183 results about "Methylating Agent" patented technology

One exemplary embodiment can be a process using an aromatic methylating agent. Generally, the process includes reacting an effective amount of the aromatic methylating agent having at least one of an alkane, a cycloalkane, an alkane radical, and a cycloalkane radical with one or more aromatic compounds. As such, at least one of the one or more aromatic compounds may be converted to one or more higher methyl substituted aromatic compounds to provide a product having a greater mole ratio of methyl to phenyl than a feed.

The invention as disclosed herein provides pharmaneutical compositions and methods for treating, ameliorating, or preventing the symptoms of Parkinson's Disease. The pharmaneutical compositions of the invention contain in an effective amount a first and a second composition, the first composition comprises an effective amount of one or more phosphatidylcholine formulations and the second composition comprises an effective amount of one or more constituents comprising essential fatty acid supplements, trace minerals, butyrate, electrolytes, methylating agents, reduced glutathione, or a combination thereof, in a suitable carrier.

This disclosure relates to a process of manufacturing para-xylene, comprising (a) contacting a pygas feedstock and methylating agent with a catalyst under reaction conditions to produce a product having para-xylene, wherein the product has higher para-xylene content than the para-xylene content of the pygas feedstock; and (b) separating the para-xylene from the product of the step (a), wherein the catalyst comprises a molecular sieve having a Diffusion Parameter for 2,2-dimethylbutane of about 0.1-15 sec⁻¹ when measured at a temperature of 120° C. and a 2,2-dimethylbutane pressure of 8 kPa-a and the pygas comprises from about 1 to about 65 wt % benzene and from about 5 to 35 wt % toluene.

The present invention relates to pharmaceutical combinations CD33 antibodies and de-methylating agents for use in treating diseases like MDS and cancer, especially AML.

The invention as disclosed herein provides pharmaneutical compositions and methods for treating, ameliorating, or preventing the symptoms of fatty acids imbalance and cell membrane dysfunction. The pharmaneutical compositions of the invention contain in an effective amount a first and a second composition, the first composition comprises an effective amount of one or more phosphatidylcholine formulations and the second composition comprises an effective amount of one or more constituents comprising essential fatty acid supplements, trace minerals, phenylbutyrate, electrolytes, methylating agents, reduced glutathione, or a combination thereof, in a suitable carrier.

One exemplary embodiment can be a process for increasing a mole ratio of methyl to phenyl of one or more aromatic compounds in a feed. The process can include reacting an effective amount of one or more aromatic compounds and an effective amount of one or more aromatic methylating agents to form a product having a mole ratio of methyl to phenyl of at least about 0.1:1 greater than the feed.

The invention discloses a making method of propylene, which is characterized by the following: contacting raw material with ethylene and methylating agent and catalyst of molecular sieve with micropore aperture at 0. 3-0. 5nm under specific reacting condition; generating the product with propylene with selectivity over 65%.

Fiber-based products and adhesives comprising the fiber-based products. The fiber-based products comprise carboxymethyl cellulose, carboxymethylated hemicellulose and carboxymethylated starch. The fiber-based product is obtained by simultaneously performing alkali extraction of hydrocolloid from the fiber and carboxymethylation, with a carboxymethylating agent, thereby converting extracted cellulose to carboxymethyl cellulose and also carboxymethylating some extracted hemicellulose, starch, and hemicellulose-cellulose complexes.

A hydrocarbon upgrading process is described in which a hydrocarbon feed is treated in at least one of a steam cracker, catalytic cracker, coker, hydrocracker, and reformer under suitable conditions to produce a first stream comprising aliphatic and aromatic hydrocarbons. A second stream comprising C₆-C₉ aliphatic and aromatic hydrocarbons is recovered from the first stream and aliphatic hydrocarbons are removed from at least part of the second stream to produce an aliphatic hydrocarbon-depleted stream. The aliphatic hydrocarbon-depleted stream is then dealkylated and/or transalkylated and/or cracked (D/T/C) by contact with a catalyst under suitable reaction conditions to produce a third stream having an increased benzene and/or toluene content compared with said aliphatic hydrocarbon-depleted stream and a light paraffin by-product. Benzene and/or toluene from the third stream is then methylated with a methylating agent to produce a xylene-enriched stream.

