22results about How to "Solve solubility" patented technology

The invention discloses a preparation method and application of a fish I-type collagen sodium alginate supramolecular assembly, fish processing byproducts are used as raw materials, and the fish I-type collagen is prepared by an acetic acid extraction and salting-out column chromatography purification integrated technology. The preparation method comprises the following steps: by taking fish type I collagen as a raw material, adding sodium alginate, and carrying out composite reaction, so as to obtain a mixed solution of the fish type I collagen, the sodium alginate and the fish type I collagen sodium alginate supramolecular assembly; and purifying the product by using a salting-out membrane separation integration technology to obtain the fish type I collagen sodium alginate supramolecular assembly. The fish type I collagen sodium alginate supramolecular assembly prepared by the invention keeps a triple helix structure of the type I collagen, shows good biocompatibility, and solves the application bottleneck problems of poor solubility and stability of the fish type I collagen and the like; the composition has the advantages of excellent solubility, high thermal stability, remarkable anti-wrinkle and moisturizing effects and good safety, so that the composition is very suitable for being applied to the field of anti-aging cosmetics.

The invention relates to a method for ultrasonic-enhanced extraction of a multicoloured leaf extract by using an ethanol and ethyl acetate cosolvent, and belongs to the technical field of chemical engineering and plant extraction. (2) synergistically degrading cellulose by using multi-component glycosidase; (3) cosolvent extraction; 4, chloroplast pigment is efficiently separated and purified, chlorophyll and other impurities in an extracting solution are effectively separated and removed through silica gel column chromatography, and therefore the high purity of the multicoloured leaf extract is achieved; according to the invention, ethanol and ethyl acetate are used as cosolvents to extract the multicoloured leaf extract, so that the extraction efficiency and the purity of the extract can be improved.

The invention relates to a preparation method of a high-performance soybean protein emulsion film, which comprises the step of carrying out fibrosis denaturation on soybean protein by adopting an acetic acid-water binary solution, so that the hydrophobic property, the film-forming ability and the environmental interference resistance of the soybean protein can be remarkably improved. And further starting from a protein self-assembly fibrosis principle and a protein film forming theory, a soybean protein-based biological membrane with certain mechanical strength and flexibility is constructed through self-assembly fibrosis denaturation of protein molecules in an aqueous solution, so that the problems of poor mechanical property and high solubility of the existing protein-based biological membrane are effectively solved.

The invention belongs to the technical field of production of high value-added chemicals and catalysts, and particularly relates to a preparation method of an In2S3 (at) PDA / SA / PDMS / MS three-phase integral photocatalyst for producing H2O2. The preparation method comprises the following steps: preparing In-Co PBA nano-cubes through a precipitation reaction of InCl3 and K3 [Co (CN) 6], obtaining In2S3 through a one-step anion exchange reaction, loading polydopamine PDA on the surface of the In2S3 through an in-situ polymerization reaction to synthesize an In2S3 (at) PDA photocatalyst, mixing the In2S3 (at) PDA with sodium alginate SA hydrogel, and loading the mixture onto a PDMS modified melamine sponge MS to obtain the In2S3 (at) PDA / SA / PDMS three-phase (gas-liquid-solid) integral photocatalyst. Under the irradiation of visible light, the yield of H2O2 produced by the monolithic catalyst within 90 minutes reaches 4.6 mmol / g. The method has the characteristics of simplicity, convenience, high efficiency and low cost, and can be applied to photocatalytic production of H2O2.

The invention relates to a small organic molecule material, a preparation method thereof and an application of the small organic molecule material in an aqueous zinc ion battery, and the small organic molecule material is an imine small organic molecule (PD-TABQ) formed by condensation of 1, 10-phenanthroline-5, 6-diketone and 2, 3, 5, 6-tetra (amino) p-benzoquinone. The small organic molecule is prepared by carrying out reflux reaction, washing and drying on 1, 10-phenanthroline-5, 6-diketone and 2, 3, 5, 6-tetra (amino) p-benzoquinone, and has the advantages of low solubility, good conductivity, large capacity density and good cycle performance. When the PD-TABQ positive electrode is applied to an aqueous zinc ion battery, the PD-TABQ positive electrode has the high initial capacity of 163.4 mAh g <-1 > under the current density of 0.1 Ag <-1 >. And excellent performance and application prospects are shown in the field of aqueous zinc ion batteries.

