50 results about "Malononitrile" patented technology

The invention relates to the technical field of organic photoelectric materials, and particularly discloses a non-condensed ring small molecule acceptor material based on a quinonoid structure as well as a preparation method and application of the non-condensed ring small molecule acceptor material. According to the invention, easily available 1, 4-diacetyl piperazine-2, 5-diketone is used as a center, an alkyl chain and Ar are used for modification, EG is used as an end group, the non-condensed ring A-D-A '-D-A type structure acceptor material based on a quinone structure is constructed, and the general formula is shown in the specification. Wherein the PCE of the acceptor material which is modified by bithiophene and takes 2-(3-ethyl-4-oxothiazolidine-2-subunit) malononitrile as a terminal group reaches 15%. The non-condensed ring small molecule acceptor material based on the quinonoid structure is simple in synthesis process, and an effective strategy is provided for solving the problem of the overall performance of an organic solar cell.

The invention relates to the technical field of organic synthesis, in particular to a method for synthesizing cyclopentane compounds through [3 + 2] cycloaddition reaction of aryl cyclopropane and olefin under the synergistic catalysis of bromide ions / visible light. The method comprises the following steps: in a nitrogen atmosphere, sequentially adding aryl cyclopropane, a benzyl malononitrile derivative, pyridine tribromide and a photocatalyst into a reaction solvent to obtain a mixture, stirring the mixture at the temperature of 40 DEG C under the irradiation of a 12W blue light LED lamp until the reaction is complete, and performing concentration and column chromatography purification to obtain the cyclopentane compound. The method has the advantages of mild reaction conditions, simple operation, simple and easily available raw materials and low cost.

The application discloses a catalyst for preparing malononitrile, a preparation method of the catalyst and a method for preparing malononitrile by using the catalyst. The catalyst is a solid catalyst, which is an acidic catalyst loaded with rare earth metal oxide. The method for preparing malononitrile is that cyanoacetic acid or cyanoacetate or cyanoacetamide and an ammonia source are subjected to ammoniation dehydration reaction in a continuous reactor to prepare malononitrile according to a certain molar ratio. Then, vacuum distillation (20 torr-25 torr) is carried out, and a fraction collected at 110 DEG C-120 DEG C is malononitrile product. The ammonia source can be ammonia gas, ammonia water, ammonium carbonate or urea. The method for preparing malononitrile can reduce production cost, improve production safety, reduce the discharge amount of three wastes in the preparation of malononitrile by using an existing process, and improve product quality, and is a sustainable and green synthesis route.

This invention belongs to the field of organic synthetic chemistry technology, specifically relating to a selenium-based indoloquinazoline derivative, its preparation method, and its application, comprising: in an organic solvent, using aromatic amine compounds, malononitrile, and diselenoether as raw materials, in the presence of a palladium catalyst and an organic base, at 90°C... o The reaction was carried out under C conditions with stirring to obtain a selenyl indoline quinazoline derivative. This method features mild reaction conditions, simple operation, high yield, and good functional group compatibility, conforming to the principles of green chemistry. Furthermore, the selenyl indoline quinazoline derivative provided by this invention exhibits good inhibitory activity against Plasmodium, providing a drug lead compound for the development of novel antimalarial drugs and holding significant importance for the prevention and / or treatment of malaria.

The method for high-efficiency catalysis of Knoevenagel condensation reaction by a porphyrin and quaternary ammonium salt synergistic catalytic system belongs to the technical field of catalyzing Knoevenagel condensation reaction. The synergistic catalytic system comprises a porphyrin ligand and a quaternary ammonium salt compound. The method for high-efficiency catalysis of Knoevenagel condensation reaction of aldehyde ketone and active methylene to generate methylene malononitrile compounds is to use the porphyrin ligand and the quaternary ammonium salt as a synergistic catalytic system to catalyze the condensation of aldehyde ketone and active methylene to generate methylene malononitrile compounds. The porphyrin ligand and quaternary ammonium salt synergistic catalytic system avoids the disadvantages of environmental pollution and difficult recycling of traditional basic homogeneous catalysts, so that the porphyrin ligand and quaternary ammonium salt synergistic catalytic system is easy to operate and recycle, has universal practicability, can be used by ordinary experimental operators, and provides an easy-to-operate, inexpensive and efficient route for the synthesis of methylene malononitrile compounds, which has a popular prospect.

