66 results about "Xanthene" patented technology

The invention relates to the technical field of organic dyes, in particular to a novel xanthene dye for blue photoresist color paste and a synthesis method of the novel xanthene dye. The invention relates to a synthesis method of a novel xanthene dye for blue photoresist color paste, which comprises the following steps: 1) taking rigid cyclic amine as a nucleophilic reagent, and carrying out aromatic nucleophilic substitution reaction on a chlorinated xanthene compound to obtain a xanthene intermediate; 2) performing chlorination reaction on the xanthene intermediate by using a chlorination reagent to obtain a chlorinated xanthene intermediate; 3) mixing active amine and the chlorinated xanthene intermediate, and performing substitution reaction under the action of alkali to obtain the novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste has the advantages of being high in solubility, good in thermal stability and high in contrast ratio.

The present application relates to the technical field of electroluminescent device preparation, in particular to an OLED light-emitting composition and an electroluminescent device comprising the composition. The OLED light-emitting composition comprises an electron transport material and a light-emitting material, the electron transport material combines o-phenanthroline and a xanthene group, and has high electron mobility and a low energy level. A boron-nitrogen compound skeleton structure with multiple benzene rings is introduced into the light-emitting material, the skeleton structure is twisted in a planar configuration, the alkyl substituents contained in the large steric group are adjusted, the π-π mutual attraction caused by the introduction of benzene rings is weakened, the intermolecular force is further weakened, and the adverse effects of concentration quenching on efficiency are weakened. The OLED device prepared by using the composition of the present application has low starting voltage, high light-emitting efficiency and better service life, can meet the requirements of current panel manufacturing enterprises for high-performance materials, and has great commercial value.

The invention discloses a xanthene nitroreductase-responsive fluorescent dye compound as well as a preparation method and application thereof, and belongs to the technical field of xanthene derivatives. The fluorescent dye compound can be used for quickly and specifically recognizing overexpressed nitroreductase in tumor cells; after the fluorescent probe acts with nitroreductase, the fluorescence intensity of the fluorescent probe at 718 nm is obviously enhanced, and the fluorescent probe has excellent targeting capability on mitochondria; meanwhile, under the excitation of illumination with the specific wavelength of 660 nm, an acting product of the fluorescent dye compound and nitroreductase can efficiently generate reactive oxygen species (ROS), and then the effect of specifically killing tumor cells is achieved. The xanthene nitroreductase response type fluorescent dye compound provided by the invention can achieve the goal of integration of diagnosis and treatment of solid tumors, and has important clinical application value.

The present application relates to an electronic device comprising a xanthene or thioxanthene compound of a particular formula. The electronic device is preferably an organic electroluminescent device (OLED). The application further relates to particular xanthene or thioxanthene compounds as such, and to the use thereof in the abovementioned devices, and to processes for preparation thereof.

The application discloses a 2-cyano-2-(9H-xanthen-9-ylidene)acetamide compound and a preparation method, a pharmaceutical composition and an application thereof. The compound structure is as shown in the formula (I), and the compound also comprises pharmaceutically acceptable salts thereof. The compound can effectively inhibit a target point ZNF207 and can be used for treating various tumors. In addition, the preparation method disclosed by the application is simple and easy to operate.

The invention belongs to the technical field of biological medicine analysis, and particularly relates to a fluorescent probe sequentially responding to gamma-glutamyltranspeptidase and monoamine oxidase and application of the fluorescent probe. The structure of the fluorescent probe is as shown in a formula 1, the fluorescent probe in the formula 1 is constructed by sequentially covalently connecting gamma-glutamyltranspeptidase and specific recognition groups of monoamine oxidase and integrating the gamma-glutamyltranspeptidase and the specific recognition groups of monoamine oxidase into a benzothiazole-xanthene fluorescent parent structure, and the fluorescent probe has near-infrared fluorescence luminescence performance. The probe adopts a double enzyme response activation strategy, and can be activated and generate a fluorescence signal only when gamma-glutamyltranspeptidase and monoamine oxidase exist at the same time, so that the fluorescence probe is high in specificity and has excellent accuracy and specificity in the aspects of pathological imaging, drug safety evaluation and the like.

Provided are compositions and methods relating to antimicrobial compositions. In particular, the disclosure relates to antimicrobial compositions providing a xanthene dye and component that acts in synergy with the xanthene dye and methods of using antimicrobial compositions for treatment of biological tissues. In particular, the component acting in synergy with the xanthene dye is a fungicide or fungistatic molecule.

