262results about How to "Post-processing is simple" patented technology

The invention discloses a self-lubricating type epoxy resin material and a preparation method thereof, belonging to the polymer material field. The self-lubricating type epoxy resin material comprises the following components in weight percentage: 60 to 80 percent of epoxy resin, 0.5 to 25 percent of lubricating oil microcapsules and 15 to 35 percent of curing agents. The preparation method for the self-lubricating type epoxy resin material comprises the following steps of well mixing the lubricating oil microcapsules, the epoxy resin with the curing agents and casting rapidly when to-be-mixed matter has gel phenomena, so as to obtain the self-lubricating type epoxy resin material. The invention also provides a lubricating oil microcapsule needed in the preparation of the epoxy resin material and a preparation method for the lubricating oil microcapsule. A technical proposal provided by the invention adds the lubricating oil microcapsules to the epoxy resin so as to prepare the epoxy resin compound material, which can remarkably improve the wear reducing-resisting performance of the epoxy resin material and has broad application prospects.

The invention provides a preparation method of an oxidized graphene and sodium alginate composite absorbing material capable of removing ciprofloxacin in an aqueous solution. The preparation method comprises the following steps: dispersing a certain amount of oxidized graphene samples in deionized water, putting the oxidized graphene samples into an ultrasonic cleaner, and performing ultrasonic treatment for 6-10 hours; dissolving a certain amount of sodium alginate into an oxidized graphene solution subjected to ultrasonic treatment, and performing ultrasonic treatment for 20 minutes; dropewise adding the mixed solution into a 0.2mol/L calcium chloride solution by virtue of a peristaltic pump, soaking for 1-3 days, and cleaning with deionized water for 3-4 times, thereby obtaining a sodium alginate and oxidized graphene sphere hydrogel material; and freeze-drying, thereby obtaining oxidized graphene and sodium alginate sphere aerogel. The preparation method is performed under a relatively mild condition, and oxidized graphene is packaged in a sodium alginate network structure by an ion bridge method, so that the nano toxicity of graphene powder is avoided, and a new nano material capable of efficiently absorbing ciprofloxacin antibiotics in the aqueous solution is prepared. The preparation process is simple, easily controllable in condition, low in cost and suitable for large-scale batch production.

The invention belongs to the field of organic synthesis, and in particular relates to a synthesis process of 4, 4'-dichlorodiphenyl sulfone. The synthesis process comprises the following steps: firstly, performing a Friedel-Crafts reaction on sulfoxide chloride and chlorobenzene under the action of a catalyst; cooling and hydrolyzing -after the reaction; heating and dissolving ; cooling, separating out crystals and filtering so as to obtain 4, 4'-dichlorodiphenyl sulfoxide; dissolving 4, 4'-dichlorodiphenyl sulfoxide in glacial acetic acid, adding hydrogen peroxide for an oxidizing reaction; lowering the temperature and cooling after the reaction is completed, and filtering so as to obtain 4, 4'-dichlorodiphenyl sulfone. Chlorobenzene is used both as a reaction material and a solvent, and other solvent impurities are not mixed in chlorobenzene, so that after-treatment is easier when the cost is saved, and the product is high in purity. The synthesis process has the advantages of simple process, low cost and few impurities. The obtained product has high purity and has the content of above 99.2% and the yield of above 90%, so that the product is good in economic benefit and is suitable for industrial production.

The invention relates to a method for refining long-carbon chain dicarboxylic acid. A long-chain dicarboxylic acid crude product prepared by a fermentation method is used as a raw material, acetic acid is used as a solvent, and the refining and purification are performed by recrystallization treatment. The method comprises the process steps of bleaching filtration, cooling crystallization, centrifugal separation, centrifugal material washing, secondary centrifugation and drying, and is characterized in that a. the long-chain dicarboxylic acid crude product to be refined does not need to be dried; b. the acetic acid solvent is recycled by an azeotropic distillation method, and isopropyl acetate is used as an azeotropic dehydrating agent; and c. the isopropyl acetate is used as a centrifugal material washing solvent for replacing the acetic acid. The purification method of the long-carbon chain dicarboxylic acid provided by the invention has the advantages of distillation equipment investment conservation, low operating power consumption, good product color, high purity, high refining yield and low production cost, the long-carbon chain dicarboxylic acid to be refined does not need to be dried and dehydrated, and the acetic acid solvent is completely recyclable. The quality of the refined product can meet the technical requirements of use of condensed monomer raw materials used by synthesis of high polymer materials.

