19 results about "Glucose absorption" patented technology

The invention relates to an application of PBX1 as an active component in preparation of type 2 diabetes mellitus drugs or medical instruments, so as to relieve symptoms of diabetes mellitus, promote repair and regeneration of damaged pancreas islets and improve functions of insulin. The symptoms comprise water intake, food intake and fasting blood glucose; the method for promoting the repair and regeneration of the damaged pancreas islet comprises the steps of inhibiting the apoptosis of pancreas islet beta cells of diabetic mice, promoting the proliferation of the beta cells and recovering the tissue structure of the damaged pancreas islet; the function of improving the pancreas islet comprises the steps of stimulating secretion of insulin, improving the level of an insulin receptor, promoting absorption of an organism to glucose and reducing serum hyperglycemia and HbA1c concentration of diabetic mice, so that the effect of treating both symptoms and root causes of diabetes is achieved.

To provide novel blood glucose level elevation inhibitors and glucose absorption inhibitors. [Solution] A blood glucose level elevation inhibitor or glucose absorption inhibitor containing sapindoside B as an active ingredient.

The application belongs to the technical field of biological medicine, and particularly relates to a micro binding protein targeting sodium-glucose cotransporter 2 and a construction method and application thereof. The amino acid sequence of the micro binding protein is shown in SEQ ID NO. 5, and the micro binding protein is a triple helix structure. The micro binding protein targeting sodium-glucose cotransporter 2 (sglt2) provided in the application can be combined with the sglt2 protein as a tool protein, is used for regulating cell glucose absorption, and can be used for fluorescence detection of the sglt2 protein through the micro binding protein marked with a specific label. The micro binding protein in the application can be applied to sglt2 function regulation and fluorescence label detection as a novel sglt2 tool.

The invention belongs to the technical field of hypoglycemic rice, and discloses a low-GI cooking-free hypoglycemic rice formula, which comprises the following components by mass: 200 g of rice, 15% of soybean, 150 g of kidney bean, 15% of konjaku flour, 10% of konjaku flour, 180 g of oat, 18% of Chinese yam, 12% of Chinese yam, and 10% of mung bean. Through scientific proportioning of 20% of rice, 15% of soybeans, 15% of kidney beans, 10% of konjaku flour, 18% of oat, 12% of Chinese yam and 10% of mung beans, a multi-dimensional cooperative sugar control system is constructed, the content of glucomannan in the konjaku flour is larger than or equal to 85%, a gel barrier can be formed, carbohydrate decomposition is delayed, an alpha-amylase inhibitor in the kidney beans can directly inhibit the activity of starch digestive enzymes, and the content of the glucomannan in the konjaku flour is larger than or equal to 20%. The content of beta-glucan in the oat is 5%-8%, so that the viscosity of chyme in the intestinal tract can be increased, the glucose absorption speed is slowed down, and the soybeans, the mung beans and the Chinese yams are complementary with protein through dietary fibers, so that the blood sugar rising period is further prolonged.

The invention provides a noninvasive blood glucose measurement method and device, electronic equipment and a storage medium, and belongs to the technical field of optical blood glucose measurement. The method comprises the steps that a target light source with the target wavelength is emitted, scattering signals of the target light source are received, and the target wavelength is the wavelength capable of being absorbed by glucose; and determining absorbance corresponding to the scattering signal, and determining blood glucose estimation information of the measured object according to the absorbance. Therefore, according to the scheme, the light source with higher correlation with the human body blood sugar is used for estimating the blood sugar, a direct and accurate basis is provided for estimating the change of the human body blood sugar level, and the accuracy of blood sugar estimation is improved. The wearable equipment is used for measuring the blood glucose, so that the blood glucose measurement convenience is improved.

The invention discloses an auricularia auricula polysaccharide-based tablet candy capable of relieving hyperglycemia and a preparation method of the auricularia auricula polysaccharide-based tablet candy, and relates to the technical field of biology, the auricularia auricula polysaccharide-based tablet candy comprises the following raw materials by weight: 20-30 parts of auricularia auricula polysaccharide; 35 to 45 parts of a filling agent; 20 to 30 parts of a disintegrating agent; 3-8 parts of a functional auxiliary material; 0.5 to 1.5 parts of a lubricant; 2-5 parts of an adhesive; wherein the auricularia auricula polysaccharide is extracted by adopting a targeted enzymolysis technology, the weight-average molecular weight is 1.0 * 10 <-2.0 > * 10 < Da >, and the bioavailability is high; the functional auxiliary material comprises an insulin secretion promoting factor and a sugar absorption inhibiting factor, and is specifically a compound of chromium yeast and a mulberry leaf extract according to a mass ratio of (1-3): 1. All the components are prepared into the tablet candy through a specific process, all the active components have a synergistic effect, and the blood sugar reducing effect can be achieved in multiple ways and multiple targets of promoting insulin secretion, inhibiting sugar absorption, improving insulin sensitivity and the like. The product is good in taste, fast in disintegration and convenient to take, can be used for preparing functional food for assisting management of type 2 diabetes, and has the blood sugar reducing effect obviously better than that of a traditional product with extracted polysaccharide or single functional factor.

