46 results about "Nitrosation" patented technology

The application provides a synthesis method of p-benzoquinone dioxime. The synthesis method comprises the following steps: (1) adding solid acid into an ethanol solution of phenol to obtain a mixed solution A, then vacuumizing and filling with inert gas; dissolving nitrite into ethanol, uniformly mixing to obtain an ethanol solution of nitrite, then vacuumizing and filling with inert gas; in an inert gas atmosphere, adding the ethanol solution of nitrite into the mixed solution A dropwise to perform nitrosation reaction, to obtain a reaction liquid B; in the inert gas atmosphere, adding an ethanol solution of hydroxylamine into the obtained reaction liquid B to perform oximation reaction; after the reaction is completed, filtering the obtained reaction liquid C, performing reduced pressure distillation on the obtained filtrate, and performing washing, filtering and drying on the obtained residual liquid of the reduced pressure distillation, to obtain p-benzoquinone dioxime. The method provided by the application reduces the occurrence of side reactions, improves the conversion rate of the reaction, and improves the yield and purity of p-benzoquinone dioxime.

The invention discloses an engineering continuous preparation method of 3-amino-4-amidoxime furazan, which is characterized in that engineering synthesis of 3-amino-4-amidoxime furazan is technically verified and optimized by adopting a continuous flow micro-channel reactor and a dynamic tubular reactor technology, and malononitrile is used as a starting raw material to react in the micro-channel reactor; the preparation method comprises the following steps: carrying out nitrosation and oximation to obtain a trioxime solution, conveying trioxime and a cyclization solution to a dynamic tubular reactor, heating to a certain temperature, reacting and curing, overflowing into a collection tank through the tubular reactor, adjusting the pH value of a reaction solution, cooling, filtering, washing with water, and drying to obtain the 3-amino-4-amidoxime furazan. The AAOF engineering manufacturing process scheme is provided, AAOF kilogram-level engineering preparation under automatic control is achieved, the problems of material precipitation, heat exchange and the like in an intermittent production mode are solved, and the synthesis efficiency and the synthesis safety are greatly improved.

The invention discloses an epinephrine drug nitrosamine impurity as well as a preparation method and application thereof. According to the method, an epinephrine drug is taken as a raw material, hydroxyl is protected through a silane protecting group, the protected hydroxyl and a nitrosation reagent are subjected to a selective nitrosation reaction, and then the target nitrosamine impurity is obtained through a deprotection reaction. According to the method, the high-purity nitrosamine impurity of the epinephrine medicine can be prepared and used as a reference substance for qualitative and content detection of the nitrosamine impurity in the production process of raw materials and medicines, so that it is ensured that the epinephrine raw material medicine and preparations meet the medicinal standard; the method has important significance in improving the quality of epinephrine drugs and guaranteeing the medication safety.

The utility model discloses a short-cut nitrification coupling anaerobic ammonia oxidation integrated reactor, a perforated plate is arranged in the reactor, and a first part for short-cut nitrification and a second part for anaerobic ammonia oxidation are respectively distributed on the upper side and the lower side of the perforated plate; sludge of nitrite bacteria is attached to the interior of the first part through a first filler so as to fix aerobic bacteria, and the first part is connected with an aeration source; anaerobic ammonia oxidizing bacteria are fixed in the second part through a second filler; the size of the filler is greater than the hole size of the perforated plate; the second part is provided with a muddy water backflow and separation module; the muddy water backflow and separation module comprises the muddy water separation area and a sludge backflow area which is integrally connected with the muddy water separation area; a water outlet pipe is connected into the mud-water separation area and is used for separating and discharging aged sludge. The reactor can stabilize the growth of dominant bacteria and improve the denitrification treatment effect.

Nitric oxide precursors for providing nitric oxide are provided. The nitric oxide precursors comprise a reaction product of a thiolactone, a primary amine, and a nitrosating compound. The nitric oxide precursors are capable of decomposing to form nitric oxide.