The present invention relates to: a photocatalyst comprising methane monooxygenase (MMO) hydroxylase (MMOH), a halogenated xanthene dye as a light harvester, and MMOB as a catalyst conductivity enhancer; and a use thereof for methanol production, and exhibits catalytic activity superior to that in a natural biocatalytic reaction using MMO-based enzymes.

The invention belongs to the technical field of organic photoelectric semiconductor materials, and discloses a xanthene-based small organic molecule material as well as a preparation method and application thereof. According to the xanthene-based organic small molecule material structure, triphenylamine is used as a core, a large-volume xanthene spirofluorene unit, a dibenzofuran unit and a carbazole unit are introduced, and the molecular size is increased while the excellent hole mobility of the triphenylamine core is preserved, so that excitons close to an active aromatic amine core are eliminated; the micromolecule has the effect of limiting electron leakage, can keep stable under the action of electrons and excitons, is beneficial to hole injection and transmission, and has the following structural general formula. The xanthene-based small organic molecule material can effectively improve the luminous efficiency and prolong the service life of an organic electroluminescent device.

Provided is a xanthene dye excellent in solubility, clarity, and heat resistance. 【Solution means】A xanthene dye represented by general formula (1). TIFF2026065145000049.tif15169 [In formula (1), Xn 1 , Xn 2 each independently represents a group represented by formula (2), Ar represents an aromatic hydrocarbon group or a heterocyclic group, An represents an anion, a represents an integer of 1 to 3, and b represents an integer of 0 to 6. When b is 2 or more, the plurality of An may be the same or different. R 1 ~R 4 each independently represents H, an alkyl group, or an aromatic hydrocarbon group. R 5 , R 6 each independently represents H, a halogen atom, an alkyl group, or an aromatic hydrocarbon group, and R 1 ~R 6 may be bonded to each other to form a ring with adjacent groups. The wavy line represents the bonding part with Ar.] TIFF2026065145000050.tif30169

Provided are compositions and methods relating to antimicrobial compositions. In particular, the disclosure relates to antimicrobial compositions providing a xanthene dye and component that acts in synergy with the xanthene dye and methods of using antimicrobial compositions for treatment of biological tissues. In particular, the component acting in synergy with the xanthene dye is a fungicide or fungistatic molecule.

The present invention contemplates a topical ophthalmic system for treating a Gram-positive bacterially-infected mammalian eye. The system comprises an ophthalmic composition containing a halogenated fluorescein or a pharmaceutically acceptable salt or ester thereof dissolved or dispersed in an aqueous ophthalmic carrier and present in an anti-bacterial keratitis-treating effective concentration of about 0.2 μg / mL to about 50 μg / mL. The ophthalmic composition has a pH value of about 6.5 to about 7.6, a viscosity of about 10 to about 300 cps and an osmolality of about 270 mOsm / kg to about 340 mOsm / kg. The ophthalmic composition is present in a vessel opaque to actinic light. Also contemplated is a method of treating a mammal having a Gram-positive bacterial infection of an eye by administering the ophthalmic composition to the infected eye and maintaining the treated eye in the substantial absence of actinic light for about 3 hours to about 12 hours.

The polyamic acid composition contains a polyamic acid and an organic solvent. The polyamic acid has a tetracarboxylic dianhydride residue and a diamine residue. The tetracarboxylic dianhydride residue includes a 3,3′,4,4′-biphenyltetracarboxylic dianhydride residue and a spiro[11H-difuro[3,4-b:3′,4′-i]xanthene-11,9′-[9H]fluorene]-1,3,7,9-tetrone residue. The diamine residue includes a p-phenylenediamine residue. At least one of the tetracarboxylic dianhydride residue or the diamine residue further includes a residue having an ester bond. At least one of the tetracarboxylic dianhydride residue or the diamine residue further includes a residue having a diphenyl ether structure.

The application discloses a curcuminoid xanthene compound shown in formula I, a preparation method of the curcuminoid xanthene compound and application of the curcuminoid xanthene compound as a photodiagnosis and treatment agent. The compound has the characteristics of long absorption and emission wavelength, good stability, high phototoxicity, large Stokes shift, good biocompatibility and good cell membrane permeability. Compared with curcumin, the photosensitizer has a longer absorption wavelength, lower dark toxicity and can generate ROS under type-I and type-II synergistic action, and is expected to be applied to PDT in an anaerobic tumor microenvironment.

