier and present in an anti-bacterial keratitis-treating effective concentration of about 0.2 μg / mL to about 50 μg / mL. The ophthalmic composition has a pH value of about 6.5 to about 7.6, a viscosity of about 10 to about 300 cps and an osmolality of about 270 mOsm / kg to about 340 mOsm / kg. The ophthalmic composition is present in a vessel opaque to actinic light. Also contemplated is a method of treating a mammal having a Gram-positive bacterial infection of an eye by administering the ophthalmic composition to the infected eye and maintaining the treated eye in the substantial absence of actinic light for about 3 hours to about 12 hours.

The polyamic acid composition contains a polyamic acid and an organic solvent. The polyamic acid has a tetracarboxylic dianhydride residue and a diamine residue. The tetracarboxylic dianhydride residue includes a 3,3′,4,4′-biphenyltetracarboxylic dianhydride residue and a spiro[11H-difuro[3,4-b:3′,4′-i]xanthene-11,9′-[9H]fluorene]-1,3,7,9-tetrone residue. The diamine residue includes a p-phenylenediamine residue. At least one of the tetracarboxylic dianhydride residue or the diamine residue further includes a residue having an ester bond. At least one of the tetracarboxylic dianhydride residue or the diamine residue further includes a residue having a diphenyl ether structure.

The application discloses a curcuminoid xanthene compound shown in formula I, a preparation method of the curcuminoid xanthene compound and application of the curcuminoid xanthene compound as a photodiagnosis and treatment agent. The compound has the characteristics of long absorption and emission wavelength, good stability, high phototoxicity, large Stokes shift, good biocompatibility and good cell membrane permeability. Compared with curcumin, the photosensitizer has a longer absorption wavelength, lower dark toxicity and can generate ROS under type-I and type-II synergistic action, and is expected to be applied to PDT in an anaerobic tumor microenvironment.

The application discloses a near-infrared carbon monoxide fluorescent probe and a preparation method and application thereof, wherein the probe has a structure shown in formula I; a fluorescent unit of the probe is constructed by connecting 2-pyridine acetonitrile and hydroxyl xanthene derivative through an olefin bond; the probe itself has weak fluorescence and can release strong near-infrared fluorescence signals after responding to carbon monoxide. The probe has the advantages of rapid response, high sensitivity and good selectivity. The probe can sensitively detect expression changes of endogenous carbon monoxide levels, realize direct diagnosis of pathological degrees of drug-induced liver injury, and realize visual evaluation of liver-protecting effects of active components of traditional Chinese medicines. The application integrates disease diagnosis and drug efficacy evaluation functions in a single probe system, and provides an efficient and intuitive molecular imaging tool for early warning of drug-induced liver injury and screening of liver-protecting components of traditional Chinese medicines.

This invention relates to the field of optical sensing and imaging detection technology, specifically to a triphenylene-oxanthracene derivative, its preparation method, and a fluorescent probe for viscosity detection. The triphenylene-oxanthracene derivative has the general formula shown in Formula I. Compared to Rhodamine B, the synthesized triphenylene-oxanthracene derivative exhibits a larger Stokes shift. Furthermore, the fluorescence intensity of the triphenylene-oxanthracene derivative increases with increasing cell viscosity. In addition, the triphenylene-oxanthracene derivative can be further used to detect mitochondrial viscosity, exhibiting good mitochondrial targeting. In summary, the probe improves the Stokes shift, has a wide optical response pH range, and possesses excellent mitochondrial targeting.

The invention discloses a microRNA (Ribonucleic Acid) response type xanthene-hemicyanine fluorescent dye as well as a two-component probe system, a synthesis method and application thereof. The structure of the fluorescent dye is shown as a general formula I, and the fluorescent dye can be connected with a targeting ligand (such as short-chain RNA) through carboxyl. The two-component probe system is composed of two short-chain RNAs which are respectively connected with the dye and a biological orthogonal reaction partner (such as tetrazine), a biological orthogonal reaction is triggered through target microRNA-21 mediated hybridization, and the near-infrared fluorescence and photosensitive activity of the dye are specifically activated. The dye and the probe system can realize fluorescence imaging with high signal-to-noise ratio for overexpressed microRNA-21 in tumors, and generate active oxygen under laser irradiation for photodynamic therapy, thereby realizing integration of diagnosis and treatment. The dye and the probe system provided by the invention have the advantages of high biological safety, simplicity and convenience in preparation, high specificity and the like, and have wide application prospects in early diagnosis and treatment of malignant tumors.