The invention discloses a flame retardant containing phosphorus, nitrogen and sulfur and used for epoxy resin and a preparation method of the flame retardant. Firstly, DOPO and aminothiazole are taken as reaction raw materials and subjected to an Atherton-Todd reaction for preparation of the flame retardant containing phosphorus, nitrogen and sulfur. The process steps of the method are simple, the yield and the purity of the flame retardant are high, and the post-treatment process is simple and convenient. The flame retardant containing phosphorus, nitrogen and sulfur and prepared with the method is used for modifying cured epoxy resin and has good compatibility with epoxy resin, and the obtained cured flame-retardant epoxy resin has excellent flame retardancy; when the phosphorus content of the epoxy curing system reaches 0.43wt%-1.23wt%, the vertical burning grade can pass UL-94 V-0 level, and the limit oxygen index is as high as 36%.

The invention discloses a linaclotide solid-phase synthesis method, and belongs to the biochemical technical field. The method includes the following steps: (1) preparation of linaclotide resin; (2) cutting the linaclotide linear peptide resin obtained in the step (1), to obtain a protection group linear peptide containing Cys(Acm) and Cys(tBu); (3) oxidizing to form a first disulfide bond, to obtain a monodisulfide cyclopeptide; (4) removing an Acm protection group in the monodisulfide cyclopeptide, to obtain a dual disulfide cyclopeptide; (5) removing a tBu protection group of the dual disulfide cyclopeptide, to obtain a trisdisulfide cyclopeptide; and (6) purifying the trisdisulfide cyclopeptide by HPLC, and freeze-drying to obtain linaclotide. The process has the characteristics of simple reaction operation, easy post-processing, low cost, high yield, and considerable economic and practical values, and besides, has wide application prospect in the polypeptide drug design and synthesis field.

The invention discloses a method for separating ethylene and acetylene from a mixed gas. The method comprises the step of using a metal organic frame material as an adsorbent for separating the ethylene and the acetylene from the mixed gas containing the ethylene and the acetylene; the metal organic frame material has a structural formula of M(C7O5H4).2H2O, wherein M is a metal ion, and the metalorganic frame material is a three-dimensional network structure formed by coordination bonds or intermolecular forces from a transition metal ion or alkaline earth metal ion and gallic acid. The metalorganic frame material has a large adsorption capacity for the acetylene and an excellent selectivity for adsorption and separation of ethylene/acetylene. The materials for the synthesis of the material is cheap and easy to obtain, the material preparation process is simple, and the cost is low; and the material has good regeneration and repetition performance, can still maintain the original adsorption effect after vacuum or heating regeneration, and has broad industrial application prospects.

The invention discloses a method for synthesizing 2-methylacrolein into 2-methyl allyl alcohol by using a catalytic hydrogenation method, belonging to the technical field of synthesis of organic intermediates. A catalyst used in the method is recyclable. The synthesis method comprises the following steps of: (1) adding 2-methylacrolein, a catalyst, a polymerization inhibitor and a high-boiling-point solvent into a high-pressure kettle and introducing hydrogen for reacting; (2) after reacting, exhausting excessive hydrogen and rectifying reaction liquid to obtain 2-methylacrolein; and (3) adding the 2-methylacrolein and the solvent into residual liquid in a rectifying kettle, transferring into the high-pressure kettle and undergoing a reaction for preparing 2-methylacrolein through hydrogenation to realize the recycling of the catalyst. The method has the advantages of atom economy, environmental friendliness, high yield, simple post-treatment and the like.

A F-Si lubricating oil is prepared from the mixture of fluoric alkylmethyl dichlorosilane and dihydroxy dichlorosilane through dechlorimating by metallic oxide, synthesizing multiple elements mixed fluoric cyclosilane, and opening-loop polymerizing under trigger of strong acid. Its advantage is high performance.

