72 results about "Sh groups" patented technology

Processes for preparing modified pigments are described. In one embodiment, the process comprises the step of combining, in any order, a pigment having attached an electrophilic group and a thiol reagent comprising at least one —SH group and at least two ionic or ionizable groups. In a second embodiment, the process comprises the step of combining, in any order, a pigment having attached an electrophilic group and a thiopolymer comprising at least one —H group. Modified pigments are also described.

A fluxing composition comprises a fluxing agent in which the fluxing agent is a compound having (i) an aromatic ring, (ii) at least one —OH, —NHR (where R is hydrogen or lower alkyl), or —SH group (iii) an electron-withdrawing or electron-donating substituent on the aromatic ring, and (iv) no imino group.

A curable composition containing an inorganic compound A having sulfur atom and/or selenium atom, a compound B represented by the following formula 1:

wherein m is an integer from 0 to 4, and n is an integer from 0 to 2,

and a compound C selected from the group consisting of thiol compounds having one SH group and disulfide compounds which are other than the compound B and have one or more disulfide linkages. The inorganic compound A is contained in an amount from 1 to 50 parts by weight and the compound B is contained in an amount from 50 to 99 parts by weight when a total of the inorganic compound A and the compound B is taken as 100 parts by weight. The compound C is contained in an amount from 1 to 20 parts by weight based on 100 parts by weight in total of the inorganic compound A and the compound B. The curable composition causes little increase in the viscosity even when subjected to prepolymerization and deaeration, thereby facilitating the operation of cast polymerization for producing optical materials, etc.

An emulsion composition for building exterior walls is provided comprising in admixture, [A] a graft copolymerized emulsion obtained by adding to (1) an oil-in-water type emulsion containing at least one organopolysiloxane having an organic group containing a radical reactive group or SH group, (2) a monomer or monomeric mixture containing at least 70 wt % of at least one monomer selected from acrylic and methacrylic monomers and effecting emulsion graft polymerization of component (2) to the organopolysiloxane, and [B] a silicone resin-containing emulsion. The emulsion composition is capable of forming an elastic, flexible coating which is endowed with water resistance, weather resistance, water repellency, adhesion and heat resistance and maintains these properties over a long period of time. It can thus be used as a base in a variety of paints and coating agents.

Provided are a polymerizable composition for giving a resin which has a high refractive index and low dispersion, and is especially excellent in impact resistance and tintability; and a resin and an optical component each obtained by curing the composition. There used a polymerizable composition comprising (A) a compound represented by Formula (1) and/or by Formula (2), at least one compound as the following component (B), and at least one compound as the following component (C):

HO—[R1-(Y)_n]_m—R2-X  (3)

• • (in above Formula (3), X is an OH group or a SH group; Y is an oxygen atom or a sulfur atom; R1 and R2 are each independently an optionally substituted methylene group or an optionally substituted alkylene group having carbon atoms of not smaller than 2 and not larger than 4; n is an integer of 0 or 1 when Y is an oxygen atom, or 0 or an integer of not smaller than 1 and not larger than 2 when Y is a sulfur atom; and m is 0 or an integer of not smaller than 1 and not larger than 3, provided that (carbon number of R1+n)×m+(carbon number of R2) is 3 or larger).

The present invention provides a polymerizable composition for giving a resin which has a high refractive index and low dispersion, and is especially excellent in impact resistance and tintability; and a resin and an optical component each obtained by curing the composition. There used a polymerizable composition comprising (A) a compound represented by Formula (1) and/or by Formula (2), at least one compound as the following component (B), and at least one compound as the following component (C): (B) polythiol compounds optionally having at least one (poly)sulfide bond in a molecule, and (C) compounds represented by Formula (3): HO-[R1-(Y) n ] m -R2-X (3) (in above Formula (3), X is an OH group or a SH group; Y is an oxygen atom or a sulfur atom; R1 and R2 are each independently an optionally substituted methylene group or an optionally substituted alkylene group having carbon atoms of not smaller than 2 and not larger than 4; n is an integer of 0 or 1 when Y is an oxygen atom, or 0 or an integer of not smaller than 1 and not larger than 2 when Y is a sulfur atom; and m is 0 or an integer of not smaller than 1 and not larger than 3, provided that (carbon number of R1+n) m + (carbon number of R2) is 3 or larger).

Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to novel compounds achieved by nitrosylation of protein thiols. Such compounds include: S-nitroso-t-PA, S-nitroso-cathepsin; S-nitroso-lipoprotein; and S-nitroso-immunoglobulin. The invention also relates to therapeutic use of S-nitroso-protein compounds for regulating protein function, cellular metabolism and effecting vasodilation, platelet inhibition, relaxation of non-vascular smooth muscle, and increasing blood oxygen transport by hemoglobin and myoglobin. The compounds are also used to deliver nitric oxide in its most bioactive form in order to achieve the effects described above, or for in vitro nitrosylation of molecules present in the body. The invention also relates to the nitrosylation of oxygen, carbon and nitrogen moieties present on proteins and amino acids, and the use thereof to achieve the above physiological effects.

