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40 results about "Oral feeding" patented technology

Systems for monitoring infant oral motor kinetics during nutritive and non-nutritive feeding

The present invention relates to a system device and method for monitoring infant oral motor kinetics (OMK), which can be used to assess the functional significance of the different sucking components, i.e., the plasticity of infant sucking skills in relation to their oral feeding performance, at a particular time, during the developmental period and/or during preventive or therapeutic intervention programs. It is a unique system and apparatus that provides a means to study the nonnutritive and/or nutritive sucking skills, i.e., the Suction and/or Expression components of sucking, of infants in the natural setting, i.e., during a normal feeding session. OMK sensors, tracked in real-time by the monitoring system, include miniature pressure transducers, or pressure sensitive pads, attached to the nipple for measuring intraoral pressure pulses during Suction, and for measuring compression/stripping pressure pulses during Expression; and a miniature flow sensor for measuring fluid flow rate, which can be integrated over time to determine the volume of milk removed (bolus) per suck. Other signals, such as respiration, swallowing, thermal, optical, and acoustic signals can be recorded and compared along with the instrumented-nipple signals, in an OMK monitoring system.
Owner:LAU CHANTAL

Oral delivery of angiotensin converting enzyme 2 (ACE2) or angiotensin-(1-7) bioencapsulated in plant cells attenuates pulmonary hypertension, cardiac dysfunction and development of autoimmune and experimentally induced ocular disorders

ActiveUS20160331816A1Improved right heart functionDecreased pulmonary vessel wall thicknessPowder deliveryPeptide/protein ingredientsDiseaseUveitis
Emerging evidence indicates that diminished activity of the vasoprotective axis of the renin-angiotensin system, constituting angiotensin converting enzyme2 (ACE2) and its enzymatic product, angiotensin-(1-7) [Ang-(1-7)] contribute to pulmonary hypertension (PH). However, clinical success for long-term delivery of ACE2 or Ang-(1-7) would require stability and ease of administration to increase patient compliance. Chloroplast expression of therapeutic proteins enables their bioencapsulation within plant cells to protect from acids and gastric enzymes; fusion to a transmucosal carrier facilitates effective systemic absorption. Oral feeding of rats with bioencapsulated ACE2 or Ang-(1-7) attenuated monocrotaline (MCT)-induced increase in right ventricular systolic pressure, decreased pulmonary vessel wall thickness and improved right heart function in both prevention and reversal protocols. Furthermore, combination of ACE2 and Ang-(1-7) augmented the beneficial effects against cardio-pulmonary pathophysiology induced by MCT administration.
Experiments have also been performed which indicate that this approach is also suitable for the treatment or inhibition of experimental uveitis and autoimmune uveoretinitis These studies provide proof-of-concept for a novel low-cost oral ACE2 or Ang-(1-7) delivery system using transplastomic technology for pulmonary and ocular disease therapeutics.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA +1

Oral delivery of angiotensin converting enzyme 2 (ACE2) or angiotensin-(1-7) bioencapsulated in plant cells attenuates pulmonary hypertension, cardiac dysfunction and development of autoimmune and experimental induced ocular disorders

Emerging evidence indicates that diminished activity of the vasoprotective axis of the renin-angiotensin system, constituting angiotensin converting enzyme2 (ACE2) and its enzymatic product, angiotensin-(1-7) [Ang-(1-7)] contribute to pulmonary hypertension (PH). However, clinical success for long-term delivery of ACE2 or Ang-(1-7) would require stability and ease of administration to increase patient compliance. Chloroplast expression of therapeutic proteins enables their bioencapsulation within plant cells to protect from acids and gastric enzymes; fusion to a transmucosal carrier facilitates effective systemic absorption. Oral feeding of rats with bioencapsulated ACE2 or Ang-(1-7) attenuated monocrotaline (MCT)-induced increase in right ventricular systolic pressure, decreased pulmonary vessel wall thickness and improved right heart function in both prevention and reversal protocols. Furthermore, combination of ACE2 and Ang-(1-7) augmented the beneficial effects against cardio-pulmonary pathophysiology induced by MCT administration.Experiments have also been performed which indicate that this approach is also suitable for the treatment or inhibition of experimental uveitis and autoimmune uveoretinitis These studies provide proof-of-concept for a novel low-cost oral ACE2 or Ang-(1-7) delivery system using transplastomic technology for pulmonary and ocular disease therapeutics.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA +1

Artificial domestication method of glyptosternum maculatum wild parent fish

The invention discloses an artificial domestication method of glyptosternum maculatum wild parent fish, and belongs to the technical field of aquaculture. The artificial domestication method comprisesthe steps of selecting wild glyptosternum maculatum parent fish; preparing a domestication pond; carrying out domestication of the parent fish; performing a paste bait feeding stage; feeding the parent fish with the paste bait by adopting an artificial oral feeding method on the day of fishing and transportation, and placing the parent fish in the domestication pond after transportation; performing a paste bait and live loach feeding stage; adopting live loaches to gradually replace paste baits for feeding, wherein the replacement method comprises the steps of carrying out feeding by the paste baits and the live loaches for 4-5 days according to the frequency ratio of 2 to 1 every day, and conducting feeding for three times every day; afterwards, carrying out feeding by the paste baits and the live loaches for 4-5 days according to the frequency ratio of 1 to 2 every day, and conducting feeding for three times every day; next, carrying out feeding with only the live loaches for 4-5 days, and conducting feeding for three times every day; executing a live loach feeding stage; after the feeding stage of the paste bait and the live loaches, continuously feeding by the live loaches; and conducting feeding twice a day. The method is used for artificial domestication of the glyptosternum maculatum wild parent fish.
Owner:HEILONGJIANG RIVER FISHERY RES INST CHINESE ACADEMY OF FISHERIES SCI

Compound walnut and linseed oil fat emulsion intravenous injection and preparation method thereof

The invention provides a compound walnut and linseed oil fat emulsion intravenous injection and a preparation method thereof. The compound walnut and linseed oil fat emulsion intravenous injection comprises the raw materials of walnut oil, linseed oil, lecithin, glycerol, sterile pure water, antioxidants, stabilizing agents, pH regulating agents and the like. The preparation method comprises the following steps of: under the protection of nitrogen, heating, dissolving and mixing the walnut oil, the linseed oil and the lecithin into an oil phase; mixing the glycerol, the antioxidants, the stabilizing agents and the sterile pure water into a water phase, slowly adding the oil phase in the violently stirred water phase and then shearing in high speed to form a primary emulsion; and regulating the pH of the primary emulsion to 6.5-8.5 by using a few pH regulating agents, emulsifying by using a high-pressure viscolizer, filtering by using a microporous membrane, and then filling, sealing and sterilizing to obtain the compound walnut and linseed oil fat emulsion intravenous injection, wherein the total oil content of the intravenous injection is 1%-50%. The compound walnut and linseed oil fat emulsion intravenous injection and the preparation method thereof are used in the fields of medical treatment and health, and the compound walnut and linseed oil fat emulsion intravenous injection can be administrated through abenteric intravenous injection or intestinal tube feeding or oral feeding and can be used as a nutritional and therapeutic medicament.
Owner:王京南
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