The present application relates to a kind of high stability water-in-oil PDRN emulsion and its preparation method, belong to the field of biotechnology;The preparation method includes the following steps: (1) PDRN enzymolysis: PDRN is added in DNaseI, supplement metal ion activates enzyme, when fragment enrichment shows <800bp, terminate enzymolysis reaction, obtain crude enzymolysis solution;(2) moderate molecular weight screening: pressurized ultrafiltration crude enzymolysis solution with ultrafiltration membrane, and screen out the target fragment of the permeate of molecular weight in 120-500bp;(3) water phase system optimization: 1,3-propanediol and ubiquinol are added in the permeate;(4) semi-continuous feeding gradient emulsification.The present application is by precise control PDRN molecular weight to take into account stability and solubility, optimize water phase component to realize system viscosity and transparency double standard, cooperate gradient emulsification to guarantee water-in-oil system stability, significantly improve product comprehensive quality and application value, with outstanding technical advantages.

The utility model discloses a water and fertilizer integration machine relates to irrigation related technical field. The utility model discloses a water and fertilizer mixing tank, water pipe, material pipe, base plate and base, and the upper fixed joint of base upper end has water and fertilizer mixing tank, and the upper portion of water and fertilizer mixing tank one side is fixed with water pipe, and the upper portion of water and fertilizer mixing tank opposite water pipe side is fixed with material pipe, and the top of material pipe is fixed with material cylinder, and the inside of material cylinder is provided with grinding parts, the bottom rotation of base plate is connected with main shaft, and the lower portion of main shaft and auxiliary shaft all are fixed with the stirring paddle of annular array distribution. The utility model discloses a main shaft, auxiliary shaft, base plate, material pipe, material cylinder, grinding parts, filter one, filter two, base, gyro wheel, water pump, liquid outlet hose, solve the problem that the water and fertilizer integration machine is short of supplementary stirring mixing structure, and solid fertilizer is short of pretreatment structure, and the impurity in water and fertilizer and irrigation water possibly blocks the pipeline, and the adaptability of fixed type water and fertilizer integration machine is lower.

The present invention relates to an anti-aging liposome composition and its application. The composition comprises 0.1-1 parts of Sophora japonica bud extract, 1-4 parts of Pueraria root extract, 2-6 parts of aminobutyric acid, 50-60 parts of polyol, 2-6 parts of emulsifier, 9-18 parts of auxiliary emulsifier, 0.2-1 parts of cholesterol, 10-35 parts of water, and the auxiliary emulsifier comprises auxiliary emulsifier I polysorbate-20 and auxiliary emulsifier II PPG-6 decyl tetradecanol polyether-30, with a mass ratio of 1-4:8-14; during preparation, the Sophora japonica bud extract, Pueraria root extract, polyol, cholesterol, emulsifier, and auxiliary emulsifier I are first mixed and homogenized, and then water and aminobutyric acid are added; then the auxiliary emulsifier II is added after cooling. The present invention innovatively combines the Sophora japonica bud extract, Pueraria root extract, and aminobutyric acid in a liposome system, solves the solubility and absorption rate problems of the main active ingredients in the Sophora japonica bud extract and Pueraria root extract, and achieves a multi-pathway anti-aging effect.

The present invention provides a kind of favipiravir solution for atomized inhalation, preparation method and application. The inhalation solution contains 1-50mg / ml favipiravir, excipients and solvent in a single dose, and the pH value is 5.5-9.0, and the inhalation solution single dose specification is 2-5ml. The excipients include a cosolvent, a pH regulator and an osmotic pressure regulator. The cosolvent is selected from meglumine, and the mass ratio of favipiravir to meglumine is 1:1.25-1:1.34, and the pH regulator can be selected from sodium dihydrogen phosphate, disodium hydrogen phosphate, and one or more of potassium dihydrogen phosphate, the osmotic pressure regulator is selected from sodium chloride, and the solvent is selected from sterile water for injection. The solution of favipiravir can be used in combination with a liquid atomizer to provide a convenient, safe, effective and stable pharmaceutical dosage form and drug delivery system of favipiravir.

