13 results about "Propyl hydroxybenzoate" patented technology

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a composition for topical application containing sucralfate wet gel. The invention relates to a local application composition containing sucralfate wet gel, which is prepared from the following components in percentage by mass: 15 to 25 percent of sucralfate wet gel, 10 to 18 percent of polyethylene glycol, 0.2 to 0.5 percent of polyethylene glycol stearate, 0.1 to 0.21 percent of sodium methyl p-hydroxybenzoate, 0.01 to 0.023 percent of sodium propyl p-hydroxybenzoate and the balance of purified water. The sucralfate wet gel dressing is smeared on a non-infected and carefully disinfected skin wound surface and dried, a solid barrier is formed on the part, the wound surface can be covered, damaged tissues below the wound surface can be protected against external stimulation, and the sucralfate wet gel dressing is used for treating non-infectious wound surfaces and ulcers, especially vascular ulcers, diabetic ulcers, bedsores and radiodermatitis, and has a good application prospect. A layer of protective barrier is formed on the broken or damaged surface, so that physiological healing is promoted.

The embodiment of the invention discloses a lidocaine hydrochloride gel preparation process, and relates to the technical field of pharmaceutical preparations. The preparation process comprises the following steps: adding 80-98% of total volume of water for injection into a preparation tank, heating a jacket to 80-95 DEG C, preserving heat, adding lidocaine hydrochloride, methylparaben and propyl hydroxybenzoate, dissolving, adding hydroxypropyl methyl cellulose while stirring, continuously stirring until the material is in a uniformly dispersed state, sequentially adjusting the pH value of the obtained suspension, sterilizing, and cooling to obtain the lidocaine hydrochloride injection. The lidocaine hydrochloride gel is obtained. According to the method, a uniform and transparent gel product without floccules can be formed, so that the working procedure time consumption and the production period are obviously shortened, the energy consumption is reduced, the production cost is effectively controlled, the bacterial contamination risk after sterilization is greatly reduced, the medication safety of the product is further improved, and the method has a good industrial application prospect.

This invention discloses a gel formulation containing human platelet-derived growth factor (PDGF). The components and dosages are as follows: PDGF 50,000-300,000 IU / mL, sodium carboxymethyl cellulose 3.0-4.5%, polyvinyl alcohol 0.5-3%, disodium hydrogen phosphate dodecahydrate 0.258-0.774%, sodium dihydrogen phosphate monohydrate 0.039-0.116%, sodium chloride 0.6-0.95%, methylparaben 0.15-0.18%, propylparaben 0.015-0.020%, and protein protectant 0.4-0.6%. This invention, through optimization of the gel matrix combination and ratio, enables the gel to possess excellent stability and skin adhesion, improves the biological activity of the formulation, and promotes cell proliferation and wound repair at the wound site. It also offers advantages such as a pleasant user experience and simple processing.

The invention relates to the technical field of traditional Chinese medicine preparations, and discloses a preparation process of a compound Jinfeng liniment, which comprises the following steps: weighing the weight of each component in the formula of the compound Jinfeng liniment; pretreating and extracting the kaempferia galanga, the ligusticum wallichii and the safflower carthamus; the preparation method comprises the following steps: mixing menthol, peppermint oil, azone and butanediol, adding part of ethanol, stirring and dissolving, and adding polysorbate and poloxamer to form a uniform solution; adding glycerol into the mixed extract of the caesalpinia kaempferi extract, the ligusticum wallichii and the safflower to form colloid, adding the uniform solution, dropwise adding the remaining ethanol, further adding pre-dissolved asiaticoside, allantoin and a hydroxypropyl methyl cellulose aqueous solution, adding methylparaben, propyl hydroxybenzoate and an edetate disodium aqueous solution, uniformly stirring, and cooling to room temperature. And fixing the volume by using purified water to obtain the compound Jinfeng liniment, and finally filtering and packaging the compound Jinfeng liniment. According to the invention, the extraction efficiency of effective components can be improved, the transdermal absorption effect is enhanced, the stability and safety of the preparation are optimized, and the clinical treatment effect is improved.