This invention relates to the field of wastewater biological treatment technology, specifically to a device and method for improving the autotrophic denitrification performance of a MABR reactor. It employs a composite membrane module combining a curtain-type silica gel filament membrane with excellent oxygen permeability with a spatial three-dimensional mesh packing material that facilitates the attachment of anaerobic ammonia-oxidizing bacteria, thereby coupling part of the nitrification reaction with the anaerobic ammonia oxidation reaction. Through the circulating reaction zone and membrane reaction zone within the reactor, nitrate nitrogen generated by anaerobic ammonia oxidation and excess nitrite nitrogen during instability adjustment are circulated and removed, thus improving the total nitrogen removal efficiency of the reactor. By adding appropriate amounts of sodium nitrite solution at appropriate times, the free nitrite concentration in the reactor mixture is increased. Simultaneously, the intermittent aeration ratio of the MABR is controlled to achieve synergistic inhibition of nitrite-oxidizing bacteria activity by low dissolved oxygen and high free nitrite, allowing the unstable short-range nitrification reaction to recover and improving the autotrophic denitrification performance of the reactor.

The invention provides a rapid biofilm culturing system and method for an autotrophic nitrogen removal membrane aeration biofilm reactor. The system comprises at least two stages of first biofilm culturing devices and second biofilm culturing devices which are connected in series, at least one first biofilm culturing device comprises a nitrosation inoculation carrier; at the same time, at least one second biofilm culturing device comprises an anaerobic ammonia oxidation inoculation carrier; conducting film assemblies to be subjected to film hanging are sequentially placed in the first film hanging device and the second film hanging device under constant micro-voltage to be subjected to film hanging; the water inlet assembly comprises a first water tank and a second water tank; ammonia nitrogen inlet water is contained in the first water tank, and the first water tank is connected with the first biofilm culturing device and the second biofilm culturing device; and the second water tank contains nitrite inlet water and is connected with the second biofilm culturing device. According to the invention, the conducting film assembly to be subjected to film hanging is subjected to layered film hanging in the first film hanging device and the second film hanging device respectively, so that rapid film hanging and starting of the MABR-PN / A process are realized.

The invention provides a nitrite quantitative detection method based on surface enhanced Raman spectroscopy, relates to the technical field of surface enhanced Raman spectroscopy, and constructs a self-correcting SERS substrate through a three-phase liquid-liquid interface co-assembly technology. In the experiment process, a sample to be detected is mixed with a thiobarbituric acid solution, the mixture is adjusted to be acidic, NO2 <-> and thiobarbituric acid are subjected to an S-nitrosation reaction, and S-nitroso mercaptan is generated. And then, immersing the self-correcting SERS substrate into a reaction solution, so that the substrate adsorbs the generated S-nitroso mercaptan, and further, a Raman signal is enhanced. After soaking is completed, the substrate is taken out and dried, finally, a Raman signal is collected through a Raman spectrometer, and the concentration of NO2 <-> is accurately analyzed through the change of the signal intensity. According to the technical scheme, rapid and high-sensitivity detection of NO2 <-> is achieved, good selectivity and anti-interference capacity are achieved, and the method is widely suitable for detection requirements of multiple fields such as environment monitoring and food safety.

The present application relates to sewage biological treatment technical field, provide a kind of ammonia nitrogen wastewater short path nitrification method and application.The method includes: S100, mature autotrophic short path nitrification sludge is inoculated into reactor, and first mixed liquor is obtained;S200, water containing ammonium salt, bicarbonate and phosphate is transported into reactor by water inlet pump;S300, first mixed liquor is mixed with water by stirrer, and aeration reaction is carried out, and second mixed liquor is obtained;S400, stop stirring, aeration and pH control to second mixed liquor, carry out solid-liquid separation, and obtain treated water and sludge;S500, enable water pump, and treated water is uniformly discharged;S600, repeat steps S200-S500, add cerium chloride solution, and carry out long-term operation.The present application uses low concentration cerium to selectively enrich endogenous heterotrophic nitrosobacteria, and cooperates with autotrophic nitrosobacteria by cerium ion, to improve the accumulation rate of nitrite.

