The invention discloses a pharmaceutical composition of propafenone or a salt thereof and a preparation method of the pharmaceutical composition, and belongs to the field of medicines. The pharmaceutical composition comprises an
active ingredient, a sustained-release material and a framework material, the
active component comprises propafenone or a pharmaceutically acceptable salt thereof. According to the propafenone
hydrochloride pharmaceutical composition disclosed by the invention, a specific sustained-release material and a framework material are preferably selected, so that the appearance property stability, the related substance stability, the
moisture stability and the content stability of the obtained propafenone
hydrochloride pharmaceutical composition are favorably improved, and an unexpected technical effect is achieved; the pharmaceutical composition provided by the invention is stable in in-vivo release, good in slow-release effect and small in
drug concentration fluctuation, can maintain safe, effective and stable
blood concentration for a long time, does not need to be injected for multiple times and does not need intravenous drip, and is beneficial to reducing the
medication frequency and improving the medication compliance of a patient.