The application discloses a near-infrared carbon monoxide fluorescent probe and a preparation method and application thereof, wherein the probe has a structure shown in formula I; a fluorescent unit of the probe is constructed by connecting 2-pyridine acetonitrile and hydroxyl xanthene derivative through an olefin bond; the probe itself has weak fluorescence and can release strong near-infrared fluorescence signals after responding to carbon monoxide. The probe has the advantages of rapid response, high sensitivity and good selectivity. The probe can sensitively detect expression changes of endogenous carbon monoxide levels, realize direct diagnosis of pathological degrees of drug-induced liver injury, and realize visual evaluation of liver-protecting effects of active components of traditional Chinese medicines. The application integrates disease diagnosis and drug efficacy evaluation functions in a single probe system, and provides an efficient and intuitive molecular imaging tool for early warning of drug-induced liver injury and screening of liver-protecting components of traditional Chinese medicines.

The invention discloses a microRNA (Ribonucleic Acid) response type xanthene-hemicyanine fluorescent dye as well as a two-component probe system, a synthesis method and application thereof. The structure of the fluorescent dye is shown as a general formula I, and the fluorescent dye can be connected with a targeting ligand (such as short-chain RNA) through carboxyl. The two-component probe system is composed of two short-chain RNAs which are respectively connected with the dye and a biological orthogonal reaction partner (such as tetrazine), a biological orthogonal reaction is triggered through target microRNA-21 mediated hybridization, and the near-infrared fluorescence and photosensitive activity of the dye are specifically activated. The dye and the probe system can realize fluorescence imaging with high signal-to-noise ratio for overexpressed microRNA-21 in tumors, and generate active oxygen under laser irradiation for photodynamic therapy, thereby realizing integration of diagnosis and treatment. The dye and the probe system provided by the invention have the advantages of high biological safety, simplicity and convenience in preparation, high specificity and the like, and have wide application prospects in early diagnosis and treatment of malignant tumors.

The application discloses a kind of based on chelating phosphine ligand Binuclear cuprous cluster luminescent material and its preparation method, and the sensing application of the material to pyridine and cyclohexylamine VOC;The luminescent material structural formula of the application is (Xantphos) Cu2I2 (4-PBO) 2, wherein Xantphos is electric neutral double phosphine ligand 4,5-bis (diphenylphosphine) -9,9-dimethyl xanthene, and 4-PBO is nitrogen-containing ligand 4- (2-benzoxazole) pyridine;It is prepared by coordination reaction of CuI and ligand by mechanical ball milling;The luminescent intensity of material itself is strong, and can be used as luminescent material;And after the material is placed in pyridine or cyclohexylamine atmosphere, different fluorescence sensing response characteristics of fluorescence enhancement and discoloration and fluorescence quenching are presented soon respectively;The material is easy to prepare, and solubility and stability are very good, and it is also easy to prepare into paper-based load or polymer-doped fluorescent sensing film, and the film also shows the fluorescence sensing performance of quick and selective response and sensitive identification.

The invention belongs to the field of organic high-molecular compounds and preparation and chemical processing thereof, and provides nano-porous flexible aerogel for ultra-wideband wireless communication and a preparation method of the nano-porous flexible aerogel. The aerogel is composed of a polyimide base material and an air phase distributed in the polyimide base material, and the polyimide base material is of a nanopore structure. The polyimide matrix material is formed by carrying out chemical crosslinking and chemical imidization of a crosslinking agent on linear polyamide acid formed by carrying out copolymerization reaction on a dianhydride monomer containing fluorine and xanthene and a diamine monomer, and assembling molecular chains subjected to chemical imidization through intermolecular acting force; the pore diameter of the nanopore structure does not exceed 100 nm, and the porosity of the aerogel is 89%-92%. According to the invention, the interface reflection, scattering and absorption of the existing aerogel on electromagnetic waves can be reduced, the loss of the electromagnetic waves in the transmission process is reduced, and the aerogel can realize efficient wave transmission and transmission of the electromagnetic waves in the frequency bands of beat Hertz, terahertz and gigahertz.