The invention provides a rapid biofilm culturing method and equipment for a membrane aeration biofilm reactor. The rapid biofilm culturing method of the membrane aeration biofilm reactor comprises the following steps: performing first-stage biofilm culturing on a nitrosation carrier and a membrane assembly in an inoculation container, and performing second-stage biofilm culturing on a nitrosation-anaerobic ammonia oxidation carrier and the membrane assembly after the first-stage biofilm culturing in the inoculation container, and carrying out third-stage biofilm culturing on the anaerobic ammonia oxidation carrier and the membrane component subjected to the second-stage biofilm culturing in the inoculation container. According to the rapid biofilm culturing method of the membrane aeration biofilm reactor, the nitrosation carrier, the nitrosation-anaerobic ammonia oxidation carrier and the anaerobic ammonia oxidation carrier are sequentially subjected to biofilm culturing on the membrane assembly in stages, so that the biofilm is formed on the surface of the membrane assembly, and each carrier has short biofilm culturing time, so that the total biofilm culturing time of the biofilm is short; and the state of the biological membrane attached to the biological membrane is uniform, compact and stable, and the community structure of the target flora of the biological membrane is stable.

A nitric oxide precursor for providing nitric oxide is provided. The nitric oxide precursor comprises a reaction product of a thiolactone, a primary amine, and a nitrosating compound. The nitric oxide precursor is capable of decomposing to form nitric oxide.

Systems and methods for producing ammonium nitrate are disclosed herein. Exemplary systems can comprise a bioreactor positioned to receive a feed including ammonia. The bioreactor can hold a liquid solution including (i) an ammonia oxidizing bacteria (AOB) and (ii) a nitrite oxidizing bacteria (NOB). The AOB can facilitate oxidation of the ammonia to produce a nitrite at a nitritation rate and the NOB can facilitate oxidation of the nitrite at a nitratation rate. Thus, the bioreactor can produce a mixed liquor comprising a nitrate biologically. The system can further comprise a filter positioned to receive the mixed liquor and produce a permeate and a sludge. A sensor can measure the concentration of the liquid solution of the bioreactor, and a controller coupled to the sensor can regulate the mass flow of nitrogen and / or phosphorus of the bioreactor feed based on the measured concentration of the liquid solution.

The present application relates to wastewater treatment technical field, especially to a kind of high organic matter high ammonia wastewater's whole process processing device and processing method.The present application provides a kind of high organic matter high ammonia wastewater's whole process processing device, including sequentially connected anaerobic tower, short-path denitrification-anaerobic ammonia oxidation pool, nitrosation-anaerobic ammonia oxidation pool, denitrification swing pool, intermediate sedimentation tank, denitrification tank, nitrification carbon removal pool and final sedimentation tank.The processing device is placed in front of short-path denitrification-anaerobic ammonia oxidation pool, effectively avoid the influence of organic matter on subsequent autotrophic denitrification microorganism denitrification.And the processing device treats high organic matter high ammonia wastewater with the characteristics of low cost, high efficiency.

The invention relates to the technical field of microbial infection treatment and molecular biology, and provides a method for inhibiting formation of a staphylococcus aureus biofilm, which is realized by inhibiting nitrosation modification of MgrA protein in staphylococcus aureus so as to inhibit formation of the biofilm. The inhibitor is nitric oxide synthase and is used for inhibiting nitrosation modification of the MgrA protein; the nitrosation modification for inhibiting the MgrA protein is realized by applying a nitric oxide synthase (NOS) inhibitor; the invention reveals that the staphylococcus aureus endogenous nitric oxide can promote the formation of a biofilm by modifying and regulating the 12th cysteine of the protein MgrA for the first time; based on the target spot, research proves that the MgrA modification level can be effectively reduced and the removal of the biofilm can be enhanced through multiple means such as gene mutation, NOS inhibitor or combination of the NOS inhibitor and antibiotics, and a new strategy and a potential drug development approach are provided for preventing and treating staphylococcus aureus intractable biofilm infection.

Compositions and methods are presented for nitric oxide precursors that release nitric oxide upon decomposition. The nitric oxide precursors include the reaction products of thiol-containing alcohols, silanes, and nitrosated compounds, allowing for technically simple (e.g., solventless, one-pot synthesis) and flexible synthesis of nitric oxide precursors and mixtures thereof, and allowing for control of the nitric oxide release rate (e.g., via the use of primary, secondary, and / or tertiary nitrosothiols, alone or in combination with additives).

