273 results about "Appetite" patented technology

Compositions and methods for administering ketone bodies to a subject include beta-hydroxybutyrate complexed with or coupled to at least one amino acid. The compositions and methods cause one or more of: weight loss, weight maintenance, reduced blood glucose level, maintenance of blood glucose level, increased muscle and physical performance, enhanced metabolic and cellular repair, improved detoxification and gut health, targeted bioavailability, sustained release and controlled absorption, increased metabolic efficiency, enhanced cellular uptake, minimized side effects, multifunctional therapeutics, improved focus, improved energy, improved cognitive function, improved mental acuity, treatment of traumatic brain injury, treatment of diabetes, treatment of neurological disorder, treatment of cancer, treatment of inflammatory condition, appetite suppression, anti-aging effects, anti-glycation effects, treatment of epilepsy, treatment of depression, improved performance, improved muscle mass, improved motor function, increased strength, increased metabolism, increased fat loss, increased fat oxidation, improved body composition, and improved mood.

The invention relates to the technical field of polypeptide drugs for metabolic diseases, in particular to a glucagon-like peptide (GLP-1), a glucose-dependent insulinotropic polypeptide (GIP) and a glucagon (GCG) triple receptor agonist (protein). According to the triple receptor agonist protein provided by the technical scheme, weight reduction is achieved, meanwhile, lower side effects are shown, and drug compliance is enhanced. The triple receptor stimulant researched and developed by the technical scheme can be applied to preparation of medicines with the effects of losing weight, reducing lipid or reducing blood sugar, solves the technical problem that the existing GLP-1, GIP and GCG triple receptor stimulants are difficult to reduce side effects while reducing body weight, and breaks through the weight loss mode that the traditional medicines depend on appetite suppression; due to the unique action mechanism and good safety, a safer and more effective treatment scheme is provided for patients, and the medicine has wide market prospects and social benefits.

The present invention relates to the technical field of food and drugs, and in particular to a hydrogel material composition, and a weight management composition, a preparation method therefor and a use thereof. The hydrogel material composition comprises konjac powder, galactomannan, and resistant dextrin. The weight management composition comprises the following components in parts by mass: 40-60 parts of a hydrogel material composition, 10-40 parts of a disintegrating agent, 0-15 parts of inorganic salt, and 10-35 parts of a filler. In the present invention, the composition prepared from specific components and by specific proportions can have good preparation performance, disintegration performance, and gelling performance; the product quality stability is high; the composition is suitable for large-scale application development; and the composition can occupy the space in the stomach after being eaten, so that satiety is promoted, and the appetite is reduced, thereby achieving the purposes of realizing weight management, blood sugar control and the like.

This invention relates to treating Prader-Willi Syndrome (PWS) using a KATP channel opener. The channel opener may be coadministered with other therapies used to treat PWS, such as human growth hormone, a wakefulness promoting agent, or a psychiatric or mood stabilizing drug, thereby allowing the baseline dosages of these other therapies to be decreased or making these other therapies unnecessary. The invention also relates to treating PWS based on the PWS nutritional phase of a patient, to prevent the patient's PWS nutritional phase from progressing or shift the patient's PWS nutritional phase back to an earlier phase. The invention further relates to treating PWS, and conditions associated with low basal metabolic rate or hyperphagia, with the KATP channel opener based on a patient's blood ketone levels.

