The invention relates to the technical field of
animal model construction, in particular to
hormone for constructing a
New Zealand rabbit atherosclerotic model and a construction method of the
New Zealand rabbit atherosclerotic model, male New Zealand rabbits are fed with
estrogen instead of
edible oil, and it is found that the blood fat of the New Zealand rabbits can be increased by using estradiol and / or
icariin; a foundation is provided for building an AS model, a unique high-fat and
hormone novel feed is developed by optimizing the
estrogen proportion, the novel feed is used for building the
New Zealand rabbit atherosclerosis model, it is found that the
new Zealand rabbit atherosclerosis model can achieve the same effect as a model built through a conventional method, no
surgical operation is needed for building the model, and the method is simple and convenient to operate. Meanwhile,
edible oil in high-fat feed is replaced by
hormone, so that the technical problems of reduction of actual
food intake, insufficient high-
fat intake and failure in
animal model construction caused by animal
diarrhea due to excessive
edible oil content are greatly reduced, and the AS model construction method is simple, convenient and efficient.