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184 results about "Methylating Agent" patented technology
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In reverse methanogenesis, methane serves as the methylating agent. [citation needed]O-Methyltransferases. A wide variety of phenols undergo O-methylation to give anisole derivatives. This process, catalyzed by enzymes such as caffeoyl-CoA O-methyltransferase, is a key reaction in the biosynthesis of lignols, percursors to lignin, a major structural component of plants.
Process for producing cyclic compounds
Owner:BATTELLE MEMORIAL INST
Aromatic aklylating agent and an aromatic production apparatus
InactiveUS20110178354A1Increase the molar ratioIncrease valueHydrocarbonsHydrocarbon by hydrocarbon condensationAlkaneMethylating Agent
One exemplary embodiment can be a process using an aromatic methylating agent. Generally, the process includes reacting an effective amount of the aromatic methylating agent having at least one of an alkane, a cycloalkane, an alkane radical, and a cycloalkane radical with one or more aromatic compounds. As such, at least one of the one or more aromatic compounds may be converted to one or more higher methyl substituted aromatic compounds to provide a product having a greater mole ratio of methyl to phenyl than a feed.
Owner:UOP LLC
Methods and compositions for treating Parkinson's disease
InactiveUS20070004639A1Low carbohydrateHigh in proteinBiocideNervous disorderMethylating AgentMedicine
The invention as disclosed herein provides pharmaneutical compositions and methods for treating, ameliorating, or preventing the symptoms of Parkinson's Disease. The pharmaneutical compositions of the invention contain in an effective amount a first and a second composition, the first composition comprises an effective amount of one or more phosphatidylcholine formulations and the second composition comprises an effective amount of one or more constituents comprising essential fatty acid supplements, trace minerals, butyrate, electrolytes, methylating agents, reduced glutathione, or a combination thereof, in a suitable carrier.
Owner:BODYBIO INC
Process of manufacturing para-xylene
InactiveUS20090000988A1Reduce diffuseCatalytic naphtha reformingHydrocarbon from oxygen organic compoundsMolecular sieveMethylating Agent
This disclosure relates to a process of manufacturing para-xylene, comprising (a) contacting a pygas feedstock and methylating agent with a catalyst under reaction conditions to produce a product having para-xylene, wherein the product has higher para-xylene content than the para-xylene content of the pygas feedstock; and (b) separating the para-xylene from the product of the step (a), wherein the catalyst comprises a molecular sieve having a Diffusion Parameter for 2,2-dimethylbutane of about 0.1-15 sec−1 when measured at a temperature of 120° C. and a 2,2-dimethylbutane pressure of 8 kPa-a and the pygas comprises from about 1 to about 65 wt % benzene and from about 5 to 35 wt % toluene.
Owner:EXXONMOBIL CHEM PAT INC
Method of producing para-substituted aromatic hydrocarbon
ActiveUS20110009682A1High purityEfficient productionHydrocarbon by isomerisationMolecular sieve catalystsMethylating AgentIsomerization
This invention relates to a method of efficiently producing a high-purity para-substituted aromatic hydrocarbon while suppressing caulking without requiring isomerization-adsorption separation steps, and more particularly to a method of producing a para-substituted aromatic hydrocarbon, characterized in that a methylating agent and an aromatic hydrocarbon are reacted in the presence of a catalyst formed by coating MFI type zeolite having a particle size of not more than 100 μm with a crystalline silicate.
Owner:JX NIPPON OIL & ENERGY CORP
Pharmaceutical combinations comprising cd33 antibodies and de-methylating agents
InactiveUS20150125447A1Enhanced ADCC activityADCC activityOrganic active ingredientsAntibody ingredientsDiseaseMethylating Agent
The present invention relates to pharmaceutical combinations CD33 antibodies and de-methylating agents for use in treating diseases like MDS and cancer, especially AML.
