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1 results about "Metallothionein" patented technology
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Metallothionein (MT) is a family of cysteine-rich, low molecular weight (MW ranging from 500 to 14000 Da) proteins. They are localized to the membrane of the Golgi apparatus. MTs have the capacity to bind both physiological (such as zinc, copper, selenium) and xenobiotic (such as cadmium, mercury, silver, arsenic) heavy metals through the thiol group of its cysteine residues, which represent nearly 30% of its constituent amino acid residues.
Agent for restoring metal homeostasis
The disclosure relates to malonic acid and derivatives thereof of formula (I) below for use as an agent for promoting metallothionein biosynthesis in a patient:X and Y are each independently selected from —O−M+, —OR1, and —NR2R3, M+ is selected from monovalent or polyvalent metal cations, and R1, R2 and R3 are each independently selected from hydrogen and saturated or unsaturated, linear, branched or cyclic hydrocarbon radicals having from 1 to 25 carbon atoms, and one or more carbon atoms are optionally substituted for O or N, R2 and R3 being optionally connected to form a heterocyclic hydrocarbon radical together with the nitrogen atom. The disclosure also relates to a pharmaceutical composition containing a compound of formula (I).
Owner:OXFORD ANTIBIOTIC GRP GMBH