The invention discloses a wear-resistant antiskid latex glove and a making method thereof. The wear-resistant antiskid latex glove comprises natural latex, potassium hydroxide, titanium dioxide, sodium lauryl sulfate, sulphur, an accelerant, zinc oxide, an antiager, a thickening agent, an antifoaming agent and a wear-resistant agent. The particle diameter of the wear-resistant agent is 10-20 nm and prepared by mixing and grinding a polyurethane elastomer, organic montmorillonite, carbon fibers, lignin, carbon black, silicon dioxide, mica powder and nano calcium carbonate. The making method ofthe glove comprises the steps of glue preparation and material preparation, hand mold cleaning, dipping and leaching, vulcanization and surface treatment. The wear-resistant antiskid latex glove has the advantages of good flexibility, wear resistance and antiskid performance.