Owner:BOEHRINGER INGELHEIM INT GMBH
Methods and compositions for treating symptomes of diseases related to imbalance of essential fatty acids
The invention as disclosed herein provides pharmaneutical compositions and methods for treating, ameliorating, or preventing the symptoms of fatty acids imbalance and cell membrane dysfunction. The pharmaneutical compositions of the invention contain in an effective amount a first and a second composition, the first composition comprises an effective amount of one or more phosphatidylcholine formulations and the second composition comprises an effective amount of one or more constituents comprising essential fatty acid supplements, trace minerals, phenylbutyrate, electrolytes, methylating agents, reduced glutathione, or a combination thereof, in a suitable carrier.
Owner:BODYBIO INC
Process of manufacturing para-xylene
InactiveUS7629498B2Catalytic naphtha reformingHydrocarbon from oxygen organic compoundsMolecular sieveMethylating Agent
This disclosure relates to a process of manufacturing para-xylene, comprising (a) contacting a pygas feedstock and methylating agent with a catalyst under reaction conditions to produce a product having para-xylene, wherein the product has higher para-xylene content than the para-xylene content of the pygas feedstock; and (b) separating the para-xylene from the product of the step (a), wherein the catalyst comprises a molecular sieve having a Diffusion Parameter for 2,2-dimethylbutane of about 0.1-15 sec−1 when measured at a temperature of 120° C. and a 2,2-dimethylbutane pressure of 8 kPa-a and the pygas comprises from about 1 to about 65 wt % benzene and from about 5 to 35 wt % toluene.
Owner:EXXONMOBIL CHEM PAT INC
Process for increasing a mole ratio of methyl to phenyl
InactiveUS20110178356A1Increase the molar ratioIncrease valueHydrocarbon by isomerisationLiquid carbonaceous fuelsMethylating AgentMethyl group
One exemplary embodiment can be a process for increasing a mole ratio of methyl to phenyl of one or more aromatic compounds in a feed. The process can include reacting an effective amount of one or more aromatic compounds and an effective amount of one or more aromatic methylating agents to form a product having a mole ratio of methyl to phenyl of at least about 0.1:1 greater than the feed.
Owner:UOP LLC
Method for preparing propylene by ethylene alkylation
The invention discloses a making method of propylene, which is characterized by the following: contacting raw material with ethylene and methylating agent and catalyst of molecular sieve with micropore aperture at 0. 3-0. 5nm under specific reacting condition; generating the product with propylene with selectivity over 65%.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Fiber-based product
InactiveUS20050061204A1Reduction in amount of boronReduce eliminateStarch dervative coatingsStarch adhesivesFiberCarboxymethyl cellulose
Fiber-based products and adhesives comprising the fiber-based products. The fiber-based products comprise carboxymethyl cellulose, carboxymethylated hemicellulose and carboxymethylated starch. The fiber-based product is obtained by simultaneously performing alkali extraction of hydrocolloid from the fiber and carboxymethylation, with a carboxymethylating agent, thereby converting extracted cellulose to carboxymethyl cellulose and also carboxymethylating some extracted hemicellulose, starch, and hemicellulose-cellulose complexes.
Owner:CORN PROD DEV INC
Method for producing guaiacol with methanol method
InactiveCN101492353AImprove product qualityHigh yieldMolecular sieve catalystsChemical recyclingMethylating AgentGuaiacol
The invention provides a method for preparing guaiacol by a methanol method. Methanol used as a methylating agent and pyrocatechol are used for synthesizing the guaiacol under the action of a solid acid catalyst in a high pressure vessel. The solid acid catalyst used for synthesizing the guaiacol has low price, is friendly to environment and can be recycled. The invention is characterized in that the invention has simple preparation technology, mild reaction condition and short reaction time; the obtained guaiacol is light yellow clear transparent liquid and has good product quality, high yield, high selectivity and few side products; and all side products in reaction liquid can be recycled.
