35 results about "CALCIUM CATION" patented technology

A new process for preparing pure amorphous rosuvastatin calcium, substantially free of impurities, is disclosed. A process comprising hydrolysing a C1 to C5 alkyl ester of rosuvastatin, preferably methyl rosuvastatin or tert-butyl rosuvastatin, with a base, e.g. sodium hydroxide, in the presence of an aprotic solvent, preferably tetrahydrofuran and N,N-dimethyl acetamide, or in the presence of a mixture of an aprotic solvent and water, to obtain a solution of rosuvastatin salt, which may be converted to another rosuvastatin salt using another cation, e.g. with calcium cation to obtain rosuvastatin calcium. Rosuvastatin amine salts may be obtained as well.In another preferred aspect of the invention rosuvastatin free acid may be converted to various rosuvastatin salts, e.g. to rosuvastatin calcium, rosuvastatin sodium or various rosuvastatin amine salts, including rosuvastatin solvates, e.g. rosuvastatin calcium hydrate.Rosuvastatin calcium is useful in the treatment of hyperlipidemia, hypercholesterolemia and atherosclerosis.

The invention is a high-yield mannitol preparing method using glucose as raw material, on acidic condition, making the glucose through epimerization reaction to obtain the mixture mannitose-glucose, separate mannitose-glucose by simulated moving bed at 40-85 deg.C, using calcium cation exchange resin as sorbent and water as eluent to continuously obtain glucose-rich component and mannitose-rich component, where the former can repeatedly make epimerization reaction, the latter can generate manitol when added with hydrogen and the mannitol content in the mixed alcohol added with hydrogen is up to above 75%, then crystallizing, centrifuging and drying to obtain the mannitol product, where mannitol productivity is 70% of dry glucose charging capacity.