The invention belongs to the field of traditional Chinese medicine preparations, and provides a pure traditional Chinese medicine preparation for treating depression and a preparation method of the pure traditional Chinese medicine preparation. The preparation method comprises the following steps: S1, weighing raw materials according to a formula, putting the raw materials into a clean container, adding water which is 8-12 times of the total weight of the raw materials, and soaking at room temperature for 1-2 hours; s2, transferring the soaked raw materials and liquid medicine into a decoction container, boiling with strong fire, then turning into slow fire, and decocting for 1.5-2.5 hours in a slightly boiling state; according to the pure traditional Chinese medicine preparation disclosed by the invention, through reasonable compatibility of various traditional Chinese medicinal materials, all the components have a synergistic effect, and the effects of soothing liver and regulating qi, strengthening spleen and harmonizing stomach, nourishing heart and tranquilizing mind, promoting blood circulation to remove blood stasis, reducing phlegm and clearing damp are jointly achieved; the pure traditional Chinese medicine preparation can effectively improve the symptoms of low mood, restless mood, insomnia and dreaminess, inappetence and hypodynamia of depression patients, and clinical practice verifies that the pure traditional Chinese medicine preparation prepared by the invention has a remarkable effect in the aspect of treating depression compared with existing conventional anti-depression western medicines.

The invention relates to the technical field of pet food, in particular to flavoring agent powder for pet dogs and a preparation method of the flavoring agent powder. Comprising the following raw materials: 40 parts of beef liver, 10 parts of hairtail, 7-40 parts of ricefield eel, 1 part of protease, 0.5-1 part of lipase, 0.5-1 part of flavor enzyme, 5-10 parts of saccharides, 10 parts of fish oil, 5-10 parts of maltodextrin, 0.5-1 part of sodium hydroxide, 5 parts of phosphoric acid, 3 parts of amino acid, 2 parts of thiamine, 1 part of yeast extract and 0.5-1 part of lactoferrin. The dog feed can increase the appetite of dogs from the sense of smell, maintain the health balance of intestinal flora of dogs and improve the micro-ecological environment of intestinal tracts.

Provided herein are therapeutic methods of treatment using agonist leptin receptor (LEPR) antibodies, antigen-binding fragments thereof, or compositions comprising the LEPR antibodies or antigen-binding fragments thereof. Such therapeutic methods include treatment for conditions related to metabolic dysfunction, including for example, lipodystrophy, adiposity or obesity, reducing body weight, non-alcoholic fatty liver disease, hyperphagia, hyperglycemia, insulin resistance, dyslipidemia, hepatic steatosis, and infertility.

Provided herein are therapeutic methods of treatment using agonist leptin receptor (LEPR) antibodies, antigen-binding fragments thereof, or compositions comprising the LEPR antibodies or antigen-binding fragments thereof. Such therapeutic methods include treatment for conditions related to metabolic dysfunction, including for example, lipodystrophy, adiposity or obesity, reducing body weight, non-alcoholic fatty liver disease, hyperphagia, hyperglycemia, insulin resistance, dyslipidemia, hepatic steatosis, and infertility.

The invention provides a thymol derivative as well as a preparation method and application thereof, and relates to the technical field of biological medicines. The preparation method comprises the following steps: carrying out esterification reaction on thymol and indole-3-carboxylic acid to prepare a thymol derivative, namely 2-isopropyl-5-methyl phenyl 1H-indole-3-carboxylic ester. Under the process conditions provided by the invention, the yield of the thymol derivative can reach 93-94%. The anti-coccidiosis index of the thymol derivative is as high as 196.51, and the thymol derivative can obviously reduce the influence of chicken coccidiosis on the weight of chicken, has a remarkable effect of promoting the growth and development of the body, and can obviously improve the clinical symptoms of chicken infected with coccidiosis, recover the mental condition and appetite of sick chicken, obviously reduce the occurrence of bloody stool and improve the intestinal tract lesion condition; the anti-coccidiosis effect of the thymol derivative provided by the invention is obvious and is obviously better than that of thymol, and the thymol derivative is expected to become a new veterinary drug for treating chicken coccidiosis infection.