Owner:BEIJING UNIV OF CHEM TECH
Method for synthesizing BTX aromatic methyl into unsym-trimethyl benzene
ActiveCN101654394ALow costConvenient sourceHydrocarbon by isomerisationHydrocarbon by hydrocarbon and non-hydrocarbon condensationMethylating AgentM-Xylene
The invention relates to a method for synthesizing BTX aromatic methyl into unsym-trimethyl benzene. The method takes BTX aromatic hydrocarbon (comprising any one or more of benzene, toluene, o-xylene, m-xylene, p-xylene and mixed xylenes) and a methylating agent (selected from one or more of methyl alcohol, dimethyl ether and methane chloride) as raw materials to prepare unsym-trimethyl benzene by a methylation reaction under the catalytic action of an acid catalyst. The acid catalyst is selected from any one of halide, liquid acid, complexacid, heteropolyacid, solid super acid, acidic ion exchange resin, acidic oxide, hydrogenous zeolite molecular sieve or supported acid catalyst. The pressure of the methylation reaction is 0.01-10.0Mpa, the temperature is 30-700 DEG C, the mass space velocity of raw material liquid is 0.1-10.0h<-1>, and the mole ratio of the aromatic hydrocarbon and the methylating agent is 1:10 to 10:1. The methylation reaction can adopt a continuous fixed bed reaction or continuous stirred-tank reaction. The method has rich raw material resources, low cost, mild reaction condition as well as higher once-through conversion of the raw materials and yield of the unsym-trimethyl benzene.
Owner:SHANGHAI NOVEL CHEM TECH
Process for the Production of Xylenes
ActiveUS20130296624A1Increased benzeneThermal non-catalytic crackingCatalytic crackingParaffin waxMethylating Agent
A hydrocarbon upgrading process is described in which a hydrocarbon feed is treated in at least one of a steam cracker, catalytic cracker, coker, hydrocracker, and reformer under suitable conditions to produce a first stream comprising aliphatic and aromatic hydrocarbons. A second stream comprising C6-C9 aliphatic and aromatic hydrocarbons is recovered from the first stream and aliphatic hydrocarbons are removed from at least part of the second stream to produce an aliphatic hydrocarbon-depleted stream. The aliphatic hydrocarbon-depleted stream is then dealkylated and / or transalkylated and / or cracked (D / T / C) by contact with a catalyst under suitable reaction conditions to produce a third stream having an increased benzene and / or toluene content compared with said aliphatic hydrocarbon-depleted stream and a light paraffin by-product. Benzene and / or toluene from the third stream is then methylated with a methylating agent to produce a xylene-enriched stream.
Owner:EXXONMOBIL CHEM PAT INC
Process for the production of opiates
A morphine component, e.g., a concentrate of poppy straw, is converted into codeine in high yield and high purity and in a highly controlled manner. The conversion process involves the following steps: (a) providing a solution or suspension of a morphine component in an inert solvent or a mixture of solvents; (b) methylating the resultant solution or suspension with a methylating agent in the presence of an alkaline ingredient; and (c) recovering the resultant codeine as the free base or as a salt.
Owner:ACURA PHARMA
New technology for recycling metribuzin methylate mother liquor
The invention provides a new technology for recycling metribuzin methylated mother liquor. The technology uses bromomethane as methylating agent to react with triazone under alkaline condition and obtain metribuzin; and methylated mother and bromine are recycled for cyclic utilization, thus achieving the aim of the reutilization of wastewater. The inorganic salt content and discharge amount of waste water in methylating working section can be effectively reduced, and the difficulty and cost of treating waste water are largely reduced. The invention has good environmental benefit, social benefit and economic benefit.
