The invention relates to a green synthesis method of 2, 4-dicumyl
phenol. The invention belongs to the field of synthesis of medical intermediates. The invention aims to solve the technical problems that the raw materials are non-renewable,
thermal runaway is easily caused by high-temperature reaction, the
energy consumption is high and the content of 3-substituted by-products is relatively high in the existing synthesis method of 2, 4-dicumyl
phenol. The method comprises the following steps: adding
vanillin into an
electrolyte, and carrying out electrochemical deoxidation in a
proton exchange membrane
electrolytic cell by taking a
titanium-based DSA
electrode as an
anode to obtain o-methoxyphenol; according to the method, o-methoxyphenol and
cumene are subjected to a free radical
coupling reaction in a flowing electrochemical reactor in the presence of a homogeneous
electron transfer catalyst by taking a
titanium-based DSA
electrode as an
anode, and high-purity 2, 4-dicumyl
phenol is obtained through extraction and
distillation after the reaction is finished. According to the method, the raw materials are 100% renewable, strong acid and high temperature are avoided,
hazardous waste emission is avoided, few trisubstituted by-products are generated, and industrial production can be carried out.