The invention discloses a nutritional composition capable of regulating appetite and body weight of people after chemotherapy and improving taste perception capability and application thereof. The nutritional composition provided by the invention contains milk powder, soybean protein, concentrated whey protein, bovine colostrum powder, hydrolyzed yolk, a red bean extract, a Chinese date extract, lily freeze-dried powder, broccoli freeze-dried powder, a radish seed extract, a peach kernel extract, xanthan gum and Arabic gum. The food can obviously increase appetite of people after chemotherapy and restore weight, and is helpful for treating or improving symptoms such as inappetence, weight loss and weakness of chemotherapy patients. When being applied to paclitaxel (PTX)-induced taste disorder model animals, the paclitaxel protein can improve the taste perception capability, increase the cross sectional area of a taste bud, remarkably repair taste structural damage, reduce the level of proinflammatory factors in serum and relieve hepatotoxicity caused by a chemotherapeutic drug PTX; and moreover, the water solubility and the stability are better, adhesion and layering are avoided, and stable storage is facilitated.

The formula comprises the following raw materials in parts by weight: 70-85 parts of base liquor, 5-15 parts of fresh pandan leaves, 0.5-3 parts of baked pandan leaf powder, 1-3 parts of a flavor modifier, 3-8 parts of a sugar source and 0.1-0.6 part of a functional additive. The unique flavor of the pandan leaves originates from the rich 2-acetyl-1-pyrroline, and the pandan leaves give out charming rice dumpling fragrance and have the effects of promoting appetite and metabolism at the same time. The pandan leaves are blended into the food, so that the delicious taste is improved, and additional nutritional value is also brought. The pandan leaves are rich in dietary fibers, vitamin B family, vitamin C and various minerals. The composition also contains squalene, linoleic acid, estragole, phytol and other active ingredients. Squalene is a natural organic terpenoid, widely exists in a living body, and has remarkable effects in the aspects of promoting blood circulation, resisting oxidation, resisting inflammation, resisting tumors and the like. The prepared pandan wine has multiple effects and is beneficial to body health after being drunk for a long time.

Methods and compositions promote weight loss in mammals, such as in humans and / or animals, such as, for example, pets. Specifically, the methods and compositions herein promote weight loss due to the production of appetite-suppressing gut hormones, increased metabolism, reduced fat and carbohydrate absorption, and reduced fat deposition through the synergistic combination of fibers and botanical extracts. Food products comprising the compositions herein provide a natural and effective means of controlling appetite and managing weight.

A traditional Chinese medicine composition for alleviating gastrointestinal toxic side effects caused by chemotherapy, the traditional Chinese medicine composition for daily administration is prepared from the following weight ratio of traditional Chinese medicine formula: Taizishen 20-30g, Fuling 10-15g, Fried Baizhu 10-15g, Zhigancao 5-10g, Jiangbanxia 5-10g, Chenpi 5-15g. The formula can effectively alleviate the gastrointestinal toxic side effects caused by chemotherapy, such as nausea, vomiting, diarrhea, poor appetite, etc.

The invention relates to a spleen-tonifying, appetite-stimulating and digestion-promoting traditional Chinese medicine preparation UPLC detection method and a fingerprint spectrum, and belongs to the technical field of medicine detection. The invention aims to solve the technical problems that the existing quality control method of the spleen-tonifying, appetite-promoting and digestion-promoting pills lacks comprehensive and objective analysis on the spleen-tonifying, appetite-promoting and digestion-promoting pills, and the problems of low precision, poor reproducibility, low efficiency and the like during detection of related components in the prior art are solved. According to the technical scheme, the UPLC detection method is characterized in that a mixed standard substance of gallic acid, 5-hydroxymethylfurfural, chlorogenic acid, sinapine thiocyanate, sinapic acid, hyperoside, 3, 6-dimustard acyl sucrose, hesperidin, naringenin, nobiletin and hesperetin is taken as a contrast, an acetonitrile-0. 1% formic acid aqueous solution is taken as a mobile phase, gradient elution is carried out, and the content of chlorogenic acid in the sample is detected. The qualitative and quantitative detection of the effective components of the spleen-tonifying, appetite-promoting and digestion-promoting pill is realized.

The present invention relates to pharmaceutical combinations for treating or preventing insulin resistance and associated disorders, in particular the use combinations comprising a 4-epimerase inhibitor and a GLP-1 receptor agonist for treating or preventing insulin resistance and associating disorders such as obesity and type-2 diabetes, supressing appetite and / or promoting weight loss.