The application discloses preparation of carbazolyl 3,5-dicyanopyridine derivatives, room temperature phosphor and anti-counterfeiting performance thereof. The preparation method comprises the following steps: adding ortho-, meta- or para-carbazolyl benzaldehyde and malononitrile into a reaction bottle, stirring and reacting under room temperature conditions with sodium hydroxide as a catalyst and anhydrous methanol as a solvent, and obtaining ortho-, meta- or para-carbazolyl 3,5-dicyanopyridine by separating and purifying the reaction crude product. Crystals of the three compounds are obtained by a solvent diffusion method with dichloromethane-petroleum ether as a solvent, and the crystal state room temperature phosphor material is obtained. The crystals are doped with urea / triphenylphosphine at a weight ratio of 1:100, the doped crystals are uniformly ground and mixed, and then heated to be molten, so that the host-guest doped phosphor material is obtained, and the novel material is used in the field of anti-counterfeiting patterns.

The invention provides a preparation method of fluorodinitrile. The preparation method comprises the following steps: reacting trifluoromethanesulfonic anhydride with fluoroalkyl alcohol to obtain fluoroalkyl substituted trifluoromethanesulfonate; then, the fluoroalkyl substituted trifluoromethanesulfonate reacts with malononitrile, and fluorodinitrile is obtained; the reaction raw materials used in the method are easy to obtain and low in price, the target product conversion rate is high, byproducts are few, the purity of the prepared fluorodinitrile is as high as 99%, the yield is higher than 84%, the content of chloride and bromide ions is lower than 5 ppm, and the fluorodinitrile can meet the requirement of serving as an electrolyte additive.

The invention belongs to the field of Velciguat synthesis, and particularly relates to a preparation method of Velciguat and an intermediate product thereof. The preparation method of the Velciguat comprises the following steps: (1) reacting aminomalononitrile with methyl chloroformate to generate an intermediate product I; (2) carrying out ring closing on the intermediate product I and formamidine under an alkaline condition to obtain an intermediate product II; (3) carrying out bromination reaction on the intermediate product II and N-bromosuccinimide to obtain an intermediate product III; (4) reacting the intermediate product III with bis (pinacolato) diboron under the action of a catalyst to obtain an intermediate product IV; and (5) carrying out a reaction on the intermediate product IV and 5-fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo [3, 4-b] pyridine to prepare the viriciguat. The method is simple to operate, low in cost and safe in production. The invention also provides the intermediate product obtained by the preparation method.

The invention belongs to the technical field of chemical analysis and detection, and provides a bimodal fluorescent probe and a preparation method and application thereof in hypochlorous acid detection, the chemical formula of the bimodal fluorescent probe is C68H44N2, and the preparation method comprises the following steps: weighing 2, 7-dibromo-9-fluorenone, 1-(4-phenylboronic acid pinacol ester)-1, 2, 4-triazole-1-one, 2, 4-triazole-1-one, 2, 4-triazole-1-one, 2, 4-triazole-1-one, 2, 4-triazole-1-one, 2, 4-triazole-1 The preparation method comprises the following steps: putting 1, 1, 2-triphenylethylene, a tetra (triphenylphosphine) palladium catalyst and potassium carbonate into a three-neck flask; sequentially injecting methylbenzene, absolute ethyl alcohol and water; carrying out heating reflux reaction, cooling to room temperature, carrying out extraction separation by using dichloromethane, collecting an organic phase, drying, carrying out rotary evaporation concentration to obtain a crude product, and purifying to obtain TPEO; dissolving TPEO and malononitrile in anhydrous dimethyl sulfoxide under the protection of argon, heating and stirring to react, cooling to room temperature, carrying out suction filtration, and washing the precipitate; the bimodal fluorescent probe can be applied to detection of hypochlorous acid, and has the advantages of specific selectivity, high sensitivity, wide detection concentration, high accuracy and the like.

