The invention discloses a process for preparing 1, 1, 1, 3-HFO-1234ze, which resolves the problem of low selectivity of HFO-1234ze. The invention takes 1, 1, 1, 3, 3-HCC-240fa as raw material, including the following steps that a, placing hydrogen fluoride (HF) and HCC-240fa into a reactor to react with fluorination catalyst, b, distilling and detaching the produced fluid in step a which flows into a distillation tower, the tower bottom components of 1, 1, 1, 3, 3-HCC-240fa, 1-chlorine-3, 3, 3-HCFC-1233zd and hydrogen fluoride recycle to the reactor, the tower top components of hydrogen fluoride and HFO-1234ze enter after-treatment system and obtaining object product HFO-1234ze after processes of deoxidation, dehydration and distillation and the like. The invention is mainly used to prepare HFO-1234ze.