The invention discloses a pH-responsive supramolecular salicylic acid nanogel and a preparation method and application thereof, and the pH-responsive supramolecular salicylic acid nanogel comprises the following preparation raw materials by mass: 3-30% of salicylic acid; 0.6 to 1.5 percent of orthoester; 30 to 50% of poloxamer; 0.5 to 5.0 percent of polyhydric alcohol; 0.5-1% of a surfactant; and the balance solvent. Through supramolecular design, salicylic acid molecules and a precursor containing a pH sensitive group (orthoester) are integrally constructed into a nanogel network through non-covalent self-assembly, so that the contradiction between solubility and irritation of high-concentration salicylic acid is fundamentally solved; the prepared pH-responsive supramolecular salicylic acid nanogel can realize the synergistic effects of stable loading of high-concentration salicylic acid, targeted response release of an inflammatory site and low skin irritation, and the preparation process is simple, convenient and environment-friendly, is suitable for industrial production, and has a wide application prospect in the field of functional skin care products.

The invention provides a luteolin-4, 4 '-dipyridyl eutectic, a eutectic solvate and a preparation method of the eutectic and the eutectic solvate, and belongs to the technical field of pharmaceutical co-crystals. According to the luteolin-4, 4 'dipyridyl eutectic and the eutectic solvate provided by the invention, O-H..N intermolecular hydrogen bonds between luteolin and 4, 4' dipyridyl are utilized for bonding, the molecular structure has excellent stability, the solubility of luteolin can be improved, and the problems of low solubility and low bioavailability of luteolin are solved. The result of the embodiment shows that the solubility of the luteolin-4, 4 'dipyridyl 1: 1 eutectic solvate provided by the invention is 2.51 times of that of luteolin, and the solubility of the luteolin-4, 4' dipyridyl 2: 1 eutectic solvate provided by the invention is 1.32 times of that of the luteolin.

The present application discloses a flurana nanostructured lipid carrier and a preparation method thereof, which belongs to the technical field of insecticide preparation. The flurana nanostructured lipid carrier semisolid cream can be administered orally or externally, and is used for preventing and treating ectoparasitic diseases of pets such as dogs and cats. The present application improves the performance of the nanostructured lipid carrier by adding a quantitative polyol to the aqueous phase and compounding with lipids, which not only makes the nanostructured lipid carrier system more stable and has a high encapsulation rate, but also improves the release and absorption of the main drug in the nanostructured lipid carrier, solves the solubility of flurana, and improves the bioavailability, promotes the drug to better exert its therapeutic effect in the body, enables pets to improve the therapeutic effect while reducing the dosage of the drug, improves the safety of the drug, reduces the damage to the pet, and has significant clinical application value.

The application discloses a kind of applied in nonpolar organic system removal divalent mercury ion mercapto activated carbon and preparation method, belong to the technical field of demercuration.The method includes: first, activated carbon is contacted with strong oxidizing acid, and the surface of activated carbon is oxidized and modified, and pre-modified activated carbon is obtained;Afterwards, pre-modified activated carbon is placed in buffer solution, and is activated and handled;Afterwards, amidinothiourea is added to carry out coupling reaction, and activated carbon intermediate is obtained;Activated carbon intermediate is placed in organic solvent system containing mercaptan donor, catalyst and dehydrating agent, and is reacted under sealing and heating condition, introduces mercapto functional group, and obtains crude product modified activated carbon;Crude product modified activated carbon is stabilized by using antioxidant reagent, and is obtained.The mercapto activated carbon prepared by the application can significantly improve the removal efficiency of divalent mercury ion in nonpolar organic system.

