477 results about "Malonic acid" patented technology

The invention discloses a high-temperature-resistant power tube and a production process thereof, and belongs to the technical field of power tube preparation. The high-temperature-resistant electric power tube is prepared from, by weight, 60-80 parts of a high-temperature-resistant base material, 10-30 parts of carbon fibers and 1-5 parts of a modified anti-aging agent, the high-temperature-resistant base material is prepared from 2, 3, 4-trifluorobenzaldehyde, malonic acid, oxynaphthalene propionic acid, trifluoroacetic anhydride and 2, 2-bis [4-(4-aminophenoxy) phenyl] propane, and the modified anti-aging agent is prepared from 2, 3, 4-trifluorobenzaldehyde, malonic acid, oxynaphthalene propionic acid, trifluoroacetic anhydride and 2, 2-bis [4-(4-aminophenoxy) phenyl] propane. The modified anti-aging agent is prepared from absolute ethyl alcohol, paeonol, sodium hydroxide and 2-methoxybenzaldehyde. The power tube prepared by the method has excellent high temperature resistance, mechanical property and aging resistance.

The invention provides a cronobacter malonate strain and application thereof, the strain is preserved in China Center for Type Culture Collection on January 15, 2025, the preservation date is January 15, 2025, and the preservation number is CCTCC M 2025146. The strain has excellent capability of producing 4-vinyl guaiacol, and the yield in a sorghum juice fermentation culture medium is 2.70 + / -0.15 mg / L; meanwhile, the strain can resist ferulic acid and has good capability of converting ferulic acid to generate 4-vinyl guaiacol, and when 0.1% (w / w) of ferulic acid is added into a fermentation culture medium, the content of 4-vinyl guaiacol reaches 2.68 + / -0.04 g / L. The strain is applied to production of Maotai-flavor liquor, the content of 4-ethyl guaiacol in raw liquor reaches 3.20 + / -0.26 mg / L and is remarkably increased by 223.23% (P is smaller than 0.01) compared with the content of 4-ethyl guaiacol without the strain, the Maotai flavor is prominent through sensory evaluation, the flower, fruit and burnt flavor is obvious, and the strain has important significance on improvement of the health quality of the liquor.

The present invention discloses a platinum electroplating solution, a preparation method thereof and an application in semiconductors, which comprises the following raw materials: 0.5-10 g / L of platinum salt PEP, 15-35 g / L of ethylenediamine sulfate, 5.0-29 g / L of malonic acid, 5.0-40 g / L of ammonium acetate, the balance being ultrapure water and ammonia water; the pH value of the platinum electroplating solution is adjusted to 7.0 with ammonia water; the method for preparing the coating comprises the following steps: S1, degreasing and pickling the semiconductor device to be processed; S2, selecting corresponding electroplating conditions and configuring a corresponding anode and its anode mask; S3, performing electroplating; S4, automatically adding the platinum salt PEP solution in a linked manner; S5, adjusting the pH value of the platinum electroplating solution; S6, stopping electroplating after reaching the target coating thickness or the preset electroplating time. The platinum metal film formed by the present invention has excellent morphology, uniform distribution, high wear resistance and excellent compactness.

The invention discloses a skin-friendly antibacterial foaming material and application thereof in footwear products, and relates to the technical field of high polymer materials. When the skin-friendly antibacterial foaming material is prepared, firstly, tetramethyl tetravinyl cyclotetrasiloxane and a flame retardant react to obtain flame-retardant cyclosiloxane, 1, 3-bis (aminopropyl-1, 1, 3, 3-tetramethyl disiloxane and maleic anhydride react to obtain an end-capping reagent, the flame-retardant cyclosiloxane and octamethyl cyclotetrasiloxane are subjected to ring opening polymerization, and the skin-friendly antibacterial foaming material is obtained. Carrying out end-capping by an end-capping reagent to obtain functionalized polysiloxane, loading a foaming agent on hollow silicon dioxide, and grafting chitosan quaternary ammonium salt; and finally, polymerizing polyether amine, furan-2, 5-dimethyl dicarboxylate, 3, 5-diaminobenzene sulfonic acid and dimethyl malonate to prepare modified polyamide, and blending and foaming the modified polyamide, the functionalized polysiloxane, the modified silicon dioxide and chitosan quaternary ammonium salt to prepare the skin-friendly antibacterial foaming material. The prepared skin-friendly antibacterial foaming material has excellent flame retardance, antibacterial performance and self-repairing performance.