The invention relates to a preparation method of a phosphinobenzene compound. The method is characterized in that a bromobenzene compound reacts with magnesium to prepare a Grignard reagent, and the Grignard reagent reacts with a chlorophosphine compound under the catalysis of tetrakis(triphenylphosphine)palladium to obtain the phosphinobenzene compound. The method concretely comprises the following steps: preparing the Grignard reagent from the bromobenzene compound, magnesium chips and an organic solvent under the protection of insert gas, and refluxing for 2-10h; adding tetrakis(triphenylphosphine)palladium at room temperature, stirring for 10min-3h, adding the chlorophosphine compound at room temperature in a dropwise manner, and carrying out a refluxing reaction for 1-10h; and adding an aqueous solution of saturated weakly-acidic and weakly-alkaline salt to the above obtained reaction solution in a dropwise manner in ice-water bath, carrying out liquid separation, removing the solvent from the obtained organic phase, adding an alcohol solvent for crystallizing, and filtering obtained crystals to obtain the phosphinobenzene compound. The preparation method has the advantages of great increase of the preparation yield, simple post-treatment, omitting of the repeated ammonia water washing process, preparation process simplification, and facilitation of large-scale industrial production.

The invention discloses a ferriporphyrin organic frame material peroxidase mimic. The erriporphyrin organic frame material is prepared from 1,6,7,12-tetrachloro-3,4,9,10-tetracarboxylic acid dianhydride and 5,10,15,20-tetra(4-aminophenyl) porphyrin iron through a solvothermal technology. The ferriporphyrin organic frame material has excellent peroxidase-like catalysis activity, can rapidly and effectively catalyze 3,3',5,5'-tetramethyl benzidine oxidation for generating a typical blue solution in the presence of hydrogen peroxide, and can be used for detecting low-concentration H2O2, and the absorbance of a catalysis product is linearly related with the concentration, in a concentration range, of the hydrogen peroxide. The linear range of detection H2O2 is 1-200 [mu]M, and the detection limit is 0.14 [mu]M.

The invention discloses application of a beta-diimide bivalent rare earth boron hydrogen complex in catalysis of hydroboration reaction of ketone and boron hydride. Beta-diimide rare earth dichloride and NaBH4 react in a tetrahydrofuran solvent, and in-situ Na/K reduction is carried out, so that the beta-diimide bivalent rare earth boron hydrogen complex, namely [2,6-ipr2-(C6H3)-NC(Me)CHC(Me)N-(C6H3)-2,6-ipr2]Ln-BH4.2THF, is obtained. The beta-diimide bivalent rare earth boron hydrogen complex disclosed by the invention can catalyze the hydroboration reaction of ketone and boron hydride with high activity under mild conditions and has the advantages of short reaction time and mild reaction conditions, and an aftertreatment method is simple and convenient.

The invention relates to a preparation method of a zinc oxide microsphere with a nanoflower-shaped microstructure. The method comprises the following steps of: (1) preparing a solution, to be specific, preparing a soluble zinc salt into an aqueous solution, and preparing a soluble alkali into an aqueous solution; (2) mixing the solutions, to be specific, mixing the soluble zinc salt aqueous solution with the soluble alkali aqueous solution at the room temperature in the volume ratio of 1:10-10:1, slowly pouring an aqueous solution of a soluble zinc salt into the aqueous solution of the soluble alkali, and stirring to obtain a clarifying solution; and (3) preparing a product, to be specific, pouring a weakly-acid solution into the clarifying solution obtained in the step (2), wherein the volume ratio of the weakly-acid solution to the clarifying solution is 1:10-10:1, stirring to obtain a turbid solution containing a large quantity of products, repeatedly washing with deionized water and absolute ethyl alcohol, and drying in a baking oven to obtain a final product. Compared with the prior art, the method has the advantages of capability of rapidly, easily and conveniently preparing a product under the room temperature condition, high yield, low cost, environmental friendliness, wide raw material selection range and contribution to industrial production.

The invention provides a method for synthesizing o-phenylenediamine from ortho-nitroaniline by virtue of catalytic hydrogenation. The method comprises the following steps: firstly, adding ortho-nitroaniline and a palladium-carbon catalyst into a high-pressure reaction kettle, introducing nitrogen to exhaust air in the kettle, and then introducing hydrogen to exhaust nitrogen in the kettle; secondly, heating and introducing hydrogen, performing catalytic hydrogenation reduction reaction under the conditions that the temperature is 110 DEG C and the pressure is 1.0MPa, reacting for 7-8 hours, then stopping introducing hydrogen, water-cooling, then filtering to recycle the catalyst, and collecting a filtrate after filtration to obtain o-phenylenediamine. According to the method provided by the invention, a raw material namely ortho-nitroaniline is subjected to direct hydrogenation without using a solvent, so that the consumption of the solvent can be greatly reduced, the after-treatment energy consumption can be saved, and large-sized solvent steaming equipment can be saved; and by adopting the method, a separation process can be simplified, the equipment investment, separation energy consumption, material consumption and environmental pollution can be reduced, and the system productivity and production safety can be improved.

