76 results about "Metal ion sequestering" patented technology

The technology of the present disclosure generally relates to the field of power storage devices, and more specifically to a solid electrolyte, an electrode, a solid-state battery, and a method for producing the same. An aspect of the present disclosure relates to a process for producing a solid electrolyte, comprising the steps of: - contacting, in the presence of a catalyst: - a polymer precursor compound comprising polyethylene glycol (PEG) and / or polytetrahydrofuran (PTHF), wherein the polymer precursor compound comprises on average per polymer precursor molecule, -at least 2.0 alkoxysilyl functional groups, with a functionality of at least 2.0, preferably at least 2.5, preferably at least 3.0; and / or -at least 1.0 alkoxysilyl functional groups, with a functionality of at least 3.0; - optionally, an organo-tri-alkoxy silane, an organo-tetra-alkoxy silane, and / or a mixture thereof comprising a metal ion (M+) chelating moiety being a cyanurate, a crown ether, an aza-crown ether, a thia-crown ether, a cryptand, a carbamate, a cyano group, a thiocyanate group, or a metallacrown,, - a metal (M+) salt, preferably does the metal salt comprises Li+, Na+, Mg+, Ca+, Al+, and / or a combination thereof, preferably lithium (Li+); - a solvent, preferably an organic solvent; and, - optionally, an ionically conductive compound; thereby obtaining a solid electrolyte; - optionally, drying the obtained solid electrolyte.

The invention relates to the technical field of daily chemicals, and particularly discloses a dishwashing liquid for a low-temperature dishwasher and a preparation method of the dishwashing liquid. The dishwashing liquid for the low-temperature dishwashing machine comprises a colored stain removal synergistic composition, in the dishwashing liquid for the low-temperature dishwashing machine, the mass percentage of the colored stain removal synergistic composition is 30-40%; the colored stain removal synergistic composition is prepared by mixing sodium glucoheptonate and trisodium methylglycine diacetate according to a mass ratio of (1-3): 1. The synergistic composition for removing the colored stains has excellent low-temperature stability and high-efficiency metal ion chelation capacity, the dishwashing liquid containing the above content can efficiently remove the colored stains such as tea stains, coffee stains and fruit stains in a low-temperature environment, the decontamination effect of the dishwashing liquid in the low-temperature environment is improved, and the dishwashing liquid has the advantages of being environmentally friendly and free of toxic and side effects. And the defect that a liquid detergent cannot clean the stains is overcome.

This invention discloses a method for preparing vicinal diamine derivatives, belonging to the field of pharmaceutical intermediates and organic synthesis technology. Specifically, under an inert atmosphere, an aldehyde imine, an N-aryl tertiary amine, a base, a cadmium selenide quantum dot catalyst, and a solvent are mixed and reacted under blue light irradiation for 8-24 hours. After extraction with ethyl acetate and saturated brine, the organic phase is collected, dried, the solvent is removed by vacuum distillation, and purified by column chromatography to obtain the vicinal diamine derivatives. The vicinal diamine derivatives synthesized by this invention can be used as synthetic intermediates and metal ion chelating agents in drug synthesis and fine chemical industries.

This invention provides a battery separator with ion adsorption capabilities and its preparation method, belonging to the field of new energy battery technology. It solves the problem of battery capacity decay and deterioration of cycle performance caused by ion leaching damaging the SEI film and consuming active lithium. The battery separator of this invention includes a base film and a ceramic coating on at least one surface of the base film. The raw materials for preparing the ceramic coating include porous organic framework materials, metal ion chelating agents, ceramic particulate materials, wetting agents, and binders. This invention significantly improves the dispersion ability of the slurry and shortens the dispersion time by using metal ion chelating agents instead of traditional dispersants. Simultaneously, the use of binders containing specific functional groups crosslinks with the porous organic framework materials and forms a synergistic effect with the chelating agents, thereby jointly enhancing the battery separator's ability to adsorb metal ions. This effectively solves the problem of poor stability in high-energy-density battery systems, thus significantly improving the battery's energy density and cycle life.