The present invention belongs to the field of pharmaceutical synthesis, and specifically relates to salviphorol derivatives and their application in drugs for treating cancer cachexia. Salviphorol compounds include compounds represented by formula (X) and / or formula (Y), or pharmaceutically acceptable salts or optical isomers of the compounds represented by formula (X) and / or formula (Y). The present invention also provides a pharmaceutical composition for treating cachexia diseases, and its application in the preparation of drugs for treating cancer cachexia, including muscle atrophy caused by tumor tissues, fat reduction caused by tumor tissues, reduced appetite caused by tumor tissues, inflammatory responses caused by tumor tissues, and cancer cachexia caused by digestive tract-related cancers, liver cancer, lung cancer, and colon cancer. The present invention also provides its application in the preparation of drugs or inhibitors for treating or inhibiting muscle atrophy, drugs or inhibitors for inhibiting or alleviating adipocyte lipolysis, and drugs or inhibitors for inhibiting or alleviating weight loss or reduction.

To provide compositions and methods for treating and preventing cognitive impairment, movement disorders, chronic pain, depression, decreased appetite, and addiction.SOLUTION: Also provided are methods for the diagnosis and monitoring of cognitive impairment, movement disorders, chronic pain, depression, decreased appetite, addiction, and other conditions such as convulsion or seizure. These compositions comprise fatty acid compounds and salts thereof which may be administered either alone, in combination with other medicaments, or as part of various treatment regimens. The provided compositions are effective for modulating markers, including, but not limited to, behavior associated with cognitive impairment, movement disorders, chronic pain, depression, decreased appetite, opiate addiction, and other related conditions. Methods for administering the compositions are also provided.SELECTED DRAWING: Figure 1

The present invention provides methods of using non-naturally occurring melanocortin analogs to increase body weight and / or increase food consumption in a subject having a kidney disease and / or a liver disease (e.g., chronic kidney disease, renal failure, non-alcoholic fatty liver disease (NAFLD)). Also provided are methods of stimulating appetite in a subject via administration of a non-naturally occurring melanocortin analogue. The non-naturally occurring melanocortin analogs may be present in pharmaceutical compositions and delivered via parenteral administration (e.g., subcutaneous injection). The methods improve appetite, increase food consumption, increase body weight, muscle mass, and / or fat mass in the subject.

The application provides a traditional Chinese medicine composition for treating diarrhea, and relates to the technical field of traditional Chinese medicine pharmacy. The application provides a traditional Chinese medicine composition for treating chronic diarrhea, which is prepared from madder, yuyulang, camphor tree bark, white peony root, jujube, licorice, lily, trichosanthes root and heron herb. The drugs are used together to have the functions of tonifying the spleen and stomach, astringing the lung to stop diarrhea and warming the middle and promoting qi. The traditional Chinese medicine composition can effectively relieve and improve the clinical symptoms of patients with chronic diarrhea, such as diarrhea, loss of appetite, lassitude and fatigue, and has a remarkable curative effect, so it is worthy of further clinical promotion and application.

The utility model discloses a built-in double-layer lunch box and relates to the technical field of lunch boxes. The lunch box comprises a lunch box body, second springs are installed on the inner walls of the two sides of the lunch box body, a first supporting frame and a second supporting frame are connected into the lunch box body, a first spring is connected between the first supporting frame and the lunch box body, and a first containing box and a second containing box are placed on the top of the first supporting frame and the top of the second supporting frame respectively. The top of the meal box body is connected with a box cover through a lock catch. According to the meal box, the first containing box and the two second containing boxes are arranged, the first containing box is used for containing staple food, the two second containing boxes are used for containing dishes, and therefore the containing capacity of the meal box is increased, the meal box can contain more meals, meanwhile, the first meal box body and the second meal box body are used for containing the meals respectively, and the meal box is convenient to use. Therefore, the food is prevented from being mixed together in the transportation process to affect the appetite during later eating.