Owner:BEIJING ZIGUANG YINGLI CHEM TECH CO LTD
Preparation method of methyl p-tolyl sulfone
InactiveCN101659635AHighlight substantiveSignificant progressOrganic chemistryOrganic compound preparationSodium bicarbonateMethylating Agent
The invention relates to a preparation method of methyl p-tolyl sulfone, which belongs to the technical field of sulphone preparation, in particular to a preparation method of the methyl p-tolyl sulfone by taking monochloro methane as a methylating agent for synthesis. The preparation method is characterized by taking p-toluenesulfonylchloride, anhydrous sodium sulfite, sodium bicarbonate and monochloro methane as synthesizing raw materials and comprising the following operation steps: a. salifying the p-toluenesulfonylchloride; b. synthesizing the methyl p-tolyl sulfone; c. adjusting pH, reducing the temperature and discharging; d. filtering, dehydrating and drying; and e. inspecting the quality and packaging and warehousing after qualification. The invention provides a preparation methodof the methyl p-tolyl sulfone without using a deadly poisonous compound of dimethyl sulfate as a raw material, and has safe operation, environmental protection, short production period, good productquality, high yield, low production cost and strong market competitiveness. The content of the methyl p-tolyl sulfone reaches up to 99.5 percent, and the yield of the methyl p-tolyl sulfone, which iscounted by the p-toluenesulfonylchloride of the raw material, is more than or equal to 85 percent.
Owner:SHANDONG XINGHUI CHEM
Method for treating wood
ActiveUS20110088590A1Promote absorptionEasy to keepFireproof paintsBiocideMethylating AgentCarboxylic salt
Described is a method for treating wood, in which the wood is brought into contact with a mixture of liquid or water-soluble organic ammonium carboxylate and an active ingredient which repels invertebrates, characterized in that the organic ammonium carboxylate has the formula (1):[NR1R2R3R4]+n[R5(COO)n]−n (1),in which R1, R2 and R3 are selected from hydrogen, substituted and unsubstituted alkyls containing 1-6 carbon atoms, R4 is a substituted or unsubstituted alkyl containing 1-6 carbon atoms, R5 is hydrogen, a substituted or unsubstituted hydrocarbon containing 1-6 carbon atoms and n is an integral 1-6 and whereby wood-preservative active ingredient contains a chelating agent which repels invertebrate, which chelating agent is selected from an aminopolycarboxylic acid or a salt thereof, a hydroxy acid or a salt thereof or a phosphonate or a salt thereof or a mixture of chelating agents which belong to two of more groups thereof.
Owner:GRANULA
Method for preparing laminine and pharmaceutically acceptable salts thereof
InactiveCN101838213ALess side effectsReduce the cost of separation and purificationOrganic active ingredientsOrganic compound preparationMethylating AgentCarboxyl radical
The invention relates to methods for preparing and using laminine and pharmaceutically acceptable salts thereof. L-lysine is used an initiative material, and the method comprises the following steps of: protecting alpha-amino groups and carboxyl with metallic salts under an alkaline condition to form a chelate complex; performing separation and purification to obtain the chelate complex with the purity of 99 to 100 percent, and performing methylation on the chelate complex on epsilon-amino groups under the action of a phase transfer catalyst with a methylating agent to generate trimethyl lysine salts; removing metallic ions with a precipitator or chelating agent to obtain crude laminine and crude pharmaceutically acceptable salts thereof; and re-crystallizing the crude laminine and the crude pharmaceutically acceptable salts thereof with a solvent to obtain the medicinal laminine and the pharmaceutically acceptable salts thereof. The methylation of the separated and purified L-lysine metallic ion chelate complex and the phase transfer catalyst are simultaneously adopted, so the method remarkably reduces the generation of monomethyl substances, dimethyl substances and other byproducts, improves the yield and achieves the product purity of over 98.5 percent (HPLC).
Owner:QINGDAO UNIV OF SCI & TECH
Method for preparing N-hydroxylamine hydrochloride by hydrolyzing N-nitromethane
The invention relates to a method for preparing N-hydroxylamine hydrochloride by hydrolyzing N-nitromethane. The method adopts N-nitrite as an isotope raw material to react with a methylating agent so as to obtain the N-nitromethane, and the N-nitromethan is hydrolyzed, condensed, crystallized and filtered to obtain the N-hydroxylamine hydrochloride. Compared with the prior art, the invention has the advantages of reasonable and simple technology, easily obtained raw materials, high isotope conversion rate, product purity, abundance and yield, and the like, can prepare a great amount of N-hydroxylamine hydrochloride with high purity and high abundance and is suitable for mass production.
