82 results about "Thiosalicylic acid" patented technology

The invention provides a method for polishing one or more layers of a multi-layer substrate that includes a first metal layer and a second layer comprising (i) contacting the first metal layer with a polishing system comprising a liquid carrier, at least one oxidizing agent, at least one polishing additive that increases the rate at which the system polishes at least one layer of the substrate, wherein the polishing additive is selected from the group consisting of pyrophosphates, condensed phosphates, phosphonic acids and salts thereof, amines, amino alcohols, amides, imines, imino acids, nitriles, nitros, thiols thioesters, thioethers, carbothiolic acids, carbothionic acids, thiocarboxylic acids, thiosalicylic acids, and mixtures thereof, and a polishing pad and / or an abrasive, and (ii) polishing the first metal layer with the system until at least a portion of the first metal layer is removed from the substrate.

The invention relates to an SERS (Surface Enhanced Raman Spectroscopy) method for detecting alpha fetal protein based on a probe-marked immunogold and magnetic composite material, and belongs to the technical field of protein analysis detection. The method comprises the following steps: combining P-thiosalicylic acid (MBA)-molecule-modified gold nanoparticle particles with an alpha fetal protein antibody, preparing a surface-functionalized Fe3O4@SiO2 magnetic composite material, absorbing the alpha fetal protein in serum onto the functionalized Fe3O4@SiO2 magnetic composite material; performing an immune reaction on an immunogold probe and the Fe3O4@SiO2 magnetic composite material modified with an alpha fetal protein antigen; performing Raman spectrum detection. The concentration of the alpha fetal protein can be detected by substituting the Raman strength value of an obtained Raman spectrum characteristic peak of protein to be detected into a working curve of Raman strength value and alpha fetal protein antigen concentration. The method has the advantages of ultrasensitiveness, high selectivity, mild detection conditions and the like, and has extremely important meanings in clinical analysis and diagnosis.

Sulfur-containing ligands and methods of their utilization for binding metals and / or main group elements and removing them from fluids, solids, gases and / or tissues are disclosed. The ligands are of the general structure:where R1 comprises benzene, pyridine, pyridin-4-one, naphthalene, anthracene, phenanthrene or alkyl groups, R2 comprises hydrogen, alkyls, aryls, a carboxyl group, carboxylate esters, organic groups or biological groups, R3 comprises alkyls, aryls, a carboxyl group, carboxylate esters, organic groups or biological groups, X comprises hydrogen, lithium, sodium, potassium, rubidium, cesium, francium, alkyls, aryls, a carboxyl group, carboxylate esters, thiophosphate, N-acetyl cysteine, mercaptoacetic acid, mercaptopropionic acid, thiolsalicylate, organic groups or biological groups, n independently equals 1-10, m=1-6, Y comprises hydrogen, polymers, silicas or silica supported substrates, and Z comprises hydrogen, alkyls, aryls, a carboxyl group, carboxylate esters, a hydroxyl group, NH2, HSO3, halogens, a carbonyl group, organic groups, biological groups, polymers, silicas or silica supported substrates.

The invention discloses a method for synthesizing a novel anti-influenza drug baloxavir marboxil. The method comprises the following steps: directly docking a thiosalicylic acid compound 1 and a 1-(halogenated methyl)-2,3-difluorobenzene compound 2 serving as initial raw materials so as to obtain a compound 3; performing PPA ring closure to obtain a 7,8-difluorodibenzo[b,e]thiozepine-11(6H)-one compound 4, and obtaining a key chiral thiazem intermediate compound 5 under catalysis of a chiral enzyme; directly condensating the compound 5 and a key chiral fragment compound 6 by virtue of a Mitsubobu reaction so as to obtain a compound 7; finally performing dealkylation protection, and condensating with ((methoxycarbonyl)oxo)4-methyl-toluenesulfonate, so as to obtain the final product compound9, namely the baloxavir marboxil. According to the synthetic route, the process operation magnification difficulty of the route is reduced, the production of by-products is reduced, the product purity is improved, and the cost of the route is reduced.

