Method for preparing L-prolinol through high-pressure hydrogenization of L-proline

Abstract

The invention discloses a method for preparing L-prolinol through high-pressure hydrogenization of L-proline. According to the method, L-proline is reduced for 4-12h in a solvent at the temperature of 120-180DEG C under the reaction pressure of 4-10MPa in the presence of a catalyst and catalytic acid, to obtain a target product L-prolinol, wherein the solvent is isopropanol preferably, the catalyst is 5% Ru / C preferably, and the catalytic acid is phosphoric acid preferably. The method for preparing L-prolinol is short in process route, high in yield and simple for aftertreatment.

Description

technical field [0001] The invention relates to a method for preparing L-prolinol, in particular to a method for preparing L-prolinol by high-pressure hydrogenation of L-proline. Background technique [0002] L-proline is one of the important amino acids for the synthesis of human protein, an important raw material for amino acid infusion, and the main intermediate for the synthesis of first-line antihypertensive drugs such as captopril and enalapril. It has been widely used in food and Pharmaceutical and other industries. Its reduction product L-prolinol is an important chiral chemical reagent, which is not only a raw material for the synthesis of excellent optical materials and chiral polymer materials, but also an important chiral source for the synthesis of chiral drugs. In recent years, with the rapid development of asymmetric catalytic technology, L-prolinol has become an excellent ligand for metal coordination catalysis, and is widely used in asymmetric metal alkylat...

AI Technical Summary

Problems solved by technology

[0009] This process is a commonly used process at present. Compared with direct reduction, the yield is about 80%, but it also has the disadvantages of troublesome post-processing, long process route, large pollution, and is not suitable for large-scale production.

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