19results about "Thiol preparation" patented technology

The present application belongs to the technical field of condensate, and particularly relates to a non-peptide small molecule condensate and preparation and application thereof. The present application provides a non-peptide small molecule condensate which is prepared by taking a small molecule shown in formula I as a precursor, wherein Y and Z are each independently NH, O or S, R = or X = O or S; R1 and R2 are each independently selected from H, C 3‑20 alkyl, -C 1‑8 alkylene-phenyl, -C 1‑8 alkylene-5-10-membered heteroaryl, -C 1‑8 alkylene-S-C 1‑8 alkyl, -C 1‑8 alkylene-SH, -C 1‑8 alkylene-O-C 1‑8 alkyl or -C 1‑8 alkylene-NH-C 1‑8 alkyl; and R1 and R2 are not H at the same time. The obtained condensate not only has good spontaneous non-classical fluorescence characteristics, but also has the abilities of drug loading and controllable release, and shows excellent resistance to enzymatic hydrolysis and good biocompatibility. Formula I

A method for producing a high purity product sulfide from an olefin is provided. 【Solution means】Hydrogen sulfide or R 1 SH, and a method for producing a high purity product sulfide from an olefin of the formula C x H (2x) comprising the steps of: feeding hydrogen sulfide or R 1 SH, and an olefin of the formula C x H (2x) to a reactor system; separating the reactor effluent stream into a first portion and a second portion; recycling the first portion of the reactor effluent stream to the reactor system; and feeding the second portion of the reactor effluent stream to a sulfide separation system, the sulfide separation system comprising: at least one recycle stream comprising at least a portion of unreacted hydrogen sulfide, unreacted olefin of the formula C x H (2x) unreacted R 1 SH, and other components, and a product stream comprising the high purity product sulfide.

This invention provides a tert-nonylthiol and its synthesis method. The synthesis steps are as follows: nonene and hydrogen sulfide are preheated separately, then the preheated nonene and hydrogen sulfide are mixed, and the mixture is reacted under the action of a catalyst to obtain tert-nonylthiol. The preheating temperature of nonene is 40-50℃, and the preheating temperature of hydrogen sulfide is 50-60℃. This invention provides mild reaction conditions and precise preheating of nonene and hydrogen chloride separately. The product prepared by this method has a purity of over 99.0%, meeting the requirements of high-end industrial applications for high-purity tert-nonylthiol.

The application discloses a co-crystal medicine and a preparation method and application thereof, relates to the technical field of organic chemical synthesis, and forms a co-crystal medicine through intermolecular hydrogen bond action of two medicines. The prepared co-crystal medicine has the advantages of good solubility, strong stability and enhanced curative effect, solves the defects of poor solubility, poor stability and poor curative effect of original medicines, and thus improves clinical application.

The application relates to the technical field of organic synthesis, in particular to a synthesis method of 2-methyl-D-cysteine hydrochloride. The method is characterized in that (R)-epoxy chloropropane is used as a chiral starting material, and the target product is efficiently constructed through continuous reactions of thioether ring opening, propandioate alkylation and methylation, ethylenediamine-mediated aminolysis, deprotection and acid-promoted hydrolysis decarboxylation. The method is suitable for large-scale production, and has the advantages of easy raw material acquisition, simple route, mild reaction condition, high operation safety, high total yield and high optical purity.

Disclosed is a resin composition comprising a polymercaptan hardener and an epoxy resin, a method for preparing the same and an adhesive, sealant, coating, or composite comprising the resin composition.

Chain transfer agent compositions that can include mixed mercaptans. Emulsion polymerization reaction mixtures that can include a chain transfer agent composition, one or more monomers, and one or more polymerization initiators. Methods of polymerization, which can include providing an emulsion polymerization reaction mixture, and isolating a polymer product from the emulsion polymerization reaction mixture.

The application discloses a synthesis process of cysteamine hydrochloride, which comprises the following steps: (1) cooling ethanolamine under an ice water bath, then adding concentrated sulfuric acid drop by drop, maintaining low temperature, heating and distilling to obtain 2-aminoethyl sulfate; (2) spraying sodium hydroxide solution to 2-aminoethyl sulfate under an ice water bath, then adding sodium hydroxide solution to dissolve, adding carbon disulfide drop by drop, stirring at room temperature after drop completion, heating and reacting, washing with water to obtain 2-mercaptothiazoline; (3) mixing 2-mercaptothiazoline with hydrochloric acid solution, pressurizing, heating and refluxing to react, adding hydrochloric acid solution drop by drop in the reaction, stirring and cooling, distilling to obtain crude cysteamine hydrochloride; and (4) sequentially cleaning the crude cysteamine hydrochloride with an ethanol aqueous solution and a hydrochloric acid solution, and drying to obtain refined cysteamine hydrochloride. The synthesis process of the cysteamine hydrochloride can improve the yield and purity of the target product, and meets the requirements of a pharmaceutical intermediate.