The application discloses a method for preparing high-purity 6-nitro-1,2-diazoxy-4-naphthalenesulfonic acid, and relates to the technical field of dye intermediates. The method comprises the following steps: taking beta-naphthol as a starting material, and sequentially performing nitrosation, reduction, transposition sulfonation, diazotization and nitration reactions to obtain the final target product. In the process of preparing 1-amino-2-naphthol-4-sulfonic acid by reducing and transposition sulfonating 1-nitroso-2-naphthol, a proper amount of an auxiliary is timely used, the reduction efficiency is improved, and the dispersibility of the substrate in the system is enhanced, so that the yield and purity of the finally prepared 6-nitro-1,2-diazoxy-4-naphthalenesulfonic acid are improved.

The invention discloses N-nitroso tadalafil and a synthesis method and application thereof, and the synthesis method comprises the following steps: adding tadalafil into a reaction container, then adding a solvent for dissolving, balancing the system at (-20) DEG C to (-2) DEG C for 8-16 minutes, adding a nitrosation reagent for sealed reaction, after the reaction is finished, extracting, drying, concentrating, and carrying out column chromatography to obtain the N-nitroso tadalafil. The target product N-nitroso tadalafil is obtained. The N-nitroso tadalafil synthesis method is simple and convenient in process, the obtained product is high in purity, a reliable standard substance can be provided for tadalafil product quality research and analysis method development and verification, and the method has good popularization value.

The application belongs to the technical field of soil treatment and sewage treatment, and particularly relates to application of 5-methylisoxazole nitrification inhibitor and a method for inhibiting nitrification. The application comprises application in inhibiting nitrification activity of ammonia-oxidizing bacteria and in inhibiting nitrification activity of nitrite-oxidizing bacteria. Through a large number of researches and experiments, the application finds nitrification inhibition activity of 5-methylisoxazole, and realizes full-path regulation of nitrification. Experiments show that the compound can inhibit ammonia oxidation activity of a typical nitrifying strain at a low dose (>=0.01‰w / v), and can effectively inhibit activity of nitrite-oxidizing bacteria at a concentration lower than 0.1‰m / v. The aqueous solution of the compound has a neutral pH, and has no significant inhibitory effect on non-target heterotrophic microorganisms, and has high selectivity and environmental friendliness.

This invention relates to a bis-Sydney ketone terminal compound, its preparation method, and its application, belonging to the field of organic synthesis technology. It solves the problems of existing synthetic methods involving multiple reaction steps, low reaction efficiency, low yield, and difficulty in efficiently and massively synthesizing bis-Sydney ketone terminal compounds. The preparation method synthesizes the bis-Sydney ketone terminal compound through a three-step organic reaction, including the following steps: Step 1: Dissolving a primary amino compound, a secondary amination reagent, and a base in a solvent to undergo a secondary amination reaction, followed by recrystallization to obtain a first intermediate; Step 2: Dissolving the first intermediate, adding a hydrolysis reagent to undergo a hydrolysis reaction, adjusting the solution to acidity, and filtering to obtain a second intermediate; Step 3: Dissolving the second intermediate, adding a nitrosating reagent to undergo a nitrosation reaction, adding a dehydrating agent to the reaction system to undergo an internal cyclization reaction, and post-treatment to obtain the bis-Sydney ketone terminal compound.

The application discloses an ammonia-nitrogen wastewater treatment method and system based on anaerobic ammonia oxidation, and the treatment method comprises successively performing a dissimilatory iron reduction treatment, a nitrosation treatment on ammonia-nitrogen wastewater, and performing anaerobic ammonia oxidation treatment on the wastewater after the nitrosation treatment by introducing the wastewater from the top of an anaerobic ammonia oxidation reactor, and performing Fenton treatment, wherein the solid phase obtained after the Fenton treatment is returned to the dissimilatory iron reduction treatment. The system for realizing the treatment method comprises a dissimilatory iron reduction reaction tank, a nitrosation reaction tank, an inverted anaerobic ammonia oxidation reactor, a Fenton reaction tank and a biological aerated filter which are connected in sequence. The ammonia-nitrogen wastewater treatment method based on anaerobic ammonia oxidation has the advantages of simple process, convenient operation, short starting time, low treatment cost, high treatment efficiency, good treatment effect, wide water quality application range, good running stability, full-quantitative disposal and the like, can effectively purify various kinds of refractory high-ammonia-nitrogen wastewater, has high use value and good application prospect.

