4results about How to "Good therapeutic effect" patented technology

The present invention belongs to the field of medical technology related to the extraction and application of natural drug components, discloses a white peony extract for treating hyperuricemia, a preparation method thereof and an application thereof, and provides a preparation method of a white peony extract for treating hyperuricemia, wherein the obtained white peony extract has a good therapeutic effect on a hyperuricemia animal model; mainly inhibiting uric acid production by inhibiting the activity of xanthine oxidase in serum and liver, while downregulating the levels of renal tissue proteins URAT1 and GLUT9, and upregulating the levels of renal tissue proteins OAT1 and OAT3 to reduce uric acid reabsorption and promote uric acid excretion, thereby achieving the purpose of reducing uric acid levels. Furthermore, the white peony extract is synergistically used with the currently commonly used uric acid-lowering drug allopurinol to develop a more effective and safe uric acid-lowering treatment plan.

The present invention belongs to the technical field of antibacterial drugs, and discloses a pyrrolylacylpiperidylamine compound and use thereof. The present invention in particular relates to a pyrrolylacylpiperidylamine compound and a pharmaceutically acceptable salt thereof, and use thereof in the preparation of a medicament for resisting infections with bacteria, mycoplasma or chlamydia. The compound has a structure shown in the following general formula:

The application is suitable for the field of biological medicine technology, and provides a preparation method and application of CAR-T cells loaded with biological calcified nanomaterials, which comprises the following steps: step one, mixing black phosphorus quantum dots, calcium peroxide and lipid components, and purifying by ultrasonic emulsification and ultrafiltration centrifugation to obtain BCLT with mitochondria-targeting molecule triphenylphosphine modified on the surface; step two, co-incubating CAR-T cells with membrane dye after staining, and adding a disulfide bond-containing reduction-responsive linker arm DSPE-S-S-NHS; and step three, co-incubating BCLT with CAR-T cells, so that the BCLT is connected to the surface of the CAR-T cells through a chemical bond to obtain CAR-T cells loaded with biological calcified nanomaterials. The application significantly improves the infiltration capacity and killing effect of the CAR-T cells on solid tumors, can relieve the problem of tumor heterogeneity, and has excellent biological safety and synergistic anti-tumor effect.

The invention belongs to the technical field of biology, and discloses application of isoliquiritigenin in preparation of a product for preventing and / or treating fish infected with a siniperca chuatsi and frog iridovirus (MRV), the EC50 of the isoliquiritigenin is 3.08 mu M, and the isoliquiritigenin has a remarkable in-vivo and in-vitro anti-MRV effect, so that the treatment administration effect is the best, the premixing administration is the second time, and the effect of preventing and / or treating the fish infected with the siniperca chuatsi and frog iridovirus is achieved. The result shows that the isoliquiritigenin possibly has a direct damage effect on MRV virus particles and inhibits MRV virus proliferation; besides, excessive inflammation and cell apoptosis caused by MRV infection can cause fish tissue damage and can promote virus proliferation and escape, and isoliquiritigenin can relieve tissue damage caused by MRV virus, inhibit virus proliferation and play a comprehensive antiviral role through anti-inflammatory and anti-apoptosis effects; meanwhile, the invention also provides a medicine containing isoliquiritigenin, a fish feed and a fish feed additive.