The invention discloses an engineering continuous preparation method of 3-amino-4-amidoxime furazan, which is characterized in that engineering synthesis of 3-amino-4-amidoxime furazan is technically verified and optimized by adopting a continuous flow micro-channel reactor and a dynamic tubular reactor technology, and malononitrile is used as a starting raw material to react in the micro-channel reactor; the preparation method comprises the following steps: carrying out nitrosation and oximation to obtain a trioxime solution, conveying trioxime and a cyclization solution to a dynamic tubular reactor, heating to a certain temperature, reacting and curing, overflowing into a collection tank through the tubular reactor, adjusting the pH value of a reaction solution, cooling, filtering, washing with water, and drying to obtain the 3-amino-4-amidoxime furazan. The AAOF engineering manufacturing process scheme is provided, AAOF kilogram-level engineering preparation under automatic control is achieved, the problems of material precipitation, heat exchange and the like in an intermittent production mode are solved, and the synthesis efficiency and the synthesis safety are greatly improved.

This application discloses a method for synthesizing chiral cyano-containing full-carbon quaternary cyclic compounds, characterized by the following steps: mixing a solvent, an oxidant, an alkynyl malononitrile compound, a carboxylic acid compound, a palladium salt, and a chiral dinitrogen ligand; reacting the mixture; drying; and separating to obtain the chiral cyano-containing full-carbon quaternary cyclic compound. This method can achieve a palladium-catalyzed tandem reaction of alkynyl malononitrile with a carboxylic acid involving asymmetric acyl oxidative cyclization / acyl migration, yielding cyano-containing full-carbon quaternary cyclic compounds with optical purity in good yields (enantiomer ratios up to 96.5:3.5). This invention features a broad substrate range, readily available raw materials, simple and practical operation, and mild reaction conditions.

The invention relates to the field of preparation of drug intermediates, and particularly discloses a synthetic method of a drug intermediate pyrazolo [1, 2-b] phthalazine-5, 10-diketone derivative and a catalytic system for synthesis. According to the synthetic method, aromatic aldehyde, phthalylhydrazine and malononitrile are used as reaction raw materials; the pyrazolo [1, 2-b] phthalazine-5, 10-diketone derivative is synthesized under the catalytic action of a catalytic system consisting of an alkaline eutectic solvent and absolute ethyl alcohol. The content of each component and reaction process parameters are optimally designed, so that the utilization rate of the reaction raw materials and the yield of the pyrazolo [1, 2-b] phthalazine-5, 10-diketone derivative can be remarkably increased, and the economical efficiency is relatively good; the catalytic system is high in catalytic activity, the usage amount in the catalytic process and the loss amount of the catalyst during recycling are small, the number of times of recycling is large, the catalytic system does not need to be treated before recycling, and operation is easy.

The invention discloses an RNA (Ribonucleic Acid) fluorescent probe as well as a preparation method and application thereof in cell nucleolus staining, and belongs to the technical field of biomedical detection. The probe is a water-soluble pyridine salt compound, the chemical name of the probe is 1-(2-(2-(2, 2-dicyanovinyl))-5-(dimethylamino phenoxy) ethyl) pyridine-1-ammonium bromide, and the preparation method of the probe is characterized in that 2-(2-bromoethoxy)-4-(dimethylamino) benzaldehyde and malononitrile are used as raw materials, and the probe is synthesized through two-step reaction. The probe has the characteristics of large Stokes shift, low cytotoxicity and fluorescence enhancement after being combined with RNA (Ribonucleic Acid). Experiments prove that the probe can specifically carry out efficient fluorescence labeling on nucleolus and cytoplasm RNA in fixed cells, and a high-contrast imaging effect is obtained. The probe disclosed by the invention is simple and convenient to synthesize and excellent in performance, and has important application value in the fields of cell nucleolus research, tumor diagnosis and the like.