The present invention relates to compositions and methods of use to increase the bioavailability of a carotenoid in a subject. The compositions include a carotenoid and either an anthocyanin or a compound having at least one —SH group or combinations of both an anthocyanin and a compound having at least one —SH group and mixtures thereof. The compositions provide that when the composition is administered, the resulting bioavailability of the carotenoid is increased relative to a carotenoid composition that is without either the anthocyanin, is without the compound having at least one —SH group or is without the combination of an anthocyanin/a compound having at least one —SH group and mixtures thereof.

The problems can be solved by using a method for producing a metal nanoparticle colloid, which comprises the steps of S1: mixing, into a nonpolar hydrocarbon oil having a vapor pressure of 10⁻³ Torr or less at room temperature, organic molecules having both a hydrophilic group and a lipophilic group and having in the end of the hydrophilic group an N, S, P, or O atom or having at the hydrophilic group a functional group of an NH₂ group, an NH group, an SH group, a PO group, or an OH group to prepare a base liquid, and S2: placing the base liquid in a rotatable vacuum drum and charging a non-magnetic metal material in a crucible provided in the vacuum drum, and depositing the vapor of the non-magnetic metal material on the base liquid which adheres to the inner wall of the vacuum drum and rotates together with the rotating drum under conditions such that the inside of the vacuum drum is under a reduced pressure and the vacuum drum is rotated, and a task of the present invention is to provide a method for producing a metal nanoparticle colloid having non-magnetic metal nanoparticles having various shapes.

The invention relates to a novel complex for oral delivery of drugs, therapeutic protein/peptides and vaccines which are loaded in a Vitamin B2 (VB12) coupled particulate carrier system with spacers in between, the carrier system with spacers having a formula VB12-R'/R''-N wherein, R' or R'' is spacer and/or agents for derivatization of VB12 to provide either NH2 or COOH or SH groups, and N is the micro or nano particle carriers for the delivery of injectable drugs, therapeutic protein/peptides and vaccines.

Disclosed is a stable organic thin film transistor having good switching property and a process for manufacturing an organic thin film transistor by a simple method. The organic thin film transistor comprises a substrate and provided thereon, at least a source electrode, a drain electrode, an organic semiconductor connecting the source electrode and the drain electrode, a gate electrode, and an insulating layer composed of a plurality of layers, the insulating layer being provided between the gate electrode and the organic semiconductor, wherein the organic thin film transistor comprises a mercapto group-containing compound represented by the following formula (I),

Formula (I)

(R)_n—Si(A)_3-n—(B)

wherein R represents an alkyl group having a carbon atom number of not more than 8; A represents an alkoxy group or a halogen atom; B represents a substituent containing an SH group; and n is an integer of from 0 to 2.

The present invention relates to a method for detecting a protein having a disulfide bond or an allergen protein, comprising: protecting by chemically modifying a free SH group of a protein in a sample to be tested; cleaving a disulfide bond of the free SH group-protected protein to expose SH groups; and detecting the exposed SH groups.

The present invention relates to a fluorescence sensor capable of real-time imaging for measuring a cellular thiol level. The present invention reveals that the fluorescence intensity of the fluorescent real-time SH group-tracer (FreSH-Tracer) of the present invention increases or decreases continuously, ratiometrically or reversibly depending on the thiol level in living cells, and thus can be usefully used as a biosensor which is remarkably susceptible to quantitative or qualitative real-time detection of the cellular thiol level in living cells.

The present invention relates to a compound of formula (I):

wherein: V and U are hydrogen, halogen, C₁-C₄ alkylamino, or together form a group that contains one or more heteroatoms, and that taken together with one or more:

• • (a) hydrogen atoms;
  • (b) carbon atoms;
  • (c) —CH═ groups;
  • (d) —CH₂— groups; or
  • (e) additional heteroatoms of the same or different type;

or any combination thereof, form a 4-7 membered homocyclic or heterocyclic ring, wherein the homocyclic or heterocyclic ring may combine with the phenyl group to form a bicyclic ring, and wherein the homocyclic or heterocyclic ring or the bicyclic ring may contain one or more oxo, thioxo, amino, mercapto, trifluoromethyl, C₁-C₄ alkyl, ═S or —SH groups;

W: is —CO—, —CH₂— or —CH₂—(C₁-C₄ alkyl)-;

X: is —CO—;

Y: is —O—, C₁-C₄ alkylene, C₁-C₄ alkynylene, cycloalkylene, aminocarbonyl, —NH—, —N(C₁-C₄ alkyl)-, -C₁-C₄ alkylene-N(C₁-C₄ alkyl)-, —CH₂O—, —CH(OH)— or —OCH₂—;

Z: is hydrogen, halogen, nitro, amino, C₁-C₄ alkyl, C₁-C₄ alkoxy, cyano, trifluoromethyl, hydroxyl or carboxyl;

R¹ and R²: are hydrogen, or together form a C₁-C₃ bridge; and

n and m: independently are 0-3, wherein n and m cannot each be 0;

or an optical antipode, racemate or pharmaceutically-acceptable salt thereof. The carboxylic acid amide derivatives of formula (I) are highly effective and selective antagonists of the NMDA receptor.