A morphine component, e.g., a concentrate of poppy straw, is converted into codeine in high yield and high purity and in a highly controlled manner. The conversion process involves the following steps: (a) providing a solution or suspension of a morphine component in an inert solvent or a mixture of solvents; (b) methylating the resultant solution or suspension with a methylating agent in the presence of an alkaline ingredient; and (c) recovering the resultant codeine as the free base or as a salt.

The invention provides a new technology for recycling metribuzin methylated mother liquor. The technology uses bromomethane as methylating agent to react with triazone under alkaline condition and obtain metribuzin; and methylated mother and bromine are recycled for cyclic utilization, thus achieving the aim of the reutilization of wastewater. The inorganic salt content and discharge amount of waste water in methylating working section can be effectively reduced, and the difficulty and cost of treating waste water are largely reduced. The invention has good environmental benefit, social benefit and economic benefit.

The invention relates to a preparation method of methyl p-tolyl sulfone, which belongs to the technical field of sulphone preparation, in particular to a preparation method of the methyl p-tolyl sulfone by taking monochloro methane as a methylating agent for synthesis. The preparation method is characterized by taking p-toluenesulfonylchloride, anhydrous sodium sulfite, sodium bicarbonate and monochloro methane as synthesizing raw materials and comprising the following operation steps: a. salifying the p-toluenesulfonylchloride; b. synthesizing the methyl p-tolyl sulfone; c. adjusting pH, reducing the temperature and discharging; d. filtering, dehydrating and drying; and e. inspecting the quality and packaging and warehousing after qualification. The invention provides a preparation methodof the methyl p-tolyl sulfone without using a deadly poisonous compound of dimethyl sulfate as a raw material, and has safe operation, environmental protection, short production period, good productquality, high yield, low production cost and strong market competitiveness. The content of the methyl p-tolyl sulfone reaches up to 99.5 percent, and the yield of the methyl p-tolyl sulfone, which iscounted by the p-toluenesulfonylchloride of the raw material, is more than or equal to 85 percent.

Described is a method for treating wood, in which the wood is brought into contact with a mixture of liquid or water-soluble organic ammonium carboxylate and an active ingredient which repels invertebrates, characterized in that the organic ammonium carboxylate has the formula (1):

[NR¹R²R³R⁴]⁺_n[R⁵(COO)_n]⁻ⁿ  (1),

in which R¹, R² and R³ are selected from hydrogen, substituted and unsubstituted alkyls containing 1-6 carbon atoms, R⁴ is a substituted or unsubstituted alkyl containing 1-6 carbon atoms, R⁵ is hydrogen, a substituted or unsubstituted hydrocarbon containing 1-6 carbon atoms and n is an integral 1-6 and whereby wood-preservative active ingredient contains a chelating agent which repels invertebrate, which chelating agent is selected from an aminopolycarboxylic acid or a salt thereof, a hydroxy acid or a salt thereof or a phosphonate or a salt thereof or a mixture of chelating agents which belong to two of more groups thereof.

The invention relates to methods for preparing and using laminine and pharmaceutically acceptable salts thereof. L-lysine is used an initiative material, and the method comprises the following steps of: protecting alpha-amino groups and carboxyl with metallic salts under an alkaline condition to form a chelate complex; performing separation and purification to obtain the chelate complex with the purity of 99 to 100 percent, and performing methylation on the chelate complex on epsilon-amino groups under the action of a phase transfer catalyst with a methylating agent to generate trimethyl lysine salts; removing metallic ions with a precipitator or chelating agent to obtain crude laminine and crude pharmaceutically acceptable salts thereof; and re-crystallizing the crude laminine and the crude pharmaceutically acceptable salts thereof with a solvent to obtain the medicinal laminine and the pharmaceutically acceptable salts thereof. The methylation of the separated and purified L-lysine metallic ion chelate complex and the phase transfer catalyst are simultaneously adopted, so the method remarkably reduces the generation of monomethyl substances, dimethyl substances and other byproducts, improves the yield and achieves the product purity of over 98.5 percent (HPLC).