The application belongs to the field of vixepiromide synthesis, and particularly relates to a preparation method of vixepiromide and intermediate products thereof. The preparation method of vixepiromide comprises the following steps: (1) reacting aminopropandinitrile with methyl chloroformate to generate an intermediate product one; (2) ring closing the intermediate product one with formamidine under alkaline conditions to generate an intermediate product two; (3) performing bromination on the intermediate product two with N-bromosuccinimide to generate an intermediate product three; (4) reacting the intermediate product three with pinacol diboron under the action of a catalyst to generate an intermediate product four; and (5) reacting the intermediate product four with 5-fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine to generate vixepiromide. The application has the advantages of simple operation, low cost and safe production. The application further provides the intermediate products generated in the above preparation method.

The application belongs to the technical field of biological medicine, and provides a photosensitizer, a targeted delivery nano platform and application. A preparation method of the photosensitizer comprises the following process: a Suzuki coupling reaction is used to synthesize an intermediate with an aldehyde group by taking a brominated or iodinated triphenylamine as a precursor and reacting with boric acid, and then a Knoevenagel condensation reaction is used to convert the terminal aldehyde group into a strong electron-withdrawing dicyanovinyl group by reacting the aldehyde group intermediate with malononitrile, so as to synthesize the photosensitizer PSs. The application takes a structure-optimized photosensitizer (used for generating ROS and inactivating viruses) and a STING agonist (used for activating the STING pathway and inducing cell death) as core treatment components, and takes a rabies virus glycoprotein peptide as a active targeting ligand, so that the "PDT-immune" synergistic inactivation of RABV can be realized.

The invention belongs to the technical field of ion detection, and particularly relates to a preparation method of a long-wavelength emission fluorescent probe for rapidly detecting bisulfite, which comprises the following steps: dissolving isophorone and malononitrile in ethanol to obtain a product 1; 3-bromoquinoline and 5-formyl-2-thiopheneboronic acid are dissolved in a mixed solvent of dry methanol and dry toluene, and a product 2 is obtained; dissolving the product 2 in dichloromethane, and adding methyl trifluoromethanesulfonate to obtain a product 3; and dissolving the product 1 and the product 3 in ethanol, and adding piperidine to obtain the required fluorescent probe LSQ. Dissolving the obtained fluorescent probe LSQ in DMSO to prepare mother liquor A; a target product is obtained. The fluorescent probe provided by the invention has the advantages of high-selectivity rapid response to bisulfite, long-wavelength emission, no organic solvent detection, simple synthesis route and simple and convenient detection equipment and method, and can be used for qualitative and quantitative detection of bisulfite in food and biological systems.

The invention discloses a hydrogen peroxide fluorescent probe based on a 7-hydroxyquinoline derivative as well as a preparation method and application of the hydrogen peroxide fluorescent probe. The fluorescent probe and a structural formula of the fluorescent probe are shown in the specification. According to the invention, 7-hydroxyquinoline is used as a bridge, (3, 5, 5-trimethylcyclohex-2-alkenyl) malononitrile and benzothiazole-2-acetonitrile are respectively used as strong electron withdrawing groups of a fluorescent probe molecule, and pinacol phenylboronic acid ester is used as a recognition group of H2O2 and is also used as a power supply group of the fluorescent probe molecule. The fluorescent probe molecules QCN and QSN have an obvious ICT effect, so that the probe molecules QCN and QSN emit fluorescence, and the prepared fluorescent probe shows high sensitivity and high selectivity on H2O2 in a solution. The preparation method of the fluorescent probes QCN and QSN has the advantages of simple steps, easily available raw materials, solid products, easy storage, wide application prospects, and large-scale production and application.