The invention provides a system for polishing one or more layers of a multi-layer substrate that includes a first metal layer and a second layer comprising (i) a liquid carrier, (ii) at least one oxidizing agent, (iii) at least one polishing additive that increases the rate at which the system polishes at least one layer of the substrate, wherein the polishing additive is selected from the group consisting of pyrophosphates, condensed phosphates, phosphonic acids and salts thereof, amines, amino alcohols, amides, imines, imino acids, nitriles, nitros, thiols, thioesters, thioethers, carbothiolic acids, carbothionic acids, thiocarboxylic acids, thiosalicylic acids, hydroxylates, carbonylates, carboxylates, and acids thereof, and mixtures thereof, (iv) at least one stopping compound, and (v) a polishing pad and / or an abrasive. The invention also provides a method of polishing a substrate comprising contacting a surface of a substrate with the system and polishing at least a portion of the substrate therewith. Moreover, the invention provides a method for polishing one or more layers of a multi-layer substrate that includes a first metal layer and a second layer comprising (a) contacting the first metal layer with the system, and (b) polishing the first metal layer with the system until at least a portion of the first metal layer is removed from the substrate.

The invention provides a novel diamine-containing farnesyl thiosalicylic acid derivative and pharmaceutically acceptable salt thereof, a preparation method for the derivative and the salt, a medicinal composition containing the derivative, and medicinal application of the derivative, the salt and the composition, particularly application to preparation of anti-tumor medicines and neuroprotection medicines.

The invention discloses a nitric oxide (NO) donor-type farnesyl thiosalicylic acid (FTA) derivative, and pharmaceutically acceptable salt, a preparation method and medical application thereof. The FTA derivative is a compound obtained by carrying out heterozygosis on a NO donor furazan nitrogen oxide and Ras protein inhibitor FTA by an ester bond or an amido bond. Pharmacological test results show that the FTA derivative can reserve the Ras protein inhibiting activity of FTA and simultaneously releases high-concertration NO to induce cancer cell apoptosis and enhance the inhibiting action on cancer cell proliferation; compared with the FTA, the FTA derivative has more excellent anti-tumor activity, and therefore, the compound can be suitable for treating various clinical malignant tumours.

Disclosed are methods for inhibiting Ras activity such as cell proliferation associated with vascular injury such as post-angioplasty restenosis and atherosclerosis. Preferred Ras antagonists are S-trans-trans farnesylthiosalicylic acid (FTS) and structurally related compounds (or analogs) thereof.

The invention relates to a surface-enhanced Raman scattering aptamer sensor for detecting polychlorinated biphenyls and application. Gold-silver core-shell nanoparticles are used as a Raman substrate;4-thiosalicylic acid as a Raman signal molecule is modified on the surface of the gold-silver core-shell nanoparticles; a PCB72 aptamer is used as a pollutant identification element for constructingto obtain the sensor. Compared with the prior art, the surface-enhanced Raman scattering aptamer sensor disclosed by the invention has the advantages that by adopting an advanced surface-enhanced Raman technology, the detection sensitivity of the sensor to PCB72 is greatly improved, the linear detection range of the sensor is 1pg / mL-1000pg / mL and the detection limit can reach 0.3pg / mL; meanwhile,by adopting the aptamer, specific recognition of the PCB72 is realized, and the detection selectivity of the sensor to the PCB72 is greatly improved. The sensor disclosed by the invention can be usedfor detection analysis of an actual water sample; compared with other analysis methods, an analysis method disclosed by the invention has the advantages that a sample does not need complex pretreatment; simplicity, quickness and ultrahigh sensitivity are realized.

The invention relates to a preparation of recombinant adenovirus, containing recombinant adenovirus, Tris buffer solution, propylene glycol and arginine; in addition, the preparation also can contain an antioxidant, such as one or combination of sodium sulfite, sodium thiosulfate, glutathione, thiosalicylic acid, cystine hydrochloride, dithioglycollil acid, thiourea, sulfosorbierite or aurothioglucose; the preparation also can contain antioxidant synergist which is one or combination of sodium citrate, sodium succinate or sodium hypophosphite. By utilizing the preparation, the recombinant adenovirus can be stored for long time at the temperature of 2-8 DEG C.

The invention provides a farnesyl thiosalicylic acid-nucleoside conjugate and pharmaceutically acceptable salts thereof. The farnesyl thiosalicylic acid-nucleoside conjugate and the pharmaceutically acceptable salts thereof have the structure as shown in a general formula I, wherein in the general formula I, X is H, F, Cl or Br; R1 represents H, OH, OAc, SH, -OP(O)(OH)2, -OPO3HNa, -OP(O)(ONA)2, -OPO3HK or -OP(O)(OK)2; R2 represents H, OH, OAc or OCH; R3 represents H, OH, F, CN, OAc or OCH3; R4 represents H, OH, F, CN, OAc or OCH3. The invention also provides a preparation method of the farnesyl thiosalicylic acid-nucleoside conjugate and the pharmaceutically acceptable salts thereof and a pharmaceutical composition containing the derivatives as well as medical applications thereof, especially application in preparation of antitumor drug medicines.