The invention belongs to the field of precious metal recovery, and particularly relates to a method for leaching silver from a silver-containing retired crystalline silicon solar cell. According to the method, the silver in the silver-containing decommissioned crystalline silicon solar cell is recycled and leached through the synergistic effect of an HNO3-H2O2-Fe < 3 + > composite leaching agent and ionic liquid, and the ionic liquid is prepared from choline chloride and malonic acid. Meanwhile, the leaching rate of silver is further improved by optimizing experimental parameters such as the reaction temperature, the reaction time and the H2O2 supply frequency in the three-section gradient temperature control leaching reaction. Compared with the traditional technology, the method disclosed by the invention is green and environment-friendly, low in cost, small in acid consumption and high in recovery rate.

The invention discloses a method for catalytic synthesis of malonic acid by using whole cells, and belongs to the field of bioengineering. According to the invention, escherichia coli BL21 (DE3) is taken as a host, an aspartic acid ammonia lyase gene aspA and an aspartic acid-alpha-decarboxylase gene panD, a succinate semialdehyde dehydrogenase gene yneI and a beta-alanine pyruvate transaminase gene, a beta-alanine pyruvate transaminase gene bauA and a malonyl-coenzyme A reductase gene mcr-C are expressed in modules, and recombinant escherichia coli is constructed. The malonic acid is produced by adopting a whole-cell catalysis method, so that the production period is shortened, the production efficiency of the malonic acid is improved, and the yield of the malonic acid can reach 51.0 g / L after the malonic acid is catalyzed for 24 hours.

The invention discloses a platinum chemical plating solution and a preparation method and application thereof in semiconductors, the platinum chemical plating solution comprises the following raw materials: 0.5-10.0 g / L of platinum salt PEP, 2.1-10.0 g / L of ethylenediamine sulfate, 1.2-8.9 g / L of malonic acid, 5-50 g / L of ammonium acetate, 1.2-9.2 g / L of thiourea dioxide, and the balance of ultrapure water and ammonia water; and the pH value of the solution is adjusted to 7.0 by ammonia water. The platinum chemical plating solution disclosed by the invention is suitable for nano precision manufacturing and processing on the surface of an electronic element product of a semiconductor device, and a formed platinum metal film has excellent uniform distribution, compactness and high wear resistance; a semiconductor electronic component product with excellent plugging performance, corrosion resistance, high-precision conductivity and high-quality electronic signal transmission performance is obtained.

The invention belongs to the technical field of separation of drug intermediates, and particularly relates to a control method for a process impurity 2-ethyl valeric acid (EP-B) in preparation of valproic acid or sodium valproate by a diethyl malonate method. According to the method disclosed by the invention, the content of 2-ethyl-2-propylmalonic acid process impurities in dipropylmalonic acid is controlled, so that the content of 2-ethylvaleric acid (EP-B) which is a process impurity in valproic acid or sodium valproate is accurately controlled; adding a polar solvent into the dipropylmalonic acid crude product, heating, pulping for a certain time, cooling, filtering and drying to obtain a high-purity dipropylmalonic acid refined product; high-purity valproic acid (RRT is equal to 1.00) is prepared through decarboxylation of the dipropyl malonic acid fine product, and the purity is 99.779%; 0.020% of 2-ethyl valeric acid (RRT is equal to 0.90); and valeric acid (RRT = 0.77), 0.039%. The valproic acid product quality meets the requirements of European Pharmacopoeia. According to the method, the problems of quality control and process evaluation of valproic acid or sodium valproate prepared by a diethyl malonate method are solved.

The present invention relates to a preparation method and application of a supramolecular aggregate surfactant, and belongs to the field of supramolecular coordination chemistry, surface modification engineering and hydrophobic coating technology. In the present invention, 4-hydroxypyridine-2,6-dicarboxylic acid and malonic acid prepare an adhesive ligand, and with the help of the coordination of the carboxyl structure and lanthanum ions on 4-hydroxypyridine-2,6-dicarboxylic acid and perfluorooctanoic acid, a supramolecular aggregate in a nano-aggregated state is obtained, which is self-assembled into a supramolecular aggregate surfactant. The active agent can solubilize fluoride and can also be applied in the field of hydrophobic coatings. The coating has the characteristics of imitating lotus leaf structure and hydrophobic wax, and has good hydrophobic properties.