The invention relates to the technical field of compound purification, and particularly discloses a malononitrile purification method. The purification method of malononitrile specifically comprises the step of separating malononitrile from a malononitrile crude product through adoption of a melt crystallization method. According to the malononitrile purification method provided by the invention, a vacuum system does not need to be arranged, the required temperature is relatively low, the energy consumption is reduced by 50% or above, the refining cost and refining time of malononitrile are greatly reduced, and the finally obtained malononitrile pure product has extremely high purity and yield.

The invention discloses a 2-(3, 6-bis (10H-phenoselenazine-10-yl)-9H-fluorene-9-vinyl) malononitrile compound as shown in a formula I as well as a preparation method and application of the 2-(3, 6-bis (10H-phenoselenazine-10-yl)-9H-fluorene-9-vinyl) malononitrile compound, IR1 is H or Cl, and R2 is any one of H, CH3, t-Bu, Cl and OMe. By introducing 2-(9H-fluorene-9-vinyl) malononitrile as an electron acceptor and phenoselenazine as an electron donor, the compound has a distorted molecular structure and intramolecular charge transfer, reduces the overlap of HOMO and LUMO, and has small delta EST, so that the compound has the characteristic of thermal activation delayed fluorescence, and the emission wavelength of the compound in a solid state is obviously red-shifted to a red light region.

The invention discloses a near-infrared fluorescent probe with an aggregation-induced emission enhancement effect. The near-infrared fluorescent probe is used for dual detection of hydrogen sulfide and hydrazine. The fluorescent probe is synthesized by carrying out Knoevenagel condensation reaction on 4-hydroxy-3-(1, 4, 5-triphenyl-1H-imidazolyl) benzaldehyde (I) and 2-(2-methyl-4H-chromene-4-subunit) malononitrile (II) under the catalytic action of piperidine, and the chemical structural formula of the fluorescent probe is as shown in the formula (III). The fluorescent probe shows high selectivity and high sensitivity to both hydrogen sulfide and hydrazine, the detection limits are as low as 50.1 nM and 89.2 nM respectively, and the fluorescent probe can be used for various scenes such as food spoilage monitoring and environmental water sample detection, can be used for biological imaging, and shows important application potential in the aspect of detection of hydrazine and hydrogen sulfide in organisms.

This invention provides a green method for preparing malononitrile using a trisubstituted phosphine oxide catalyst. The method includes the following steps: in a solvent, cyanoacetamide and solid phosgene or phosgene react in the presence of the trisubstituted phosphine oxide catalyst; the solvent is then recovered by vacuum distillation, and the residue is distilled under vacuum to obtain malononitrile; the three substituents in the trisubstituted phosphine oxide catalyst are each independently selected from aromatic or alkyl groups, and the three substituents may be the same or different. This invention offers a simple preparation method, uses inexpensive and readily available raw materials, resulting in low cost; the organic solvent and catalyst used are recyclable and reusable, generating no wastewater or solid waste, making it environmentally friendly; the reaction conditions are easy to achieve, and the product yield and purity are high.