The invention relates to a method for preparing alpha-amino alcohol by taking alpha-amino acid as raw material and a catalyst used in the method and a preparation method for the catalyst. The catalyst consists of three components; a first component is selected from the elements of Ru and Pd and one or more salts and oxides thereof; a second component is selected from the elements of cuprum, nickel, iron, bismuth, stannum, cadmium, magnesium, aluminum, cobalt, lead, titanium, selenium, zinc, zirconium, germanium, rhodium and cerium and one or more of oxides and salts thereof; a third component is a carrier. The alpha-amino acid is deoxidized by hydrogen in a water solution or the mixed solution of water and a water-miscible dissolvent in the effect of the catalyst and synthesized into the alpha-amino alcohol with one-step method. The method is characterized by simple steps, short production period, little pollution, and low production cost, etc.

The invention relates to a method for preparing Nesiritide. In the method, HMPB-AM resin is taken as an initial raw material, amino acids with Fmoc blocking groups are sequentially connected in a solid phase synthesis way under the action of condensing agent and transpeptidase reagent to obtain side chain full-protection linear Nesiritide HMPB-AM resin; linear Nesiritide raw peptides are obtained by schizolysis, Nesiritide raw peptides are obtained by liquid phase oxidation, and Nesiritide fine peptides are obtained by purification, salt transfer and freeze drying. The invention has the advantages of simple operation, easy post treatment, few raw materials, low cost, high yield coefficient, and the like, thereby having considerable economy and utility value and also having extensive application prospect in the polypeptide drug design synthesis field.

The invention discloses a preparation method for a functional film capable of simultaneously realizing oil-water emulsion separation and dye removal. The method comprises the following steps: (1) preparing a polymer matrix solution; and (2) combining a hydroxyl-containing substrate with the polymer matrix solution, and enabling acceleration of gelation and introduction of charged functional groupsto be realized in one step to obtain the functional film capable of simultaneously realizing the oil-water emulsion separation and the dye removal. According to the method disclosed by the invention,the polymer matrix solution gives high specific surface energy to the hydroxyl-containing substrate, so that super-hydrophilic underwater super-oleophobic performance is obtained, and high-efficiencyseparation of oil and water can be realized; and the charged functional groups are introduced, organic dye is adsorbed through electrostatic interaction, so that the organic dye is removed, and finally dye pollutants are removed while an oil-water emulsion is separated only by gravity.

This invention involves an industrial scale preparation method for hydroxyacetonitrile by using acrylonitrile production byproduct hydrocyanic acid through a synthesis reaction with acetonitrile at the presence of catalyst. The method is characterized by (1) taking acrylonitrile production byproduct hydrocyanic acid as the raw material with content of 95% or above, (2) controlling a molar ratio of hydrocyanic acid : formaldehyde : catalyst at 1 : 1.0~1.5 : 0.001~ 0.015, (3) adding catalyst in formaldehyde while stirring, adding hydrocyanic acid at 0-20DEG C, and reacting at 0~40DEG C for 1~6 h, and (4) adjusting pH of 6 or below with inorganic acid to obtain hydroxyacetonitrile. The invention has the advantages of low cost, product content of 50% or above, simplified aftertreatment, no wastes discharge, and product with formaldehyde and hydrocyanic acid content less than 0.05%. Hydroxyacetonitrile can be used as the intermediates of glycin, malononitrile, and indigo dye to solve transport inconvenience of hydrocyanic acid and geographical limitation of production.

The invention relates to a closed wearable panoramic photographing and processing system and an operation method thereof. The system comprises a camera assembly and a built-in processor; the built-in processor comprises a video image processor, a computing processor, a coding processor and a built-in/built-out storage medium; the system also comprises a built-in gravity sensing, acceleration sensing and compass and gyroscope chip; the chip is used for detecting actions in photographing and wearing, thus carrying out anti-shake processing to the photographing contents, determining photographing directions and/or being used for other man-machine interaction applications; the system also comprises a virtual reality display, a near-eye display or a general liquid crystal display for receiving and displaying the processed video signals transmitted from the built-in processor, and a built-in power supply for supplying power to each component of the closed wearable panoramic photographing system. The closed wearable panoramic photographing and processing system provided by the invention is compact in appearance and strong in function and is convenient for a user to wear.