Owner:SHANGHAI RES INST OF CHEM IND
Process for preparing olanzapine
A process for preparing olanzapine comprising methylation of N-demethyl olanzapine with a methylating agent in a solvent comprising dichloromethane, methanol, or a mixture thereof.
Owner:DR REDDYS LAB LTD +1
Method for preparing triclabendazole
ActiveCN101555231AReduce usageAvoid hyperbaric reactionsOrganic chemistryChemical synthesisTriclabendazole
The invention discloses a method for preparing triclabendazole related to chemical synthesis methods. The invention comprises the following steps: using the 3,4-dichloroaniline as a raw material, preparing 4-chloro-5-(2,3-dichlorophenoxy)-2-mercapto-1H-benzimidazole through acylating, nitrating, hydrolyzing, etherifying, reduction and cyclization in succession and synthesizing triclabendazole using dimethyl sulfate as methylating agent. The invention avoids the use of the hazardous material sodium and a high pressure reaction, uses easily available dimethyl sulfate as methylating agent, and the yield thereof is equivalent to the report of literature. The invention is characterized by simplified work, moderate reaction condition, cheap production cost and the method is also environmentally-benign and easy to commercial process.
Owner:YANGZHOU TIANHE PHARM CO LTD
Process for the Production of Xylenes and Light Olefins
In a hydrocarbon upgrading process, a hydrocarbon feed is treated in at least one of a steam cracker, catalytic cracker, coker, hydrocracker, and reformer under suitable conditions to produce a first stream comprising olefinic and aromatic hydrocarbons. A second stream composed mainly of C4+ olefinic and aromatic hydrocarbons is recovered from the first stream and is fed together with a methylating agent to a reaction zone containing a catalyst under reaction conditions including a temperature of about 450° C. to about 700° C., such that aromatics components in the second stream undergo dealkylation, transalkylation and / or methylation and aliphatic components undergo cracking and aromatization to produce a third stream having an increased xylene content compared with said second stream and a C3− olefin by-product. The C3− olefin by-product is recovered and para-xylene is removed from at least part of said third stream.
Owner:EXXONMOBIL CHEM PAT INC
Method for making 3α-hydroxy, 3β- substituted-5α-pregnan-20-ones
ActiveUS8362286B2Simple and cost-effectiveHigh yieldOrganic active ingredientsNervous disorderMethylating AgentRegioselectivity
Applicants have discovered a method for the stereoselective and regioselective synthesis of 3α-hydroxy, 3β-methyl-5α-pregnan-20-one (ganaxolone) comprising reacting 5α-pregnane-3,20-dione; with an organometallic methylating agent in an inert solvent to provide a compound of the formula
Owner:MARINUS PHARMA
Method for preparing heterocyclic compounds of methyl mercapto under ionic liquid catalysis
InactiveCN101514190AHigh yieldSimple and fast operationOrganic chemistryOrganic-compounds/hydrides/coordination-complexes catalystsMethylating AgentMethyl carbonate
The invention relates to a method for preparing heterocyclic compounds of methyl mercapto under ionic liquid catalysis, including the followings: (1) mercapto heterocyclic compound and methyl carbonate with the mole ratio of 1: 1.2 to 2 are added to ionic liquid, and are heated to the temperature of 50 to 150 DEG C while stirring during the reaction of 0.5 to 15 hours; (2) after reaction, the temperature is decreased to room temperature to extract products, and the solvent is recycled after vacuum concentration, thus obtaining the compound. The method has the advantages of easy, simple and safe operation as well as obviously improved substrate conversion and product selectivity, and the methyl carbonate used as methylating agent and the ionic liquid used as solvent are environmentally friendly; and simultaneously the ionic liquid is easy to recycle and can be in cycle use.