The present disclosure relates to a method for preparing a Gynostemma pentaphyllum leaf extract, a Gynostemma pentaphyllum leaf extract prepared by the method, and a composition for improving exercise performance capacity containing the same as an active ingredient.The Gynostemma pentaphyllum leaf extract according to the present disclosure exhibits superior effect of improving exercise performance capacity and enhancing muscle strength, endurance and physical strength. In addition, the Gynostemma pentaphyllum leaf extract according to the present disclosure has the efficacy of increasing AMPK activity, facilitating beta oxidation and facilitating glucose uptake and, thus, has superior effect of reducing body weight and body fat and preventing, alleviating or treating diabetes.Because the composition of the present disclosure is derived from a natural product, it can be used usefully and safely for drugs, foods, etc. without side effects.

The presently-disclosed subject matter relates to using choline kinase inhibitors to treat obesity, hyperglycemia, type 2 diabetes, supporting weight loss, increasing glucose uptake, activating brown-adipose tissue thermogenesis in a subject in need thereof and / or reducing fat deposition in the liver.

The present invention relates to a novel quinoline compound and a use thereof and to a novel quinoline compound exhibiting CYP4A inhibition activity and a use thereof for preventing, alleviating, treating a metabolic disease. The compound disclosed in the present invention has a remarkable effect of inhibiting CYP4A and exhibits the activities of promoting the absorption of glucose into hepatocytes, inhibiting fat accumulation in hepatocytes, suppressing endoplasmic reticulum-induced reactive oxygen species, and treating steatohepatitis, and thus can be very advantageously used for developing therapeutics for metabolic diseases such as diabetes mellitus and fatty liver.

The invention discloses a composition for losing weight, reducing fat, burning fat and controlling sugar as well as a preparation method and application thereof. The composition is composed of coconut components, coffee powder, cinnamon extract, clinacanthus nutans extract, L-carnitine, guarana extract, balsam pear extract, turmeric powder, psicose and other raw materials, all the components have a synergistic effect, carbohydrate digestion and glucose absorption are delayed by inhibiting the activity of glucosidase and amylase in the intestinal tract, and the effects of improving the immunity of the intestinal tract and improving the immunity of the intestinal tract are achieved. Meanwhile, insulin sensitivity and glucose tolerance are improved, so that accurate glucose control is achieved; secondly, by inhibiting differentiation of precursor fat cells, fat accumulation is reduced from the source, and effective lipid lowering is achieved; finally, the fat metabolism rate is accelerated by promoting the fat to be transferred into mitochondria, so that the fat is efficiently combusted, and finally the purposes of losing weight, reducing fat, combusting fat and controlling sugar are achieved. The traditional Chinese medicine composition can be prepared into various dosage forms, is suitable for people who are obese, hyperlipidemia, hyperglycemia and people who need to control body weight for slimming management, and has a wide application prospect.

In the field of biomedicine, the importance and potential value of the carbon-glycoside compounds are increasingly prominent. Carbon-glucoside widely existing in medicinal plants shows remarkable physiological activity in the aspects of oxidation resistance, inflammation resistance, bacteria resistance and the like; wherein the natural product of beta-acyl-carbon-glucoside, namely Sclerpentasides A-F, is separated from a semi-parasitic plant Dendrophthoe pentras, and is used for treating the hypertension and the diabetes mellitus in the Thailand traditional medicine, so that the Sclerpentasides A-F can be used for treating the hypertension and the diabetes mellitus. Beta-acyl-carbon-glycoside is formed by acyl and glycosyl, keto carbonyl of the beta-acyl-carbon-glycoside has potential chemical conversion capacity, and a new thought is provided for modification of existing carbon-glycoside drugs. In pharmaceutical chemistry, carbon-glycosides are often used as stable mimetics of oxygen-glycosides and nitrogen-glycosides, which are designed according to the characteristics that carbon-glycosides are used as electron isosteres of oxygen glycosides in pharmaceutical chemistry and can resist hydrolase and other decomposition pathways in vivo. A high-efficiency synthetic route is designed, and beta-acyl-carbon-glucoside can be successfully constructed through two-step reaction from sugar bromoglycoside. Wherein the beta-acyl-carbon-glucoside has excellent SGLT2 inhibitory activity, can effectively inhibit glucose absorption, and can be used for controlling blood sugar and treating diabetes mellitus.