The invention discloses a preparation method and a detection method of a high-sensitivity fluorescent probe for detecting cysteine, and belongs to the technical field of chemical analysis and detection. The preparation method comprises the following steps: uniformly mixing 4-hydroxyphenylboronic acid, 5-bromine-2-furaldehyde, tetrakis (triphenylphosphine) palladium and potassium carbonate, adding a mixed solution of distilled water, ethanol and toluene, vacuumizing, filling nitrogen, stirring, extracting, washing with water, drying, filtering, evaporating a solvent under reduced pressure, and purifying to obtain 5-(4-hydroxyphenyl) furan-2-formaldehyde; the preparation method comprises the following steps: dissolving 5-(4-hydroxyphenyl) furan-2-formaldehyde and 2-(3, 5, 5-trimethylcyclohex-2-ene-1-subunit) malononitrile, adding piperidine, stirring, freezing, washing, evaporating to remove a solvent, purifying to obtain Y-1, weighing Y-1, dissolving, stirring, adding triethylamine and acryloyl chloride, reacting, evaporating to remove the solvent, and purifying to obtain Probe 1. The fluorescent probe provided by the invention is simple to prepare, can be used for trace detection and is low in cost.

The invention belongs to the field of organic photoelectric materials and biomedical treatment, and discloses preparation and application of a malononitrile-based near-infrared luminescent material. On the basis of a strong electron withdrawing group 2-(2-methyl-4H-benzo-4-subunit) malononitrile, 2-vinyl thiophene is used as a pi bridge to construct a near-infrared material with three strong electron donating groups. According to the invention, 2-(2-methyl-4H-benzo-4-subunit) malononitrile is used as an electron withdrawing group, and 2-vinyl thiophene is used as a pi bridge to be connected with a plurality of donors, so that three D-pi-A type near infrared molecules are designed and synthesized. When an electron-deficient acceptor (A) is connected with an electron-rich donor (D), an electron push-pull effect occurs, and intramolecular charge transfer (ICT) is beneficial to narrowing of delta EST. For such molecules, stronger D or A is more conducive to enhancing the ICT process, effectively promoting wavelength redshift. A thought is provided for the design of the molecules.

The present disclosure is directed, in general, to synthesizing optionally substituted 2-dicyanomethylene-3-cyano-4-methyl-5-phenyl-5-perfluoromethyl-2,5-dihydrofuran comprising (i) reacting tributyl (1-ethoxyvinyl) tin with n-butyllithium at a temperature of between −30° C. and 10° C. to produce a first reaction product; (ii) reacting the first reaction product with 2,2,2-trifuoroacetophenone to produce a second reaction product: (iii) quenching the second reaction product with an acid to produce 3-hydroxy-3-phenyl-4,4,4-trifluoro-2-butanone; and (iv) reacting the 3-hydroxy-3-phenyl-4,4,4-trifluoro-2-butanone with malononitrile in the presence of base to produce 2-dicyanomethylene-3-cyano-4-methyl-5-phenyl-5-perfluoromethyl-2,5-dihydrofuran.

The invention discloses a basic column aromatic hydrocarbon catalyst and application thereof in efficient catalysis of a Knoevenagel condensation reaction and a Michael addition reaction, belongs to the technical field of catalysts, and particularly discloses a basic column [5] aromatic hydrocarbon catalyst (Interdazole-P [5] A) which efficiently catalyzes aldehyde ketone and active methylene to generate a methylene malononitrile compound in the aspect of the Knoevenagel condensation reaction. In the aspect of Michael addition reaction, the catalyst efficiently catalyzes alpha, beta-unsaturated nitro or carboxyl or ester compounds and active methylene to generate corresponding addition products; meanwhile, the catalyst is also successfully applied to a'one-pot two-step method 'reaction of a Knoevenagel condensation reaction and a Michael addition reaction. According to the catalyst, the defects that a traditional alkaline homogeneous catalyst pollutes the environment and is difficult to recycle are overcome.

