Method for synthesizing 2, 3-dimethyl-2-isopropyl butyronitrile
The described method addresses the inefficiencies of existing synthesis methods by using organic amine solvents and phase transfer catalysts to enhance the reaction rate and yield of 2,3-dimethyl-2-isopropyl nitrile while eliminating hazardous solvents, achieving a 95% yield in a safer process.
CN120309511AActive Publication Date: 2025-07-15INNER MONGOLIA HUAKUN BIOTECHNOLOGY CO LTD
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Patent Information
- Application Number
- CN202510811759.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-18
- Publication Date
- 2025-07-15
- Estimated Expiration
- 2045-06-18
AI Technical Summary
Technical Problem
The prior art synthesis of 2,3-dimethyl-2-isopropylbutyribide nitrile has problems such as long reaction time, low yield and use of dangerous solvents.
Method used
Using a combination of organic amine solvent, sodium iodide and phase transfer catalyst, the reaction was carried out by dropping the mixture of propionitrile and 2-bromopropane, and the high activity of sodium iodide and phase transfer catalyst were used to improve the solubility, shorten the reaction time and improve the yield.
Benefits of technology
The reaction time is shortened to 2 hours, and the yield reaches 95%, avoiding the use of dangerous solvents, which improves safety and efficiency.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention belongs to the field of fine chemical engineering, and discloses a method for synthesizing 2, 3-dimethyl-2-isopropyl butyronitrile, which comprises the following steps of: adding an organic amine solvent into a high-pressure reaction kettle, adding sodium amide, sodium iodide and a phase transfer catalyst into the reaction kettle under the protection of nitrogen and in a stirring state, stirring for a certain period of time, and reacting for 2-3 hours to obtain 2, 3-dimethyl-2-isopropyl butyronitrile. Dropwise adding a mixed solution of propionitrile and 2-bromopropane into the reactor, controlling the dropwise adding speed and the reaction temperature, continuously reacting for a period of time after the dropwise adding is finished to obtain a reactant solution, cooling the reactant solution, adding water, standing for layering, collecting an organic phase, distilling the organic phase at normal pressure to recover a solvent, and rectifying at reduced pressure to obtain 2, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3-pentanediol. According to the method, the sodium iodide, the phase transfer catalyst and the organic amine have a synergistic effect, so that the reaction time is shortened, and the yield of the product is improved.
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