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39results about How to "Easily redispersible" patented technology

Modified-release particles of polyelectrolytes and pharmaceutical formulations thereof

The present invention relates to novel particles comprising polyelectrolyte polymers which are transporters of active principle (AP), in particular protein and peptide active principle, and to novel modified-release pharmaceutical formulations comprising said AP microparticles.
These novel particles loaded with AP release the AP over a prolonged period of time of several days, or even several weeks.
The invention relates, in a first aspect, to particles comprising:
    • a) a first polyelectrolyte polymer (PE1) in a charged state, carrying side hydrophobic groups (GH), wherein said first polyelectrolyte polymer (PE1) can spontaneously form, in water, a colloidal solution of particles at least one pHm value of the pH of between 3 and 8;
    • b) a second polyelectrolyte polymer (PE2) of opposite polarity to the first polyelectrolyte polymer (PE1), wherein said second polyelectrolyte polymer (PE2) forms, in water, a solution or a colloidal solution at said pHm value of the pH; and
    • c) at least one active principle (AP) associated noncovalently with the particles of the colloidal solution of the first polyelectrolyte polymer (PE1);
wherein said particles are obtained by mixing, at a pH equal to pHm, the first polyelectrolyte polymer (PE1), in the form of a colloidal solution of particles associated with the active principle (AP), with the second polyelectrolyte polymer (PE2), in the form of a solution or colloidal solution.
The invention also relates to the process for the preparation of these particles, to a pharmaceutical formulation comprising such particles and to a process for the preparation of medicaments.
Owner:FLAMEL TECHNOLOGIES

Cross-linked food protein stabilized nanometer medicament delivery system capable of being solidified directly

The invention belongs to the technical field of medicament preparations and relates to a cross-linked food protein stabilized nanometer medicament delivery system capable of being 'solidified' directly. The medicament delivery system is prepared from food protein, an oil phase, a cross-linking agent and water by adopting the steps of modifying the protein, adding the oil phase containing the cross-linking agent, dispersing at high speed, homogenizing at high pressure, and 'solidifying' the product by a nanometer suspension. The medicament delivery system is used for promoting oral absorption of indissolvable medicaments, can obviously reduce the toxicity of the medicaments to human body, and can obviously improve the nanometer particle production efficiency and prevent aggregation problem in crosslinking by adding the cross-linking agent into the internal oil phase to cause crosslinking. The prepared nanometer suspension can be directly freeze-dried or laminated on the surface of a small pellet by a fluidized bed and then transformed into a solid preparation; re-solidified nanometer particles are easy to be re-dispersed in water, and the particle size is kept unchanged. According to the medicament delivery system, the stability is improved for a long time, and the compliance of patients is improved; and the preparation process is simple and easy for industrialization.
Owner:FUDAN UNIV

Montmorillonite suspension for treating acute diarrhea, and preparation method thereof

The invention belongs to the technical field of medicinal preparations, and especially relates to a montmorillonite suspension for treating acute diarrhea, and a preparation method thereof. Sodium carboxymethyl cellulose contains sodium cations, which can switch with some calcium cations in montmorillonite, so that partial CMC-Na can enter the interlayer or surface of the montmorillonite; when theconcentration of the CMC-Na and the exchangeable calcium cations on the surface of the montmorillonite can reach a balance state, deflocculation effects can be achieved, so that the settlement volumeratio of the formed montmorillonite suspension can be qualified and stabilized, and easy re-dispersion can be realized; and two bacteriostatic agents which are methyl hydroxybenzoate and propyl hydroxybenzoate can have antibacterial activity when pH is 4-8, can give protons with the increasing of the pH, so that anions of phenol groups can be formed, and bacteriostatic effects can decrease with the increasing of the pH. The composition formula of the montmorillonite suspension is in a balanced deflocculation state, so that the montmorillonite suspension with stable settlement volume ratio reliable in dispersing and qualified in bacteriostatic effect can be obtained.
Owner:昆明正祺医药科技有限公司
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