The invention relates to a novel preparation of a green chelating agent glutamic diacetate tetracetic acid metal salt. The preparation comprises the steps of synthesizing GLDA-4Na tetrasodium glutamate diacetate (GLDA-4M) through L-glutamic acid, 2-chloroacetonitrile organic alkali, zinc chloride and sodium hydroxide; carrying out cyanation and hydrolysis of L-glutamic acid to obtain the aqueous solution of the GLDA-4Na; and then carrying out decolorizing and concentrating to obtain the product. According to the preparation, the 2-chloroacetonitrile organic alkali is adopted to replace the common HCN (hydrogen cyanide) in the prior art, so that the use of the extremely toxic substance is reduced, and the produced wastewater can be easily processed; and green chelating agent glutamic diacetate tetracetic acid metal salt has high yield, high purity, and low cost, and is simple in technology, and easy to realize post-treatment to the wastewater, and achieve industrial production.

The microwave polysaccharide degrading process includes compounding polysaccharide solution of 5-150 g/L concentration and adding acid in concentration of 0.1-2.5 mol/L; setting the solution inside microwave generator and regulating power to 50-300 W to degrade at 10-90 deg.c for 1-30 min; and neutralizing pH to 7 with alkali, dialyzing to eliminate generated small molecular salt and freeze drying to obtain polysaccharide oligomer. The polysaccharide is originated from plant, animal and microbe and has numerically average molecular weight of 5-2000 KDa. The present invention has simple technological process, low cost and less pollution. The said technological process makes it possible to obtain various polysaccharide in specific molecular weight section and with greatly raised clinical bioavailability.

The invention provides a preparation method of propacetamol hydrochloride. The preparation method is characterized in that chloracetyl chloride and paracetamol carry out an acetylization chloride reaction in a polar aprotic solvent to obtain chloroactic acid-4-acetylamino phenyl ester which is directly aminated with diethylamine to obtain N, N'-diethylglycine 4-acetylamino phenyl ester, hydrochloric acid is used for adjusting the pH to be 4, and the propacetamol hydrochloride is obtained. The preparation method has the advantages of mild condition, convenient separation and purification, the total product yield is greatly increased, the use of the amount of the reaction solvent is low, and the preparation method reduces industrial pollution, and is applicable to industrialized production.

The invention discloses a 3-Schiff base-2(1H)-quinolinone derivative and a preparation method and application thereof. The 3-Schiff base-2(1H)-quinolinone derivative is prepared by disposing 3-formaldehyde base-2(1H)-quinolinone or 3-formaldehyde base-6 methyl-2(1H)-quinolinone, primary-amine-contained compound and organic solvent into a reactor and condensing at the temperature of 80-100 DEG C. Compared with antioxidant activity of the 3-formaldehyde base-2(1H)-quinolinone or the 3-formaldehyde base-6 methyl-2(1H)-quinolinone, the antioxidant activity of the 3-Schiff base-2(1H)-quinolinone derivative is enhanced obviously. The structural formula thereof is shown as the formula (I), wherein the R1 is H or methyl, and the R2 is aromatics substituent or aliphatic hydrocarbon substituent.

The invention discloses a preparation method for an organic silicone thickening agent. The method comprises the following steps: (1) using dimethyl terminal hydroxy silicone oil, vinyl trimethoxy silane and 3-glycidoxypropyltrimethoxysilane as raw materials, adding barium hydroxide monohydrate, and performing a non-hydrolytic sol-gel reaction under heating and stirring conditions to prepare a crude product of the thickening agent; and (2) firstly performing reduced-pressure filtration on the crude product prepared in the step (1), and performing reduced-pressure distillation on the filtrate, so as to prepare the organic silicone thickening agent. The prepared organic silicone thickening agent provided by the invention is a colorless transparent viscous liquid, has low viscosity and is easyto use; and the preparation process has simple operation and good repeatability and controllability, does not use an organic solvent, saves energy, protects the environment, can obviously improve bonding strength between silicone rubber and a copper substrate, and has good compatibility.