Disclosed are alkoxyalkyl S-prenylthiosalicylates and pharmaceutical compositions containing the same and a pharmaceutically acceptable carrier. Methods for treating a human afflicted with cancer, including solid tumors, or a hematological malignancy by administering to the human in need thereof an effective amount of an alkoxyalkyl S-prenylthiosalicylate are also disclosed.

The invention discloses an alcohol-free fountain solution which is a mixture containing water, citric acid, zinc nitrate, glycerol, alkylphenol polyoxyethylene polyoxypropylene ether, thiosalicylic acid, sodium dehydroacetate, sodium ethylenediaminetetraacetate, polyoxypropylene polyoxyethylene glyceryl ether and Arabic gum, wherein the mixture contains the following components by mass percent: 45-65% of water, 3-7% of citric acid, 0.5-2.0% of zinc nitrate, 20-30% of glycerol, 2-8% of alkylphenol polyoxyethylene polyoxypropylene ether, 0.2-1.5% of thiosalicylic acid, 0.3-1.5% of sodium dehydroacetate, 0-5% of sodium ethylenediaminetetraacetate, 0.2-1% of polyoxyethylene polyoxypropylene glyceryl ether and 3-10% of Arabic gum. According to the invention, the alcohol-free fountain solution can completely replace the alcohol fountain solution widely used at present, has the appropriate surface tension and good adhesion, and is easy to control the use of materials, high in stability, green and environmental friendly.

The invention relates to a dendritic polymer and particularly relates to a dendritic polymer with a high refractive index and a preparation method thereof. The dendritic polymer with the high refractive index is prepared by reaction on a dendritic polymer and a benzene ring or sulfydryl-containing organic compound under the action of a catalyst and a high-temperature-resistant oxidant, wherein the dendritic polymer is one or more of PAMAM-G1, PAMAM-G2 or PAMAM-G3; the benzene ring-containing organic compound is one or two of benzoic acid or hydroxyl salicylic acid and the sulfydryl-containing compound is one or more of thiosalicylic acid, sulfydryl sulfonic acid or sulfydryl phenylboronic acid. The dendritic polymer with the high refractive index as an additive is added into well-illuminated epoxy resin and an organic silicon material, so that the refractivity can be remarkably improved. The preparation method provided by the invention is simple in process and easy to realize.

Disclosed are methods of treating ovarian cancer by administering an effective amount of FTS (farnesylthiosalicylic acid), or various analogs thereof, or a pharmaceutically acceptable salt, optionally with, a platinum-based chemotherapy drug to a human diagnosed with ovarian cancer.

A premium wear resistant lubricant comprises a base stock, preferably a GTL liquid or the liquid isomerization product of slack wax or F-T wax, and a non-ionic ashless anti-wear additive. The non-ionic ashless antiwear additive is preferably at least one of thiosalicylic acid or alkyl ester thereof, thioxomalonate, 2,2-dithiopyridine and thiazolidine. The lubricant may also contain additional base stock materials selected from other hydrocarbonaceous and synthetic base stock materials in admixture with the GTL liquid or slack wax or F-T derived base stock.

The invention belongs to the technical field of ultra-precision finishing, and discloses an electrolyte for electrochemical mechanical polishing of a copper interconnecting layer and a preparation method of the electrolyte. The electrolyte is characterized in that benzotriazole, thiosalicylic acid, dodecyl ammonium sulfate and the like with good inhibitory effect are used as an inhibitor in the electrolyte; and rutile-type titanium oxide, anatase-type titanium oxide and the like with good dielectric properties are used as abrasive particles, and a proper amount of complexing agent and dispersant are added to prepare into the electrolyte. The prepared electrolyte can effectively inhibit further corrosion of the recesses on a finished surface, increase the electric field gradient in the vicinity of the finished surface, improve the selective dissolution removal capacity to the salient parts on the finished surface, improve the surface quality after polishing, and realize ultra-precision polishing of the copper interconnecting layer under low polishing pressure.

Disclosed are methods of treating ovarian cancer by administering an effective amount of FTS (farnesylthiosalicylic acid), or various analogs thereof, or a pharmaceutically acceptable salt, optionally with, a platinum-based chemotherapy drug to a human diagnosed with ovarian cancer.