The invention relates to the technical field of wastewater treatment, in particular to an anaerobic ammonia oxidation denitrification reactor and process based on one-stage and two-stage switching. The anaerobic ammonia oxidation denitrification process comprises the following steps: based on an anaerobic ammonia oxidation denitrification reactor, inoculating nitrifying bacteria Nitrosomonas europaea SZG-AOB-002 and anaerobic ammonia oxidation granular sludge, and adjusting the aeration rate, HRT, trace element supply and the like of a nitrosation area according to the water quality condition of inlet water, so that the anaerobic ammonia oxidation reaction is switched between a two-stage type and a one-stage type; the operation stability and the denitrification efficiency of the system are improved.

This specification describes a membrane-aerated biofilm reactor (MABR) and method for nitrosation, nitrosation-denitrosation, or deammonification. Oxygen supply through a gas transfer membrane is limited to inhibit growth of nitrite oxidizing bacteria (NOB). Exhaust gas from the MABR unit can have an oxygen concentration of 4% or less. The method can optionally include one or more of the following: intermittent (batch) feed process air; process air conditioning; process air direction reversal; process air recirculation; and, process air step flow. The method can optionally include adding inoculum sludge containing anammox to the reactor, optionally after pretreatment and selection.

The invention relates to the technical field of medicine preparation, in particular to a synthesis method of dalbavancin demethylated B2 nitrosamine. The synthesis method comprises the following steps: S1, taking a dalbavancin precursor A-40926-B0 as a raw material, and carrying out methylation reaction to obtain an intermediate I; s2, performing esterification protection on the intermediate I to obtain an intermediate II; s3, carrying out condensation reaction on the intermediate II and 3-methylaminopropylamine to obtain an intermediate III, and carrying out alkaline hydrolysis to obtain an intermediate IV; s4, carrying out nitrosation on the intermediate IV through a nitrosation reagent to obtain dalbavancin demethylated B2 nitrosamine; the synthesis method is high in reaction yield, the purity of the demethylated B2 nitrosamine compound of the dalbavancin can be as high as that of the dalbavancin, and a reference substance is provided for quality control of the dalbavancin.

Provided are compounds that can find use as nitrosation reagents. Provided are nitrosation methods that include reacting a substrate with one of the provided nitrosation reagents and thereby generating a nitrosation product. Provided are kits including a nitrosation reagent. Provided are compositions wherein the nitrosation reagent is enriched in the 15N isotope.

The invention discloses an efficient green synthesis and purification method of 1-amino-4-methylpiperazine, and belongs to the technical field of organic synthesis. According to the method, N-methyl piperazine is used as a raw material and is subjected to electrophilic amination reaction with hydroxylamine-O-sulfonic acid (HOSA) under an alkaline condition. The method is characterized in that a compound reaction synergist composed of polyethylene glycol and disodium ethylene diamine tetraacetate is introduced into a reaction system, and a feeding strategy combining segmented temperature control and dynamic pH adjustment is adopted; after the reaction is finished, organic sulfonic acid is directly added into the reaction liquid without distillation for salifying precipitation, and high-purity 1-amino-4-methyl piperazine sulfonate is obtained. According to the method, the carcinogenic risk of a traditional nitrosation route is avoided, the atom utilization rate of HOSA is remarkably increased, high-temperature rectification decomposition of the product is avoided, the process is safe and environmentally friendly, the method is suitable for industrial production, the product yield can reach 85% or above, and the purity is larger than 99.5%.

The invention provides a composite biological nitrogen removal method and system based on thallus sorting, and belongs to the technical field of sewage treatment.The composite biological nitrogen removal method comprises the steps that after to-be-treated wastewater is subjected to anaerobic treatment through serial anaerobic ammonia oxidation reaction and anoxic-aerobic reaction, one path of anaerobic effluent is subjected to nitrosation reaction and anaerobic ammonia oxidation reaction, and the other path of anaerobic effluent is subjected to anoxic-aerobic reaction; the other path of anaerobic effluent and the effluent of the anaerobic ammonia oxidation reactor are jointly and sequentially subjected to an anoxic reaction and an aerobic reaction, and the effluent of the aerobic tank is precipitated to obtain treated wastewater. Through the whole process combination path, the denitrification efficiency and the effluent index stability can be effectively improved, the solid waste discharge amount is reduced, the operation stability is improved, the operation cost is reduced, and maintenance and operation are convenient.