The invention belongs to the technical field of food engineering, and particularly relates to a wild mushroom sauce packet and instant konjac rice / rice noodles containing the sauce packet, and the wild mushroom sauce packet is prepared from the following raw materials in parts by weight: 5g of bolete, 3g of tricholoma matsutake, 4g of termitomyces albuminosus, 6g of pleurotus eryngii and 2 parts of morchella; the konjac rice bag is prepared from the following raw materials in parts by weight: 6 parts of konjac glucomannan, 2 parts of oat beta-glucan and 1 part of buckwheat flour; the konjak rice noodle bag is prepared from food-grade konjak powder and food-grade sodium carbonate; konjac glucomannan or konjac powder is adopted as the main raw material of the staple food, so that the product has multiple functions of konjac, such as strong water absorption, significant satiety enhancement, calorie intake reduction, auxiliary control of body weight, delay of glucose absorption of small intestines, reduction of postprandial blood sugar peak value and helpful adjustment of blood sugar level.

The invention discloses application of < 18 > F-lactitol in preparation of a diabetic nephropathy detection product, and belongs to the technical field of biomedical detection. In order to solve the problem that the action and mechanism of STRs in the kidney through SGLT2-dependent glucose reabsorption and transport are not clear yet, 18F-labeled lactitol is used, the in-vivo glucose level, kidney pathology and SGLT2 expression are detected through PET / CT, and the glucose uptake rate is labeled through in-vitro fluorescence, so that the effect and mechanism of STRs in the kidney through SGLT2-dependent glucose reabsorption and transport are determined. The method is used for evaluating the glucose reabsorption effect and mechanism of the STRs in STZ (streptozotocin)-induced diabetic mice and HK-2 cells. The result shows that the 18F-lactitol can be sensitively and specifically combined with the STRs, the biological distribution of the 18F-lactitol and the expression of the STRs in the kidney of a diabetic mouse are obviously reduced, the expression of the SGLT2 is up-regulated, and the lactitol or siRNA-STRs can obviously reduce the influence of high glucose on the expression of the STRs and the SGLT2 and glucose absorption. Therefore, the STRs can be used as a new therapeutic target for diabetes, and the < 18 > F-lactitol labeled PET / CT can become a novel probe for detecting diabetic kidney injury.

The present invention discloses selenium-enriched wheat ingredient-containing rolled dough wrappers and a unique preparation technology thereof, and relates to the technical field of food processing, and the selenium-enriched wheat ingredient-containing rolled dough wrappers are prepared from the following raw materials: selenium-enriched wheat flour, soybean flour, trehalose, chitosan, almond powder, agaric powder, resistant dextrin, chia seed powder, fructo-oligosaccharide, Chinese yam powder, poria cocos powder and water. The added resistant dextrin can delay glucose absorption, the chia seed powder can increase satiety, and the resistant dextrin and the chia seed powder cooperate to help control total calorie intake; fructo-oligosaccharide can promote the growth of beneficial bacteria in intestinal tracts; chinese yam polysaccharide contained in the Chinese yam powder and beta-pachyman contained in the poria cocos powder can synergistically regulate the intestinal environment and relieve the irritation of gluten to the intestinal tract; according to the present invention, the composite strain composed of saccharomyces cerevisiae and lactobacillus plantarum is adopted to ferment, and the strain activation scheme of adding the selenium-rich malt extract to the YPD culture medium and adding the trehalose to the MRS culture medium is matched, such that the poor taste such as boring flavor, acerbity and the like easily occurring in the traditional natural fermentation or single strain fermentation is avoided;

The invention belongs to the technical field of plant medicine refining and improvement, and particularly relates to a formula method of a hypoglycemic composition based on large yellow tea and the hypoglycemic composition. According to the composition method, an ethanol water solution is adopted for extracting the Huangdan tea, GRA and PLSR are adopted for correlation analysis by means of the blood glucose change dynamic of an animal model and the change dynamic of blood entering components and metabolites after animals take drugs, the blood glucose reducing composition composition method based on the Huangdan tea is constructed, four active components are obtained, and the composition is prepared through a traditional Chinese medicine method. And the composition ratio of the four active components is adjusted and screened to obtain the hypoglycemic composition with a good glucose absorption inhibition effect.