The invention discloses a bio-responsive high polymer material and application thereof, and belongs to the technical field of biomedical materials. The bio-responsive high-molecular material provided by the invention contains polymers shown as formulas i to viii. Wherein the polymers of the formulas i to viii have excellent fluorescence performance, aggregation-induced fluorescence enhancement performance, multicolor luminescence performance and biological response capability based on a redox reversible switch, and can be applied to sensing, counterfeiting prevention, metal ion detection, multicolor imaging of in-vivo and in-vitro cells and / or tissues and quantitative detection of in-vivo and in-vitro oxidized and / or reducing substances; active oxygen in in-vivo and in-vitro tissues and cells can be removed to achieve long-acting anti-inflammatory and anti-oxidation effects, and the compound can be used for treatment of oxidative stress related diseases and visual monitoring of the treatment process; the biological activity of enhancing tissue retention, stimulating collagen generation, repairing tissue and resisting oxidation and aging of the tissue is achieved, and the effect of filling and repairing in-vivo cells and tissue can be effectively improved; the compound also has the capability of being chelated with metal ions to form a high-molecular metal complex, and can be used for resisting tumors, resisting bacteria, filling and repairing tissues, promoting collagen generation and the like.

The application discloses a comprehensive treatment agent for recycling fracturing flowback fluid, which comprises the following components: boron shielding agent, metal ion chelating dispersant, bactericide, pH regulator, clay stabilizer, filtrate reducer and water. The application can form a spatial net structure by using a composite multi-hydroxyl molecule to shield residual boron crosslinking agent, use a multi-metal chelating dispersant to treat high-valence metal ions such as iron, calcium and magnesium, use a high-efficiency bactericide to reduce the influence of bacteria on the prepared liquid, use a slow-release acid to properly adjust the pH value of the prepared liquid system, and add a clay stabilizer and a filtrate reducer to cope with the adverse influence of the formation on the fracturing fluid. The above additives jointly form the comprehensive treatment agent for recycling fracturing flowback fluid. The treatment agent can treat the influence of residual boron, iron, calcium, magnesium and other elements in the fracturing flowback fluid by a small amount of addition, kill bacteria, adjust the pH value and ensure the successful recycling of the fracturing flowback fluid after treatment.

This invention discloses a stable nalmefene hydrochloride injection and its preparation method, relating to the field of biomedical technology. The injection consists of nalmefene hydrochloride, sodium chloride, hydrochloric acid, and water for injection, and contains no metal ion chelating agents, with a pH value controlled between 3.5 and 3.6. The method includes: preparing the solution and adjusting the pH under high-purity nitrogen protection in a solution preparation system with low metal ion introduction risk; filtering the solution through a polyethersulfone membrane with low metal leaching, and then filling it into ampoules with a vulcanized inner surface. This invention, through the systematic integration of multiple measures such as source control of the solution preparation system, inert atmosphere protection, precise pH control, surface passivation of packaging materials, and the use of high-purity materials, synergistically inhibits the metal ion catalytic oxidation of the active ingredient, ensuring that the content of the key degradation impurity II (2,2'-bisnalmefene) remains stably below the quality standard during long-term storage, solving the problem of chemical stability control of products in chelator-free formulations, and combining safety and process robustness.

The invention provides a flax roving scouring and bleaching process which comprises the following steps: 1, loading flax roving into a creel with a Teflon coating in a loose uniform winding manner, and controlling the total yarn loading amount to be 75 + / -5% of the effective volume of a main scouring and bleaching pot; 2, soft water is injected into a saucepan according to the liquid ratio of 1: 10-1: 15, the temperature is increased to 65-75 DEG C, a nonionic penetrant is added, the creel in the step 1 is hung into the saucepan after operation is conducted for 5 minutes, heat preservation operation is conducted for 25-35 minutes in a positive and negative circulation alternating mode, and after waste liquid is discharged, normal-temperature soft water is used for washing twice in an overflow mode, and washing is conducted for 10 minutes each time; 3, formic acid and a metal ion chelating agent are added into a main pot, water is added till the liquid ratio is 1: 12, a circulating pump is started, the temperature is increased to 50-55 DEG C, the washed creel is put into the main pot, the temperature is kept, the stirring reaction is conducted for 20-30 minutes, the pH value is monitored and maintained to be 3.0-3.5 in the process, and after pickling is completed, waste liquid is pumped into a neutralization pool to be treated after being filtered through a stainless steel filter screen.