A synthesis method of metixene hydrochloride relates to a synthesis process of an antiparkinsonian drug. The synthesis method comprises the following steps: taking thiosalicylic acid as a raw material to obtain 2-thiophenyl benzoic acid by coupling with iodobenzene; then dehydrating and cyclizing to obtain 9-thioxanthone; reducing a carbonyl to obtain thioxanthene; and finally allowing the thioxanthene to react with 3-chloromethyl-1-pipecoline to obtain the target product (5) metixene hydrochloride shown as a formula (5) below. The synthesis method has the advantages of available raw materials, low cost, short preparation course, simple operation and easy industrialization, and helps produce the metixene hydrochloride which is the antiparkinsonian drug.

A process for preparing a dibenzothiazepine derivative such as dibenzo[b,f][1,4]thiazepin-11-one employable as a starting material for the preparation of 11-[4-(2-(2-hydroxyethoxy)ethyl)]-1-piperadinyldibenzothiazepine derivative which is known to be effective as an antipsychotic pharmaceutical, has the steps of reacting a nitrobenzene derivative with a thiosalicylic acid derivative, reducing the obtained 2-nitro-2′-carboxy-diphenylsulfide derivative, and subjecting the obtained 2-amino-2′-carboxy-diphenylsulfide derivative to dehydration-condensation reaction.

The invention discloses a thioxanthone photoinitiator containing cyclic acetal shown as below and a preparation method thereof. The 1,3-benzodioxolane or 1,3-benzodioxane and derivative thereof and 2-thiosalicylic acid are used as raw materials and concentrated sulphuric acid is used as solvent to react at 0-70 DEG C for 1-24 hours and prepare the thioxanthone containing cyclic acetal. As cyclic acetal group is introduced in thioxanthone and cyclic acetal can be used as the co-initiator of thioxanthone, the compound of the invention can be directly used as photoinitiator to replace the thioxanthone / amine initiation system and reduce the yellowing and toxicity caused by amine co-initiator and have wide application prospect in the photocuring industrial field.

The invention belongs to the technical field of supercapacitor electrode materials, and particularly relates to a nickel-cobalt bimetallic oxide composite material, a nickel-cobalt bimetallic sulfidecomposite material and a supercapacitor. According to the invention, thiosalicylic acid is used as a ligand, Co<2+> and Ni<2+> are added, a nickel-cobalt bimetallic organic complex is hydrothermally synthesized, and the nickel-cobalt bimetallic oxide composite material is prepared by calcining at 400 DEG C. Furthermore, the nickel-cobalt bimetallic oxide composite material with excellent electrochemical performance is used as a precursor; the nickel-cobalt bimetallic sulfide composite material is obtained through one-step hydrothermal vulcanization, the electrochemical performance of the nickel-cobalt bimetallic sulfide composite material is obviously superior to that of a nickel-cobalt bimetallic oxide composite material, and high energy density, high power density, good conductivity andlong cycle life can be kept while the specific capacitance is improved.

The invention discloses a thioxanthone acetylfluorene photoinitiator and a preparation method thereof. The preparation method comprises the following steps: adding a solvent, thiosalicylic acid and 2-acetylfluorene in a reactor, reacting under the condition of heating until the reaction is finished; and cooling reaction liquid obtained after reaction, carrying out aftertreatment including washing and recrystallizing to obtain thioxanthone acetylfluorene. Under the same light condition, the thioxanthone photoinitiator with larger molar absorption coefficient has stronger photo-initiation function. The synthesis method of the thioxanthone acetylfluorene photoinitiator is simple; the thioxanthone acetylfluorene photoinitiator has an absorption platform in a near ultraviolet light region, and has a molar absorption coefficient of 7983L.mol<-1>.cm<-1> at the wavelength of 398nm; as an efficient near ultraviolet photoinitiator, the thioxanthone acetylfluorene photoinitiator can be capable of greatly improving the photo-initiation efficiency and has the beneficial effects of conservation of energy sources and improvement of the output and quality of related products.

The invention provides a method for synthesizing benzisothiazolinone compounds by catalyzing oxidization of molecular oxygen in an aqueous phase. A water-soluble transition metal phthalocyanine compound is taken as a catalyst, and a thiosalicylic acid amide compound reacts in the aqueous phase for 2 to 24h at the temperature of 80 to 100 DEG C in an oxygen environment to generate the benzisothiazolinone compounds. The reaction is carried out in the aqueous phase without adding other organic solvents; the catalyst has high catalytic activity and high reaction efficiency; the method for generating the benzisothiazolinone compounds by catalyzing the oxidization of the molecular oxygen in the aqueous phase is simple in synthesis process, high in product selectivity and less in by-products andwaste and environment-friendly, and further has a stronger industrial application prospect.

