The invention relates to a method for preventing disease of konjac, and the method comprises the following five aspects of: konjac seed treatment, soil treatment, sowing pre-treatment, a sowing method and field management. The method disclosed by the invention has the beneficial effects that the konjac seed treatment is carried out, thus diseased konjac seeds can be avoided from being mixed and the konjac seeds can be prevented from being infected with a disease; the soil treatment is carried out, thus harmful bacteria can be avoided from being carried in soil, the harmful bacteria in the soil can be killed, and meanwhile the living environment of the harmful bacteria can be destroyed; the sowing pre-treatment is carried out, thus the diseased konjac seeds can be avoided from being mixed, the disease resistance of the konjac seeds can be enhanced, and sprouting and sowing can be used for reducing the opportunity that the harmful bacteria are immersed into the konjac seeds; interplanting can be used for reducing the survival chance of the harmful bacteria and filtering part of sunlight, and a base fertilizer is applied well, thus top dressing can be reduced, and the influence on a konjac plant can be reduced; the filed management can be used for preventing the harmful bacteria from intruding in the whole journey; and a series of comprehensive methods can be used for preventing the disease of the konjac in every aspect.