The invention discloses a preparation method of enzyme-treated isoquercitrin jelly for improving circadian rhythm and glycolipid metabolism, the enzyme-treated isoquercitrin jelly comprises the following raw materials by mass: 0.1-0.5% of enzyme-treated isoquercitrin, 0.1-0.5% of konjac glucomannan, 0.05-0.25% of pectin, 1.0-2.0% of carrageenan, 4-8% of xylitol, 4-12% of milk and the balance of water, and the invention relates to the technical field of deep processing of enzyme-treated isoquercitrin. According to the preparation method of the enzyme-treated isoquercitrin jelly capable of improving circadian rhythm and glycolipid metabolism, quercitrin or a derivative thereof is taken as a core active component and is compounded with three colloids, namely konjac gum, pectin and carrageenan, so that good gel characteristics and taste of the jelly can be ensured, the quercitrin or the derivative thereof can be in synergistic effect, and the effect of improving circadian rhythm and glycolipid metabolism is achieved. Glucose absorption is delayed, and the postprandial blood sugar level is reduced; meanwhile, the colloid component serves as dietary fiber and can adjust intestinal flora balance, and the jelly can improve circadian rhythm disorder and inhibit chronic diseases such as obesity, glucagon and the like caused by staying up late, irregular sleep and irregular eating.

This invention discloses the effects and mechanisms of nicotinamide supplementation during the peripartum period on glucose and lipid metabolism in lambs from dairy goats. Starting with maternal nicotinamide supplementation, the study investigated its effects and mechanisms on lamb intestinal morphological development, nutrient transporter expression, glucose metabolism, blood biochemical indicators, and lipid metabolism. The study found that peripartum nicotinamide supplementation in dairy goats can improve glucose absorption in the lamb intestine, inhibit hepatic gluconeogenesis, promote hepatic lipolysis, and reduce liver damage. It can also promote abdominal fat deposition and intestinal morphological development in lambs, thus promoting lamb growth and development. The research results provide a theoretical basis for regulating lamb growth and development.

The invention discloses a sugar-controlling and fat-reducing functional chenopodium quinoa dietary composite food and a preparation method and application thereof, and relates to the technical field of sugar-controlling food, the sugar-controlling and fat-reducing functional chenopodium quinoa dietary composite food comprises chenopodium quinoa rice, buckwheat, white kidney beans, chickpeas and resistant starch according to the weight part ratio of (15-30): (15-25): (35-50): (20-30): (15-20); the resistant starch contains 70 to 85 weight percent of amylose. The food has the effects of inhibiting absorption of intestinal tracts on glucose and increasing insulin sensitivity, so that the problem of blood glucose fluctuation caused by diet is solved, and meanwhile, the purpose of meeting the requirements of organisms on various nutrient substances is achieved.

The invention relates to the technical field of health-care products, in particular to a formula and preparation method of pure plant medicinal and edible health-care tea helpful for reducing blood sugar, and the pure plant medicinal and edible health-care tea helpful for reducing blood sugar comprises 14.5%-16.5% of dendrobium officinale, 14.2%-16.1% of radix puerariae, 9.6%-10.7% of lucid ganoderma, 9.6%-10.7% of rhizoma polygonati, 12.5%-13.6% of raisin tree seed, 9.1%-10.7% of emblic leafflower fruit, 9.1%-11.7% of Chinese waxgourd peel, 2.8%-3.1% of fructus amomi, 5.6%-7.3% of seville orange flower and 5.6%-6.7% of hyacinth bean flower. The main difference between the prepared health-care tea and hypoglycemic drugs in the market at present is that the hypoglycemic drugs achieve the purpose of reducing blood sugar through supplementing insulin, promoting insulin secretion, reducing intestinal absorption of glucose and the like, have certain side effects, and need to be used for treatment throughout the life; the tea prepared by the scheme is refined from the traditional pure natural plant raw materials with homology of medicine and food, has the effects of tonifying qi and yin, strengthening spleen and tonifying kidney, removing food retention and resolving dampness, improving circulation and assisting in improving the physical state so as to maintain stable blood sugar, and the raw materials adopted by the health-care tea in the scheme are all food, so that the health-care tea can be drunk for a long time without any side effect.