The invention relates to the technical field of active peptide chelate preparation, and discloses a high-chelation-rate colla corii asini peptide-metal ion chelate preparation method, which comprises: preparing a colla corii asini protein solution; adding a metal ion solution into the colla corii asini protein solution to carry out pre-reaction so as to construct a metal ion template; then adding a core function protease with a self-speed-limiting characteristic on a product, and carrying out synchronous enzymolysis-chelation reaction under the guidance of a template; and finally terminating the reaction to obtain a product. According to the method, oriented cutting of protease hydrolysis sites is realized by pre-constructing a metal ion template, and excessive hydrolysis of the product is avoided by utilizing the self-speed-limiting characteristic of the core function protease. Enzymolysis and chelation reaction are carried out synchronously, so that the process flow is obviously simplified, and the loss of intermediate products is avoided. The colla corii asini peptide-metal ion chelate prepared by the method has the technical effects of high chelation rate, concentrated molecular weight distribution and high utilization rate of raw material protein.

According to a natural detergent composition, a detergent composition according to one aspect does not use synthetic chemical components such as metal ion chelating agents, unlike conventional synthetic detergents, so it does not cause environmental pollution, is harmless to the human body, is non-irritating to the skin, has low mineral salt precipitation, and has excellent cleaning power.

The application relates to the technical field of biological detection, and particularly discloses a rapid detection kit for Helicobacter pylori and an application method thereof; the kit comprises a sample processing liquid, an antigen pre-enrichment particle suspension and an immunochromatography test paper card; the sample processing liquid comprises an antigen-induced release system, a composite lysis system, a matrix interference blocking system and a chromatography promoter; the antigen pre-enrichment particle is a magnetic nanoparticle with an anti-Helicobacter pylori antibody coupled on the surface; and the immunochromatography test paper card is provided with a first detection line, a second detection line and a quality control line on a nitrocellulose membrane in sequence. The antigen is mildly and efficiently released through the antigen-induced release system, the bacterial cell wall is synergistically lysed through non-ionic and anionic surfactants, the interference substance is blocked through a double mechanism of a protein blocking agent and a metal ion chelating agent, the low-abundance antigen is enriched through the magnetic nanoparticle, and the sample effectiveness is monitored through the second detection line.

The application belongs to the technical field of biosensing, and particularly relates to a giant magnetoresistance biosensor for detecting protease, a preparation method and application thereof, which comprises a giant magnetoresistance sensor, a glass sheet plated with a gold film, a functional polypeptide and metal ion chelated magnetic beads; wherein the glass sheet plated with the gold film is fixed on the giant magnetoresistance sensor, one end of a peptide chain of the functional polypeptide is connected with the glass sheet plated with the gold film, and the other end is connected with the metal ion chelated magnetic beads; the giant magnetoresistance biosensor provided by the application can realize monitoring of protease activity, has high sensitivity, strong anti-interference ability, stable performance, and is easy to integrate, so that the giant magnetoresistance biosensor can develop into a portable detection device for large-scale promotion, and has wide application prospects in the fields of diagnosis, treatment and related drug development of major diseases.

The invention relates to the technical field of deodorization, and particularly discloses an N-containing compound peculiar smell removing liquid. The N-containing compound peculiar smell removing liquid is prepared from the following raw materials in parts by weight: 0.5 to 5 parts of polyene polyamine, 1 to 10 parts of cyclodextrin, 0.1 to 3 parts of weak acid, 0.1 to 2 parts of a nonionic surfactant, 0.01 to 0.5 part of a metal ion chelating agent, 0.01 to 0.5 part of plant essential oil and 80 to 95 parts of deionized water, the preparation method comprises the following steps: reducing a cyano group into a primary amino group by using ethylenediamine and acrylonitrile, decolorizing by using activated carbon, distilling and purifying to obtain polyene polyamine, dissolving a polyene polyamine intermediate, cyclodextrin, weak acid, a nonionic surfactant and a chelating agent in water at controlled temperature to form a base solution, finally adding a plant essential oil mixture and a preservative, and cooling to obtain a finished product. The composition / product provided by the invention can be used for treating the environment polluted by the peculiar smell of the nitrogen-containing compound, and has the advantages of high-efficiency broad-spectrum deodorization and good environmental compatibility.