The invention relates to the technical field of biological extraction, in particular to a preparation method of selenium polysaccharide in cardamine violifolia, which comprises the following steps: extracting selenium polysaccharide in cardamine violifolia by using a deep eutectic solvent as an extraction solvent and adopting an ultrasonic method, and removing protein in the selenium polysaccharide by using an isoelectric precipitation method and an enzymolysis method, thereby obtaining the selenium polysaccharide in cardamine violifolia. Removing water, enzymolysis product amino acid, inorganic selenium and other impurities by a membrane separation concentration system to obtain cardamine violifolia selenium polysaccharide; wherein the eutectic solvent comprises choline chloride and malonic acid in a molar ratio of 1: 1-1: 3, and the water content is 40-60% (mass percent); the compound enzyme is prepared from bromelain and papain in a mass ratio of 1: 1. Protein in the selenium polysaccharide is removed by adopting deep eutectic solvent ultrasonic extraction and an isoelectric precipitation method combined with an enzymolysis method, enzymolysis product amino acid, inorganic selenium and other impurities are removed by adopting an ultrafiltration membrane separation and concentration system, the structure of the polysaccharide is not damaged, and the high-purity cardamine violifolia selenium polysaccharide is obtained.

The invention belongs to the technical field of separation of drug intermediates, and particularly relates to a method for preparing a high-purity dipropylmalonic acid refined product by adding a polar solvent into a dipropylmalonic acid crude product, heating, pulping for a certain time, cooling, filtering and drying. Decarboxylating the refined dipropylmalonic acid product to obtain high-purity valproic acid; distilling the filtrate to recover the polar solvent to obtain 2-methyl-2-propylmalonic acid, and carrying out decarboxylation on the 2-methyl-2-propylmalonic acid to obtain 2-methylpentanoic acid; 2-methylvaleric acid is used as a perfume additive. According to the method disclosed by the invention, the process impurity 2-methyl-2-propylmalonic acid in dipropylmalonic acid is separated, and the process impurity 2-methylvaleric acid (EP-L) in valproic acid or sodium valproate is precisely separated; the quality of the valproic acid product prepared by the method disclosed by the invention meets the requirements of European Pharmacopoeia EP-11 (2023). According to the invention, the problems of quality control and process evaluation of valproic acid or sodium valproate prepared by a dimethyl malonate method are solved.

The invention discloses a synthesis process of chiral cyclic ether indole. The synthesis process comprises the following steps: reacting 4-bromobenzaldehyde with malonic acid under the catalysis of piperidine to generate olefin carboxylic acid CHP-1; carrying out condensation reaction to prepare CHP-2; under the catalysis of a copper reagent, carrying out Michael addition reaction to obtain CHP-3; preparing a chiral alcohol intermediate CHP-4 through a reduction reaction; trifluoromethanesulfonic acid is used, and a chiral ether intermediate CHP-5 is prepared through ring closing; reacting with protected hydrazine by using a copper ion catalyst to obtain an intermediate CHP-6; the method comprises the following steps: by taking alcohol as a solvent, adding strong acid, and removing a protecting group of hydrazine to obtain an intermediate CHP-7; and carrying out ring closing by taking lewis acid as a catalyst to obtain an indole product CHP-8. The use of a noble metal catalyst palladium is avoided, and the cost is greatly reduced. The chiral center is directly constructed through a chemical method, and SFC is not needed for resolution, so that the cost is remarkably reduced, and industrial production is successfully realized.

The invention discloses an improved self-induction culture medium and a culture process, and belongs to the technical field of bioengineering. The improved self-induction culture medium is prepared from 10 g / L of glucose, 3-5 g / L of glycerin, 3 g / L of lactose, 24 g / L of yeast extract, 8 g / L of casein hydrolysate, 0.02-0.05 mM of malonic acid, 1 mM of methionine and 1-3 mM of MgSO4, a phosphate buffer solution is added to control the pH to be 7.2, and the improved self-induction culture medium is prepared by mixing after sterilization. Cells are inoculated to an improved self-induction culture medium for culture, automatic switching of growth-induction stages can be realized based on a pH and DO linkage dynamic feeding control method, the operation complexity is reduced, and the controllability is higher. The culture medium does not need a special inducer, cost is reduced, and protein expression quantity is improved.

