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Method for establishing blood correlated fatty acid spectrum

A method for establishing fatty acid technology, which is applied in the field of establishing blood-related fatty acid profiles, and can solve problems such as inability to prepare food

Inactive Publication Date: 2014-03-05
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There is no data on the types of fatty acids in the Chinese diet, because people cannot prepare all the food at home, and the amount of fat consumed in the food is highly variable, so there is no precise way to evaluate the individual fatty acids in the diet intake, thus requiring the use of biomarkers to improve the accuracy of the assessment

Method used

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  • Method for establishing blood correlated fatty acid spectrum
  • Method for establishing blood correlated fatty acid spectrum
  • Method for establishing blood correlated fatty acid spectrum

Examples

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Effect test

Embodiment 1、2

[0088] The establishment method of the plasma phospholipid fatty acid spectrum of embodiment 1, type 2 diabetes crowd

[0089] Research Background:

[0090]Type 2 diabetes (Type 2 Diabetes Mellitus, T2DM) is a chronic disease that seriously affects individuals and society. Its incidence rate has risen sharply in the world, making people pay more and more attention to diabetes. It is estimated that by 2030, there will be nearly 360 million diabetics worldwide, and the health problems caused by diabetes will bring huge changes to the quality of life. Weight gain, accompanied by MS-related symptoms, is the most obvious and common clinical symptom of type 2 diabetes. Studies have shown that dietary factors play an important role in the occurrence and development of T2DM. Increased dietary intake of n-3 polyunsaturated fatty acids (n-3 PUFA) can improve lipid composition in the body and improve insulin resistance. A 12-year follow-up study of male medical professionals observed a...

Embodiment 2

[0164] Example 2, the establishment of serum phospholipid fatty acid profile of metabolic syndrome population

[0165] Research Background

[0166] Metabolic syndrome (MS) is a pathological state of abnormal aggregation of various metabolic components. It may be related to insulin resistance (IR), and it has become a common focus of cardiology and diabetes (DM) physicians. There are many disputes about it at home and abroad. Metabolic syndrome usually includes three or more different factors, including abdominal obesity, high blood pressure, and dyslipidemia. The number of people living with MS worldwide has increased significantly over the past two decades, but the incidence varies among different ethnic groups. A cross-sectional study conducted in China showed that the incidence of metabolic syndrome in males was 9.8%, and that in females was 17.8%. Such a large area of ​​MS in China has become an important public health problem, so urgent measures are needed to prevent t...

Embodiment 3

[0203] Example 3 Establishment of plasma phospholipid fatty acid profile of hypertensive population

[0204] Research Background:

[0205] Hypertension is the most common chronic disease and the most important risk factor for cardiovascular and cerebrovascular diseases. Stroke, myocardial infarction, heart failure and chronic kidney disease are its main complications. Practice at home and abroad has proved that hypertension is a disease that can be prevented and controlled. Reducing the blood pressure level of hypertensive patients can significantly reduce stroke and heart disease events, significantly improve the quality of life of patients, and effectively reduce the burden of disease. The harmfulness of hypertension is not only related to the blood pressure level of the patient, but also depends on the coexistence of other cardiovascular disease risk factors, target organ damage, and other combined diseases.

[0206] Long-term dietary supplementation with high-purity n-3 p...

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Abstract

The invention discloses a method for establishing a blood correlated fatty acid spectrum. The method comprises the following steps: 1) choosing a research object, and carrying out extraction, separation and concentration on plasma, serum or platelet disengaged from the body of the research object, so as to obtain total lipids; 2) separating phospholipids and triglycerides from the total lipids by a thin-layer chromatography method; 3) conducting methyl esterification on the separated phospholipids and triglycerides; 4) determining fatty acid components in the fatty acid subjected to methyl esterification by a gas chromatography method; 5) carrying out atlas analysis and SPSS data statistical analysis on the fatty acid; and 6) systemizing and summarizing the analysis data. The invention creates a simple, effective and practical method for establishing fatty acid spectrum; and a fatty acid spectrum of healthy people with current chronic diseases is established, so as to provide potent guidance for the health of human and fat intake.

Description

technical field [0001] The invention belongs to the fields of medicine and epidemiology, and specifically relates to the establishment of a fatty acid profile for measuring blood-related (plasma, serum, platelets, red blood cells, etc.) total esters, phospholipid membranes, or triglycerides by gas chromatography, and The fatty acid profiles of people with chronic diseases related to lipid metabolism (diabetes, metabolic syndrome, hyperlipidemia, non-alcoholic fatty liver, hypertension, etc.) were analyzed to establish relevant fatty acid profiles. That is, the present invention relates to methods for establishing blood fatty acid profiles of healthy people and patients with chronic diseases. Background technique [0002] With the rapid development of China's economy, people's daily diet structure is gradually Westernized. The situation of malnutrition-based diseases in the middle of the last century has changed to the prevalence and rapid growth of over-nutrition-related chr...

Claims

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Application Information

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IPC IPC(8): G01N30/88G01N30/90
Inventor 李铎杨静黄涛
Owner ZHEJIANG UNIV
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