The present application relates to a kind of perovskite solar cell and preparation method thereof, the perovskite solar cell between the hole transport layer and the perovskite film layer, and / or, the electron transport layer and the perovskite film layer are provided with passivation layer, the passivation layer includes organic covalent framework material.The organic covalent framework material used in the present application combines porphyrin unit with pyridine unit, ordered one-dimensional pore structure not only provides efficient adsorption site for noble metal ions, while the structure in pyridine group and formed imine bond can also absorb metal ions, and polybasic heterocyclic structure can also be chelated with metal ions, inhibit migration.In addition, the organic covalent framework material contains abundant passivation group, which can also significantly reduce the defects on the surface of perovskite, improve the performance of perovskite solar cell.

The present invention relates to a process for fractionation and complete recovery of flavonoids, terpenes and polysaccharides from the peel of plant material, such as citrus peels, without generating waste liquids. The present invention also relates to the flavonoids, terpenes and polysaccharides obtained by the process, as well as their use in various applications in the food, cosmetic, pharmaceutical or chemical fields. The process developed by the inventors allows the complete recovery of the flavonoids, terpenes and polysaccharide components, without using extreme pH and temperature conditions, and without generating waste liquids, providing a clean and sustainable process, since citrus peels are used as the starting point material, and the process comprises a step of acid synthesis by metal ion chelation mechanism.

The application belongs to the technical field of materials, and discloses a non-noble metal catalyst for biomass hydrogenation reaction, and a preparation method thereof, which comprises the following steps: adding A fuel and B metal salt into distilled water, heating, stirring and dissolving, and obtaining a gel along with water evaporation; placing the gel into a high-temperature device, and obtaining metal oxide powder with a spinel structure through a combustion reaction; and reducing the metal oxide powder, thereby obtaining the catalyst. The preparation method of the catalyst uses nitrate or acetate of the non-noble metal B as raw material, and A fuel is chelated with metal ions as a ligand during mixing and stirring, and uniformly disperses the metal ions, and is oxidized by the metal salt as fuel during the solution combustion synthesis, releases heat, decomposes to generate gas, and brings abundant mesopores to the obtained spinel oxide. The raw material is low in cost, green and environment-friendly, the preparation process is simple, the period is short, and the catalyst has great industrial application potential.

This invention provides a cell culture additive composition for preventing antibody disulfide bond reduction and its application, relating to the biopharmaceutical field. It comprises the following raw materials: a redox regulator, a metal ion chelator, an antioxidant, an adjuvant, and a cell protectant. This invention inhibits antibody disulfide bond reduction from multiple aspects through the synergistic effect of the redox regulator, metal ion chelator, antioxidant, and buffer. Specifically, the redox regulator maintains a suitable redox potential, the metal ion chelator removes harmful metal ions, the antioxidant removes free radicals, and the buffer maintains pH stability. The components work together synergistically to enhance the effect.

The invention discloses a process for reducing metal residues in an ethylene-cycloolefin copolymer, and relates to the technical field of ethylene-cycloolefin copolymers. A specific chelating agent is added into an ethylene-cycloolefin copolymer solution, three high-activity sites, namely a phosphate group, a hydroximic acid group and a carboxylic acid group, contained in molecules of the chelating agent are utilized, and uniform mixing mass transfer under the assistance of a phase transfer catalyst and ultrasonic oscillation is performed through a unique three-functional-group structure of the chelating agent; a stable chelate with a five-membered ring structure can be formed with metal ions (titanium, zirconium, aluminum and the like); meanwhile, the introduced hydrogen peroxide plays a key role in activation and cleaning instead of a direct chelating agent, and forms a soluble metal complex by oxidizing a metal center, so that the efficiency of capturing metal ions by the chelating agent is remarkably improved, and the high purity and high performance of the polymer are ensured; finally, simple, convenient and efficient metal ion chelation, adsorption and removal are realized.

The application provides a nucleic acid preservative for giant panda fecal samples and a preparation method thereof. The preservative is composed of the following components in the final concentration: buffer, 1-200 mM; metal ion chelator, 0.01-1 M; ion strength maintaining agent, 0.01-2 M; denaturant, 0.01-10 M; antioxidant, 1%-5% (V / V); antifreeze, 5%-30% (V / V); nucleic acid protective agent, 0.1%-5% (W / V); bacteriostatic agent, 0.5-500 ppm; and all the components are dissolved in deionized water. The preservative has the characteristics of convenient field operation and safe transportation. The DNA structure of the giant panda can be effectively prevented from being damaged by various fecal inhibitors by only soaking at room temperature, the preservative is suitable for the preservation of fresh or old fecal samples, and the DNA in the giant panda fecal samples can be stably preserved for a long time (6 months).

