Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A treatment method for the solidification process of nano-suspension

A technology of nano-suspension and processing method, which is applied in the direction of pharmaceutical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the unfavorable follow-up process of nano-crystalline powder and the low drug content of nano-crystalline powder , Reduce patient compliance and other issues, achieve the effects of reducing industrial production costs, easy to redisperse, and simple methods

Active Publication Date: 2019-10-25
SHENYANG PHARMA UNIVERSITY
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the commonly used sugar protective agents are used in large amounts, which makes the drug content in the nanocrystalline powder very low, which is not conducive to the subsequent process of preparing nanocrystalline powder into other preparations, and reduces the compliance of patients taking medicine

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A treatment method for the solidification process of nano-suspension
  • A treatment method for the solidification process of nano-suspension
  • A treatment method for the solidification process of nano-suspension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: Preparation and post-treatment of a kind of glibenclamide nanosuspension

[0027] First, prepare the water phase containing the HPMC E5 of 0.3% (w / v), after stirring, the glibenclamide of 7% (w / v) is suspended in the above water phase, after that, the suspension is transferred to In the ball mill jar, the ball mill was used to grind for 80 minutes, and the average particle size of the obtained nanosuspension was measured to be 302.3 nm. Before spraying dry, add the distilled water of suspension total volume 50% (v / v), the mannitol of 1.0% (w / v), the Tween80 of 0.5% (w / v) in gained nanosuspension, after spraying Dry machine peristaltic pump feeding liquid speed is 5mL / min, air flow rate is 50mL / min, and the inlet temperature is 160 ℃ under the conditions of spray drying to obtain solidified glibenclamide nanocrystalline powder. After reconstitution, the average particle diameter was measured to be 318.7nm. The results show that the nano-suspension treatme...

Embodiment 2

[0028] Embodiment 2: Preparation and post-processing of a teniposide nanosuspension

[0029] First, prepare an aqueous phase containing 0.5% (w / v) of PVP K30, and after stirring, suspend 6% (w / v) teniposide in the above aqueous phase, and then transfer the suspension to In a ball mill jar, use a ball mill to grind for 45 minutes. The average particle diameter of the obtained nanosuspension was measured to be 467.1 nm. Before spraying dry, add the distilled water of suspension total volume 100% (v / v), the Tween 80 of 3.5% (w / v) in gained nanosuspension, feed liquid speed in spray drying machine peristaltic pump is 3mL / min, an air flow rate of 60 mL / min, and an inlet temperature of 140° C. to obtain solidified teniposide nanocrystalline powder. After reconstitution, the average particle diameter was measured to be 491.2nm. The results show that the nano-suspension processing method of the present invention can effectively maintain the particle size of teniposide nanoparticle...

Embodiment 3

[0030] Embodiment 3: the preparation of a kind of glimepiride nanosuspension and its aftertreatment

[0031] First, prepare the water phase containing the HPMC E50 of 0.1% (w / v), after stirring, the glimepiride of 5% (w / v) is suspended in the above water phase, after that, the suspension is transferred to In a ball mill jar, the mixture was ground for 45 minutes with a planetary ball mill, and the average particle diameter of the obtained nanosuspension was measured to be 298.0 nm. Before spraying dry, add the glucose of 4.0% (w / v), the SDS of 0.02% (w / v) in gained nanosuspension, in the peristaltic pump feeding speed of spray drying machine, be 2.5mL / min, air velocity is Spray-dry under the conditions of 60mL / min and an inlet temperature of 130°C to obtain solidified glimepiride nanocrystalline powder. After reconstitution, the average particle diameter was measured to be 306.6nm. The results show that the nano-suspension treatment method of the present invention can effect...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a treating method for a nanometer suspension solidification process, and belongs to the field of medicine preparations. The nanometer suspension comprises a medicine, a stabilizing agent and water. The method includes adding a surfactant into the medicine nanometer suspension before solidification, and solidifying. Before solidification of the nanometer suspension, 0.01-10% (w / v) of the surfactant is added to inhibit particle aggregation in the solidification process and to maintain the particle size, thus preparing nanometer crystal powder uniform in particle size distribution and easy in redispersion. The method reduces the using amount of a conventional solidification protective agent, and even can fully replace the conventional protective agent, thus increasing the medicine content in the nanometer crystal powder, reducing the cost of auxiliary materials and improving medicine taking compliance.

Description

technical field [0001] The invention relates to a treatment method for the solidification process of a nano-suspension, so as to facilitate the preparation and obtaining of nano-crystalline powder and improve the physical stability of the nano-suspension, belonging to the field of pharmaceutical preparations. Background technique [0002] According to statistics, about 70% of the candidate compounds with pharmacological activity are poorly soluble or insoluble compounds. The low solubility of these compounds limits their oral bioavailability and clinical efficacy, and even leads to their inability to be drugged. Nanocrystallization technology is a new preparation technology emerging in recent years, which can effectively improve a series of problems of poorly soluble drugs. Nanosuspension is a kind of sub-suspension prepared by dispersing drug in dispersion medium (water, aqueous solution or non-aqueous medium), using surfactant or / and polymer as stabilizer, and preparing by...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/64A61K31/7048A61K31/4422A61K31/216A61K31/4439A61K47/26A61K47/32A61K47/38
CPCA61K9/145A61K9/146A61K31/216A61K31/4422A61K31/4439A61K31/64A61K31/7048
Inventor 付强孙进侯彦先卲靖博杨文倩何仲贵
Owner SHENYANG PHARMA UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com