377 results about "Xanthene" patented technology

The invention discloses a spirofluorene xanthene material and a preparation method and an application method thereof, and relates to application of the material in the fields such as organic electroluminescence, photovoltaic cell, organic electrical storage, organic nonlinear optics, chemical and biological sensing, organic laser and so on. The material has the following structure. The material has the advantages that (1) the material is prepared through a one pot process and has simple steps and mild conditions; (2) the material has the advantages of spirobifluorene materials, and shows high thermal stability and vitrification temperature; and (3) the material has high hole or electron mobility and so on. An electroluminescent device prepared by utilizing the material achieves satisfactory results in aspects such as illumination, luminous efficiency, voltage withstand stability and so on.

Envelopes and other containers intended for mail transportation possess a biological agent / toxin indicator operative upon the interior in detection of volatile bases including gaseous amines released from bacterial biological agents including Bacillus antracis, i.e. anthrax. The biological agent indicator has an acidic acid-base indicator compound that irreversibly changes color when neutralized by volatile bases. The compound is applied in liquid form to an appropriately porous substrate. A polymeric matrix is specifically suggested for this substrate. Irreversible indication of the presence of volatile bases including amines produced by live bacterial agents as toxins at temperate ambient conditions down to below freezing is provided. An indicator compound having a pH of 2-5 is recommended. Halogenated xanthene, sulphonated azo, and sulphonated hydroxy-functional triphenylmethane dyes are suggested. The presence of toxins produced by live bacterial biological agents within a package or container upon which the indicator is mounted is indicated by a slowly reversible color change. Primary public use envelopes and collection containers, secondary transportation and stationary quarantine enclosures, and articles worn inside a room with mail and when handling mail including a badge and gloves are specifically suggested.

New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. Preferably, the halogenated xanthene is Rose Bengal or a functional derivative of Rose Bengal. The halogenated xanthenes constitute a family of useful chemotherapeutic agents that afford selective, persistent accumulation in certain tissues. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations useful for intracorporeal or topical administration, including in liquid, semisolid, solid or aerosol delivery vehicles.

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

Atropisomeric energy-transfer dye compounds are disclosed. A variety of molecular biology applications utilize atropisomeric xanthene fluorescent dyes as labels for substrates such as nucleotides, nucleosides, polynucleotides, polypeptides and carbohydrates. Methods include DNA sequencing, DNA fragment analysis, PCR, SNP analysis, oligonucleotide ligation, amplification, minisequencing, and primer extension.

The invention provides a novel organic electroluminescent compound and a preparation method thereof. The compound is synthesized by connecting heterogeneous functional groups to 2,7 positions of spirofluorene xanthene as a center unit, and has a structure represented by a general formula in the specification; and in the general formula, R represents a secondary amino group, a pyrryl group, an indolyl group, a carbazyl group, a benzimidazolyl group, or derivative groups of the above groups. The compound is synthesized through a one-step method, the synthesis method is simple, the above prapred micro-molecular compound luminescence material has a good dissolvability, and the organic electroluminescent compound emits blue light, and can be used in luminescent materials, so the compound is hopeful to be used for making efficient organic light-emitting diode devices, and can be widely used in organic electrical storage devices, organic solar batteries, organic laser diode devices and organic field effect transistors.

The invention provides a blue colored composition for a color filter, a color filter and a color display, which are used during the manufacture of color filters of high color characteristic, heat resistance, light resistance and solvent resistance.The blue colored composition for color filters comprises a binder resin and a colorant.The colorant comprises a blue pigment and a salt forming product.The salt forming product is formed by a xanthene series acid dye and a compound with cationic groups.

The invention discloses a preparation method of BiVO4-BiOBr photocatalyst has a visible-light response, wherein the catalyst may be used under visible light, ultraviolet light, or sunlight. The preparation method of BiVO4-BiOBr photocatalyst that is in a multilevel nest-like nanostructure and is formed by nanosheets is: heating for 8 to 24 h under an alcohol-heating temperature of 100 to 200 DEG C with pH of 5 to 10. The catalyst of the invention can decompose water-soluble organic pollutant containing chlorine and sulfur, water-soluble organic pollutant of azo, xanthene, and anthraquinone type, and biological contaminant microcystic toxins generated by harmful algal bloom.