The invention discloses a phenyl acrylic acid farnesyl thiosalicylic acid (FTA) derivative as well as a preparation method and an application. The phenyl acrylic acid farnesyl thiosalicylic acid derivative is a compound of a formula (I) in the specification, wherein X1 represents O or NH; X2 represents O or NH; n is equal to 1- 3; R represents H or OCH3. By coupling ferulic acid and p-hydroxy cinnamic acid fragments with carboxyl of FTA, the capability of a target molecule in scavenging free radicals is improved, the anti-tumor effect of the molecule is improved, and then a compound with anti-tumor activity or anti-inflammatory activity higher than those of FTA is obtained.

The invention discloses a method for preparing an antibacterial material by use of nano silver, and relates to a preparation method of the antibacterial material. The preparation method comprises the following steps: (1) adding a prepared 2.5g / L nitrate solution into a formaldehyde solution added with 10% of a reducing agent, adding catalyst organic base triethylamine and protective agent thiosalicylic acid for mixing for reaction; (2) adding excess triethylamine into the reacted solution of the step (1) to make the solution more stable and obtain a nano silver solution with the nano silver average particle size being less than 10nm; (3) preparing a 2-3g / L nano silver mixed solution, using a sprayer to spray onto a medical fabric, and drying; (4) filling the medical fabric sprayed with the nano silver with absorbent cotton to make the bactericidal effect better. The nano silver medical product prepared by the method has strong antibacterial, bactericidal effect and broad spectrum antibacterial activity, and is free of drug resistance and high in safety, and the bactericidal effect is greatly enhanced.

A process for preparing a dibenzothiazepine derivative such as dibenzo[b,f] [1,4]thiazepin-11-one employable as a starting material for the preparation of 11-[4-(2-(2-hydroxyethoxy)ethyl)]-1-piperadinyldibenzothiazepine derivative which is known to be effective as an antipsychotic pharmaceutical, has the steps of reacting a nitrobenzene derivative with a thiosalicylic acid derivative, reducing the obtained 2-nitro-2′-carboxy-diphenylsulfide derivative, and subjecting the obtained 2-amino-2′-carboxy-diphenylsulfide derivative to dehydration-condensation reaction.

Disclosed are methods for treating multiple sclerosis patients that entail co-administration of effective amounts of a Ras antagonist which is farnesylthiosalicylic acid or an analog thereof, and a second active agent selected from glatiramer acetate, laquinimod and combinations thereof. Therapeutic compositions and methods of making them are also disclosed.

A dibenzothiazepine compound is suitably prepared by subjecting a 2-amino-2′-carboxy-diphenylsulfide compound to dehydration-condensation reaction in the presence of an acidic catalyst; the 2-amino-2′-carboxy-diphenylsulfide compound is suitably prepared by reducing a 2-nitro-2′-carboxy-diphenylsulfide compound in a lower aliphatic ester solvent; and the 2-nitro-2′-carboxy-diphenylsulfide compound is suitably prepared by reacting a nitrobenzene compound with a thiosalicylic acid compound in a mixture of a lower aliphatic alcohol and water.

Sulfur-containing ligands and methods of their utilization for binding metals and / or main group elements and removing them from fluids, solids, gases and / or tissues are disclosed. The ligands are of the general structure (A): or structure (B) where R1 comprises benzene, pyridine, pyridin-4-one, naphthalene, anthracene, phenanthrene or alkyl groups, R2 comprises hydrogen, alkyls, aiyls, a carboxyl group, carboxylate esters, organic groups or biological groups, R3 comprises alkyls, aryls, a carboxyl group, carboxylate esters, organic groups or biological groups, X comprises hydrogen, lithium, sodium, potassium, rubidium, cesium, francium, alkyls, aryls, a carboxyl group, carboxylate esters, thiophosphate, N-acetyl cysteine, mercaptoacetic acid, mercaptopropionic acid, thiolsalicylate, organic groups or biological groups, n independently equals 1-10, m = 1 -6, Y comprises hydrogen,; polymers, silicas or silica supported substrates, and Z comprises hydrogen, alkyls, aryls, a carboxyl group, carboxylate esters, a hydroxyl group, NH2, HSO3, halogens, a carbonyl group, organic groups, biological groups, polymers, silicas or silica supported substrates.