The invention designs a prefabricated vegetable Maoshi braised pork which is prepared by the following steps: cleaning streaky pork, blanching and frying the cleaned streaky pork, and adding lemon juice on the traditional basis to achieve the effects of removing fishy smell, supplementing nutrition, promoting appetite, assisting in improving constipation, losing weight and the like. And finally, heating and reducing juice in a pot, and sterilizing after vacuum packaging, so as to prepare the instant food which can be heated or cooked. The braised pork in brown sauce prepared by the explored processing method is fat but not greasy, melts in the mouth, is fresh and soft in meat feel, and is capable of preserving health and much lower in calorie compared with the traditional method. According to the high-quality produced prefabricated braised braised pork in brown sauce provided by the invention, the time of people can be saved on the basis of a traditional braised pork preparation mode, and the taste and nutritional ingredients of the traditional preparation mode are reserved and increased.

The present invention discloses a compound solution of a sulfonamide and an antimicrobial synergist, its preparation method, and application. The compound solution further comprises a solvent, a pH buffer system, and a diluent; the solvent is N-methylpyrrolidone, and the pH buffer system is triethanolamine and an organic acid. The present invention discloses a stable, clear compound solution of a sulfonamide and an antimicrobial synergist, and its preparation method. The compound solution can be mixed with water for administration, exhibits excellent stability and lacks a distinctive odor after mixing with water, and eliminates problems such as uneven mixing of existing premixes and low intake of sick animals when their appetite decreases.

The invention provides a process for preparing a plasticised superporous hydrogel material comprising subjecting initial hydrogel material to treatment with an acidic solution, an optional treatment with a monovalent metal salt solution, freeze drying and plasticisation. Optionally, the process of the invention produces moulded plasticised superporous hydrogel material bodies that have one or more through-holes formed therein. The plasticised superporous hydrogel material of the present invention may be formulated as a suitable oral dosage form for use an appetite suppressant and for use to deliver a pharmaceutical and / or nutraceutical into a human or animal body.

Provided herein are methods of treating, preventing, or reducing conditions and / or side effects associated with anti-cancer agents (e.g., chemotherapeutic agents) via administration of a non-naturally occurring melanocortin analog prior to, during, and / or after administration of the anti-cancer agents. The methods reduce adverse effects associated with the anti-cancer agent, such as anorexia, weight loss, muscle mass loss, fat mass loss, wasting, reduced appetite, and loss of appetite, thereby enhancing tolerance of the anti-cancer agents and survival of the subject having cancer or having a disease or condition that is not cancer but is treated, reduced, or prevented by administration of an anti-cancer agent.

The invention provides application of a stevia rebaudiana extract, and belongs to the technical field of pure natural plant extracts, the stevia rebaudiana extract at least contains phenols, flavones and potassium ions, and when a health care product and / or a composition are given to a subject, at least one of the following components is achieved: antioxidant activity, antioxidant activity, antioxidant activity, antioxidant activity, antioxidant activity, antioxidant activity, antioxidant activity and the like. The expression of IRS protein, tyrosine phosphorylation of IRS and the content of GLUT4 protein are increased; bacteria are inhibited, and viruses and allergy are resisted; the intraocular pressure is reduced; the appetite is promoted; the hair loss is prevented or the hair growth is promoted. The application comprises application of the stevia rebaudiana extract in preparation of hair loss preventing or hair growth promoting products. The health-care product containing the stevia rebaudiana extract can prevent or treat type 2 diabetes mellitus, inhibit bacteria or resist viruses or allergy, and can be used as auxiliary food and / or sports food for sub-health people, type 2 diabetes mellitus patients, patients receiving glaucoma treatment, cancer patients, hepatitis patients, overweight people, picky and anorexia children or patients during general disease rehabilitation. The hair loss can be prevented or the hair growth is promoted.