The invention discloses a four-color fluorescence labeling reversible terminal and a use thereof in DNA (Deoxyribonucleic Acid) sequencing. The structural formula of the reversible terminal is as shown in a formula (I) in the specification, wherein R1 is triphosphate; R2 is H or OH; the basic group is U, C, A, G or derivatives thereof; the connecting unit is a bifunctional compound which is breakable under a mild condition; the fluorescence group is one selected from a combination of BODIPY, fluorescein, rhodamine, coumarin, xanthene, cyanin, pyrene, phthalocyanine, alexa, squarene dye and an energy transferring dye, and derivatives thereof. The reversible terminal provided by the invention can be used for DNA single-molecule sequencing; simultaneously, raw materials required by the synthesis of the reversible terminal provided by the invention are simple and easy to get and the synthesis process of the reversible terminal is completely involved with conventional chemical reactions, so that the four-color fluorescence labeling reversible terminal can be popularized and utilized to a large scale; biological evaluation results indicate that the reversible terminal is capable of completely meeting the biochemical reaction requirements of high-flux sequencing and has a good practical prospect.

The invention discloses a novel dimolecular fluorescence probe of which the chemical name is 6-((4-nitrobenzyl)oxy)-2,3,4,4a-tetrahydro-xanthene-1-one. The invention also discloses application of the two-photon fluorescence probe in detecting nitroreductase in cells. The fluorescence intensity of the probe obviously increases as the nitroreductase content increases. The probe disclosed by the invention can be used for detecting the nitroreductase content in the tumor anoxic zone by a fluorescent imaging technique, thereby evaluating and researching the anoxic level of the tumor anoxic zone.

A spiro [fluorene-9, 9-xanthene]-class hole transport material and application thereof are disclosed, the spiro [fluorene-9, 9-xanthene]-class hole transport material is an aromatic-amine compound using spiro [fluorene-9, 9-xanthene] as a core-shell structure, the aromatic-amine compound has one or more than 1 N nuclear structure unit, two adjacent N nuclear structure units are connected by a connecting group, the N nuclear structure unit meets the general formula F, and Rx, Ry and Rz are substitutes or connecting groups. Compared with similar products in the prior art, the spiro [fluorene-9, 9-xanthene]-class hole transport material is the aromatic-amine compound using the spiro [fluorene-9, 9-xanthene] as the core-shell structure, has higher glass transition temperature and thermal decomposition temperature, higher redox potential, and higher hole mobility and conductivity, and has great application value and broad application prospects in the field of perovskite solar cells and other organic electronic devices.

The invention relates to the technical field of perovskite solar cells, and aims at providing a dinaphtho heterocyclic ring small molecular hole-transport material as well as a synthesis method and application thereof. An effective component of the material is any one of dioxaanthanthrene, dithioanthanthrene, dinaphthofuran, dinaphthothiophene or dinaphthopyrrole. According to the synthesis methoddisclosed by the invention, five kinds of small molecular hole-transport materials are designed and synthesized by taking the dioxaanthanthrene, the diethianthanthrene, the dinaphthofuran, the dinaphthothiophene and the dinaphthopyrrole as nuclei and introducing dialkoxy diphenylamine group to an active site. The material disclosed by the invention has the advantages of low synthesis cost, good film forming property and high hole mobility; the material as a non-doped hole-transport material can be applied to perovskite solar cell devices, so that higher device efficiency is achieved.

A method for the treatment of cancer comprising administration of a therapeutically effective amount of an intralesional chemoablative pharmaceutical composition, or variant of said composition, in combination with a therapeutically effective amount of a systemic immunomodulatory anticancer agent. A further method for the treatment of cancer comprising administration of a therapeutically effective amount of an intralesional chemoablative pharmaceutical composition, or variant of said composition, in combination with a therapeutically effective amount of a systemic targeted anticancer agent. The present invention is further directed to pharmaceutical compositions for treatment of cancer. The intralesional chemoablative pharmaceutical composition can comprise an IL chemoablative agent comprising primarily a halogenated xanthene.

The present invention relates to the field of medical technology, and in particular relates to a category of novel sulphonyl substituted xanthene ketone compounds that have a structural formula as shown in the right, a preparation method and application thereof. The compound has high inhibitory activity for ACAT1 / ACAT2; most of the compounds have high inhibitory activity for acyl coenzyme A cholesterol acyltransferase (ACAT). The compounds can be used for preparing anti-atherosclerosis drug combination. Furthermore, the compounds can be used as a preventive or a treating agent of such diseases as angina, myocardial infarction, cerebral infarction, apoplexy, Alzheimer's disease, acute coronary syndrome, PTCA or restenosis of coronary artery after a bracket is arranged. The compounds can be used as a treating agent to adjust the function of sebaceous glands of the skin and inhibit the excessive generation of sebum. And the compounds can be used for treating such diseases as acne-like damage caused by oily skin, acne, seborrhea and corticosteroids.