Suitable thermoplastic compositions for use in rotational molding applications include a) a polyethylene composition having a melt index I2 of 0.5 to 10 g / 10 min and a melt flow rate of 0.930 to 0.965 g / cm³. 3 The density of; and b) the additive package. The additive package contains i) a first hindered phenolic antioxidant compound selected from d,l-α-tocopherol, d,l-β-tocopherol, d,l-γ-tocopherol, d,l-δ-tocopherol, propyl gallate (3,4,5-trihydroxybenzoate), and mixtures thereof; and ii) a first phosphite antioxidant compound having formula I: (I) wherein R 1 R 2 R 4 and R 5 Independently selected from hydrogen atoms and C1-C 12 Alkyl; R 3 Selected from hydrogen atoms and C1-C8 alkyl groups; L represents a single bond or has the formula -CHR 6 - alkylene groups, wherein R 6 It is a hydrogen atom or C1-C 12 Alkyl group; A is an alkyl group having the formula -CHR 7 - Alkylene, having the formula -C*(=O)CHR 7 - carbonyl group, where C * Bonded to O in formula I, or having a carbonyl group of formula -(C=O)-, wherein R 7 It is a hydrogen atom or C1-C 12 Alkyl; wherein one of Y and Z is selected from hydroxyl, alkoxy, aryloxy, alkylaryloxy, and arylalkoxy, and the other of Y and Z is selected from hydrogen and C1-C. 12 alkyl.

The invention relates to the field of pharmaceutical analysis, in particular to a method for determining the content of cetirizine hydrochloride and various preservatives in a cetirizine hydrochloride oral solution. According to the detection method provided by the invention, octadecyl bonded silica gel is used as a filler of a chromatographic column, a mixed solution with specific composition and proportion is used as a mobile phase, isocratic elution is adopted, a test solution is prepared by using an internal volume transfer pipette, and the test solution and a reference substance mixed solution are respectively injected into a liquid chromatograph for liquid chromatography testing. Respectively obtaining a chromatogram of the test solution and a chromatogram of the reference substance mixed solution; and calculating by peak areas according to an external standard method so as to respectively obtain the content of cetirizine hydrochloride, the content of a methylparaben preservative and the content of a propyl hydroxybenzoate preservative in the cetirizine hydrochloride oral solution. The method provided by the invention has the advantages of strong specificity, high accuracy, good precision, linear relationship and stability, and is beneficial to evaluation of sample quality.

The invention discloses an anti-aging and cell-maintenance essence cream containing squalane soy isoflavone and apple cell culture extract and a preparation method of the anti-aging and cell-maintenance essence cream. The essence cream is prepared from the following components: water, mineral oil, glycerol, butanediol, petrolatum, squalane, cetyl alcohol, C12-20 alkyl glucoside, soy isoflavone, polydimethylsiloxane, a chrysanthellum indicum extract, stearate, sorbitan stearate, a ginseng root extract, glyceryl stearate, an acrylamide / ammonium acrylate copolymer, carbomer, allantoin and triethanolamine. The coating is prepared from polyisobutene, methylparaben, vanillyl butyl ether, bis (hydroxymethyl) imidazolidinyl urea and trace components. The trace components comprise a radix puerariae extract, propyl hydroxybenzoate, polysorbate-20, essence, CI 14700 and a ginger root extract.

The invention belongs to the field of insect feeding and insect resistance identification, and particularly relates to an inter-field insect medium for armyworms and / or grassland spodoptera exigua and application. The invention provides an inter-field insect medium for armyworms and / or grassland spodoptera exigua, which comprises puffed corn flour, puffed soybean flour, corn leaf meal, wheat germ, beer yeast, milk powder, wheat bran, casein, ascorbic acid, multivitamin glucose, erythromycin, sodium sorbate, methyl p-hydroxybenzoate, propyl p-hydroxybenzoate, cholesterol, inositol and streptomycin sulfate. Vermiculite and water. The raw materials of the field insect inoculation medium are easy to obtain, the cost is low, preparation is easy, storage is convenient, the field large-scale artificial insect inoculation efficiency of armyworms and spodoptera frugiperda can be improved, the influence of natural factors on the insect inoculation effect is reduced, meanwhile, the stability and repeatability of the insect inoculation effect are guaranteed, and optimization of the economic cost is achieved.