The invention relates to the field of dermatological external preparations, in particular to a compound external ointment for treating trichophyton rubrum infection and a preparation process of the compound external ointment. The ointment specifically comprises the following components in percentage by weight: 0.50-1.50% of an antifungal active ingredient; 0.50% to 2.00% of saturated phosphatidylcholine; 0.20%-0.40% of a cross-linked acrylic rheology modifier; 4.0 to 10.0% of an oil phase; 0.10%-0.30% of a cationic film forming agent; 0.02 to 0.05 percent of a metal ion chelating agent; and water to 100%. And the pH value is adjusted to 4.6-4.9. Through cooperation of the saturated phosphatidylcholine, the cross-linked acrylic acid gel, the cationic film-forming agent and the chelating agent and pH control, the formula does not collapse, does not cause phase separation and is stable in release in the presence of sweat, the effective dose of the skin superficial layer can be maintained, and trichophyton rubrum can be continuously inhibited.

The invention belongs to the technical field of biological medicines, and particularly relates to a temperature-sensitive spray for promoting healing of a wound difficult to heal, in particular to a spray taking yak bone peptide as an active component and poloxamer as a temperature-sensitive matrix as well as a preparation method and application of the spray. The spray is prepared from the following components in percentage by weight / volume: 0.01 to 1.5 percent of yak bone peptide solution, 10 to 20 percent of poloxamer F127 and the balance of buffer solution. The spray is a solution capable of freely flowing in an environment below 25 DEG C, can be converted into semi-solid gel within 1 minute after being in contact with a wound surface at 32-37 DEG C, and has the advantages of convenience in use, in-situ gelation, good drug retention, capability of sustainably releasing drugs and capability of effectively promoting healing of the wound difficult to heal. The yak bone peptide has certain free radical scavenging and metal ion chelating capabilities, can relieve oxidative stress injury, optimizes a cell repair microenvironment, and can prevent chronic development of a wound healing process by regulating inflammatory factor expression and inhibiting early excessive inflammatory response.

This invention belongs to the field of exosome preservation technology and discloses a stabilizer composition for exosome cryopreservation and its application. The stabilizer composition for exosome cryopreservation provided by this invention consists of the following components and their amounts: phytosphingosine: 0.1%-0.2%; cerebroside sulfate: 0.05%-0.1%; trehalose: 2%-5%; lipid-soluble antioxidant: 0.01%-0.05%; HEPES buffer: 10-20 mM; metal ion chelating agent: 0.01%-0.05%. The composition of this invention forms a "gradient protection" through the membrane insertion of phytosphingosine and the shallow negative charge shielding of cerebroside sulfate, enabling stable cryopreservation of exosomes for more than one week with a bioactivity retention of >85%. This preservative is animal-free, easy to use, and effective, making it suitable for the clinical translation and practical application of exosomes.

The invention discloses a rare earth doped aluminate nanocrystal capable of emitting light in a near-infrared second region through ultrasonic excitation as well as a preparation method and application of the rare earth doped aluminate nanocrystal. The preparation method comprises the following steps: mixing an alkaline earth metal ion compound, an aluminum ion compound, a rare earth ion compound and a polydentate ligand in water for complex reaction to prepare a metal ion chelate precursor; performing high-temperature solid-phase thermal decomposition reaction on the metal ion chelate precursor, performing surface fat-soluble molecular modification in a thermal solvent, and performing surface hydrophilization modification by adopting an amphiphilic polymer to prepare the rare earth doped aluminate nanocrystal capable of emitting near-infrared second region by ultrasonic excitation. The rare earth doped aluminate nanocrystal is prepared by adopting an amorphous complex high-temperature solid-phase thermal decomposition method, the reaction condition is controllable, the operation is simple, the repeatability is good, the used reagent is cheap and easy to obtain, the rare earth doped aluminate nanocrystal has the property of ultrasonic excitation near-infrared second-region luminescence, and the wavelength can be adjusted within 900-2500 nm.

