Antibacterial active peptide

Abstract

The invention discloses an antibacterial active peptide. An amino acid sequence of a polypeptide molecule of the antibacterial active peptide is Ac-RRPVPIIYCNRRKGRCQKM-NH2; a preparation method of theantibacterial active peptide comprises the following steps: by taking Rink-MBHA resin as a solid phase carrier, and adding the Rink-MBHA resin into a main reaction kettle and carrying out treatment;carrying out amino acid condensation by adopting a linear synthesis mode, and performing drying in a vacuum dryer after synthesis to obtain peptide resin; and cracking the peptide resin to obtain a polypeptide crude product, and purifying the polypeptide crude product to obtain the antibacterial active peptide. The antibacterial active peptide disclosed by the invention is high in antibacterial activity, has a remarkable antibacterial effect when the concentration is 10mu g / ml, is wide in antibacterial spectrum, and has a remarkable antibacterial effect on escherichia coli, staphylococcus aureus, candida albicans and the like; the antibacterial active peptide destroys cell membranes of bacteria through a physical effect so as to achieve the antibacterial purpose, drug resistance is not generated, and the antibacterial active peptide raw material is low in price, easy to obtain, easy to prepare and produce and capable of bringing a better use prospect.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to an antibacterial active peptide. Background technique [0002] Commonly used antibacterial drugs include various antibiotics, sulfonamides, imidazoles, nitroimidazoles, and quinolones. These small molecular compounds generally have special receptors when they are antibacterial. For example, antibiotics generally achieve the purpose of sterilization by inhibiting the synthesis of bacterial cell walls, proteins or DNA, etc. Therefore, bacteria are easy to develop drug resistance through mutation. Over the past few decades, there has been growing concern over the increasing resistance of bacteria to antibiotics, which in some cases may even lead to infections such as methicillin-resistant Staphylococcus aureus (MRSA). , the emergence of superbugs such as vancomycin-resistant bacteria (VRE); [0003] Due to the problem of drug resistance of existing small molecule antibacterial drugs, pa...

AI Technical Summary

Problems solved by technology

[0003] Due to the problem of drug resistance of existing small molecule antibacterial drugs, pathogenic bacteria are becoming more and more evolved, and the development of antibacterial drugs is becoming more and more difficult

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