The invention relates to the technical field of health-care herbal tea, in particular to a formula and a using method of spleen-tonifying and kidney-tonifying herbal tea. The traditional Chinese medicine is prepared from the following raw materials by weight: 6-11g of radix pseudostellariae, 6-11g of rhizoma atractylodis macrocephalae, 6-11g of poria cocos, 3-6g of liquorice, 6-10g of ginger processed pinellia, 6-11g of pericarpium citri reticulatae, 9-13g of angelica sinensis, 6-10g of rehmannia, 6-11g of polygala tenuifolia, 6-13g of fructus alpiniae oxyphyllae, 11-16g of tortoise plastron, 6-13g of rhizoma drynariae, 9-14g of vinegar turtle shell, 10-16g of rhizoma cibotii, 9-13g of dipsacus root, 6-13g of dendrobe, 9-16g of sanguisorba officinalis and 6-11g of rhizoma cimicifugae. Liujunzi decoction is matched with radix angelicae sinensis and radix rehmanniae to construct a qi-blood tonifying basis, and cooperates with tortoise plastron, vinegar turtle shell and rhizoma drynariae to fill kidney essence and strengthen tendons and bones, meanwhile, the rhizoma cimicifugae is combined to enhance the qi lifting effect of ginseng, and symptoms of inappetence, abdominal distension and sticky stool caused by spleen deficiency and dampness stagnation and soreness and weakness of waist and knees and weakness of limbs caused by kidney deficiency and bone weakness are synchronously improved.

The invention discloses a breeding feed based on a traditional Chinese medicine compound additive for meat improvement, and belongs to the technical field of livestock and poultry breeding feeds, the breeding feed comprises a basic concentrate supplement and the traditional Chinese medicine compound additive, and the traditional Chinese medicine compound additive is divided into an early fattening stage additive and a middle and later fattening stage additive according to the growth stage of fattening sheep; traditional Chinese medicine compound additives with different proportions are designed according to the physiological characteristics of the fattening starting period of the fattening sheep 30 days before and the rapid fattening period of the fattening sheep 30 days after, hawthorn fruits, malt and folium cortex eucommiae are used as main materials in the fattening early stage, focuses on appetizing and digestion promotion, and a growth foundation is laid; eucommia ulmoides leaves and mulberry leaves are used as main materials in the middle and later fattening periods, hawthorn fruits, dried tangerine or orange peel and liquorice are matched, fat control, muscle building and cavity oil degradation are focused on, and especially the problem of cavity oil degradation of ewes is solved in a targeted mode.

1. Name of the design product: dog food (similar series). 2. Use of the design product: dog food for dogs to have more appetite. 3. Design points of the design product: combination of shape and pattern. 4. Picture or photo that best indicates the design points: design 1 front view. 5. Design 1 is designated as the basic design.

The present application relates to the technical field of bioactive peptides, and in particular to an oat oligopeptide, preparation thereof and application thereof in preparing a product for regulating the expression of brain appetite suppressor factor. The oat oligopeptide can effectively stimulate the release of cholecystokinin (CCK) from intestinal endocrine cells, and stimulate the central nervous system through the vagus nerve pathway, thereby promoting the expression of the appetite suppressor factor pro-opiomelanocortin (POMC) in the hypothalamus. Compared with the prior art, the oat oligopeptide has the advantages of stable structure, high safety, simple preparation process (conventional enzymatic hydrolysis and chromatographic purification can achieve the preparation), easy scale production and the like. The oat oligopeptide is suitable for being used as a functional ingredient or a drug precursor to develop a related health product with the functions of regulating appetite and promoting satiety, and has a wide application prospect in the field of preparing functional products (food, medicine and the like).

A composition comprising a soy protein isolate, a soy fibre, a phospholipid, and a carbohydrate for use in the treatment or prevention of obesity, type 2 diabetes or cardiovascular disorders, wherein the composition is administered together with a first pharmaceutical composition comprising an appetite suppressant agent.