Owner:DONGHUA UNIV
Method for preparing methylnaltrexone bromide
ActiveCN101845047ANo irritating smellHigh reaction yieldOrganic chemistryBulk chemical productionMethylating AgentOrganic base
Owner:NANJING CHENGONG PHARM CO LTD
Process for the production of opiates
A morphine component, e.g., a concentrate of poppy straw, is converted into codeine in high yield and high purity and in a highly controlled manner. The conversion process involves the following steps: (a) providing a solution or suspension of a morphine component in an inert solvent or a mixture of solvents; (b) methylating the resultant solution or suspension with a methylating agent in the presence of an alkaline ingredient; and (c) recovering the resultant codeine as the free base or as a salt.
Owner:ACURA PHARMA
10-deacetylbaccatin iii and method for methoxylation of its derivative
The invention relates to 10-deacetylbaccatin III and a method for methoxylation of its derivative, which belongs to the medicine synthesis technical field. The invention is characterized in that the under the condition that 10-DAB, the 7 position and the 10 position of its derivative are hydroxy or one of them is hydroxyl, a phase transfer catalyst quaternary ammonium salt N<+>R4X<-> is added under the existence of a methylating agent, and dissolved according to a weight ratio of 1:10-100 of solute to organic solvent, and reacted with low temperature, a lower layer water phase is separated after finishing the reaction, an organic phase is washed by a saturated salt solution, and the organic phase is concentrated by concentrated acid, a petroleum ether is added for completely deposing, filtered, deposed and dried to obtain the product. The invention provides a simple and easy method for preparing the 10-DAB and a methoxy compound of the 7 position and the 10 position hydroxy of its derivative. The method for large scale intermediate preparation enables possibility of preparation of docetaxel with large dosage, and is a key step for preparing cabazitaxel.
Owner:无锡紫杉药业股份有限公司
Preparation method for producing ainothiazoly loximate by utilizing phase transfer technology
InactiveCN102070560AReduce wasteThe production process is safe and reliableOrganic chemistrySodium acetateMethylating Agent
The invention discloses a preparation method for producing ainothiazoly loximate by utilizing a phase transfer technology. The preparation method comprises the following steps: A, in an aqueous system, adding ethyl acetoacetate and sodium nitrite into a reaction kettle in proportion for reacting to obtain a nitrosation product; B, reacting the product of the ethyl acetoacetate subjected to nitrosation with a saturated aqueous solution of a methylating agent and sodium carbonate in the presence of a phase transfer catalyst by controlling the temperature, separating an aqueous layer after the reaction, and then directly carrying out chlorination; C, controlling the reaction temperature, introducing chlorine gas into the product subjected to the methylation, washing with water, and layering to obtain a chlorination reactant; D, adding thiourea, sodium acetate and phase transfer catalyst tetrabutyl ammonium chloride into the chlorination reactant, controlling the reaction temperature, and centrifugalizing the product; E, adding flake caustic soda and water into a cyclization product, regulating the pH value with hydrochloric acid, and centrifugalizing; and F, adding methyl alcohol into the centrifugalization product for refining, centrifugalizing and drying to obtain the ainothiazoly loximate. The method disclosed by the invention is easy to implement, is simple and convenient to operate, has low production cost, greatly improves the quality and yield of the product, and ensures safe and reliable production processes.
Owner:湖北楚阳科技股份有限公司
Synthesis method of eugenol methyl ether
ActiveCN102351663ALess corrosiveEasy post-processingEther preparation by ester reactionsMethylating AgentMethyl carbonate
The invention discloses a synthesis method of eugenol methyl ether. In the method, eugenol and dimethyl carbonate (DMC) are taken as raw materials, and eugenol methyl ether is prepared through liquid-solid phase reaction under pressurization while base catalysis is performed. The green organic chemical raw material, namely DMC, is utilized for replacing traditional dimethyl sulfate, bromomethane, phosgene and other toxic and harmful methylating agents, and solid base is selected as a catalytic system. The synthesis method is a clean synthesis route of the eugenol methyl ether, is environmentally friendly, economic in preparation, convenient in post-treatment and low in corrosion to equipment. The method has great industrial application prospects.
Owner:黄山市巨龙生物能源科技有限公司
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