The invention discloses a synthesis method of 5-bromoindole-2-carboxylic acid methyl ester, and the synthesis route comprises the following steps: S1, taking 2-iodo-4-broronitrobenzene and dimethyl malonate as raw materials, and under the catalysis of a solid sulfonic acid resin catalyst, carrying out nucleophilic substitution reaction to prepare 2-(5-bromo-2-nitrophenyl) dimethyl malonate; s2, taking the dimethyl 2-(5-bromo-2-nitrophenyl) malonate prepared in the step S1 as a raw material, taking a ZSM-5 molecular sieve loaded with cobalt acetate as a catalyst, and introducing hydrogen for reduction reaction to prepare a 5-bromoindole-2-carboxylic acid methyl ester crude product; and S3, carrying out recrystallization on the 5-bromoindole-2-carboxylic acid methyl ester crude product prepared in the step S3 by using ethanol, so as to prepare a 5-bromoindole-2-carboxylic acid methyl ester pure product. The synthesis yield is relatively high, the environmental protection property is relatively good, and the prepared 5-bromoindole-2-carboxylic acid methyl ester is relatively excellent in quality and relatively low in cost.

The invention discloses a low-temperature cured polyurethane varnish resin for automobiles and a preparation method thereof, and belongs to the technical field of chemical product processing, the low-temperature cured polyurethane varnish resin comprises a resin matrix and a curing agent, the resin matrix comprises a component A and a component B. The component A comprises a crosslinking system A1, a crosslinking system A2 and an auxiliary agent, the component B is a curing activity regulator of a double-crosslinking system of the crosslinking system A1 and the crosslinking system A2; the curing agent is diethyl malonate blocked isocyanate; the cross-linking system A1 is mainly composed of hydroxy acrylic resin containing beta-diketone metal ligand and a bismuth neodecanoate catalyst; the bismuth neodecanoate catalyst and a beta-diketone metal ligand form a bismuth complex; the cross-linking system A2 is mainly composed of hydroxyl acrylic resin containing alkoxy silane groups; the component B is prepared from poly (decane-4, 6-diyne diacid) modified nano porous fibers and a silane coupling agent. The service life of the varnish is prolonged on the basis of ensuring low-temperature rapid curing.

The invention discloses a purification device and method for malonic acid mono-p-nitrobenzyl ester, and relates to the technical field of malonic acid mono-p-nitrobenzyl ester production.The purification device comprises a base, a storage barrel is installed at the top of the base, a first fan-shaped groove is formed in a rotary disc, and a second fan-shaped groove is formed in a disc-shaped frame; a box frame is fixedly arranged at the inner end of the charging barrel, an annular pushing part is arranged on the outer side of the rotary sleeve, a transmission part is arranged on the inner side of the filter cone, and a spray head is rotationally mounted on the box frame. According to the invention, firstly, through the rotation of the rotary disc and the vertical movement of the baffle disc, dynamic filtration and impurity discharge are realized, the filtration efficiency and the impurity discharge reliability are improved, secondly, through the cooperative movement of a mechanical structure, the utilization efficiency of the equipment is improved, the downtime caused by cleaning is reduced, and the production cost is reduced. For the purification process needing long-time continuous operation, the design can reduce the downtime caused by cleaning and improve the working efficiency of the equipment.

The invention belongs to the technical field of fine chemical engineering, and discloses a synthesis method of a malonate compound, which comprises the following steps: under the action of a heterogeneous catalyst, carrying out hydrolysis-esterification reaction on cyanoacetic acid and alcohol, and after the reaction is finished, carrying out post-treatment to obtain the malonate compound, the heterogeneous catalyst comprises a carrier and an active component; the active component comprises ionic liquid and active metal; the carrier is an ordered mesoporous material; the active metal is alkaline earth metal. According to the method, malonate products can be obtained, the problems of low yield, serious equipment corrosion and large amount of three wastes are solved, efficient synthesis of malonate compounds is realized, meanwhile, the production efficiency is improved, and the environmental pollution is greatly reduced.

The invention discloses a solid electrolyte, a secondary battery and an electric device, and belongs to the technical field of batteries, the solid electrolyte comprises a polymer solid electrolyte, a lithium salt and a cross-linked copolymer; the cross-linked copolymer comprises a polymer solid electrolyte containing a carbon-carbon double bond and bis (10-undecylene-1-yl) malonate grafted fullerene. The solid electrolyte can effectively improve the transference number of lithium ions, improve the mechanical property of the solid electrolyte and effectively prolong the cycle life of a secondary battery.

