1 results about "MBHA resin" patented technology

The invention belongs to the technical field of biomedical materials, and particularly relates to a targeted NPY polypeptide nuclide ligand as well as a preparation method and application thereof. The structural formula of the targeted NPY polypeptide nuclide ligand is as shown in formula (1), wherein L is a metal chelating agent. The preparation method comprises the following steps: (1) adding tyrosine, an activating agent, a condensing agent and a solvent into Rink Amide MBHA Resin, reacting at room temperature for 1-5 hours, and grafting tyrosine on the Rink Amide MBHA Resin; (2) adding arginine, an activating agent, a condensing agent and a solvent, reacting at room temperature for 1-5 hours, grafting arginine, and sequentially grafting glutamine, arginine, tryptophan, isoleucine, proline, asparagine, asparagine, tyrosine, histidine, arginine and a metal chelating agent according to the steps, so as to obtain polypeptide resin L-Arg-His-Tyr-Asp-Asp-Pro-Iso-Try-Arg-Gln-Arg-Tyr-Rink Amide MBHA Resin; and (3) adding the obtained polypeptide resin into a lysis solution, and reacting at room temperature for 1-5 hours to obtain the targeted NPY polypeptide nuclide ligand with good in-vivo and in-vitro stability.