6 results about "Propyl hydroxybenzoate" patented technology

The embodiment of the invention discloses a lidocaine hydrochloride gel preparation process, and relates to the technical field of pharmaceutical preparations. The preparation process comprises the following steps: adding 80-98% of total volume of water for injection into a preparation tank, heating a jacket to 80-95 DEG C, preserving heat, adding lidocaine hydrochloride, methylparaben and propyl hydroxybenzoate, dissolving, adding hydroxypropyl methyl cellulose while stirring, continuously stirring until the material is in a uniformly dispersed state, sequentially adjusting the pH value of the obtained suspension, sterilizing, and cooling to obtain the lidocaine hydrochloride injection. The lidocaine hydrochloride gel is obtained. According to the method, a uniform and transparent gel product without floccules can be formed, so that the working procedure time consumption and the production period are obviously shortened, the energy consumption is reduced, the production cost is effectively controlled, the bacterial contamination risk after sterilization is greatly reduced, the medication safety of the product is further improved, and the method has a good industrial application prospect.

This invention discloses a gel formulation containing human platelet-derived growth factor (PDGF). The components and dosages are as follows: PDGF 50,000-300,000 IU / mL, sodium carboxymethyl cellulose 3.0-4.5%, polyvinyl alcohol 0.5-3%, disodium hydrogen phosphate dodecahydrate 0.258-0.774%, sodium dihydrogen phosphate monohydrate 0.039-0.116%, sodium chloride 0.6-0.95%, methylparaben 0.15-0.18%, propylparaben 0.015-0.020%, and protein protectant 0.4-0.6%. This invention, through optimization of the gel matrix combination and ratio, enables the gel to possess excellent stability and skin adhesion, improves the biological activity of the formulation, and promotes cell proliferation and wound repair at the wound site. It also offers advantages such as a pleasant user experience and simple processing.

Suitable thermoplastic compositions for use in rotational molding applications include a) a polyethylene composition having a melt index I2 of 0.5 to 10 g / 10 min and a melt flow rate of 0.930 to 0.965 g / cm³. 3 The density of; and b) the additive package. The additive package contains i) a first hindered phenolic antioxidant compound selected from d,l-α-tocopherol, d,l-β-tocopherol, d,l-γ-tocopherol, d,l-δ-tocopherol, propyl gallate (3,4,5-trihydroxybenzoate), and mixtures thereof; and ii) a first phosphite antioxidant compound having formula I: (I) wherein R 1 R 2 R 4 and R 5 Independently selected from hydrogen atoms and C1-C 12 Alkyl; R 3 Selected from hydrogen atoms and C1-C8 alkyl groups; L represents a single bond or has the formula -CHR 6 - alkylene groups, wherein R 6 It is a hydrogen atom or C1-C 12 Alkyl group; A is an alkyl group having the formula -CHR 7 - Alkylene, having the formula -C*(=O)CHR 7 - carbonyl group, where C * Bonded to O in formula I, or having a carbonyl group of formula -(C=O)-, wherein R 7 It is a hydrogen atom or C1-C 12 Alkyl; wherein one of Y and Z is selected from hydroxyl, alkoxy, aryloxy, alkylaryloxy, and arylalkoxy, and the other of Y and Z is selected from hydrogen and C1-C. 12 alkyl.

The invention discloses a method for determining a preservative in a children oral liquid preparation, and belongs to the technical field of detection. Comprising the following steps: preparing a mixed reference substance standard stock solution; preparing a series of standard solutions; the method comprises the following steps: precisely measuring a to-be-measured sample, putting the to-be-measured sample into a measuring flask, diluting the to-be-measured sample to a scale by using an acetonitrile-water solution with a volume ratio of 1: 1, uniformly shaking, and passing through a 0.22 mu m filter membrane to obtain a sample solution for later use; and precisely sucking the series of standard solutions and the sample solution, injecting into a gas chromatograph, and determining. According to the method, whether various preservative components such as p-benzyl alcohol, sorbic acid, benzoic acid, methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate and butyl p-hydroxybenzoate exist in the oral liquid preparation for children or not can be determined at the same time through the gas chromatography, and the recovery rate and precision are high. When an acetonitrile aqueous solution with the volume fraction of 50% is selected as an extraction solvent, a sample to be detected can be quickly and uniformly dispersed and dissolved.

An agent for three-dimensional (3D) printing includes at least 3 wt % active, based on a total weight of the agent, of a paraben selected from the group consisting of methyl paraben, ethyl paraben, propyl paraben, butyl paraben, isopropyl paraben, isobutyl paraben, heptyl paraben, benzyl paraben, salts thereof, and combinations thereof; and an aqueous vehicle. The aqueous vehicle includes up to 85 wt % active, based on the total weight of the agent, of a co-solvent package including at least one co-solvent present in an amount sufficient to increase a solubility of the paraben in the aqueous vehicle; and a balance of water.

This invention relates to a desonide lotion and its preparation method. The desonide lotion comprises desonide, an oil phase component, a humectant, a surfactant, 1,3-butanediol, propylene glycol alginate, a preservative, and water. Specifically, the desonide lotion is composed of desonide, liquid paraffin, dimethyl silicone oil, glycerin, Span 80, sodium dodecyl sulfate, 1,3-butanediol, propylene glycol alginate, methylparaben, propylparaben, and water. This invention, by combining 1,3-butanediol and propylene glycol alginate as a stabilizing matrix and functional additive, has successfully developed a desonide lotion with excellent physicochemical stability, good spreading and wetting properties, high transdermal absorption rate, and a simple preparation process, possessing extremely high clinical value and promising industrial application prospects.