The utility model discloses a disposable oral ulcer encapsulating film which comprises a body, the body comprises a first adhesion layer, a second adhesion layer and a sealing layer, one side of the first adhesion layer is adhered to the inner wall of an oral cavity, and the first adhesion layer is provided with a channel penetrating in the thickness direction of the first adhesion layer; the permeable layer is positioned on the other side of the first adhesion layer; a protective layer; wherein the first adhesion layer, the permeable layer and the protective layer are all food-grade water-soluble film layers, and the water-soluble duration required by the protective layer is smaller than the curative effect duration of the medicine; that is, spaces for adsorbing drugs are formed between the permeable layer and the first adhesion layer, and the permeable layer has the function of releasing drugs. According to the embodiment of the utility model, the disposable oral ulcer encapsulating film can be locally sealed after targeted medicine is given according to the specific condition of oral mucosa of a patient, so that the medicine is prevented from being quickly diluted, dissolved and swallowed to a certain extent, the medicine effect is fully exerted, and the optimal effect is achieved.

This invention relates to a method for preparing a kilogram-scale water-soluble nitrogen-containing actinide element extractant, comprising the following steps: S1. Synthesizing amide hydrazone via nucleophilic addition reaction: Adding hydrazine hydrate or anhydrous hydrazine to a dimethyl nitrile solution, performing a nucleophilic addition reaction, and then separating the solid and liquid phases to obtain the amide hydrazone; S2. Synthesizing pyridine triazine derivative via condensation cyclization reaction: Dispersing or dissolving the ground amide hydrazone and diphenylethylene glycol in a solvent, performing a condensation cyclization reaction, and then separating the solid and liquid phases to obtain the pyridine triazine derivative; S3. Obtaining the extractant via substitution reaction: Adding a sulfonating agent to the pyridine triazine derivative, refluxing to perform a substitution reaction, and then slowly adding the reaction mixture dropwise to a phase inversion agent to precipitate the extractant. Compared with the prior art, the preparation method of this invention is simple and feasible, with a simple reaction system, high product yield, short production cycle, simple processing technology, low energy consumption, inexpensive and readily available raw materials, and easy to industrialize, showing broad application prospects in the field of high-level radioactive waste disposal.

The utility model relates to the technical field of spice powder processing, and provides a spice powder soaking device which comprises a device body, a soaking barrel is movably embedded in the device body, sliding grooves are formed in the periphery of the interior of the device body, a plurality of sliding blocks are fixedly installed on the outer surface of the soaking barrel, and the sliding blocks are arranged in the device body. The outer surfaces of the multiple sliding blocks are connected to the inner surfaces of the sliding grooves in a sliding mode, telescopic columns are arranged at the bottoms of the multiple sliding blocks, and reset springs are arranged at the bottoms of the multiple sliding blocks. The contact mode of spice powder and liquid is continuously changed, the mixing effect of the spice powder and the liquid is enhanced, and the spice powder is more uniformly dispersed in the liquid through the mechanical lifting motion, so that the mixing efficiency is improved, and the problem of too slow mixing caused by static soaking is avoided.

The invention provides solid electrolyte slurry, electrode slurry and application. The solid electrolyte slurry comprises a solid electrolyte, a binder and a mixed solvent, wherein the content of the solid electrolyte accounts for 80wt%-99wt% of the total solid material, the content of the binder accounts for 0.1 wt%-5wt% of the total solid material, and the solid content of the solid electrolyte slurry is 20wt%-80wt%; the mixed solvent comprises N solvents, N is greater than or equal to 2, the boiling point of the mixed solvent is 100-200 DEG C, and the ionic conductivity attenuation of the solid electrolyte in the mixed solvent is less than or equal to 40%. According to the present invention, a plurality of different solvents are adopted to cooperate with a certain ratio according to the respective performance, such that the problems of low slurry viscosity, poor solubility and unstable rheological property caused by the adoption of the conventional low-polarity solvent in the solid-state battery are overcome.

The invention relates to the technical field of pharmacy and materials, in particular to a preparation method and application of chitosan oral microcapsules of tripterine, and the preparation method comprises the following steps: S100, dissolving tripterine in absolute ethyl alcohol to prepare a primary solution; s200, dissolving porous starch in the primary solution and carrying out ultrasonic dispersion; s300, carrying out rotary evaporation under the action of reduced pressure to remove ethanol so as to obtain a primary product; and S400, dissolving chitosan in an acetic acid solution to prepare a mixed solution, adding the primary precipitation product, and freeze-drying to obtain the (C-PS / tripterine). According to the invention, the oral bioavailability of the tripterine is successfully improved through the chitosan microencapsulated porous starch carrier.