To provide novel thiol compounds and applications thereof, and specifically, novel thiol compounds, methods for synthesizing the thiol compounds, curing agents containing the thiol compounds, resin compositions containing the curing agents and epoxy compounds, resin compositions containing the curing agents and enic compounds having an intramolecular carbon-carbon double bond, and adhesives, sealants and cured products containing these resin compositions.SOLUTION: The thiol compounds are obtained by reaction between 1,2,3-triallyloxypropane represented by chemical formula (II) and thiocarboxylic acid represented by chemical formula (III), and following solvolysis. (In the formula, R is a methyl group, ethyl group, propyl group, or phenyl group.)SELECTED DRAWING: None

This invention provides a method for synthesizing methyl phthalate benzyl sulfonamide, belonging to the field of pesticide intermediate technology, comprising the following steps: S1. Adding water to a solution of methyl phthalate, stirring, then adding sodium hydrosulfide to carry out a substitution reaction. After the reaction is completed, cooling to room temperature, adding dichloroethane for extraction, separating and discarding the dichloroethane phase, yielding an aqueous solution of methyl phthalate benzyl mercaptan; S2. Adding methanol to the aqueous solution of methyl phthalate benzyl mercaptan, and passing chlorine gas to carry out an acylation reaction. After the reaction is completed, filtering and vacuum drying to obtain methyl phthalate benzyl sulfonyl chloride; S3. Dissolving methyl phthalate benzyl sulfonyl chloride in dichloroethane, and passing dry ammonia gas to carry out an amination reaction. After the reaction is completed, filtering and vacuum drying to obtain methyl phthalate benzyl sulfonamide. This invention reduces waste treatment costs while improving yield, and has industrial application value.

The application discloses a methanethiol synthesis catalyst with a wide hydrogen sulfide to methanol ratio and a preparation method thereof. The catalyst comprises the following components in parts of mass: 1-10 parts of magnesium oxide, 60-80 parts of aluminum oxide, 10-25 parts of potassium tungstate and 2-10 parts of vanadium pentoxide. The catalyst can keep high activity, high selectivity and long service life in a wide methanethiol ratio range, and has wide application value.

The application discloses a kind of light-driven solid nitroaromatics spontaneous hydrogen transfer amination method, it is related to organic synthesis technical field, comprising the following steps: step one: weighing solid p-nitroanisole, according to certain amount of proportion, 4,4'-dipyridyl and B2 (OH) 4 are sequentially added to corresponding amount of p-nitroanisole.The application is combined by using the method of photocatalysis and solid phase catalysis method, photocatalysis and solid phase catalysis method are combined, the best reaction duration, the best illumination condition that can convert nitro group into amino group are screened out to p-nitroanisole as substrate, and the best reaction ratio of p-nitroanisole and B2 (OH) 4 and 4,4'-dipyridyl, i.e.the scheme does not need combustible hydrogen, high pressure equipment or metal catalyst, and also does not need the participation of solid state catalytic reaction of organic solvent, using light source catalysis, nitroaromatics containing sensitive groups such as N heterocycle, halogen, aldehyde group, alkynyl, conjugated group can obtain product with higher yield.

The present invention relates to a process for the preparation of freeze-dried 2-[(3-aminopropyl)amino]ethanethiol comprising the following steps: a) the reaction of a solution of amifostine with a strong acid, to obtain a solution of 2-[(3-aminopropyl)amino]ethanethiol, and b) the freeze-drying of the solution of 2-[(3-aminopropyl)amino]ethanethiol, with or without addition of excipients.

The present invention relates to the use of at least one catalyst comprising at least one Mo-W bimetallic compound and at least one promoter for the production of methyl mercaptan.

This invention relates to the synthesis of methyl thioglycolate, and discloses a method and apparatus for the continuous flow synthesis of methyl thioglycolate, as well as its applications. The method includes: introducing a catalyst, methyl thioglycolate, and methanol into a micromixer for contact; introducing the resulting feedstock into a microreactor for reaction; subjecting the resulting reaction solution to a first vacuum distillation to obtain an overhead effluent and a bottom effluent; heating the overhead effluent and then subjecting it to atmospheric distillation to obtain a methanol effluent and a wastewater effluent; refluxing the methanol effluent for the contact process; heating the bottom effluent and then subjecting it to a second vacuum distillation to obtain a methyl thioglycolate product and a feedstock effluent; cooling the feedstock effluent and then refluxing for the contact process; the feedstock effluent contains unreacted methyl thioglycolate and catalyst. This method and apparatus enable the continuous preparation of methyl thioglycolate, allowing for the reuse of feedstock and catalyst, resulting in a short reaction time, minimal environmental pollution, and high purity, yield, and selectivity of the methyl thioglycolate product.

This application discloses a method for preparing alkyl thiols from α-olefins, comprising the following steps: in a reactor, contacting α-olefins and hydrogen sulfide with a catalyst, reacting I to obtain alkyl thiols; wherein the α-olefin is selected from at least one of C6-C16 α-olefins; and the catalyst is an acidic ionic liquid catalyst supported on fumed silica. This method has advantages such as good catalyst stability, high catalytic activity, and high selectivity.