The invention relates to a method for preparing N-hydroxylamine hydrochloride by hydrolyzing N-nitromethane. The method adopts N-nitrite as an isotope raw material to react with a methylating agent so as to obtain the N-nitromethane, and the N-nitromethan is hydrolyzed, condensed, crystallized and filtered to obtain the N-hydroxylamine hydrochloride. Compared with the prior art, the invention has the advantages of reasonable and simple technology, easily obtained raw materials, high isotope conversion rate, product purity, abundance and yield, and the like, can prepare a great amount of N-hydroxylamine hydrochloride with high purity and high abundance and is suitable for mass production.

A process for preparing olanzapine comprising methylation of N-demethyl olanzapine with a methylating agent in a solvent comprising dichloromethane, methanol, or a mixture thereof.

The invention discloses a method for preparing triclabendazole related to chemical synthesis methods. The invention comprises the following steps: using the 3,4-dichloroaniline as a raw material, preparing 4-chloro-5-(2,3-dichlorophenoxy)-2-mercapto-1H-benzimidazole through acylating, nitrating, hydrolyzing, etherifying, reduction and cyclization in succession and synthesizing triclabendazole using dimethyl sulfate as methylating agent. The invention avoids the use of the hazardous material sodium and a high pressure reaction, uses easily available dimethyl sulfate as methylating agent, and the yield thereof is equivalent to the report of literature. The invention is characterized by simplified work, moderate reaction condition, cheap production cost and the method is also environmentally-benign and easy to commercial process.

In a hydrocarbon upgrading process, a hydrocarbon feed is treated in at least one of a steam cracker, catalytic cracker, coker, hydrocracker, and reformer under suitable conditions to produce a first stream comprising olefinic and aromatic hydrocarbons. A second stream composed mainly of C₄+ olefinic and aromatic hydrocarbons is recovered from the first stream and is fed together with a methylating agent to a reaction zone containing a catalyst under reaction conditions including a temperature of about 450° C. to about 700° C., such that aromatics components in the second stream undergo dealkylation, transalkylation and/or methylation and aliphatic components undergo cracking and aromatization to produce a third stream having an increased xylene content compared with said second stream and a C₃− olefin by-product. The C₃− olefin by-product is recovered and para-xylene is removed from at least part of said third stream.

The invention relates to 10-deacetylbaccatin III and a method for methoxylation of its derivative, which belongs to the medicine synthesis technical field. The invention is characterized in that the under the condition that 10-DAB, the 7 position and the 10 position of its derivative are hydroxy or one of them is hydroxyl, a phase transfer catalyst quaternary ammonium salt N<+>R4X<-> is added under the existence of a methylating agent, and dissolved according to a weight ratio of 1:10-100 of solute to organic solvent, and reacted with low temperature, a lower layer water phase is separated after finishing the reaction, an organic phase is washed by a saturated salt solution, and the organic phase is concentrated by concentrated acid, a petroleum ether is added for completely deposing, filtered, deposed and dried to obtain the product. The invention provides a simple and easy method for preparing the 10-DAB and a methoxy compound of the 7 position and the 10 position hydroxy of its derivative. The method for large scale intermediate preparation enables possibility of preparation of docetaxel with large dosage, and is a key step for preparing cabazitaxel.

The invention discloses a synthesis method of eugenol methyl ether. In the method, eugenol and dimethyl carbonate (DMC) are taken as raw materials, and eugenol methyl ether is prepared through liquid-solid phase reaction under pressurization while base catalysis is performed. The green organic chemical raw material, namely DMC, is utilized for replacing traditional dimethyl sulfate, bromomethane, phosgene and other toxic and harmful methylating agents, and solid base is selected as a catalytic system. The synthesis method is a clean synthesis route of the eugenol methyl ether, is environmentally friendly, economic in preparation, convenient in post-treatment and low in corrosion to equipment. The method has great industrial application prospects.