The invention discloses total mixed pellet feed for meat sheep and a manufacturing method and application of the feed. The feed comprises: 20.00-40.00% of straw, 0.00-30.00% of caragana korshinskii, 0.00-30.00% of sunflower shells, 0.00-30.00% of leymus chinensis, 10.00-30.00% of corn, 5.00-10.00% of molasses, 5.00-8.00% of soybean meal, 0.00-10.00% of cottonseed meal, 0.00-5.00% of sesame meal, 0.00-15.00% of maize germ meal, 0.00-5.00% of rapeseed meal, 0.00-8.00% of corn bran with slurry, 0.00-3.00% of wheat bran, 0.00-5.00% of rice bran, 0.00-20.00% of corn distiller's dried grains with soluble, 0.00-3.00% of bentonite, 0.40-0.80% of salt, 0.10-0.50% of calcium hydrogen phosphate, 0.50-1.50% of stone flour, 0.00-0.80% of slow-release protein, 0.50-1.50% of sodium bicarbonate, 0.04-0.08% of a mildew inhibitor, 0.40-0.50% of ammonium chloride, 1.00-3.00% of Chinese herbal medicine premix and 0.80-1.50% of meet goat fattening premix. The feed can replace common refined feeding and roughage, the breeding process is simplified, the breeding cost is saved, and the total mixed pellet feed can prevent the occurrence of rumen acidosis and urinary calculus of meet sheep.