The invention discloses feed for controlling medicine residues of channel catfishes, which comprises the following components in the mass percent: 13.85% of puffed soybean meal, 4.0% of fermented soybean meal, 12.0% of steamed fish meal, 18.0% of rapeseed meal, 16.5% of cottonseed protein, 16.0% of rice bran, 14.32% of secondary powder, 1.8% of calcium biphosphate, 2.0% of IV-grade soybean oil, 1.0% of premix compound, 0.01% of vitamin E, 0.02% of vitamin C, 0.05% of high-temperature resistant complex enzyme preparation, 0.05% of cure accelerator and 0.4% of Chinese herbal medicine additive, and the total percent is 100%. By optimizing the components of the feed, adding Chinese herbal medicines in the feed to replace antibiotics and adding high-temperature resistant enzyme preparations, biological live bacterial preparations and the like, the purposes of improving the stability of the feed, promoting the health growth of channel catfishes, enhancing the immunity of the physique and theorganisms of fish bodies and preventing diseases are achieved, thereby finally achieving the purposes of improving the growth rate of channel catfishes, reducing the feeding cost, discarding antibiotics and controlling the medicine residues in bodies under the normal water quality environment.