The invention discloses a method for determining a preservative in a children oral liquid preparation, and belongs to the technical field of detection. Comprising the following steps: preparing a mixed reference substance standard stock solution; preparing a series of standard solutions; the method comprises the following steps: precisely measuring a to-be-measured sample, putting the to-be-measured sample into a measuring flask, diluting the to-be-measured sample to a scale by using an acetonitrile-water solution with a volume ratio of 1: 1, uniformly shaking, and passing through a 0.22 mu m filter membrane to obtain a sample solution for later use; and precisely sucking the series of standard solutions and the sample solution, injecting into a gas chromatograph, and determining. According to the method, whether various preservative components such as p-benzyl alcohol, sorbic acid, benzoic acid, methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate and butyl p-hydroxybenzoate exist in the oral liquid preparation for children or not can be determined at the same time through the gas chromatography, and the recovery rate and precision are high. When an acetonitrile aqueous solution with the volume fraction of 50% is selected as an extraction solvent, a sample to be detected can be quickly and uniformly dispersed and dissolved.

An agent for three-dimensional (3D) printing includes at least 3 wt % active, based on a total weight of the agent, of a paraben selected from the group consisting of methyl paraben, ethyl paraben, propyl paraben, butyl paraben, isopropyl paraben, isobutyl paraben, heptyl paraben, benzyl paraben, salts thereof, and combinations thereof; and an aqueous vehicle. The aqueous vehicle includes up to 85 wt % active, based on the total weight of the agent, of a co-solvent package including at least one co-solvent present in an amount sufficient to increase a solubility of the paraben in the aqueous vehicle; and a balance of water.

The invention belongs to the technical field of medicine, and discloses metoclopramide hydrochloride oral liquid and a preparation method thereof.The metoclopramide hydrochloride oral liquid is prepared from 0.5 mg / ml to 1.5 mg / ml of metoclopramide hydrochloride, 1 mg / ml to 3 mg / ml of bacteriostatic agent, 1 mg / ml to 4 mg / ml of hydroxyethyl cellulose, 0.2 mg / ml to 1 mg / ml of sweetening agent, essence and water; the bacteriostatic agent is a mixture of hydroxypropyl methyl ester and propyl hydroxybenzoate; the sweetening agent is a mixture of stevioside and saccharin sodium salt. The metoclopramide hydrochloride oral solution prepared by the invention is simple in process, suitable for large-scale production and high in control degree of product quality, the stability and taste of the obtained product are better than those of commercially available products, and the effectiveness and compliance of taking medicines by patients are improved.

This invention relates to a desonide lotion and its preparation method. The desonide lotion comprises desonide, an oil phase component, a humectant, a surfactant, 1,3-butanediol, propylene glycol alginate, a preservative, and water. Specifically, the desonide lotion is composed of desonide, liquid paraffin, dimethyl silicone oil, glycerin, Span 80, sodium dodecyl sulfate, 1,3-butanediol, propylene glycol alginate, methylparaben, propylparaben, and water. This invention, by combining 1,3-butanediol and propylene glycol alginate as a stabilizing matrix and functional additive, has successfully developed a desonide lotion with excellent physicochemical stability, good spreading and wetting properties, high transdermal absorption rate, and a simple preparation process, possessing extremely high clinical value and promising industrial application prospects.

The invention provides a compound lidocaine hydrochloride mucilage composition for endoscopic anesthesia. The compound lidocaine hydrochloride mucilage composition comprises water and the following raw materials in parts by weight: 2 parts of lidocaine hydrochloride; 2 parts of simethicone; 10 thousand to 30 thousand units of streptavidin; 1-4 parts of a cellulose derivative; 0.1 to 0.5 part of xanthan gum; 0.001 to 0.05 part of 2, 6-di-tert-butyl p-cresol; 0.01 to 0.1 part of methylparaben; 0.01 to 0.1 part of propyl hydroxybenzoate; 0.1 to 1.5 parts of polysorbate 80; 0.1 to 2 parts of ethanol; 0.01 to 0.1 part of a flavoring agent; 0.01-2 parts of an aromatic agent; and 0.01 to 0.015 part of a pH regulator. The product disclosed by the invention can play roles in relieving pain, defoaming and eliminating gastric mucus at the same time, and provides a clearer endoscope view field; meanwhile, the viscosity of the preparation can be increased, the residence time of the medicine acting on the mucosa surface is delayed, the local anesthesia action time is prolonged, and the medication frequency is reduced.