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372 results about "Xanthene" patented technology

Xanthene (9H-xanthene, 10H-9-oxaanthracene) is the organic compound with the formula is CH₂[C₆H₄]₂O. It is a yellow solid that is soluble in common organic solvents. Xanthene itself is an obscure compound, but many of its derivatives are useful dyes.

Biological toxin detection system for mailed materials

Envelopes and other containers intended for mail transportation possess a biological agent/toxin indicator operative upon the interior in detection of volatile bases including gaseous amines released from bacterial biological agents including Bacillus antracis, i.e. anthrax. The biological agent indicator has an acidic acid-base indicator compound that irreversibly changes color when neutralized by volatile bases. The compound is applied in liquid form to an appropriately porous substrate. A polymeric matrix is specifically suggested for this substrate. Irreversible indication of the presence of volatile bases including amines produced by live bacterial agents as toxins at temperate ambient conditions down to below freezing is provided. An indicator compound having a pH of 2-5 is recommended. Halogenated xanthene, sulphonated azo, and sulphonated hydroxy-functional triphenylmethane dyes are suggested. The presence of toxins produced by live bacterial biological agents within a package or container upon which the indicator is mounted is indicated by a slowly reversible color change. Primary public use envelopes and collection containers, secondary transportation and stationary quarantine enclosures, and articles worn inside a room with mail and when handling mail including a badge and gloves are specifically suggested.
Owner:ROBINSON JR WILLIAM L

Medicaments for chemotherapeutic treatment of disease

New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. Preferably, the halogenated xanthene is Rose Bengal or a functional derivative of Rose Bengal. The halogenated xanthenes constitute a family of useful chemotherapeutic agents that afford selective, persistent accumulation in certain tissues. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations useful for intracorporeal or topical administration, including in liquid, semisolid, solid or aerosol delivery vehicles.
Owner:PROVECTUS PHARMATECH

Four-color fluorescence labeling reversible terminal and use thereof in DNA (Deoxyribonucleic Acid) sequencing

The invention discloses a four-color fluorescence labeling reversible terminal and a use thereof in DNA (Deoxyribonucleic Acid) sequencing. The structural formula of the reversible terminal is as shown in a formula (I) in the specification, wherein R1 is triphosphate; R2 is H or OH; the basic group is U, C, A, G or derivatives thereof; the connecting unit is a bifunctional compound which is breakable under a mild condition; the fluorescence group is one selected from a combination of BODIPY, fluorescein, rhodamine, coumarin, xanthene, cyanin, pyrene, phthalocyanine, alexa, squarene dye and an energy transferring dye, and derivatives thereof. The reversible terminal provided by the invention can be used for DNA single-molecule sequencing; simultaneously, raw materials required by the synthesis of the reversible terminal provided by the invention are simple and easy to get and the synthesis process of the reversible terminal is completely involved with conventional chemical reactions, so that the four-color fluorescence labeling reversible terminal can be popularized and utilized to a large scale; biological evaluation results indicate that the reversible terminal is capable of completely meeting the biochemical reaction requirements of high-flux sequencing and has a good practical prospect.
Owner:SHANGHAI JIAO TONG UNIV

Spirofluorene xanthene phosphine oxide electro-phosphorescent main materials and synthesis and application methods thereof

The invention relates to spirofluorene xanthene phosphine oxide electro-phosphorescent main materials and synthesis and application methods thereof, belongs to the field of photoelectric material science and technology, and in particular relates to four spirofluorene xanthene organic phosphine oxide materials and application of the materials in the field of organic electronics such as organic electroluminescent materials, organic solar cells, organic field-effect tubes, dye laser, organic nonlinear optical materials, fluorescent probes and the like. The series of materials are obtained by introducing diphenyl phosphine oxide groups to the 2nd site, the 2nd and 7th sites, the 2nd' site and the 2nd' and 7th' sites of spirofluorene xanthene respectively. The series of compounds have good charge transfer performance, thermal stability and high triplet energy level (ET=-2.86eV), and can be used as main materials and applied in phosphorescent devices. When the series of compounds are applied in the organic electro-phosphorescent devices, the maximum external quantum efficiency is 10.78 percent and the maximum brightness is 8,582cd/m<2> in the blue phosphorescent device; and in the green phosphorescent device, the maximum external quantum efficiency is 19.1 percent, and the maximum brightness is 16,943cd/m<2>.
Owner:NANJING FANGYUAN GLOBAL DISPLAY TECH

Preparation method for 9,9-diaryl thiophene xanthene-10,10-dioxide

The invention discloses a preparation method for 9,9-diaryl thiophene xanthene-10,10-dioxide, and belongs to the field of fine organic synthesis and organic semiconductor material preparation. The preparation method comprises the following steps: using diphenylsulphone as a starting material and tetrahydro furan as a solvent, conducting ortho metalation reaction on diphenylsulphone under the action of n-butyllithium within a temperature range of -78-0 DEG C to obtain a corresponding aryl lithium salt; allowing the aryl lithium salt to react with an added aryl formic ether ester derivative, and performing hydrolysis to obtain a corresponding tertiary alcohol; dissolving the tertiary alcohol and electron-rich aromatic with an acetate or methylene chloride solution, using Lewis acid as a catalyst, and carrying out friedel-crafts reaction to obtain the 9,9-diaryl thiophene xanthene-10,10-dioxide. The preparation method has the advantages that the reactions are easy to control, the operation is simple, the cost is low, the repeatability is good, the productivity is high, and the product quality is high; an organic modular unit and an organic functional semiconductor can be conveniently made; the 9,9-diaryl thiophene xanthene-10,10-dioxide is used in the fields of organic light emitting diodes, organic transistors, organic laser, and organic nonlinear optics, and the like.
Owner:NANJING UNIV OF POSTS & TELECOMM

Xanthene fluorescent dye molecular fluorescent probe as well as preparation method and application thereof

The invention discloses a xanthene fluorescent dye molecular fluorescent probe. Under different acid and alkali conditions, a fluorescent dye is transformed between isomers of a single loop coil open loop and a double-loop coil open loop, and the structure transformation ensures that a conjugated system of the dye is changed, and the color of a corresponding solution, the wavelengths for absorption and emission peaks and the fluorescence intensity are changed; and a xanthene fluorescent dye is used for preparing a xanthene fluorescent dye esterification derivative which can be used as a fluorescent molecular probe material to realize fluorescent detection of NADH. The xanthene fluorescent dye molecular fluorescent probe disclosed by the invention has the advantages that the molecular fluorescent probe has a double-loop coil hexatomic ring condensing system, the release of optical signals of the dye is controlled by the double-loop coil structure, and a switch of the loop coil structure is used for adjusting and controlling a fluorophore xanthene conjugated system in the whole molecular structure, and widening the adsorption and emission wavelengths of the conjugated system to ensure that the optical signal intensity is changed correspondingly; and the probe material is quick in response to NADH, high in selectivity and good in biological membrane permeability, and a preparation method of the probe material is simple and feasible, low in cost and obvious in economic and technical effects.
Owner:TIANJIN UNIVERSITY OF TECHNOLOGY
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