The invention discloses a waterproof impact-resistant fireproof cable, and relates to the technical field of cables. The preparation method comprises the following steps: firstly, forming a silane hydroxide compound by using 2-bromo-1, 5-hexadiene, trimethoxysilane and trioctylamine, and carrying out hydrolysis reaction on the silane hydroxide compound and infiltrated moisture to prevent moisture invasion; forming a first waterproof layer on the surface of the insulating layer by utilizing ultraviolet-assisted electrospinning; zinc nitrate water vapor is introduced to react with the first waterproof layer to obtain a second waterproof layer, so that the waterproof effect of the cable is enhanced; after the cable is coated with the shielding layer and the inner sheath layer, diallyldiethoxysilane and graphene are sequentially sprayed to form an aerogel protection layer, so that the cable has a fireproof effect; then aluminum sulfate is sprayed to form aluminum hydroxide to coat the surfaces of the pore channels of the aerogel, and then triethoxysilylbutyraldehyde and malonic acid are sequentially sprayed to be grafted to the surface of the aerogel, so that the fireproof effect of the cable is improved. The cable prepared by the invention has waterproof and fireproof effects.

The invention relates to the field of road asphalt, and discloses high-modulus modified asphalt for improving road performance and a preparation method thereof, the modified asphalt comprises matrix asphalt, coal liquefied asphalt, modified rubber seed oil, ethylene-vinyl acetate copolymer and modified carbon nanotubes; the modified rubber seed oil is prepared from epoxy rubber seed oil and a carboxylated flame-retardant component prepared by reaction of amino trimethylphosphonic acid, trimethylolpropane and malonic acid; the modified carbon nano tube is prepared from a toluene-2, 4-diisocyanate isocyanated carbon nano tube and an aminated modifier through a reaction; the amination modifier is prepared by performing acylating chlorination grafting on 3-(3, 5-di-tert-butyl-4-hydroxyphenyl) propionic acid by using thionyl chloride and then grafting with p-phenylenediamine. According to the invention, the coal liquefaction asphalt, the modified rubber seed oil, the ethylene-vinyl acetate copolymer and the modified carbon nanotube are added into the matrix asphalt; the high and low temperature performance, the flame retardant performance and the anti-aging performance of the asphalt material can be improved.

The invention relates to a Cu3Ni / NF nanosheet self-supporting electrode and a preparation method thereof, and belongs to the technical field of electro-catalysis. The preparation method of the Cu3Ni / NF nanosheet self-supporting electrode comprises the following steps: mixing CuCl2. 2H2O, polyethylene glycol and malonic acid, heating and stirring to obtain a deep eutectic solvent DESs; the surface of a foamed nickel substrate is coated with a deep eutectic solvent DESs, heating treatment is carried out in an inert atmosphere, and the Cu3Ni / NF nanosheet self-supporting electrode is obtained. The preparation method is simple in preparation process, mild in condition, low in preparation cost, good in element compatibility, capable of achieving industrial production and free of pollution to the environment. And the obtained Cu3Ni / NF nanosheet self-supporting electrode has excellent electrocatalytic activity.

The present invention discloses a golden chrysanthemum flavonoid glycoside derived from golden chrysanthemum, wherein the golden chrysanthemum flavonoid glycoside is apigenin 7-O-(6"-O-malonyl)-β-D-glucoside derived from golden chrysanthemum. The present invention separates and purifies apigenin 7-O-(6"-O-malonyl)-β-D-glucoside from golden chrysanthemum for the first time, completes the first synthesis through a 5-step synthesis process with a total yield of 2.7%, and discovers for the first time that the compound has activity in improving hyperlipidemia and fatty liver in vitro and in vivo. Therefore, the compound can be used in the preparation of products for treating related diseases such as hyperlipidemia and fatty liver.

The present invention relates to P2X3 inhibitor compounds and their salts, crystalline polymorphs and uses.The present invention provides the crystalline form of the compound of formula I with good medicinal properties.The present invention also obtains medicinal salts of the compound of formula I, and further obtains crystalline form products of salts, such as hydrochloride crystalline form A, maleate crystalline form A, p-toluenesulfonate crystalline form A, benzenesulfonate crystalline form A, malonate crystalline form A, etc., which has important significance for the development of effective therapeutic drugs.

A whitening dentifrice composition includes malonic acid or a salt thereof and a thickening system comprising xanthan gum, carrageenan, and about 1.5% or greater, by weight of the composition, of thickening silica. The whitening dentifrice composition has a pellicle cleaning ratio (PCR) value of at least 115.

The present invention relates to a method of adding an isocitrate lyase specific inhibitor to a lactic acid fermentation process to block the production of succinic acid as a byproduct of fermentation. The specific inhibitor includes a combination of one or more of glycolic acid methyl ester, malonic acid dimethyl ester, hydroxymalonic acid diethyl ester, 3-nitropropionic acid ethyl ester, mercuric chloride, or 5,5'-dithiobis(2-nitrobenzoic acid) to effectively reduce the amount of succinic acid in the lactic acid.