To provide a colored curable composition from which a film excellent in suppression of hue change before and after alkali development and suppression of hue change due to heating after alkali development is obtained, and to provide a film, a color filter, a solid-state imaging device or an image display device.SOLUTION: A colored curable composition, a film, a color filter, a solid-state imaging element, or an image display device, containing a colorant including a xanthene colorant multimer, a compound A including at least one structure selected from the group consisting of a lactone structure, a sultone structure, and a cyclic carbonate structure, a resin which is a compound different from the xanthene colorant multimer and the compound A and has an acid group, a polymerizable compound, and a photopolymerization initiator.SELECTED DRAWING: None

The application discloses 2-boronic acid pinacol ester-9,9'-spirobis(xanthene) and a synthesis method thereof, and belongs to the field of organic chemical synthesis. A structural formula of the 2-boronic acid pinacol ester-9,9'-spirobis(xanthene) is as follows: the 2-boronic acid pinacol ester-9,9'-spirobis(xanthene) is synthesized by the following method: 2-bromoxanthone is used as a starting material, reacts with phenol to synthesize 2-bromo-9,9'-spirobis(xanthene), and then is subjected to Suzuki-Miyaura reaction to synthesize. The synthesis method is simple in operation, low in production cost, and high in product content (greater than 99.9%); the synthesis method can meet the requirements of industrial production and application, is suitable for industrial production, and expands the application of spiro compounds as intermediates in the design and synthesis of organic optoelectronic functional materials.

The invention relates to the technical field of dyeing characterization of surface functional layers of composite materials, in particular to a hydrophilic functional layer specific coloring agent and a preparation method and application thereof, and the hydrophilic functional layer specific coloring agent is composed of 0.01%-0.5% by mass of xanthene fluorescent dye, 0.1%-5% by mass of hydrophilic polymer additive and the balance of water. Wherein the xanthene fluorescent dye is 9-(2-carboxyl phenyl)-3, 6-bis (diethylamino) xanthyleione chloride, and the structural formula of the xanthene fluorescent dye is shown in the description. After a hydrophilic film is dyed by the specific dyeing agent for the hydrophilic functional layer, an extremely high color contrast can be presented between the hydrophilic functional layer and a base material layer, and the background is clean and clear. For the defects such as uneven coating, microcracks and pinholes which cannot be recognized by conventional visual observation and are in the order of nanometer to micrometer, the coloring agent can clearly expose the defects through the difference of local color depth or fluorescence intensity, and visual precision diagnosis of the quality of the hydrophilic functional layer is achieved.

The application discloses a novel method for synthesizing thioglycoside, which is a one-pot method for synthesizing thioglycoside compounds via DDQ-mediated xanthene compounds and glycosyl mercaptan. The method is simple in operation, mild in reaction condition, free of metal catalysis, and good in substrate universality, and is favorable for large-scale production.

The application provides a pH and near-infrared light dual-response photocage compound and application thereof. The photocage compound comprises a silicon-xanthene ion skeleton and a molecular residue Cargo, and the silicon-xanthene ion skeleton is connected with the Cargo through a Linker. The PPG core skeleton of the application not only responds to near-infrared light irradiation, but also introduces a response mechanism to pH conditions. Compared with the existing PPG which only depends on light triggering, the dual-gating of 'environment (tumor acidity) + external triggering (NIR light)' is realized, the spatiotemporal accuracy and targeting selectivity of active molecule release are significantly improved, and the non-specific release in non-target tissues is reduced, thereby reducing systemic toxicity.

A polyimide precursor composition contains a polyimide precursor and an organic solvent. The polyimide precursor has a structural unit into which a specific xanthene structure has been introduced. The imidization ratio of the polyimide precursor is 10 mol % or more and 100 mol % or less. The organic solvent may be one or more solvents selected from N-methyl-2-pyrrolidone, 1-butyl-2-pyrrolidone, 3-methoxy-N,N-dimethylpropanamide, 3-butoxy-N,N-dimethylpropanamide, N,N-dimethylpropionamide, N,N-diethylformamide and 1,3-dimethyl-2-imidazolidinone.

This invention relates to the preparation and application of a thiazolinone-oxanthracene peroxynitroso fluorescent probe. The probe has the following structural formula: This invention provides a method for synthesizing this fluorescent probe using thiazolinone-oxanthracene dye, pinacol ester of 4-bromomethylphenylboronic acid, etc., as raw materials; this fluorescent probe is a peroxynitroso fluorescent probe with near-infrared emission; firstly, this fluorescent probe is effective against ONOO... ‑ It exhibited good sensitivity, with a 7.5-fold increase in fluorescence intensity; secondly, this fluorescent probe showed good sensitivity to ONOO. ‑ It exhibits high selectivity, unaffected by other reactive oxygen species, biothiols, and amino acids; furthermore, this fluorescent probe is compatible with ONOO. ‑ It acts rapidly, with a response time of less than 5 minutes; in addition, the fluorescent probe is used to detect the content of peroxide nitrosamines in living cells.