The utility model discloses a herbicide sprayer for agricultural production, which relates to the technical field of sprayers and comprises an unmanned aerial vehicle and a spraying mechanism, a heating mechanism and a filtering mechanism are arranged on the spraying mechanism, the spraying mechanism comprises a pesticide storage box, a submersible pump, a battery pack and an atomizing nozzle, and a pesticide adding port is arranged at the top of the pesticide storage box. The pesticide storage box is fixedly installed on the lower end face of the unmanned aerial vehicle, the submersible pump is fixedly installed in the pesticide storage box to supply pesticide to the atomization spray head, the heating mechanism comprises a heating jacket and a disc-shaped electric heating wire, the disc-shaped electric heating wire is installed in the pesticide storage box, and the heating jacket is fixedly installed on the atomization spray head. The utility model has the advantage of integrating heating and filtering functions, and solves the problems that the liquid medicine is easy to freeze to block the nozzle and the spraying precision is influenced by undissolved particles in a low-temperature environment.

The invention discloses a three-dimensional organic eutectic material and a preparation method and application thereof, and belongs to the technical field of chemistry. The organic eutectic material is formed by donor molecules and acceptor molecules through self-assembly non-covalent bonds, three-dimensional organic eutectic crystals which are good in crystallinity, clear in crystal face and different in morphology are formed, and structural diversity preparation is achieved. The preparation process is flexible and controllable, and crystallization can be controlled by direct co-crystallization of donor molecules and acceptor molecules and by in-situ synthesis of donor molecules. The problem of solubility of donor and acceptor molecules is solved, and the ability to regulate and control morphology diversity is achieved. Under the water system condition of 0-100 DEG C, the preparation can be finished by only 1-10 minutes of reaction time, so that the limitations of slow crystallization under solvent evaporation speed control and lengthy preparation process in the traditional method are avoided; the dependence on an organic solvent is solved; the method is environment-friendly and beneficial to large-scale production, and the practical application process of the three-dimensional material is promoted. The organic eutectic material shows good performance in photocatalytic preparation of hydrogen peroxide.

Ellagic acid is a recognized whitening agent, antioxidant and nutrient, but its solubility is extremely low, which greatly limits its application. The present invention provides an ellagic acid nanosuspension for this problem, comprising ellagic acid nanoparticles with a particle size of 100-1000 nm, which are composed of ellagic acid and a preparation solvent, and the preparation solvent is preferably selected from water, ethanol, propylene glycol, butylene glycol, pentanediol or a mixed solvent thereof; a supersaturated ellagic acid solution is prepared by an ultrasonic process as a preferred embodiment, and the ellagic acid feed amount during preparation is ≥20mg / mL, and the ultrasonic temperature is ≥35°C as a preferred embodiment. The present invention does not need to add auxiliary materials, does not need a complex preparation process, can solve the problems of ellagic acid solubility (equilibrium solubility increases by more than 100 times), oral bioavailability (increased to 4.69 times) and in vitro transdermal absorption (significantly increasing intradermal content and transdermal amount), and simultaneously shows antioxidant activity significantly better than free ellagic acid and positive drug VC. Comprehensively display the development prospects of ellagic acid nanosuspension in the fields of oral, topical preparations and cosmetics.

The invention relates to the technical field of sodium ion batteries, in particular to an electrolyte and a sodium ion battery. The electrolyte comprises an organic solvent, a sodium salt and an additive, the additive comprises at least one of compounds with the structure shown in the specification; in the formula # imgabs0, R is selected from at least one of hydrogen, halogen, silyl, substituted or unsubstituted C1-C6 alkyl, phenyl, substituted phenyl, amido, pyrrolyl, thienyl, furyl, pyridyl, pyrazinyl and pyrimidyl. According to the electrolyte disclosed by the invention, by adding the additive containing fluorine and silicon, the problems of transition metal dissolution and electrode corrosion caused by HF are effectively solved, and construction of a complete, compact, high-stability and rigid-flexible positive solid electrolyte membrane is realized; therefore, the cycle performance of the sodium-ion battery is improved.