A method for preparing 4,6-dichloropyrimidine, comprising the following steps: mixing malononitrile, methanol and an organic solvent to obtain a mixed solution, introducing the mixed solution and hydr

The invention relates to a method for preparing malononitrile through catalysis, and belongs to organic synthesis. The reaction formula is as follows; wherein R is H or alkyl of C1-C6; the specific preparation method comprises the following steps: (1) heating a compound shown as a formula I, and introducing the heated compound and ammonia gas into a fixed bed reactor filled with a catalyst for reaction; (2) condensing the reaction mixture obtained in the step (1), performing gas-liquid separation, and collecting liquid; and (3) carrying out negative pressure rectification on the liquid collected in the step (2) to obtain malononitrile. According to the method for preparing malononitrile through catalysis, cyanoacetic acid or ester thereof and ammonia gas are subjected to a catalytic dehydration reaction, and malononitrile can be synthesized in one step. According to the method, highly toxic raw materials are not used, the synthesis steps are short, the reaction conditions are mild, the raw materials can be recycled, the yield is high, and the method has good practicability and economical efficiency and is convenient for industrial production.

The invention discloses a preparation method of a 2, 6-dicyanoaniline compound, which comprises the following steps: reacting an allyronitrile compound as shown in a chemical structural general formula (1), aldehydes as shown in a formula (2) and malononitrile as raw materials in an organic solvent at 60-120 DEG C for 12-24 hours under the action of a catalyst and an additive to obtain the 2, 6-dicyanoaniline compound as shown in a structural formula (3). The invention discloses a 2, 6-dicyanoaniline compound. According to the invention, aldehydes and allylononitrile compounds are used as raw materials, and the method has the characteristics of simple synthesis, high conversion rate, wide substrate application range, low raw material cost, small pollution, few reaction byproducts and environmental protection; in addition, the method disclosed by the invention has the characteristics of mild reaction conditions, few reaction steps, simplicity in operation, high yield and the like, so that the method has a wide application prospect.

The invention provides a silsesquioxane porous material with a near-infrared light catalytic effect as well as a preparation method and application of the silsesquioxane porous material. The preparation method of the silsesquioxane porous material comprises the following steps: (1) in a solvent A, under the action of piperidine, enabling (3, 5, 5-trimethylcyclohex-2-alkenyl) malononitrile to react with a donor compound to obtain a D-A compound; (2) dissolving octavinyl silsesquioxane and the D-A compound obtained in the step (1) in a solvent B, adding a catalyst, uniformly stirring, and reacting; after the reaction is finished, cooling, filtering and washing to obtain a solid; and carrying out Soxhlet extraction on the obtained solid, and carrying out vacuum drying on the obtained solid to obtain the silsesquioxane porous material with the near-infrared light catalytic effect. The prepared silsesquioxane porous material has the advantages of wide absorption of near-infrared light, high light absorption and conversion efficiency, high catalytic activity, chemical stability and water stability.

The invention discloses a 3, 4 '-pyrano [2, 3-c] pyrazole spirooxindole derivative as well as a preparation method and application thereof.The 3, 4'-pyrano [2, 3-c] pyrazole spirooxindole derivative is obtained by reacting isatin or substituted isatin, 5-phenyl-2, 4-dihydro-3H-pyrazole-3-ketone and malononitrile according to the molar ratio of 1: 1: 1 in a solvent, and the 3, 4 '-pyrano [2, 3-c] pyrazole spirooxindole derivative can be used for preparing the 3, 4'-pyrano [2, 3-c] pyrazole spirooxindole derivative. The synthesis method has the advantages of being very simple and convenient, simple in post-treatment, green and environment-friendly, high in atom economy, cheap and easily available in raw materials and the like. The compound is an important drug molecule analogue, wherein the inhibitory activity of 18 compounds such as HDY-01, HDY-02 and HDY-03 on an A549 cell strain is superior to that of a positive control drug cis-platinum; the inhibitory activity of 20 compounds such as HDY-01, HDY-02, HDY-03 and the like on a drug-resistant strain A549 / DDP is superior to that of a positive control drug cis-platinum; 10 compounds such as HDY-02, HDY-03, HDY-05 and the like have better selectivity on the drug-resistant strain A549 / DDP cells. The compound is likely to be developed into a high-efficiency, low-toxicity and high-selectivity anti-lung cancer medicament, and has certain application and economic values.