Disclosed are a flux containing rosin, an active agent, and a solvent, the active agent containing an imidazole compound and two dicarboxylic acids, the two dicarboxylic acids being combined with malonic acid using one selected from succinic acid, adipic acid, and sebacic acid, and a method for preparing a joined body using the flux. Or the soldering flux contains rosin, an active agent and a solvent, the active agent contains an imidazole compound and two dicarboxylic acids, and the two dicarboxylic acids are combined with succinic acid and one selected from suberic acid, sebacic acid, methylsuccinic acid, malic acid and malonic acid. According to the present invention, it is possible to provide a flux capable of increasing the leg size and suppressing the occurrence of bridging during soldering.

The invention provides a synthesis method of 1-methyl-L-histidine, which comprises the following steps: firstly, carrying out methylation reaction on a compound 1 and N, N-dimethylformamide dimethyl acetal to obtain a compound 3; the compound 3 and NCS are subjected to a chlorination reaction, and a compound 4 is obtained; then reacting the compound 4 with diethyl acetamidomalonate to obtain a compound 5; then carrying out hydrolysis decarboxylation on the compound 5 to obtain a compound 6; and finally, splitting the compound 6 by using acetyl hydrolase to obtain a chiral compound 7 (namely 1-methyl-L-histidine). The synthesis route is short, the raw materials are cheap, the production cost can be reduced, the product yield and purity are high, and large-scale industrial production is facilitated.

The application belongs to the field of organic synthesis, and discloses a method for preparing chiral 2-(1,3-diarylallyl)malonate by using a Pd / phosphine oxygen bidentate phosphine phenol ligand catalysis, which comprises the following steps: under a protective atmosphere, mixing P, O-bidentate phosphine phenol ligand, a palladium catalyst, N, O-bis(trimethylsilyl)acetamide, a malonate nucleophilic reagent and an allyl acetate electrophilic reagent in dichloromethane, and reacting to obtain chiral 2-(1,3-diarylallyl)malonate product. The system has the advantages of high enantioselectivity, high catalytic efficiency, wide substrate application range and mild conditions.

The invention belongs to the technical field of medicine detection, and particularly relates to dipropyl malonic acid prepared by a dimethyl malonate method and a detection method of impurities of the dipropyl malonic acid. According to the detection method provided by the invention, the dipropyl malonic acid prepared by a dimethyl malonate method and impurities thereof are detected through high performance liquid chromatography (HPLC) for the first time; the impurities comprise propyl malonic acid, 2-methyl-2-propyl malonic acid, 2-propyl-2-butyl malonic acid, propyl malonic acid monomethyl ester, 2-methyl-2-propyl malonic acid monomethyl ester, dipropyl malonic acid monomethyl ester, 2-propyl-2-butyl malonic acid monomethyl ester, propyl malonic acid dimethyl ester, dipropyl malonic acid monopropyl ester and propyl malonic acid dimethyl ester; the invention relates to a method for preparing dipropyl malonic acid, which is selected from one or more of dipropyl malonic acid dimethyl ester, dipropyl malonic acid methyl ester propyl ester and 2-propyl-2-butyl malonic acid dimethyl ester, and solves the problems of quality control and process evaluation of dipropyl malonic acid serving as an intermediate of sodium valproate prepared by a dimethyl malonate method.

The invention discloses a method for catalytically synthesizing alpha-disubstituted ester, amide, malonic acid monoester or monoamide from disubstituted Meldrum's acid. By developing a new strategy for promoting the ring-opening reaction of the disubstituted Meldrum's acid by alkali, the disubstituted malonic acid monoester or monoamide can be efficiently prepared, and compared with the previous method, the strategy can obtain the target product at the room temperature at the yield of 99%. The method successfully breaks through the limitation of the existing disubstituted malonic acid monoester synthesis method, and enriches the types of target compounds. Besides, a series of novel disubstituted malonic acid monoesters are obtained, and simple chemical conversion is applied to obtain a series of disubstituted malonic acid derivatives with quaternary carbon centers. Then, under the action of a chiral organic catalyst, chiral disubstituted malonic acid monoester is obtained with high yield and high enantioselectivity. And a solid foundation is laid for subsequent application of the compounds in subjects of materials, medicines and the like.