The invention discloses a long-acting mildew-proof sealant composition, which consists of trimethoxy-terminated polydimethylsiloxane, nano-silver anti-mold agent, hydroxyl scavenger, cross-linking agent, coupling agent and catalyst. The hydroxyl scavenger is a silicon nitrogen heterocyclic compound. Compared with the prior art, the long-acting anti-mildew sealant composition of the present invention uses a silicon nitrogen heterocyclic compound as a hydroxyl scavenger, has good compatibility with the alcohol-type silicone sealant system, and can significantly improve the single-component sealant composition. Dealcoholized silicone rubber has a long storage life and can effectively improve the adhesion of the substrate; the introduction of nano-silver antibacterial agent can continuously and stably release silver ions into the bacteria through ionization, allowing them to penetrate the cell wall into the cell and react with the SH group , to coagulate the protein, destroy the activity of cell synthetase, and then release it again, so as to maintain the anti-mildew and anti-bacterial effect for a long time, with environmental protection, non-toxic, high-efficiency, stable and long-lasting anti-mold and anti-bacterial effect.

A nanoparticle contains a core including superparamagnetic nanoparticles and having an outer surface, and siloxanyl moieties covalently coupled to the outer surface of the core and having Formula (I):

In formula (I): X¹ and X² independently represent methylene, ethylene or propylene; R represents an optionally substituted pyridyl group, or —S—R is a group derived from a targeting ligand containing —SH group and effective to bind specifically with a predetermined targeted cell in an object; n and m independently represent an integer ranging from 1 to 3; and p represents an integer ranging from 9 to 45. The nanoparticles are suitable for use as a magnetic resonance imaging contrast agent.

[Problem] To provide the following: a novel fluorescent probe for detecting a compound, such as glutathione, that contains a —SH group; a detection method using said fluorescent probe; and a detection kit containing said probe.

[Solution] A fluorescent probe for detecting a compound containing an —SH group, wherein the fluorescent probe comprises a compound represented by formula (I) or a salt thereof (In the formula, X represents Si(Ra)(R^b), Ge(R^a)(R^b), Sn(R^a)(R^b), C(R^a)(R^b), or O (wherein R^a and R^b each independently represent a hydrogen atom or alkyl group); R¹ represents a hydrogen atom, or 1-4 identical or different substituents independently selected from the group consisting of a cyano group, alkyl group, carboxyl group, ester group, alkoxy group, amide group, and azide group, each of which may be optionally substituted; R² represents a hydrogen atom, halogen atom, hydroxyl group, cyano group, or an alkyl group, alkynyl group, alkoxy group, aryl, or heteroaryl, each of which may be optionally substituted; R³ and R⁴ each independently represent a hydrogen atom or 1-3 identical or different substituents independently selected from the group consisting of a hydroxyl group, halogen atom, or an alkyl group, sulfo group, carboxyl group, ester group, amide group and azide group, each of which may be optionally substituted; R⁵, R⁶, R⁷ and R⁸ each independently represent a hydrogen atom or alkyl group, wherein, R⁵ or R⁶, respectively together with R³, may form a ring structure including the nitrogen atoms bonded thereto, or R⁷ or R⁸, respectively together with R⁴, may form a ring structure including the nitrogen atoms bonded thereto).

The invention discloses a preparation method for synthesizing proteidin with a solid phase peptide. The technical scheme of the invention comprises the following steps of: connecting amino acids with Fmoc-protection groups in sequence by taking Rink Amide MBHA resin as an initial raw material and taking HBTU/HOBt as a concentration agent according to a solid phase synthesis method to obtain protected heptadeca-peptide resin, wherein Boc-Arg-OH.HCl is taken as a last amino acid; adding a peptide cutting reagent for cutting peptides; adding diethyl ether for precipitating to obtain a reduced crude product; protecting the -SH groups of 5-bit and 14-bit Cys with Trt; oxidizing with hydrogen peroxide at the pH 8.5-10.0; protecting the -SH groups of 7-bit and 12-bit Cys with Acm; oxidizing with iodine in a methanol solution to obtain a dual disulfide bond Cys5-14Cys7-12 crude product; and separating by adopting a C8 high-efficiency liquid phase column for purifying to obtain a target product, wherein the purity of the target product is 99.21 percent, and the total yield is 23.68 percent. The method has the advantages of low production cost, simple process, low environmental pollution, high yield and convenience for industrial implementation.

In the present invention, provided is a method of forming a conductive pattern exhibiting excellent adhesion of the conductive pattern to a substrate and high fine line reproduction via a simple process, and an organic thin film transistor exhibiting excellent element properties. Disclosed is a method of forming a conductive pattern, possessing a step of treating a substrate surface employing a compound represented by the following Formula (1), a step of decomposing the compound represented by Formula (1) via a photocatalytic action, and a plating step: Formula (1) (R)_n—Si(A)_3-n-(B) wherein R represents an alkyl group having 8 carbon atoms or less, A represents an alkoxy group or a halogen atom, B represents a substituent comprising a SH group, and n represents an integer of 0-2.