The invention discloses an L-
prolinol synthetic method. The method comprises the following steps that 1, ethyl
alcohol is added in a reaction kettle,
thionyl chloride is dropwise added at 10-15 DEG C, then, L-
prolinol is added, the temperature is increased to 40 DEG C, a heat-preservation reaction is carried out for 10-12 h, the mixture is concentrated to be thick liquid after the reaction is finished,
ethyl acetate is added for
dissolution, the pH value is adjusted through
triethylamine to be 7-8, and salt is filtered away to obtain L-
proline ethyl ester; 2, the L-
proline ethyl ester is in a methyl
alcohol system,
lithium chloride is added at 5-10 DEG C, the
sodium borohydride is added many times, a heat-preservation reaction is carried out at 20-25 DEG C for 2-2.5 h,
hydrochloric acid is added, heat-preservation
hydrolysis is carried out for 2 h, methyl
alcohol is recycled, the pH value is adjusted through 25%
sodium hydroxide to be 12, a product is extracted through
dichloromethane,
anhydrous sodium sulfate drying is carried out, and filtering is carried out; 3,
dichloromethane is recycled from mother liquid at 30-40 DEG C and normal pressure, oily matter is obtained,
pressure reduction and
distillation are carried out, and therefore the pure L-
prolinol is obtained. According to the L-prolinol synthetic method, the
reaction temperature is mild, the
safety coefficient is low, no
solid waste is produced, and
environmental protection is achieved.