A spherical nickel hydroxide used as positive electrode with high-multiple charging-discharging power has a chemical formula: Ni1-xMx(OH)2, where M is chosen from Co, Zn, Cd, Mn, Mg, Ca, Fe, Al and their mixture and x=0.1-15. It is prepared through adding the solution of M's inorganic salt, Ni salt solution, ligand compound solution and alkaline solution to basic liquid in reactor, reacting whilecontrolling Ni ions concentration, pH value and stirring speed, and treating by hot alkali. The battery with it has high specific energy and long service life.

The invention discloses a method for preparing 6-hydroxy-2(1H)-quinolone in ionic liquid by using a one-pot method. The invention synthesizes the 6-hydroxy-2(1H)-quinolone by through bromination, acidation and intramolecular Heck reaction of p-methoxy aniline and acryloyl chloride as raw materials in the ionic liquid by using the one-pot method. The method has simple synthesis line, low product cost and high yield, is environmental friendly and is easy to realize industrial production.

The invention discloses a self-thermal-insulation mortar including, by weight, 20-40 parts of cement, 5-60 parts of yellow sand and 1-8 parts of a main activator, wherein the main activator is hydrotalcite or a hydrotalcite-like material. In the formula of the self-thermal-insulation mortar, the cement, the yellow sand and the main activator are compounded so that a synergetic effect is achieved. A complex reaction between microscale polyvalent metal ions in the cement and the main activator is carried out, and then the microscale polyvalent metal ions is complexed at a quartz sand-water interface or a silicon dioxide-water interface for activating surfaces of the cement and the quartz sand to change a conventional stacking status of the cement, thereby forming a giant network complexing structure in the system. Meanwhile, when the main activator is complexed with the microscale polyvalent metal ions, interlayers in the main activator is expanded to uniformly form nanopores of which diameters are about 1-5 nm, so that the building block is excellent in strength, thermal-insulating performance, water-retaining property, constructability and the like.

A process for preparing sodium chlorite includes such steps as dissolving hydrogen peroxide and solid sodium chlorate in water, adding the resultant solution along with sulfuric acid to a ClO2 generator to generate the mixture of ClO2 and oxygen, loading the mixed absorbing liquid containing sodium hydroxide and hydrogen peroxide into an absorbing tower, adding ClO2 to the absorbing tower while escaping oxygen, and finally generating sodium chlorite. Its advantages are high output rate (more than 95%) and high purity (more than 95%) of product.

The invention relates to a preparation method of N,N-dimethylglycine and belongs to the field of chemical engineering. The preparation method comprises the following steps of: preparing N,N-dimethyl amino acetonitrile by taking hydroxyacetonitrile and dimethylamine as raw materials, obtaining an N,N-dimethylglycine crude product by alkalizing the reaction liquid with an inorganic base and neutralizing the reaction liquid with an organic acid on the basis of N,N-dimethyl amino acetonitrile reaction liquid, and finally separating and purifying the N,N-dimethylglycine crude product to obtain the high-quality N,N-dimethylglycine product. The preparation method has the advantages that the raw materials are environmentally-friendly and easily available, reaction conditions are mild, the environmental pollution is little, the after-treatment is simple and easy, the production efficiency is high, and the preparation method is suitable for industrial popularization and application.

The invention discloses a preparation method of alpha-chloro-alpha-acetyl-gamma-butyrolactone. The method comprises the steps that alpha-acetyl-gamma-butyrolactone is cooled to low temperature, chlorine is introduced at the temperature, the saturation state of chlorine is kept, reacting is conducted for 5 h or above, after reacting is finished, introduction of chlorine is stopped, nitrogen is introduced to drive excess chlorine in a system and hydrogen chloride gas generated through reacting away, washing is conducted with a sodium bicarbonate aqueous solution, and a target product is obtained. Under the low temperature condition, alpha-acetyl-gamma-butyrolactone reacts with chlorine to generate the target product, a traditional chloride reagent such as sulfonyl chloride is substituted with cheap chlorine, generation of waste gas such as sulfur dioxide is avoided, the reaction time is shortened, aftertreatment of reacting is simplified, the yield of the product alpha-chloro-alpha-acetyl-gamma-butyrolactone is increased to 98% or above from 90%, the production cost is greatly lowered, and a positive effect is achieved for industrial development of prothioconazole.