The application provides a preparation method of a silicon point composite siloxane modified xanthene polymer thickening system, which comprises the following steps: S0, preparing silicon points by taking 3-aminopropyltrimethoxysilane as raw material and L-ascorbic acid as a reducing agent; S1, preparing a siloxane modified xanthene polymer by taking 1,3,5-tripropenyl-hexahydrotriazine as raw material and using 1,3,5,7-tetramethylcyclotetrasiloxane for modification; and S2, mixing the silicon points prepared in the step S0 with the siloxane modified xanthene polymer prepared in the step S1 to obtain the silicon point composite siloxane modified xanthene polymer thickening system. The silicon point composite siloxane modified xanthene polymer thickening system prepared by the method has good solubility in CO2, is safe and non-toxic, has a good thickening effect on supercritical carbon dioxide, and has good temperature resistance and shear resistance.

The application provides a spirofluorene xanthene-based organic light-emitting device and panel, the organic light-emitting device comprising a cathode, an anode and a light-emitting layer between the cathode and the anode, a first stack is arranged between the anode and the light-emitting layer, and a second stack is arranged between the cathode and the light-emitting layer; at least three layers in the first stack and the second stack contain a compound with a spirofluorene xanthene structure shown in formula I. The spirofluorene xanthene group comprises a xanthene part and a fluorene part, both of which can introduce different substituents to adjust the HOMO / LUMO energy level of the material, and at the same time have good carrier transport capacity, and can play a role in regulating hole or electron transport. The materials on the left and right sides of the light-emitting layer contain the same spirofluorene xanthene main structure, which can reduce the energy level difference between different organic layers, reduce the injection barrier caused by the energy level difference, improve the transport of carriers, and thus improve the efficiency and service life of the device.

The application belongs to the technical field of fluorescent probes, and particularly relates to a fluorescent probe for detecting HSO3 ‑ / ClO ‑ and viscosity, a preparation method and property research of the fluorescent probe. The preparation method of the fluorescent probe in the application is simple, the product yield is high, and the method is suitable for scale promotion and use. The probe (E) -4- (2- (6- (4- (diphenylamino) phenyl) -2, 3- dihydro-1H- xanthene-4-yl) vinyl) -3- ethylbenzothiazole-3- onium iodide (TXET) is first used to detect HSO3 ‑ , and the fluorescence intensity (I ‑ ) gradually increases with the increase of the HSO3 500 concentration. When the HSO3 ‑ concentration is within 0-0.13 millimoles per liter, a good linear relationship is obtained. When ClO ‑ is detected under a low polarity condition, the fluorescence intensity (I ‑ ) gradually increases with the increase of the ClO 530 concentration. Secondly, when the ClO ‑ concentration is within 40-80 micromoles per liter, a good linear relationship is obtained. Finally, the fluorescence intensity (I 720 ) gradually increases with the increase of the viscosity, and a good linear relationship is obtained within 7.9-880 centipoises. The biological experiment results show that the probe TXET can be used to monitor the change levels of HSO3 ‑ / ClO ‑ and viscosity in cells and animals, and can be used as a sensitive tool for identifying liver damage.

The invention discloses a fluorine-containing diamine monomer, polyimide and a preparation method and application of the fluorine-containing diamine monomer, the fluorine-containing diamine monomer is generated by reacting phenol with amino and dialkyl with hexafluorobenzene, and the fluorine-containing diamine monomer and specific tetracarboxylic dianhydride with a non-rigid structure, including 4, 4 '-(hexafluoroisopropylidene) diphthalic anhydride, 4, 4'-oxydiphthalic anhydride, 9, 10-di-tert-butyl-4-methyl-1, 3, 4, 5-tetracarboxylic dianhydride, 9, 10-di-tert-butyl-4-methyl-1, 3, 5-tetracarboxylic dianhydride and 9, 10-di-tert-butyl-4-methyl-1, 3, 5-tetracarboxylic dianhydride. According to the present invention, the polyimide film with characteristics of good light transmission performance, good thermal performance and good mechanical strength can be prepared through the reaction of 2, 9-bis (trifluoromethyl) xanthene-2, 3, 6, 7-tetracid dianhydride and bisphenol A diether dianhydride, and has good application prospects in the fields of flexible display substrates, printed circuit boards, solar cell substrates, flexible packaging films and other optical films.

The invention provides a preparation method of 1 '-bromospirofluorene xanthene, and relates to the technical field of organic chemical synthesis. 2-phenylbenzoic acid with low price is used as a raw material, and the 1'-bromospirofluorene xanthene with high purity and high yield is obtained through acylation reaction, nucleophilic addition reaction, Grignard reaction, ring closing reaction, demethylation reaction and other reactions.