The invention discloses a cast polyurethane storage battery protection case and a manufacturing method thereof, and belongs to the technical field of storage battery protection. The manufacturing method comprises the following steps: by taking high temperature resistant inorganic hybridized melamine resin polyhydric alcohol or inorganic hybridized polyhydric alcohol etherified melamine resin, an emulsifier, a composite catalyst, a phosphate flame retardant, and a foaming agent such as water or sodium silicate as main raw materials, preparing compounded polyether, preparing a melamine polyurethane hard foamed material from the compounded polyether and polyisocyanate, and casting the melamine polyurethane hard foamed material between the inner shell and the outer shell of the storage battery protection case. The melamine polyurethane hard foamed material is free of low-boiling-point hydrocarbon compound or hydrogen chlorofluorocarbon compound, does not damage the ozone layer when being foamed with water, and is free of greenhouse effect, good in environment-friendliness, and excellent in flame retardancy, that is, the flame retardancy is improved by at least 20%, the oxygen index of the material is greater than 30%, the cast polyurethane storage battery protection case has functions of temperature insulation, flame retardancy, water resistance and battery protection, and problems that a vehicle-mounted battery protection case has high temperature, water leakage, flame retardancy and the like for a long time can be solved.