The utility model relates to the technical field of chemical equipment, and discloses an accurate proportioning nitre nitrosation reaction kettle, which comprises a kettle body, the upper surface of the kettle body is connected with a top cover in a sliding manner, the outer wall of the kettle body is electrically connected with a control panel, the inside of the top cover is fixedly connected with a material storage barrel, the outer wall of the material storage barrel is fixedly connected with a connecting piece, and the connecting piece is fixedly connected with the top cover. A cylinder is fixedly connected to the lower surface of the connecting piece, a pushing piece is fixedly connected to the output end of the cylinder, a pushing plate is fixedly connected to the lower surface of the pushing piece, a sliding groove is formed in the pushing plate, a sealing cover is slidably connected to the outer wall of the storage barrel, and a sliding column is fixedly connected to the interior of the sealing cover; a supporting assembly is arranged on the lower surface of the kettle body. According to the utility model, the air cylinder is started to push the push sheet to slide, and the sealing cover is rotated to place raw materials in the storage barrel in the kettle body through the matching of the control panel, the push plate and the sliding column, so that the effects of accurately controlling the opening and closing of the sealing cover, accurately proportioning the raw materials and improving the product quality are achieved.

The application discloses a kind of ammonia oxygen synergistic enhanced partial nitrosation-anaerobic ammonia oxidation denitrification method, belong to sewage biological denitrification field, this method is completed in denitrification device, based on NH4 + -N and DO concentration dependence relationship with denitrification function microorganism, by coordinating control NH4 + -N and DO concentration, control DO concentration is: R 2 =0.9863, wherein C DO =DO concentration, NH4 + -N concentration, NH4 + -N concentration range is to achieve inhibition to NOB, more suitable in low NH4 + -N concentration sewage treatment facility application.

The invention relates to the technical field of medicine preparation, in particular to a method for preparing a nitrosamine compound. The method comprises the following steps: S1, carrying out esterification protection by taking a dalbavancin precursor A-40926-B0 as a raw material to obtain an intermediate I; s2, carrying out condensation reaction on the intermediate I and 3-methylaminopropylamine to obtain an intermediate II, and carrying out alkaline hydrolysis to obtain an intermediate III; s3, protecting secondary amine on a parent nucleus of the intermediate III through a protective reagent to obtain an intermediate IV; s4, carrying out nitrosation on the intermediate IV through a nitrosation reagent to obtain an intermediate V; s5, after the intermediate V is subjected to deprotection, dalbavancin demethylated B0 nitrosamine is obtained; the product prepared by the method is high in purity, a reference substance can be provided for quality control of dalbavancin, and important guiding significance is provided for safe medication.

The invention relates to a high-organic-toxicity anaerobic digestion biogas slurry treatment system and method based on anaerobic ammonia oxidation split-flow detoxification. The treatment system comprises an adjusting tank, a nitrosation reactor and an anaerobic ammonia oxidation reactor which are sequentially connected in the flowing direction of biogas slurry, and further comprises a bypass detoxification reactor arranged on a bypass. The bypass detoxification reactor is divided into a catalytic oxidation area and a biological treatment area along the liquid flowing direction; wherein the catalytic oxidation area is used for loading a Fe3O4 / polyacrylamide catalyst and a persulfate oxidant and carrying out oxidative degradation on organic matters in the biogas slurry, and the biological treatment area is used for loading short-cut nitrification-anaerobic ammonia oxidation co-embedded particles and carrying out biological treatment on the biogas slurry. Compared with the prior art, the method has the advantages that the concentration of toxic substances in the ANAMMOX stage in the PN / A process is remarkably reduced, the denitrification efficiency of the reactor is improved, the water treatment amount and the load of the reactor are increased, and efficient and stable high-organic-toxicity anaerobic digestion biogas slurry treatment is successfully realized.