The invention discloses a Fe<3+> molecular fluorescence sensor based on Rhodamine B and a preparation method and application of the Fe<3+> molecular fluorescence sensor. Rhodamine B is taken as a precursor, and a target product N1-(benzene[d] thiazole-2-yl)-N4-(2-(3',6'-bi(diethylin)-3-carbonyl screw[iso-indoline-1,9'-xanthene]-2-yl)ethyl) maleimide is synthesized at two steps. Detection on Fe<3+> by using the target product shows that the target product has a very good detection effect on Fe<3+>; and meanwhile the raw materials of the Fe<3+> molecular fluorescence sensor are easy to obtain, synthesis steps are simple, after-treatment is convenient to implement, and large-scale production can be relatively easily achieved.

The invention relates to spirofluorene xanthene phosphine oxide electro-phosphorescent main materials and synthesis and application methods thereof, belongs to the field of photoelectric material science and technology, and in particular relates to four spirofluorene xanthene organic phosphine oxide materials and application of the materials in the field of organic electronics such as organic electroluminescent materials, organic solar cells, organic field-effect tubes, dye laser, organic nonlinear optical materials, fluorescent probes and the like. The series of materials are obtained by introducing diphenyl phosphine oxide groups to the 2nd site, the 2nd and 7th sites, the 2nd' site and the 2nd' and 7th' sites of spirofluorene xanthene respectively. The series of compounds have good charge transfer performance, thermal stability and high triplet energy level (ET=-2.86eV), and can be used as main materials and applied in phosphorescent devices. When the series of compounds are applied in the organic electro-phosphorescent devices, the maximum external quantum efficiency is 10.78 percent and the maximum brightness is 8,582cd / m<2> in the blue phosphorescent device; and in the green phosphorescent device, the maximum external quantum efficiency is 19.1 percent, and the maximum brightness is 16,943cd / m<2>.

The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and / or treatment of disease conditions.

The invention discloses an organic compound containing xanthene and an application thereof. A structural general formula of the organic compound is shown as a general formula (1). The vitrification temperature of the organic compound is high, the molecular thermal stability is strong, the organic compound has appropriate HOMO and LUMO energy level and high Eg, and the photoelectric property of an OLED device and life of the OLED device are effectively increased through optimization of a device structure.

The invention discloses an application of a rhodamine B based fluorescence sensor which can specifically detect tin ions. According to the application, benzyl 3-(3', 6'-bis(diethyl amino)-3-oxo-spiro [isoindoline-1, 9'-xanthene]-2-yl) ethyl propionate is taken as a substrate, different heavy metal ions such as MgCl2*6H2O, SnCl2*H2O, CrCl3*6H2O, AgNO3, CaCl2, NaCl, PbCl2, KCl, MnCl2*4H2O, ZnCl2, CuCl2*2H2O, LiCl*H2O, Ba(NO3)2, HgCl2, CoCl2, FeCl2*4H2O, FeCl3*6H2O, CdCl2*2.5H2O, AlCl3 and the like are added, and fluorescent response is found only when SnCl2*H2O is added, so that the fluorescence sensor which can specifically detect tin ions is developed. The sensor has the advantages of high specificity and sensitivity and the like and has important application potentials in the aspects of disease diagnosis and health evaluation.

A thermoplastic polymeric composition having a xanthene or xanthenes-based compound as a plasticizer, a method to modify the thermoplastic polymeric materials to increase their relative plasticity while maintaining good strength or “toughness” characteristics, and various articles of manufacture that can be made using the polymer composition are described.

A thermoplastic polymeric composition including a xanthene or xanthenes-based compound as a plasticizer, a method to modify the thermoplastic polymeric materials to increase their relative plasticity, and various articles of manufacture that can be made using the polymer composition are described.

The invention provides a salt. The salt contains at least one anion selected from anodes respectively represented by formulas ( I ), (II), (III) and (IV) and cation having xanthene skeleton, wherein in the formula (I), X1 and X2 respectively represent fluorine atoms or alkyl fluoride group with carbon number of 1-4, or X1 and X2 are bonded to form alkylene fluoride group with carbon number of 2-4; in the formula (II), X3-X5 respectively represent fluorine atoms or alkyl fluoride groups with carbon number of 1-4; in the formula (III), Y1 represents the alkylene fluoride group with carbon number of 1-4; in the formula (IV), Y2 represents the alkyl fluoride group with carbon number of 1-4.