The invention provides a multistage-structure sepiolite coating diaphragm and a preparation method thereof, the multistage-structure sepiolite coating diaphragm comprises a base membrane and a composite coating, the composite coating is coated on the surface of one side or two sides of the base membrane, and the composite coating is coated on the surface of the other side or two sides of the base membrane. The composite coating is composed of the following components in percentage by mass: 15-25% of modified sepiolite, 5-8% of a conductive polymer, 5-8% of a lithium salt dispersion liquid, 5-8% of a binder and the balance of deionized water, and the modified sepiolite is an ammonia water assisted silane grafting-metal ion chelating-mesoporous silica coated modified product. The composite material has a'one-dimensional fiber-nanoparticle-mesoporous shell layer 'three-stage interwoven structure. The one-dimensional sepiolite fiber provides a macroscopic transmission path, the surface-chelated nanoparticles reduce an ion migration energy barrier, and the mesoporous silica shell layer realizes rapid transmission of lithium ions. And meanwhile, by combining the pre-dispersion design of the lithium salt and the synergistic effect of the conductive polymer, the conductivity of the lithium ions is further improved.

The application discloses a method for growing carbon nanotubes with high growth rate, and relates to the technical field of new carbon materials.The metal ions are chelated and fixed in the block-shaped graphene aerogel or graphene aerogel microspheres by the action of metal ligands, the metal ions are in-situ reduced into nano metal particles by high-temperature thermal reduction, the graphene aerogel microspheres or block-shaped graphene aerogel loaded with metal nano particles are obtained, and high-purity carbon nanotubes are further prepared by high-temperature catalytic cracking of organic gas.The metal nano particles are uniformly dispersed in the porous structure of the graphene aerogel, the catalytic activity is greatly improved, the growth rate of the carbon nanotubes is more than 100, and the carbon nanotubes are high in purity and do not need to be further acidified and purified.

The application discloses a metal ion chelating structure applicable to mass spectrometry flow detection, and discloses a preparation method and application of the metal ion chelating structure. The metal ion chelating structure can efficiently chelate metal ions such as lanthanide metal ions and transition metal ions, and can directly connect the metal ions such as the lanthanide metal ions and the transition metal ions to antibodies, has high application performance, and meets the application requirement of mass spectrometry flow detection. The metal ion chelating structure has wide applicability, can improve the number of metal markers of mass spectrometry flow detection, and expands more detection channels. The preparation method of the metal ion chelating structure is simple in process, easy to synthesize, and low in cost.

The invention discloses an antioxidant stable multivitamin injection and a preparation process thereof, and relates to the technical field of medicines. The injection comprises a fat-soluble vitamin component, a water-soluble vitamin component, a graded targeting anti-oxidation system, a compound stabilizer and water for injection, the graded targeting anti-oxidation system is matched with an exclusive antioxidant combination according to vitamin solubility difference, and the compound stabilizer synergistically exerts pH stabilization and metal ion chelation effects. The preparation technology comprises the steps of raw material pretreatment, grouped dissolution, mixing and constant volume, low-temperature pulse sterilization and encapsulation, targeted protection of all-component vitamins is achieved through measures of grouped dissolution, whole-process nitrogen protection, precise sterilization parameter control and the like, oxidative degradation and activity loss are reduced, and the quality of the product is improved. The normal-temperature storage stability of the product and the safety and effectiveness of clinical medication are improved.

This invention provides a ligand compound and chelate for targeting PSMA, and their applications. The structural formula of the compound is shown in Formula I-1, wherein X is -(CH2). m -CONH-CHR3(CH2) n -R4, R3 are selected from hydrogen, C1-C5 straight-chain or branched alkyl, C1-C5 straight-chain or branched alkoxy, C1-C5 straight-chain or branched alkylthio, halogen, cyano, nitro, hydroxy, carboxyl, sulfonic acid, phenyl, and amino-substituted C1-C5 straight-chain or branched alkyl; R4 is selected from optionally substituted C1-C5 straight-chain or branched alkyl, optionally substituted C1-C5 straight-chain or branched alkoxy, optionally substituted C1-C5 straight-chain or branched alkylthio, optionally substituted 6-14 aryl, optionally substituted 5-14 heteroaryl, as well as halogen, cyano, nitro, hydroxy, carboxyl, sulfonic acid, C1-C5 straight-chain or branched alkylamide and C1-C5 straight-chain or branched alkylsulfonamide; m is an integer from 2 to 4; n is an integer from 1 to 3; Z is a radioactive metal ion chelating group. The stability and safety of this PSMA-targeting ligand compound were significantly improved, and it exhibited superior tumor-suppressive effects.