The invention discloses a preparation method for 9,9-diaryl thiophene xanthene-10,10-dioxide, and belongs to the field of fine organic synthesis and organic semiconductor material preparation. The preparation method comprises the following steps: using diphenylsulphone as a starting material and tetrahydro furan as a solvent, conducting ortho metalation reaction on diphenylsulphone under the action of n-butyllithium within a temperature range of -78-0 DEG C to obtain a corresponding aryl lithium salt; allowing the aryl lithium salt to react with an added aryl formic ether ester derivative, and performing hydrolysis to obtain a corresponding tertiary alcohol; dissolving the tertiary alcohol and electron-rich aromatic with an acetate or methylene chloride solution, using Lewis acid as a catalyst, and carrying out friedel-crafts reaction to obtain the 9,9-diaryl thiophene xanthene-10,10-dioxide. The preparation method has the advantages that the reactions are easy to control, the operation is simple, the cost is low, the repeatability is good, the productivity is high, and the product quality is high; an organic modular unit and an organic functional semiconductor can be conveniently made; the 9,9-diaryl thiophene xanthene-10,10-dioxide is used in the fields of organic light emitting diodes, organic transistors, organic laser, and organic nonlinear optics, and the like.

The invention provides spirofluorene xanthene benzoxazine containing a benzoyloxy group and a preparation method thereof. The method comprises the following steps: by taking spirofluorene xanthene bisphenol as a raw material, reacting spirofluorene xanthene bisphenol with 4-nitrobenzoyl chloride, carrying out a hydrazine hydrate-Pd / C catalytic reduction reaction, thereby obtaining 4-aminobenzoyl spirofluorene xanthene and obtaining a series of benzoxazine monomers through a Mannich condensation reaction. Due to the introduction of spirofluorene xanthene and benzoyloxy group, the polybenzoxazine resin has high glass transition temperature and excellent thermal stability; due to the introduction of alkyl or alkoxy, the thermal performance of the polybenzoxazine resin is reduced, the toughness and processing performance of the polymer are greatly improved, the comprehensive performance is greatly improved, and the polybenzoxazine resin can be widely applied to the fields of photoelectric materials, insulating materials, composite material matrix resins, ablation resistant resins and the like.

The invention provides a novel spirofluorene xanthene organic electroluminescent material and a preparation method thereof. The material is synthesized by connecting a functional group to the 2 position of spirofluorene xanthenes as a center unit, and has a structure represented by a general formula in the specification; and in the general formula, R represents a secondary amino group, a pyrryl group, an indolyl group, a carbazyl group, a benzimidazolyl group, or derivative groups of the above groups. The compound has the advantages of simple synthetic method, easy processing, easy purification and low cost. The above organic electroluminescent compound emits blue light, can be used in luminescent materials, can be used as a hole transport material or an electron transfer material, and is hopeful to be widely used in organic light-emitting diode devices, organic electrical storage devices, organic solar batteries, organic laser diode devices and organic field effect transistors.

There is provided a compound represented by the following Formula (3):wherein in Formula (3), R201, R202 and R203 each independently represent a monovalent substituent, n201 and n202 each independently represent a number of 0 to 4, and n203 represents a number of 0 to 4, when n201, n202 and n203 each represent a number of 2 or more, a plurality of R201's, R202's and R203's may be the same or different, M represents a hydrogen atom or a counter cation, and M's may be the same or different, and a coloring composition containing the compound.

The invention discloses a xanthene fluorescent dye molecular fluorescent probe. Under different acid and alkali conditions, a fluorescent dye is transformed between isomers of a single loop coil open loop and a double-loop coil open loop, and the structure transformation ensures that a conjugated system of the dye is changed, and the color of a corresponding solution, the wavelengths for absorption and emission peaks and the fluorescence intensity are changed; and a xanthene fluorescent dye is used for preparing a xanthene fluorescent dye esterification derivative which can be used as a fluorescent molecular probe material to realize fluorescent detection of NADH. The xanthene fluorescent dye molecular fluorescent probe disclosed by the invention has the advantages that the molecular fluorescent probe has a double-loop coil hexatomic ring condensing system, the release of optical signals of the dye is controlled by the double-loop coil structure, and a switch of the loop coil structure is used for adjusting and controlling a fluorophore xanthene conjugated system in the whole molecular structure, and widening the adsorption and emission wavelengths of the conjugated system to ensure that the optical signal intensity is changed correspondingly; and the probe material is quick in response to NADH, high in selectivity and good in biological membrane permeability, and a preparation method of the probe material is simple and feasible, low in cost and obvious in economic and technical effects.